曾被評(píng)為江蘇省“六大”人才高峰人選，江蘇省“333”工程第二層次人選，校跨世紀(jì)學(xué)術(shù)帶頭人。

　　聯(lián)系方式：

　　電話： 025-83271369

　　email: minigene1@yahoo.com.cn

　　地址： 南京市童家巷24號(hào) 中國(guó)藥科大學(xué) 生命科學(xué)與技術(shù)學(xué)院 微基因藥物實(shí)驗(yàn)室

　　郵編： 210009

　　主要研究

　　(1)在美國(guó)North Texas大學(xué)醫(yī)學(xué)中心做博士后工作期間，在世界上首次從人視網(wǎng)膜發(fā)現(xiàn)了一種新型血管內(nèi)皮生長(zhǎng)因子－VEGF183，基因序列首先在國(guó)際基因庫(kù)登錄，并于1999年在Invest Ophthalmol Vis Sci.以第一作者發(fā)表（IF5.2）。

　　(2)以劉景晶為主完成的抗癌藥—門冬酰胺酶，已收載于2000年版中國(guó)藥典，榮獲江蘇省科技進(jìn)步二等獎(jiǎng)。以劉景晶為主完成的“酶法生產(chǎn)丙氨酸”項(xiàng)目也在省內(nèi)企業(yè)實(shí)現(xiàn)了產(chǎn)業(yè)化生產(chǎn)，獲得國(guó)家醫(yī)藥總局科技進(jìn)步二等獎(jiǎng)；完成了“用基因工程菌酶法生產(chǎn)D－對(duì)羥基苯甘氨酸”通過了江蘇省科技廳組織的專家鑒定（蘇科鑒字[2002]第321號(hào)； 排名第一）。

　　(3) 在技術(shù)創(chuàng)新方面，在國(guó)內(nèi)外首次提出了“微基因藥學(xué)”的學(xué)科設(shè)想，沿該研究思路開展了與重大疾病相關(guān)的一系列微基因藥學(xué)相關(guān)技術(shù)研究，在國(guó)外著名雜志Journal of Immunology（影響因子6.293）、Vaccine上發(fā)表了20多篇論文，完成了微基因藥物制備技術(shù)平臺(tái)研究的“863”項(xiàng)目，建立的“微基因藥學(xué)”相關(guān)的技術(shù)平臺(tái)。

　　(4)申請(qǐng)并公開的國(guó)家專利23項(xiàng)；在國(guó)內(nèi)外核心學(xué)術(shù)期刊上發(fā)表論文130多篇，其中SCI論文30多篇，多篇論文在J Immunol（IF 6.293）、J Biol Chem（IF 5.808）、Invest Ophthalmol Vis Sci（IF 5.2）Endocr Relat Cancer（IF 4.7）、Vaccine（IF 3.159）等國(guó)際著名學(xué)術(shù)雜志上刊登。

　　(5)曾多次承擔(dān)國(guó)家“863”計(jì)劃課題、國(guó)家自然科學(xué)基金課題，目前領(lǐng)導(dǎo)的團(tuán)隊(duì)仍有四項(xiàng)國(guó)家自然科學(xué)基金項(xiàng)目和兩項(xiàng)省自然科學(xué)基金項(xiàng)目，研究經(jīng)費(fèi)共計(jì)140萬(wàn)多元。

　　微基因藥物實(shí)驗(yàn)室現(xiàn)狀：

　　劉景晶教授建立的實(shí)驗(yàn)室擁有HPLC，毛細(xì)管電泳，高速冷凍離心機(jī)，酶標(biāo)儀，5L和50L的發(fā)酵罐等多臺(tái)先進(jìn)儀器。除了常規(guī)實(shí)驗(yàn)室以外，實(shí)驗(yàn)室還配備有專門的動(dòng)物房和細(xì)胞房。目前劉老師領(lǐng)隊(duì)的科研團(tuán)隊(duì)主要致力于核酸和多肽類疫苗的研發(fā)，包括動(dòng)脈粥樣硬化，糖尿病，腫瘤等相關(guān)疫苗和多肽類生物技術(shù)藥物。實(shí)驗(yàn)室擁有二十多個(gè)從事分子、生化、免疫、藥理的碩士和博士研究生。另外，微基因藥物實(shí)驗(yàn)室還與上海一就生物醫(yī)藥有限公司（www.bioyijiu.com）建立了長(zhǎng)期的互助合作關(guān)系。

　　上海一就生物醫(yī)藥有限公司是一家致力于生物活性肽衍生肽開發(fā)和多肽表達(dá)技術(shù)研究的現(xiàn)代生物技術(shù)公司。公司根據(jù)現(xiàn)代藥物研發(fā)的最新理念和技術(shù)，建立了生物活性肽高效表達(dá)和大規(guī)模制備技術(shù)平臺(tái)。在生物活性肽衍生肽研究和生物活性肽高效率表達(dá)等方面處于領(lǐng)先水平。

