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  • 黃曉華

    黃曉華

    黃曉華,從事化學(xué)與生物學(xué)交叉研究領(lǐng)域,主要研究方向?yàn)樯餆o機(jī)化學(xué),即將生物物理化學(xué)研究手段、細(xì)胞化學(xué)方法與細(xì)胞生物學(xué)技術(shù)優(yōu)化組合,研究稀土元素、重金屬離子、醫(yī)用納米材料對(duì)細(xì)胞及其生物酶分子的結(jié)構(gòu)、功能及其微觀化學(xué)過程的影響。

    在研項(xiàng)目

    (1)稀土對(duì)辣根的劑量效益評(píng)價(jià)及其研究(GFZ20612108,2007-2009)

    (2)重金屬Tb作用于植物細(xì)胞膜的微觀化學(xué)行為研究(2009-2012)

    (3)聚氨酯無機(jī)仿生表面構(gòu)建的關(guān)鍵技術(shù)及生物醫(yī)用研究(2009-2012)

    (4)稀土作用于辣根細(xì)胞膜的若干生物無機(jī)化學(xué)行為研究(2010-2012)

    成果介紹

    作為項(xiàng)目主持人近三年來, 完成中美合作項(xiàng)目、國(guó)家自然科學(xué)基金、國(guó)家發(fā)改委、江蘇省高技術(shù)及教育部重點(diǎn)項(xiàng)目等8項(xiàng)、在研項(xiàng)目3項(xiàng)。在J.Biol.Inorg.Chem., J.Phys.Chem., Dalton Transactions, Ecotoxicology and Environmental Safety, Annals of Botany,Electrochimica Acta., J. Electro. Chem.,J. Mater. Chem.等學(xué)術(shù)期刊上合作發(fā)表SCI論文60余篇(其中第一及通信作者42篇)。被國(guó)外SCI期刊如Journal of Physical Chemistry(B、C), Dalton Transactions, International Journal of Biological Sciences, Biological Trace Element Research, Langmuir, Ecotoxicology and Environmental Safety, Annals of Botany, Environmental Chemistry Letters等他引223次,單篇最高引用17次。2007年應(yīng)邀在 “13th International Conference on Biological Inorganic Chemistry(ICBIC13,維也納)”會(huì)上報(bào)告;2009年又收到“ICBIC14,日本”會(huì)議報(bào)告的邀請(qǐng)。獲得1項(xiàng)美國(guó)專利及6項(xiàng)中國(guó)(授權(quán))發(fā)明專利。其中,一項(xiàng)特色研究成果用于出口經(jīng)濟(jì)作物,05-07連續(xù)三年該產(chǎn)品獲得歐盟生態(tài)證書及出口美國(guó)、加拿大、丹麥、德國(guó)等國(guó)家和地區(qū),凈增經(jīng)濟(jì)效益96萬美元。

    黃曉華

    近三年主持的國(guó)家及江蘇省主要項(xiàng)目

    (1)稀土生態(tài)轉(zhuǎn)光膜分子設(shè)計(jì)及研制(BG2005040. 2005-2007);

    (2)稀土離子對(duì)辣根植物過氧化酶的結(jié)構(gòu)和生物活性影(20471030, 2005-2007);

    (3)稀土離子對(duì)辣根植物過氧化酶的毒害機(jī)理(IFZ2051210,2006-2008);

    近三年完成的主要研究成果代表

    (1) Huang, X.H., Zhou, Q., Lu,T.H., Guo, S.F (2009). Design and preparation of plant growth regulator of rare earth element-amino acid-vitamine, United States Patent(EFSID;4978659;PCT/CN07/01912).

    (2) Guo , X.Y., Yin,W.Q., Sun, X.H., Huang, X.H.*,. Lu, T.H.(2009). Study on intreaction between Eu(III) and thermosensitive microsphere. Polym.Bull. 62:337-344.

    (3) Guo, S.F., Cao, R., Lu, A.H., Zhou, Q., Lu, T.H., Ding, X.L., Li, C.J., Huang, X.H.* (2008) One of the Possible Mechanisms for the Inhibition Effect of Tb (III) on Peroxidase Activity in Horseradish (Armoracia Rusticana) Treated with Tb (III). Journal of Biological Inorganic Chemistry. 13(4): 587-597.

