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  • 鄧小燕

    鄧小燕

    博士,教授,博士生導(dǎo)師。1975年大學(xué)本科畢業(yè)于 華中科技大學(xué),1982年畢業(yè)于成都科技大學(xué) 工程力學(xué)系,獲生物力學(xué)專業(yè)碩士學(xué)位(是我國第一位被授予生物力學(xué)碩士學(xué)位的 研究生)。1991年畢業(yè)于 加拿大麥吉爾大學(xué)(McGill University)化學(xué)工程系及臨床研究所,獲生物醫(yī)學(xué)工程專業(yè)博士學(xué)位。1991年至1995年在加拿大 魁北克拉瓦爾大學(xué)生物材料研究所從事 博士后研究工作,1995年至2000年任加拿大魁北克拉瓦爾大學(xué)生物材料研究所研究員兼職拉瓦爾大學(xué)醫(yī)學(xué)院外科系研究教授,曾任重慶大學(xué)生物工程學(xué)院教授,院長,現(xiàn)為北京航空航天大學(xué)生物工程系教授。

    學(xué)習(xí)經(jīng)歷

      1/1986-10/1991年 生物醫(yī)學(xué)工程專業(yè) 博士  加拿大麥吉爾大學(xué) (McGill University),化學(xué)工程系及臨床研究所  12/1982 年 生物力學(xué)專業(yè) 碩士  成都科技大學(xué),工程力學(xué)系  10/1975 年 畢業(yè)文憑  武漢華中理工大學(xué),火電站專業(yè)

    工作經(jīng)歷

      2001—現(xiàn)在 北京航空航天大學(xué)生物工程系 教授  7/1995--11/2000 加拿大魁北克拉瓦爾大學(xué)生物材料研究所 研究員  加拿大魁北克拉瓦爾大學(xué)醫(yī)學(xué)院外科系 科研教授  11/1991--6/1995 加拿大魁北克拉瓦爾大學(xué)生物材料研究所 博士后  1/1983—6/1985 成都科技大學(xué) (現(xiàn) 四川大學(xué))

    工程力學(xué)系生物力學(xué)教研室 助教

      1978u20139/1980 四川省 環(huán)境保護(hù)研究所 助理工程師  10/1975 --1978 西南核反應(yīng)堆研究設(shè)計(jì)院 反應(yīng)堆 操縱員