　　劉景晶教授近年發(fā)表的主要SCI論文：

　　(1)Guojun W, Wei G, Kedong O, Yi H, Yanfei X, Qingmei C, Yankai Z, Jie W, Hao F, Taiming L, Jingjing L, Rongyue C. A novel vaccine targeting gastrin-releasing peptide: efficient inhibition of breast cancer growth in vivo. Endocr Relat Cancer, 2008,15(1):149-59

　　(2)Jin L, Zhu A, Wang Y, Chen Q, Xiong Q, Li J, Sun Y, Li T, Cao R, Wu J, Liu J. A Th1-recognized peptide P277, when tandemly repeated, enhances a Th2 immune response toward effective vaccines against autoimmune diabetes in nonobese diabetic mice. J Immunol, 2008,180(1):58-63

　　(3)Xu J, Zhu Z, Wu J, Liu W, Shen X, Zhang Y, Hu Z, Zhu D, Roque RS, Liu J. Immunization with a recombinant GnRH vaccine conjugated to heat shock protein 65 inhibits tumor growth in orthotopic prostate cancer mouse model. Cancer Lett, 2008,259(2):240-50

　　(4)Zhang Y, Xu J, Zhao R, Liu J. Wu JInhibition effects on liver tumors of BALB/c mice bearing H22 cells by immunization with a recombinant immunogen of GnRH linked to heat shock protein 65. Vaccine, 2007,25(39-40):6911-21

　　(5)Chunxiao W, Jingjing L. Yire X, Min D, Zhaohui W, Gaofu Q, Xiangchun S, Xuejun W, Jie W, Taiming L. Study on preparation and activity of a novel recombinant human parathyroid hormone (1-34) analog with N-terminal Pro-Pro extension. Regul Pept, 2007,141(1-3):35-43

　　(6)Jin L, Wang Y, Xiong Q, Chen Q, Li J, Zhu A, Cao R, Wu J, Liu J. Long-lasting specific antibodies against P277 induced by mucosal administration of P277 repeat sequences carried by Hsp65 in the absence of adjuvants. Vaccine, 2007,25 (11):2043-50

　　(7)Xu J, Zhu Z, Duan P, Li W, Zhang Y, Wu J, Hu Z, Roque RS, Liu J. Cloning, expression, and purification of a highly immunogenic recombinant gonadotropin-releasing hormone(GnRH) chimeric peptide. Protein Expr Purif, 2006,50(2):163-70

　　(8)Xu J, Li W, Wu J, Zhang Y, Zhu Z, Liu J, Hu Z. Stability of plasmid and expression of a recombinant gonadotropin-releasing hormone(GnRH) vaccine in Escherichia coli. Appl Microbiol Biotechnol, 2006,73(4):780-8

　　(9)Yankai Z, Rong Y, Yi H, Wentao L, Rongyue C, Ming Y, Taiming L, Jingjing L, Jie W. Ten tandem repeats of beta-hCG 109-118 enhance immunogenicity and anti-tumor effects of beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65. Biochem Biophys Res Commun, 2006,345(4):1365-71

　　(10)Mao D, Kai G, Gaofu Q, Zheng Z, Li Z, Jie W, Jingjing L, Rongyue C. Intramuscular immunization with a DNA vaccine encoding a 26-amino acid CETP epitope displayed by HBc protein and containing CpG DNA inhibits atherosclerosis in a rabbit model of atherosclerosis. Vaccine, 2006,24(23):4942-50

　　(11)Gaofu Q, Rongyue C, Dan M, Xiuyun Z, Xuejun W, Jie W, Jingjing L. Asparaginase display of human cholesteryl ester transfer protein(CETP) B cell epitopes for inducing high titers of anti-CETP antibodies in vivo. Protein Pept Lett, 2006,13(2):149-54

　　(12)Tang SS, Du MH, Zhang XW, Zhang JH, Wu J, Mahanmad E, Liu JJ. A novel hGHRH analog and its comparative activity. Comb Chem High Throughput Screen, 2006,9(3):197-20

　　(13)Yi H, Rong Y, Yankai Z, Wentao L, Hongxia Z, Jie W, Rongyue C, Taiming L, Jingjing L. Improved efficacy of DNA vaccination against breast cancer by boosting with the repeat beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65. Vaccine, 2006,24(14):2575-84

　　(14)Jinshu X, Jingjing L, Duan P, Zheng Z, Ding M, Jie W, Rongyue C, Zhuoyi H, Roque RS. A synthetic gonadotropin-releasing hormone(GnRH) vaccine for control of fertility and hormone dependent diseases without any adjuvant. Vaccine, 2005,23 (40):4834-43

　　(15)Gaofu Q, Jun L, Xiuyun Z, Wentao L, Jie W, Jingjing L. Antibody against cholesteryl ester transfer protein(CETP) elicited by a recombinant chimeric enzyme vaccine attenuated atherosclerosis in a rabbit model. Life Sci, 2005,77(21):2690-70

