學(xué)習(xí)與工作經(jīng)歷
學(xué)習(xí)經(jīng)歷
1994 - 1998 , 理學(xué)博士 , 生化與分子生物學(xué) , 東京農(nóng)工大學(xué)
1998 - 2002 , 博士后研究員 , 美國(guó) 賓夕法尼亞州大學(xué)
工作經(jīng)歷
2002 - 2008 , 副教授 , 北京大學(xué) 生命科學(xué)學(xué)院
2008 - 至今 , 教授 , 北京大學(xué) 生命科學(xué)學(xué)院
研究?jī)?nèi)容
鄭曉峰教授和羅明教授課題組對(duì)一個(gè)新的NADP(H)結(jié)合蛋白(HSCARG) 的結(jié)構(gòu)與功能特征進(jìn)行了研究。NADP和一氧化氮是兩個(gè)重要的具有廣泛調(diào)節(jié)功能的信號(hào)分子，是否存在連接這兩個(gè)信號(hào)通路的調(diào)節(jié)蛋白一直是人們關(guān)注的問(wèn)題。
對(duì)HSCARG蛋白的晶體結(jié)構(gòu)進(jìn)行了解析，其最突出的特點(diǎn)是HSCARG能夠形成一個(gè)不對(duì)稱的二聚體，該蛋白N端的Rossmann折疊與NADP(H)結(jié)合后發(fā)生明顯的構(gòu)象變化。
HSCARG是一個(gè)新的NADPH sensor蛋白，它是連接細(xì)胞氧化還原狀態(tài)與一氧化氮信號(hào)通路的一個(gè)關(guān)鍵的蛋白：HSCARG通過(guò)感應(yīng)細(xì)胞內(nèi)NADP(H)濃度的變化，發(fā)生構(gòu)象的變化來(lái)發(fā)揮其調(diào)節(jié)功能。
所獲榮譽(yù)
北京大學(xué)優(yōu)秀班主任 , 2005
北京大學(xué)東寶教師獎(jiǎng) , 2006
北京市優(yōu)秀輔導(dǎo)員 , 2006
談家楨基金生命科學(xué)九源導(dǎo)師獎(jiǎng) , 2006
北京大學(xué)青年教師教學(xué)基本功優(yōu)秀獎(jiǎng) , 2007
北京大學(xué)東寶教師獎(jiǎng) , 2009
北京大學(xué)東寶教師獎(jiǎng) , 2013
北京大學(xué)東寶教師獎(jiǎng) , 2013
參與學(xué)術(shù)會(huì)議
1. Straightening of bulged RNA by the double-stranded RNA-binding domain from the protein kinase PKR,Second International Conference: Proteins that bind RNA , 2001.2
.2. Activation of the protein kinase PKR by small double-stranded RNAs flanked by single-stranded regions.,The 3rd Annual Meeting of the China RNA Society & 1st International RNA Workshop in China , 2003.7
3. Restructuring of the dinucleotide binding fold in a NADP(H) sensor protein,International Symposium on Synchrotron Radiation and Biology , 2007.11
4. 北京生物化學(xué)學(xué)會(huì)2007年年會(huì) , 2007.12
5. Serum presence of preS antigen in chronic hepatitis B: a significant serological marker in HBV prognosis,Advances in Protein Sciences, Hongkong , 2005.12
發(fā)表論文
1. Li, T,T., Guan J., Li, S.Z., Zhang, X.D.,Zheng, X.F.,HSCARG downregulates TNF-induced NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination., Cell Difference & Diseases. , 2014 , 5: e1229.
2. Peng YY, Xu RD,Zheng XF,HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1, PLoS Pathogen , 2014 , Accepted
3. Hu B, Li SZ, Zhang XD,Zheng XF,HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation, Nucleic Acid Res , 2014 , Accepted
4. Xiao W, Meng G, Zhao Y, Yuan H, Li T, Peng Y, Zhao Y, Luo M, Zhao, WM, Li Z,Zheng XF,Human SI-CLP aggravates the inflammation of the arthritis and is a potential macrophage inflammatory regulator, Arthritis Rheumatol , 2014 , doi: 10.1002/art.38356
5. Li TT, Guan JH, Huang ZJ, Hu X,Zheng XF,RNF168-mediated H2A neddylation antagonizes its ubiquitination and regulates DNA damage repair, Journal Cell Science , 2014 , Accepted
6. Li G, Qu L, Ma S, Wu Y, J CW,Zheng XF,Structures determination of human Fas Apoptosis Inhibitory Molecule and identification of the critical residues linking the interdomain interaction to the anti-apoptotic activity, Acta crystallgrophy D , 2014 , Accepted
7. Bai, D.M., Zhang, J., Xiao, W.C.,Zheng, X.F,Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress., Nucleic Acid Res. , 2014 , 42(3):1799-1811.
8. Zhang JF, Bai DM, Ma XW, Guan JH,Zheng XF,hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14, Oncogene , 2014 , 33, 246-254. doi: 10.1038/onc.2012.560 ,
9. Meng G, An X, Ye, S, Liu Y, Zhu W, Zhang R,Zheng XF,The crystal structure of LidA, a translocated substrate of the Legionella pneumophila Type IV secretion system, reveals a novel folding, Protein & Cell , 2013 , 4(12):897-900
10. Bai DM, Zhang J, Xiao WC,Zheng XF,Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress, Nucleic Acid Res , 2013 , doi: 10.1093/nar/gkt971