    主要學(xué)術(shù)及社會兼職

      計(jì)算力學(xué)學(xué)報 編委;中國生物物理學(xué)會生物流變學(xué)專業(yè)委員會 委員

    研究領(lǐng)域研究課題

       生物醫(yī)學(xué)工程,生物力學(xué),血流動力學(xué)及心血管介入器械

    指導(dǎo)碩、博士生研究方向

      生物力學(xué),血流動力學(xué)及心血管介入器械

    科研論文

      1. Deng X.Y. (1983) Investigation on electrochemical measurement of wall shear stresses in the flow field of cardiac valve prostheses. Proceedings of the Second Asian Congress of Fluid Mechanics, Beijing, China. (EI檢索)   2. Kang, Z.H. and Deng X.Y. Swirling jet rate sensor and its flow field (1985) In: Fluid Control and Measurement, edited by M. Harada, Pergamon Press, Oxford, England, pp. 599-609.(EI檢索)   3. Deng, X.Y., King, M. and Guidoin, R. (1993) Localization of atherogenesis at arterial junctions - Modeling the release rate of low density lipoproteins (LDL) and its breakdown products accumulated in blood vessel walls. American Society for Artificial Internal Organs (ASAIO) Journal 39: 489-495.   4. Chakfé, N., Marois, Y., Guidoin, R., Deng, X.Y., Marois, M., Roy, R. and Douville, Y. (1993) Biocompatibility and biofunctionality of a gelatin impregnated polyester arterial prosthesis. Polymer and Polymer Composites, 1, 229-251. (EI檢索)   5. Deng, X.Y., Marois, Y., King, W. M. and Guidoin, R. (1994) Uptake of 3H-7-cholesterol along the arterial wall at an area of stenosis. ASAIO Journal 40: 186-191. (EI檢索)   6. Dadgar, L., Deng, X.Y., King, M., Marois, Y., Martin, L. and Guidoin, R. (1994) Longitudinal forces acting on a knitted polyester arterial prosthesis when implanted as a thoracic aorta substitute in the dog. J. Invest. Surg. 7: 377-391.   7. Deng, X.Y., Marois, Y., How, T., Merhi, Y., King, W. M. and Guidoin, R. (1995) Luminal surface concentration of lipoprotein (LDL) and its effect on the wall uptake of cholesterol by canine carotid arteries. J. Vasc. Surg. 21: 135-145. (SCI檢索)   8. Deng, X.Y., King, W. M. and Guidoin, R. (1995) Localized atherogenesis at arterial junctions-Concentration distribution of low density lipoproteins (LDL) at the luminal surface in the region of disturbed flow. ASAIO Journal, 41: 58-67. (EI檢索)   9. King, M., Marois, Y., Guidoin, R., Ukpabi, P., Deng, X.Y., Martin, L., Paris, E. and Douville, Y. (1995) Evaluating the Dialine® vascular prosthesis knitted from an alternative source of polyester yarns. J. Biomed. Mater. Res. 29: 595-610. (EI, SCI檢索)   10. Dadgar, L., Downs, A. R. Deng, X.Y., Marois, Y., King, M. and Guidoin, R. (1995) Longitudinal forces acting at side-to-end and end-to-side anastomoses when a knitted polyester arterial prosthesis is implanted in the dog. J. Invest. Surg. 8: 163-178. (SCI檢索)   11. Ukpabi, P., Marois, Y., King, M., Deng, X.Y., Martin, L., Laroche, G., Douville, Y. and Guidoin, R. (1995) The GelweaveR polyester arterial prosthesis. Can. J. Surg. 38: 322-331. (SCI檢索)   12. Marois, Y., Chakfé, N., Deng, X.Y., King, M.W., Marois, M. and Guidoin, R. (1995) Carbodiimide cross-linked gelatin, a new coating for porous polyester arterial prosthesis. Biomaterials 16: 1131-1139. (EI, SCI檢索)   13. Deng, X.Y., Stroman, P.W. and Guidoin, R. (1996) Theoretical modelling of the release rate of low-density lipoprotein and their breakdown products at arterial stenoses. Clinical and Investigative Medicine 19: 83-91. (SCI檢索)   14. Deng, X.Y., Marois, Y., Guidoin, R., Merhi, Y., Stroman, P., King, M. and Douville, Y. (1996) Efficiency of external wrap to reduce lipid infiltration into venous grafts: in vitro evaluation. Artificial Organs 20: 1208-1214. (SCI檢索)   15. Karino, T. and