近幾年承擔(dān)的科研項(xiàng)目:1.國(guó)家自然科學(xué)基金重大國(guó)際合作(20920102035),2010.1~2012.122.973前期計(jì)劃課題(2008CB617510),2008.1~2009.123.教育新世紀(jì)優(yōu)秀人才支持目(20634030) ,2007.1~2010.125.國(guó)家自然科學(xué)基金(20974086)2010.1~2012.126.國(guó)家自然科學(xué)基金項(xiàng)目(20574055),2006.1~2008.127.國(guó)家自然科學(xué)基金項(xiàng)目(90606013),2007.1~2009.128.人事部留學(xué)人員科技活動(dòng)項(xiàng)目擇優(yōu)資助,2005.1~2007.129.高等學(xué)校博士點(diǎn)專項(xiàng)科研基金,2007.1~2009.1210.教育部科學(xué)技術(shù)研究重點(diǎn)項(xiàng)目(107080),2007.1~2009.1211.湖北省杰出青年人才基金(2005ABB02),2005.1~2007.12近幾年的科研成果1. “Nano-catalyst” for DNA transformation. L. Yuan, H. Wang, Q. Yu, Z. Wu, J. L .Brash,H. Chen*,J. Mater.Chem.,2011, 21 (17), 6148 - 61512. Surface Modification to Control Protein/Surface Interactions. L. Yuan, Q. Yu, D .Li,H. Chen*Macromol. Biosci., doi: 10.1002/mabi.201000464 (invited feature article)3. Tissue plasminogen activator-containing polyurethane surfaces for fibrinolytic activity. Z. Wu,H. Chen* et al.Acta Biomater., 2011,7,1993-19984. Gold Nanoparticle Layer: A Promising Platform for Ultra-Sensitive Cancer Detection. F. Zhou L. Yuan, H. Wang, D. Li,H. Chen*Langmuir,2011, 27, 21555. Lysine-poly (2-hydroxyethyl methacrylate) modified polyurethane surface with high lysine density and fibrinolytic activity. D. Li,H. Chen* et al.Acta Biomater., 2011,7,9546. Anti-fouling bioactive surfaces. Q. Yu, Y. Zhang, H. Wang, J. L. Brash,H. Chen*.Acta Biomater., 2011, 7,15507. Protein Adsorption and Cell Adhesion/Detachment Behavior on Dual-Responsive Silicon Surfaces Modified with Poly (N-isopropylacrylamide)-block-polystyrene Copolymer. Q. Yu, Y. Zhang,H. Chen*et al.Langmuir, 2010,26, 85828. A surface decorated with diblock copolymer for biomolecular conjugation. Y. X. Zhang., Q Yu. , H. Huang, F. Zhou, Z. Wu, L. Yuan., D. Li,H. Chen*,Soft Matter,2010, 6, 26169. PH-Reversible, High-Capacity Binding of Proteins on a Substrate with Nanostructure. Q Yu.H. Chen*et al.,Langmuir,2010, 26, 1781210. Lysine-PEG-modified polyurethane as a fibrinolytic surface: Effect of PEG chain length on protein interactions, platelet interactions and clot lysis, D. Li,H. Chen*,et al.,Acta Biomater., 2009,5, 186411. A Facile Approach to Modify Polyurethane Surfaces for Biomaterial Applications, Z. Wu,H. Chen*et al.,Macromol. Biosci., 2009,9, 116512. Protein Adsorption on poly (N-vinylpyrrolidone) Modified Silicon Surfaces Prepared by Surface-Initiated Atom Transfer Radical Polymerization, Z. Wu,H. Chen*et al.,Langmuir, 2009,25, 290013. Biocompatible polymer materials: Role of protein-surface interactions,H. Chen*, et al.,Prog. Polym. Sci., 2008,33, 1059.(invited review)14. Fibrinolytic poly (dimethyl siloxane) surfaces.H. Chenet al.,Macromol. Biosci.2008,8,86315. Generic bioaffinity silicone surfaces,H. Chenet al.,Bioconjugate Chem., 2006,17, 2116. Protein repellant silicone surfaces by covalent immobilization of poly (ethylene oxide),H. Chenet al.,Biomaterials, 2005,26, 2391.17. Immobilization of heparin on a silicone surface through a heterobifunctional PEG spacer,H. Chenet al.,Biomaterials, 2005,26, 741818. Silicone elastomers for reduced protein adsorption.H. Chenet al.Biomaterials.2004, 25, 2273