個(gè)人簡(jiǎn)介
董欣年，女，美國(guó)分子生物學(xué)、植物生理學(xué)家，1959年出生于湖北省武漢市，籍貫浙江省寧波市。杜克大學(xué)生物學(xué)系教授。2012年獲選美國(guó)科學(xué)院院士。
家庭及經(jīng)歷簡(jiǎn)介
董欣年教授籍貫是浙江寧波，出身于學(xué)術(shù)世家。父親是有“一代經(jīng)濟(jì)學(xué)泰斗”之稱(chēng)的董輔礽。母親劉藹年，是中國(guó)著名眼科醫(yī)生、教授。一家都是武漢大學(xué)校友。其中董輔礽1946年畢業(yè)于國(guó)立武漢大學(xué)，后來(lái)成為武大教授和經(jīng)濟(jì)系主任。母親劉氏1949年畢業(yè)于武大，曾是解放軍海軍總醫(yī)院眼科主任。有弟董欣中，美國(guó)約翰霍普金斯大學(xué)神經(jīng)生物學(xué)教授。丈夫王小凡，是董欣年在武大的同學(xué)，與董欣年同為杜克大學(xué)教授，任教于藥理系。
董欣年1978年考入武漢大學(xué)生物學(xué)系，1982年，獲武大學(xué)士。參加首屆“中美生物化學(xué)聯(lián)合招生項(xiàng)目”（CUSBEA，發(fā)起人為吳瑞教授），獲得留美資格。丈夫王小凡為在同屆CUSBEA考試中獲得第一名。夫妻雙雙留學(xué)美國(guó)。1983年至1988年，就讀于美國(guó)西北大學(xué)（位于芝加哥），獲得分子生物學(xué)理學(xué)博士。1988至1991年，在哈佛大學(xué)醫(yī)學(xué)院從事博士后研究。自1992年起，歷任杜克大學(xué)生物系助理教授、副教授、教授。
主要研究領(lǐng)域?yàn)橹参锓肿由飳W(xué)和生理學(xué)，特別是水楊酸和茉莉酸在植物細(xì)胞內(nèi)和體內(nèi)的信號(hào)轉(zhuǎn)導(dǎo)途徑，及其相互作用的機(jī)制。
論文專(zhuān)著
Specialties:
Cell and Molecular Biology
Genetics
Genomics
Research Categories:
Current projects: (1) Functional analysis of NPR1, a positive regulator of SAR, (2) Functional analysis of SNI1, a negative regulator of SAR, (3) Study of cross-talks between different defense pathways, (4) Study of programmed cell death in plant defense, (5) Expression profiling of plant defense responses, (6) Study of protein secretory pathway in plant defense, (7) Characterization of antifungal proteins in seeds
Research Description: Using Arabidopsis thaliana as a model system, my laboratory studies the mechanisms of plant defense against microbial pathogens. We focus on a specific response known as systemic acquired resistance (SAR). SAR, which can be induced by a local infection, provides the plants with long lasting, systemic resistance against a broad spectrum of pathogens. Salicylic acid (SA; an active ingredient of aspirin) has been found to be the endogenous signal of SAR. Using a genetic approach, our laboratory identified genes involved in the regulation of SAR. Molecular and genetic analyses are being carried out to understand the gene function and to elucidate the SAR signaling pathway. These SAR-regulating genes are also favorite targets for molecular engineering of disease-resistance crops.
Areas of Interest:
signaling transduction mechanisms
plant-microbe interaction
regulation of gene expression
functional genomics
Representative Publications (More Publications) (search)
Wang, W., Barnaby, J. Y., Tada, Y., Li, H., Tör, M., Caldelari, D., Lee, D.-u. Fu, X.-D. and Dong, X.,, Nature, vol. 470 (2011), pp. 110u2013114 .
Wang, S., Durrant, W. E., Song, J., Spivey, N. W., and Dong X., , Proc. Natl. Acad. Sci. USA (2010) [doi] .
SH Spoel, Z Mou, Y Tada, NW Spivey, P Genschik, X Dong, , Cell, vol. 137 (May, 2009), pp. 860-72 [abs].
Tada, Y., Spoel, S. H., Pajerowska-Mukhtar, K., Mou Z., Song, J., Dong, X., , Science (2008) [8he5p3s6CA6g&keytype=ref&siteid=sci] [abs].
Dong, W., Weaver, N.D., Kesarwani, M., Dong, X., , Science, vol. 308 (2005), pp. 1036-1040 .
Mou, Z. Fan, W., and Dong, X., , Cell, vol. 113 (2003), pp. 935 .
Durrant, W. E., and Dong, X., , Annual Review of Phytopathology, vol. 42 (2004), pp. 185-209 .
Li, X., Zhang, Y., Clarke, J.D., Li, Y., and Dong, X, , Cell, vol. 98 (1999), pp. 329 .
Kinkema, M., Fan, W., and Dong, X., , Plant Cell, vol. 12 (2000), pp. 2339-2350 .
Zhang, Y., Fan, W., Kinkema, M., Li, Xin, and Dong, X, , Proc. Natl. Acad. Sci. USA, vol. 96 (1999), pp. 6523 .
Clarke, J.D., Volko, S.M., Ledford, H., Ausubel, F.M., and Dong, X., , Plant Cell, vol. 12 (2000), pp. 2175-2190 .
Cao, H., X. Li, and X. Dong, , Proc. Natl. Acad. Sci. USA, vol. 95 (1998), pp. 6531-6536 .
Cao, H., J. Glazebrook, J. D. Clarke, S. Volko, and X. Dong., , Cell, vol. 88 (1997), pp. 57-63 .
Cao, H., S. A. Bowling, A. S. Gordon, and X. Dong, , Plant Cell, vol. 6 (1994), pp. 1583-1592 .
Durrant, W. E., Wang, S., Dong, X., , PNAS USA, vol. 104 no. 10 (2007), pp. 4223-7 [abs].
D Wang, K Pajerowska-Mukhtar, AH Culler, X Dong, , Current biology : CB, England, vol. 17 no. 20 (October, 2007), pp. 1784-90 [abs].
Wang, D., Amornsiripanitch, N., Dong, X., , PloS Pathogens, vol. 2 (2006), pp. 1042-1050 .
SH Spoel, JS Johnson, X Dong, , Proceedings of the National Academy of Sciences of the United States of America, United States, vol. 104 no. 47 (November, 2007), pp. 18842-7 [abs].
A. Heidel, J. D. Clarke, J. Antonovics, and X. Dong, , Genetics, vol. 168 (2004), pp. 2197-2206 .