Deng, X. Y. and Naiki, T. (1995) Flow-dependent concentration polarization of lipoproteins at the blood-endothelium boundary. Proceedings of the 1995 Bioengineering Conference, Beaver Creek, Colorado, USA, pp. 13-14. (EI檢索)   16. Guidoin, R., Marois, Y., Deng, X.Y., Chakfé, N., Marois, M., Roy, R., King, M., and Douville, Y. (1996) Can collagen-impregnated polyester arterial prostheses be recommended as blood conduits of small diameter? ASAIO Journal 42: 974-983. (EI, SCI檢索)   17. Ghalichi, F., Deng, X. Y., Marois, Y., De Champlain, A. and Guidoin, R. (1996) Hemodynamic performance of polyester arterial prostheses: Recent developments from the Czech Republic and Poland. ASAIO Journal 43: 69-83. (EI, SCI檢索)   21. Guidoin, R., Deng, X.Y., and Marois, Y. (1997) Failure modes and performance of synthetic, autologous and endovascular grafts. ASAIO Journal 43: 239-241. (EI, SCI檢索)   22. Marois, Y., Guidoin, R., Deng, X.Y., King, M., Martin, L. and Roy, R. (1997) The Dialine II, A new collagen-impregnated warp-knitted polyester arterial prosthesis. Ann. Vasc. Surg. 11: 133-140. (SCI檢索)   23. Yang, M., Deng, X.Y., Laroche, G., Hahn, C., King, M. and Guidoin, R. (1997) A capillary method to measure water transmission through polyurethane membranes. ASAIO Journal. 43: 890-896. (EI, SCI檢索)   24. Deng, X.Y, Marois, Y, Guidoin, R. (1998) Fluid Filtration Across the Arterial Wall under Flow Conditions: Is Wall Shear Rate Another Factor Affecting Filtration Rate? Annals of New York Academy of Sciences 858: 105-115. (SCI檢索)   25. Fatouraee, N. Deng, X.Y., De Champlain, A. and Guidoin, R. (1998) Concentration polarization in the arterial system. Annals of New York Academy of Sciences 858: 137-146. (SCI)   26. Ghalichi, F., Deng, X.Y., De Champlain, A., Douville, Y., King, M. and Guidoin, R. (1998) Low Reynolds number turbulence modeling of blood flow in arterial stenoses. Biorheology 35: 281-294. (SCI檢索)   27. Ghalichi, F., Deng, X.Y., Marois, Y., De Champlain, A., King, M and Guidoin, R. (1998) Theoretical prediction on hemodynamic performance of polyester protein-impregnated arterial prostheses after implantation: A plea for faster resorption of the coating. ASAIO Journal 45: 18-24. (EI, SCI檢索)   28. Marois, Y., Zhang, Z., Vert, M., Deng, X.Y., Lenz, R. and Guidoin, R. (1999) Effect of sterization on the physical and structural characteristics of polyhydroxyoctanoate (PHO). Journal of Biomaterials Science: Polymer Edition 10: 469-482.(SCI檢索)   29. Marois, Y., Zhang, Z., Vert, M., Deng, X.Y., Lenz, R. and Guidoin, R. (1999) Hydrolytic and enzymatic incubation of polyhydroxyoctanoate (PHO): A short-term in vitro study of a degradable bacterial polyester. Journal of Biomaterials blood conduits: could the porosity of synthetic prostheses be the key to long-term biofunctionality? Medical & Biological Engineering & Computing 38, 219-225. (EI, SCI檢索)   33. Wang, G.X., Cai, S.X., Deng X.Y., Ouyang, K., Xie, G.M. and Guidoin R (2000) Secretory response of endothelin-1 in cultured human glomerular microvascular endothelial cells to shear stress. Biorheology 37, 291-299. (SCI檢索)   34. Wang, G.X., Deng X.Y. and Guidoin R (2002) Concentration polarization of macromolecules in canine carotid arteries and its implication for the localization of atherogenesis. Journal of Biomechanics (付印).   35. Deng X.Y. and Wang, G.X. (2002) 動脈系統(tǒng)中致動脈粥樣性脂質(zhì)的濃度極化現(xiàn)象。 《 中國科學(xué)》(中英文版) (付印).   36. Deng X.Y. (2002) 動脈狹窄內(nèi)低密度脂蛋白傳輸?shù)臄?shù)值研究:LDL的濃度極化現(xiàn)象! 計(jì)算力學(xué)》 (付印).