　　(16)Gaofu Q, Jie L, Rongyue C, Xin Y, Dan M, Jie W, Xiangchun S, Qunwei X, Roque RS, Xiuyun Z, Jingjing L. Asparaginase display of polypeptides in the periplasm of Escherichia coli: potential rapid pepscan technique for antigen epitope mapping. J Immunol Methods, 2005,299(1-2):9-19

　　(17)Gaofu Q, Jun L, Xin Y, Wentao L, Jie W, Xiuyun Z, Jingjing L. Vaccinating rabbits with a cholesteryl ester transfer protein(CETP) B-Cell epitope carried by heat shock protein-65(HSP65) for inducing anti-CETP antibodies and reducing aortic lesions in vivo. J Cardiovasc Pharmacol, 2005,45(6):591-8

　　(18)Gaofu Q, Dan M, Jie W, Liao Z, Li Z, Roque RS, Jingjing L. Long-lasting specific antibodies against CETP induced by subcutaneous and mucosal administration of a 26-amino acid CETP epitope carried by heat shock protein 65 kDa in the absence of adjuvants. Vaccine, 2004,22(23-24):3187-94

　　(19)Jinshu X, Jingjing L, Duan P, Zheng Z, Ding M, Jie W, Rongyue C, Zhuoyi H. The immunogenicity of recombinant and dimeric gonadotrophin-releasing hormone vaccines incorporating a T-helper epitope and GnRH or repeated GnRH units. J Immunol Methods, 2004,289(1-2):111-22

　　(20)Gaofu Q, Jie W, Xin Y, Roque RS, Jingjing L. Expressing and purifying an anti-atherosclerosis polypeptide vaccine in Escherichia coli. Protein Expr Purif, 2004,36(2):198-206

　　(21)Tang SS, Zhang JH, Du MH, Wu J, Liu JJ. Construction and activity of a novel GHRH analog, Pro-Pro-hGHRH(1-44)-Gly-Gly-Cys. Acta Pharmacol Sin, 2004,25(11):1464-70

　　(22)Tang SS, Chen ZL, Liu JJ. Production and enhanced biological activity of a novel GHRH analog, hGHRH with an N-terminal Pro-Pro extension. Protein Expr Purif, 2004,34(2):296-301

　　(23)Evert BA, Salmon TB, Song B, Jingjing L, Siede W, Doetsch PW. Spontaneous DNA damage in Saccharomyces cerevisiae elicits phenotypic properties similar to cancer cells. J Biol Chem, 2004,279(21):22585-94

　　(24)Yuehua L, Jing G, Kai F, Hongwei W, Jingjing L. Left atrial myxoma presenting with erythematous macules and loss of memory. Clin Exp Dermatol, 2003,28(4):383-6

　　(25)Zhang Y, Taiming L, Liu J. Low temperature and glucose enhanced T7 RNA polymerase-based plasmid stability for increasing expression of glucagon-like peptide-2 in Escherichia coli. Protein Expr Purif, 2003,29(1):132-9

　　(26)Tan S, Wu W, Liu J, Kong Y, Pu Y, Yuan R. Efficient expression and secretion of recombinant hirudin III in E. coli using the L-asparaginase II signal sequence. Protein Expr Purif, 2002,25(3):430-6

　　(27)Ming Xin, Yang Li, Lin Jie, Ding Min and Jingjing Liu. An X-Prolyl Dipeptidyl Aminopeptidase from Lactococcus lactis: Cloning, Expression in Escherichia coli, and Application for Removal of N-Terminal Pro-Pro from Recombinant Proteins. Protein Expr Purif, 2002,2(3):530-8

　　(28)Jingjing L, Srinivasan B, Roque RS. Ectodomain shedding of VEGF183, a novel isoform of vascular endothelial growth factor, promotes its mitogenic activity in vitro. Angiogenesis, 2001,4(2):103-12

　　(29)Jingjing L, Srinivasan B, Bian X, Downey HF, Roque RS. Vascular endothelial growth factor is increased following coronary artery occlusion in the dog heart. Mol Cell Biochem, 2000,214(1-2):23-30

　　(30)Jingjing L, Xue Y, Agarwal N, Roque RSHuman Müller cells express VEGF183, a novel spliced variant of vascular endothelial growth factor. Invest Ophthalmol Vis Sci, 1999,40(3):752-9

　　(31)Roque RS, Rosales AA, Jingjing L, Agarwal N, Al-Ubaidi MRRetina-derived microglial cells induce photoreceptor cell death in vitro. Brain Res, 1999,836 (1-2):110-9

　�。�32）Harold J，Sheedlo，Raghu Krishnamoorthy，Tammy Nelson，Neeraj Agarwal，Jingjing Liu，Rouel S. Roque，Robert J Retina-derived fetuin (RDF): Analysis by immunocytochemistry, reverse transcriptase-polymerase chain reaction and Southern blot Current Eye Research, 1999，19（6）, 465-71