人物經(jīng)歷
陳曄光 博士
教授、博士生導(dǎo)師
長江特聘教授
1979-1983，就讀于江西大學(xué)生物系，獲生物學(xué)學(xué)士學(xué)位。
1983-1986，就讀于江西大學(xué)生物系，獲動(dòng)物學(xué)碩士學(xué)位。
1988-1990，就讀于Fordham University，獲細(xì)胞生物學(xué)碩士學(xué)位。
1991-1996，就讀于美國Albert Einstein College of Medicine，獲Ph.D.學(xué)位。
1996-2000, Post-doctoral Research Associate, Memorial Sloan-Kettering Cancer Center/Howard Hughes Medical Institute.
2000-2002, Assistant Professor, University of California, Riverside.
2002-至今，清華大學(xué)教授。
科研方向
■細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)：利用分子生物學(xué)、生物化學(xué)及細(xì)胞生物學(xué)等多學(xué)科技術(shù)手段研究TGF-β受體的調(diào)控、TGF-β和Wnt在腫瘤形成及血管形成中的作用。
論文目錄
Selected Publications:
■ Ma J, Wang Q, Fei T, Han JD, Chen YG# 2007 MCP-1 mediates TGF-β-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood, 109:987-994.
■ Chen YG#, Wang Z, Ma J, Zhang L, Lu Z 2007 Endofin, a FYVE domain protein, interacts with Smad4 and facilitates TGF-β signaling. Journal of Biological Chemistry, 282:9688-9695.
■ Huang W, Chang HY, Fei T, Wu H, Chen YG# 2007 GSK3β mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene, 26:2471-2482.
■ Gu Y, Jin P, Zhang L, Zhao X, Gao X, Ning Y, Meng A, Chen YG# 2006 Functional analysis of mutations in the kinase domain of the TGF-β receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia. Blood, 107:1951-1954.
■ Zhang L, Gao X, Wen J, Ning Y, Chen YG# 2006 Dapper 1 antagonizes Wnt signaling by promoting Dishevelled degradation. Journal of Biological Chemistry, 381:8607u20138612.
■ Zhang, L., Zhou, H., Su, Y., Sun, S., Zhang, H., Zhang, L., Zhang, Y., Ning, Y., Chen, YG# and Meng, A# 2004 Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114-117
■ Lu, Z., Murray, J. T., Luo, W., Li, H., Wu, X., Xu, H., Backer, J. M. and Chen, Y.G# 2002 Transforming growth factor-β activates Smad2 in the absence of receptor endocytosis. Journal of Biological Chemistry, 277:29363-29368.
■ Wu G*, Chen YG*, Ozdamar B, Gyuricza C, Chong PA, Wrana JL, Massagué J, Shi Y. 2000 Structural basis of Smad2 recognition by the Smad Anchor for Receptor Activation. Science. 287:92-97.
■ Massagué, J. and Chen, YG 2000 Controlling TGF-β signaling. Genes & Development, 14:627-644. (Review)
■ Onichtchouk, D*, Chen, YG*, Dosch, R., Gawantka, V., Delius, H., Massagué, J. and Nierhs, C. 1999 Silencing of TGF-β signaling by the pseudoreceptor BAMBI. Nature, 401:480-485.
■ Chen, YG, Hata, A, Lo, R.S., Wotton, D., Shi, Y., Pavletich, N.P. and Massagué, J. 1998 Determinants of specificity in TGF-β signal transduction. Genes & Development, 12:2144-2152.
■ Chen, YG, Liu, F. and Massagué, J. 1997 Mechanism of TGF-β receptor inhibition by FKBP12. EMBO Journal, 16:3866-3876.
人物榮譽(yù)
2017年11月，2017年新當(dāng)選中國科學(xué)院院士名單公布，陳曄光當(dāng)選生命科學(xué)和醫(yī)學(xué)學(xué)部院士。