    著述 Book chapters

      1. Guidoin, R., King, M., Deng, X.Y., Paris, E. and Douville, Y. (1992) Les protheses arterielles en polyester: Une fibre unique pour des modèles variés. In: Les Substituts Arteriels, Edited by Edouard Kieffer, AERCV, Paris, pp. 3-51.   2. Paris, E., King, M., Guidion, R., Delorme, J., Deng, X.Y., and Douville, Y. (1994) Innovations and deviations in therapeutic vascular devices. In: Polymeric Materials for Biomedical Applications. Edited by Severian Dumitriu. Marcel Dekker Inc. (New York), pp.245-275.   3. Deng, X.Y. and Guidoin, R. (1998) Engineering data on human arteries, veins and lymphatic vessels. In: Handbook of Biomaterials Properties. Edited by Black, J. and Hastings, G.W., Chapman&Hall, London, pp. 81-105

    論文摘要

      1. Deng, X. Y. and Karino, T. (1986) Flow patterns at venous junctions and their implication in the pathogenesis of venous thrombosis. Biorheology 23, 222. (SCI 檢索)   2. Deng, X. Y. and Karino, T. (1988) Mass transfer to and from the vessel wall distal to a sudden tubular expansion. World Congress on Medical Physics and Biomedical Engineering, San Antonio, Texas, USA.   3. Deng, X. Y. and Karino, T. (1988) Fluid dynamics and mass transfer to and from the vessel wall in the models of arterial stenoses. World Congress on Medical Physics and Biomedical Engineering, San Antonio, Texas, USA.   4. Deng, X. Y. and Karino, T. (1989) Theoretical study on flow and mass transfer to and from the vessel wall in an axisymmetric arterial stenosis. Biorheology 26, 597.   5. Deng, X. Y. and Karino, T. (1989) Effects of steady laminar recirculation flows on mass transfer from a flowing fluid to a semi-permeable vessel wall. Biorheology 26, 604.   6. Karino T. and Deng X. (1990) Lipoprotein concentration at the blood-endothelium boundary and its implications for the pathogenesis of vascular diseases. J. Japanese College of Angiology 30, 710.   7. Deng, X. Y., King, M. and Guidoin, R. (1993) Localized atherogenesis at arterial junctions - Modeling the effect of flow disturbances on the transfer of low density lipoproteins (LDL). The 39th Annual Meeting of ASAIO, New Orleans, USA, p. 119.   8. Deng, X. Y., King, M. and Guidoin, R. (1993) Localized atherogenesis at arterial junctions - Modeling the effect of flow disturbances on the transfer of low density lipoproteins (LDL). The 39th Annual Meeting of ASAIO, New Orleans, USA, p. 119.   9. Ukpabi, P., King, M., Deng, X. Y., Marois, Y., Martin, L. and Guidoin, R. (1993) Biofunctionality and biostability of new polyester vascular prostheses. The 14th Annual Canadian Biomaterials Society Conference, Hamilton, Canada, p. 1.   10. Guidoin, R., Marois, Y., King , M., Ukpabi, P., Deng, X. Y., Martin, L., Laroche, G., Douville, Y. and Awad, J. (1994) The Gel Weave polyester arterial prosthesis. The 40th Annual Meeting of ASAIO, San Francisco, USA, p. 18.   11. Dadgar, L., Deng, X. Y., and Guidoin, R. (1994) Flow induced wall vibration: a mechanical factor which could cause the formation of anastomotic false aneurysms. The 15th Annunal Canadian Biomaterials Society Conference, Quebec, Canada, p. 35.   12. Deng, X. Y., Marois, Y., Guidoin, R., King, W. M. and Douville, Y. (1994) Effect of pressure on filtration property and 3H-cholesterol uptake rate of blood vessel walls by blood vessel walls. The 15th Annual Canadian Biomaterials Society Conference, Quebec, Canada, p. 39.   13. Marois, Y., Deng, X. Y., King, M. and Guidoin, R. (1995) In vitro and in vivo characterization of a new polyester arterial prosthesis sealed with irradiated collagen. ASAIO Journal (Suppl): p. 110.   14. Deng, X. Y., Marois, Y., Guidoin, R., Merhi, Y., Stroman, P., King, M. and Douville Y. (1995) Rigid external support can prevent vein grafts from atherosclerosis by reducing lipid infiltration. Artificial Organs, 19: p. 1062.   15. Yang, M., Deng, X. Y., Julien, M., Zhang, Z., Desaulniers, D. and Guidoin, R. (1995) Physical and chemical characterization of used polyurethane intraaortic balloon: a survey study of 127 used intraaortic balloons. Artificial Organs, 19: p. 1048.   16. Deng, X. Y., Guidoin, R. and Marois, Y. (1996) The static properties of the canine thoracic duct. The 5th World Biomaterials Congress Vol. II, p. 382. (EI檢索)   17. Yang, M., Deng, X. Y., Guidoin, R. (1996) Water permeability of polyurethane membranes. The 5th World Biomaterials Congress Vol. II, p. 820. (EI檢索)   18. Deng, X. Y., Karino, T. and Guidoin, R. (1996) Particle adhesion to a semi-permeable wall exposed to flow disturbance: Simulation of the transport of blood components. Haemostasis Vol. 26, Abstact 218.   19. Marois, Y., Vert, M., Zhang, Z., Deng, X. Y., Lenz, R. and Guidoin, R. (1996) Degradability of polyhydroxyoctanoate films: An hydrolytic or enzymatic process. International Symposium on Bacteria Polyhydroxyalkanoates, Section 9/03. Davos, Switzerland.   20. Karino, T. and Deng, X. Y. (1997) The effects of recirculation flows on mass transfer from a vessel wall to a flowing fluid. International Journal of Cardiovascular Medicine and Science, Vol. 1, p. 128. (First International Interdisciplinary Conference on Cardiovascular Medicine, Surgery, Science, and Mechanics. Washington, DC, USA, June 6-9, 1997)   21. Fatouraee, N., Deng, X. Y., De Champlain, A. and Guidoin, R. (1997) LDL transport of low density lipoprotein transport of blood flow and lipid transport in human carotid artery. Annals of Biomedical Engineering, vol. 25 (Supp. 1), p.s-26. (1997 Annual Fall Meeting of Biomedical Engineering Society, San Diego, California, USA, October 2-5, 1997.)   24. Deng, X.Y, Marois, Y, Guidoin, R. Fluid Filtration Across the Arterial Wall under Flow Conditions: Is Wall Shear Rate Another Factor Affecting Filtration Rate? Biotransport-98, International Symposium of Heat and Mass Transfer in Biological and Medical Engineering, Kusadasi, Turkey, June 8 u2013 12, 1998.   25. Fatouraee, N., Deng, X.Y., De Champlain, A. and Guidoin, R. Concentration polarization in the arterial system. Biotransport of lipid transport through arterial stenoses. (Abstract) 1999 ASME Bioengineering Conference, Big Sky, Montana, (USA), June 16-20, 1999. (EI檢索)   29. Deng, X.Y., Fatouraee, N. and Guidoin R Concentration polarization of atherogenic lipids and its implication in the localization of atherosclerosis. (Abstract) European Medical & Biological Engineering Conference EMBEC’99, Vienna (Austria), Nov. 04 - 07, 1999.   30. Deng, X.Y., Fatouraee, N. and Guidoin R. Concentration polarization of atherogenic lipids and its implication in the localization of atherosclerosis. (Abstract) European Medical & Biological Engineering Conference EMBEC’99, Vienna (Austria), Nov. 04 - 07, 1999.   31. Wang G. X., Guidoin R., Deng X. Y. An in vitro experimental study on concentration polarization of macromolecules in canine carotid arteries . Proceedings of the 5th Asian Symposium on Biomedical Materials, Hong Kong, December 9-12, 2001, p. 34.   And more...

