研究方向
病毒基因轉(zhuǎn)錄調(diào)控與免疫信號(hào)轉(zhuǎn)導(dǎo)，研究正致力于鑒定介導(dǎo)艾滋病毒（HIV-1）激活卡波濟(jì)肉瘤相關(guān)皰疹病毒（KSHV or HHV-8）復(fù)制的重要信號(hào)通路。
學(xué)術(shù)兼職
1、中國(guó)微生物學(xué)會(huì)理事；
2、中華醫(yī)學(xué)會(huì)醫(yī)學(xué)病毒學(xué)分會(huì)委員；
3、江蘇省微生物學(xué)會(huì)秘書長(zhǎng)；
代表論文
- Li W, Yan Q, Ding X, Shen C, Hu M, Zhu Y, Qin D, Lu H, Krueger BJ, Renne R, Gao SJ,Lu C*. The SH3BGR/STAT3 pathway regulates cell migration and angiogenesis induced by a gammaherpesvirus microRNA.PLoS Pathog, 2016 Apr 29;12(4):e1005605.Yao S, Hu M, Hao T, Li W, Xue X, Xue M, Zhu X, Zhou F, Qin D, Yan Q*, Zhu J, Gao SJ,Lu C*. MiRNA-891a-5p mediates HIV-1 Tat and KSHV Orf-K1 synergistic induction of angiogenesis by activating NF-κB signaling.Nucleic Acids Res, 2015 Oct 30;43(19):9362-78.Hu M, Wang C, Li W, Lu W, Bai Z, Qin D, Yan Q*, Zhu J, Krueger BJ, Renne R, Gao SJ,Lu C*. A KSHV microRNA directly targets G protein-coupled receptor kinase 2 to promote the migration and invasion of endothelial cells by inducing CXCR2 and activating AKT signaling.PLoS Pathog, 2015 Sep 24;11(9):e1005171.Xue M, Yao S, Hu M, Li W, Hao T, Zhou F, Zhu X, Lu H, Qin D, Yan Q*, Zhu J, Gao SJ,Lu C*. HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway.Nucleic Acids Res, 2014 Sep;42(15):9862-79.Zhu X, Guo Y, Yao S, Yan Q, Xue M, Hao T, Zhou F, Zhu J, Qin D*,Lu C*. Synergy between Kaposi’s sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef in promotion of angiogenesis and oncogenesis: role of the AKT signaling pathway.Oncogene, 2014 Apr 10;33(15):1986-96.
成就榮譽(yù)
近五年來(lái)，先后主持國(guó)家自然科學(xué)基金3項(xiàng)，霍英東青年教師基金、教育部新世紀(jì)優(yōu)秀人才支持計(jì)劃和江蘇省自然科學(xué)基金青年創(chuàng)新人才項(xiàng)目各1項(xiàng)。
獲得省級(jí)以上獎(jiǎng)勵(lì)3次，包括江蘇省科技進(jìn)步二等獎(jiǎng)1次、第九屆江蘇省青年科技獎(jiǎng)1次、安徽省科技進(jìn)步三等獎(jiǎng)1次。