    (4) Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2008) Inhibition Mechanism of Tb-III on Horseradish Peroxidase Activity. Chemistry & Biodiversity. 5(10): 2050-2059.

    (5) Ye, Y.X., Wang, L.H., Huang, X.H.*, Lu, T.H., Ding, X.L., Zhou, Q.*, Guo, S.F. (2008) Subcellular Location of Horseradish Peroxidase in Horseradish Leaves Treated with La(III), Ce(III) and Tb(III). Ecotoxicology and Environmental Safety. 71(3): 677-684.

    (6) Wang, L.H., Huang, X.H.*, Zhou, Q.* (2008) Effects of Rare Earth Elements on the Distribution of Mineral Elements and Heavy Metals in Horseradish. Chemosphere. 73(3): 314-319.

    (7) Liu, H.K. *, Huang, X.H.*, Lu, T.H., Wang, X.J., Sun, W.Y., Kang, B.S. (2008) Discrete and Infinite 1d, 2d/3d Cage Frameworks with Inclusion of Anionic Species and Anion-Exchange Reactions of Ag3l2 Type Receptor with Tetrahedral and Octahedral Anions. Dalton Transactions. (24): 3178-3188.

    (8) Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2008) Spectroscopic Studies of Interactions Involving Horseradish Peroxidase and Tb3+. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy. 70(4): 818-823.

    (9) Zhou, H., Lu, T.H., Shi, H.X., Dai, Z.H., Huang, X.H.* (2008) Direct Electrochemistry and Electrocatalysis of Catalase Immobilized on Multi-Wall Carbon Nanotubes Modified Glassy Carbon Electrode and Its Application. Journal of Electroanalytical Chemistry. 612(2): 173-178.

    (10) Guo, X.Y., Lu, T.H., Huang, X.H.* (2008) Eu(III)-Modified Properties of Thermosensitive Core-Shell Microspheres. Colloid and Polymer Science. 286(4): 469-473.

    (11) Guo, X.Y., Chen, M.Q., Lu, T.H., Huang, X.H.* (2008) Effect of Tb(III) on the Properties of P(Nipam-Co-St) Copolymer Microspheres. Journal of Polymer Research. 15(2): 141-145.

    (12) Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2007)Inhibition Effect of Tb(III) on Horseradish Peroxidase Activity. Journal of Biological Inorganic Chemistry. 12, (S1): S203.

    (13) Guo, X.S., Zhou, Q., Zhu, X.D., Lu, T.H., Huang, X.H.* (2007) Migration of a Rare Earth Element Cerium(III) in Horseradish. Acta Chimica Sinica. 65(17): 1922-1924.

    (14) Guo, X.S., Zhou, Q., Lu, T.H., Fang, M., Huang, X.H.* (2007) Distribution and Translocation of Ce-141 (III) in Horseradish. Annals of Botany. 100(7): 1459-1465.

    (15) Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2007) Interaction between La3+ and Mp-11 in the Physiological Solution. Electrochimica Acta. 52(5): 2032-2038.

    (16) Zhao, B.*, Rong, Y.Z., Huang, X.H., Shen, J.S. (2007) Experimental and Theoretical Study on the Structure and Electronic Spectra of Imiquimod and its Synthetic Intermediates. Bioorganic & Medicinal Chemistry Letters. 17(17): 4942-4946.

    (17) Huang, X.H.*, Guo, S.F., Zhou, Q., Lu, T.H.*, Ding, X.L. (2007) Effect of La3+ on Structure and Electrochemical Reaction of Microperoxidase-11 in Imitated Physiological Solution. Journal of Electroanalytical Chemistry. 600(2): 227-235.

    (18) Yin, W.Q., Chen, M.Q., Lu, T.H., Akashi, M., Huang, X.H.* (2007) Properties of Complex of Tb(III) and Poly(N-Isopropylacrylamide)-G-Poly(N-Isopropylacrylamide-Co-Styrene) Core-Shell Nanoparticles. Journal of Alloys and Compounds. 432(1-2): L18-L21.

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