    譯著

      <日>岡小天著 心血管血液流變學(xué) 第八章 北京 計(jì)量出版社 (1984)

    科研成果及所受獎勵

      1993年 全美人工器官年會青年 科學(xué)家論文獎(美國 新奧爾良)! 1989年 第7屆 國際生物流變學(xué)學(xué)術(shù)大會優(yōu)秀學(xué)生論文獎 (法國蘭西) 。

    基本情況

      計(jì)算力學(xué)學(xué)報u2019編委; u2018醫(yī)用生物力學(xué)u2019編委;u2018 生物醫(yī)學(xué)工程雜志u2019編委;中國生物醫(yī)學(xué)工程學(xué)會理事;中國生物物理學(xué)會生物力學(xué)及生物流變學(xué)專業(yè)委員會委員;中國力學(xué)學(xué)會及生物醫(yī)學(xué)工程學(xué)會生物力學(xué)專業(yè)委員會副主任;國家自然科學(xué)基金委員會數(shù)理學(xué)部第十屆評審專家;國家自然科學(xué)基金委員會生命學(xué)部第十一屆評審專家. 目前主持國家自然科學(xué)基金重點(diǎn)項(xiàng)目一項(xiàng)、面上兩項(xiàng)等。 招聘 博士后:因研究項(xiàng)目需要,招聘博士后4名,待遇優(yōu)厚。 1、生物力學(xué)(或力學(xué)、機(jī)械專業(yè))、血流動力學(xué)或計(jì)算流體力學(xué)兩名。 2、細(xì)胞生物學(xué)兩名。

    研究方向

       流體力學(xué)、血流動力學(xué)

    獲獎

      1993年 全美人工器官年會青年 科學(xué)家論文獎(美國 新奧爾良)。 1989年 第7屆 國際生物流變學(xué)學(xué)術(shù)大會優(yōu)秀學(xué)生論文獎 (法國蘭西) 。 1986年-- 1991年 加拿大麥吉爾大學(xué)博士生獎學(xué)金。 2005年 重慶市自然科學(xué)三等獎“動脈系統(tǒng)中致動脈粥樣性脂質(zhì)的濃度極化現(xiàn)象”證書號:ZR050300801,第一獲獎人,2005/3/3。 科研: 1. 主持完成了美國Whitaker Foundation科學(xué)基金課題”Flow-dependent luminal surface concentration of atherogenic lipoproteins: Role of hemodynamic factors in atherosclerosis” 2. 主持完成了拉瓦爾大學(xué)醫(yī)學(xué)研究中心的課題”Hemodynamics and anastomotic intimal hyperplasia”。 3. 作為主要合作者,參與了多項(xiàng)由加拿大和魁北克政府醫(yī)學(xué)科學(xué)基金組織資助的科研課題。 4. “Coeur Artificiel”Foundation, Geneva, Switzerland課題”Design and development of a totally implantable artificial heart”。 主要參加人(負(fù)責(zé)人工心臟的血流動力學(xué)研究)。 5. 國家自然科學(xué)基金: “血流動力學(xué)與動脈循環(huán)系統(tǒng)物質(zhì)傳輸?shù)南嚓P(guān)性研究”(批準(zhǔn)號:10172027,2002.1-2004.12), 主持人,24萬 人民幣。 6. 國家自然科學(xué)基金: “動脈旁路搭橋術(shù)后血管內(nèi)膜增生及血流流場相關(guān)性研究”(批準(zhǔn)號:30270360,2003.1-2005.12),主持人,經(jīng)費(fèi)20.0萬人民幣。 7. 重慶市教委:“小口徑人造血管漩流導(dǎo)引器的研制” (2004.1-2006.12)主持人,經(jīng)費(fèi):滾動支助,第一年10.0萬人民幣(批準(zhǔn)號030001)。 8. 重慶大學(xué)生物力學(xué)與組織工程教育部重點(diǎn)實(shí)驗(yàn)室開放基金會(2003.1-2003.12),主持人,經(jīng)費(fèi)5.0萬人民幣 9. 重慶大學(xué)科研啟動經(jīng)費(fèi):“動脈旁路或再造手術(shù)后血管內(nèi)膜增生的血流動力學(xué)成因” (2003.7-2006.6) 主持人,經(jīng)費(fèi)20.0萬人民幣。 10. 重慶大學(xué)“電動人工全心的研制” 種子經(jīng)費(fèi),主持人,經(jīng)費(fèi)30.0萬人民幣。 11. 重慶市科委“電動人工全心預(yù)研” 主持人,經(jīng)費(fèi)15.0萬人民幣(CSTC.2004ac3031) 12. 國家重點(diǎn)基礎(chǔ)研究計(jì)劃(973計(jì)劃):轉(zhuǎn)基因高等動物的創(chuàng)建與高級腦功能分析(2003CB716600)二級子課題:轉(zhuǎn)基因載體構(gòu)建及模式動物大腦基因表達(dá)的研究(2003CB716601)主要負(fù)責(zé)人,經(jīng)費(fèi)50.0萬人民幣 13. 國家科技部 u2018新型抗血栓和再狹窄血管內(nèi)支架的研制u2019(批準(zhǔn)號: 2004DFA064002004.12-2009.12), 第二主持人,經(jīng)費(fèi)80萬 14. 國家自然科學(xué)基金: “胚胎滋養(yǎng)層細(xì)胞在子宮脈管系統(tǒng)逆血流遷移的血流動力學(xué)研究”(批準(zhǔn)號:10572017,2006.1-2008.12),主持人,經(jīng)費(fèi)36.0萬人民幣。 15. 國家自然科學(xué)基金: “動脈系統(tǒng)中脂質(zhì)的濃度極化與脂質(zhì)在血管內(nèi)皮層中沉積的相關(guān)性研究”(批準(zhǔn)號:30670517,2007.1-2009.12),主持人,經(jīng)費(fèi)30.0萬人民幣。 16. 國家自然科學(xué)基金: “動脈系統(tǒng)中的旋動流現(xiàn)象-它對血小板運(yùn)動、粘附和物質(zhì)(LDL)輸運(yùn)的影響及其在臨床中的應(yīng)用”(批準(zhǔn)號:10632010,2007.1-2010.12),主持人,經(jīng)費(fèi)190.0萬人民幣。

    鄧小燕

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