個(gè)人資料
王峰博士，男，教授，博士生導(dǎo)師。2003年畢業(yè)于曲阜師范大學(xué)生命科學(xué)院，生命科學(xué)專業(yè)，2008年在武漢大學(xué)獲得生物物理學(xué)博士學(xué)位。后在美國(guó)Cincinnati University進(jìn)行博士后研究。2014年回國(guó)任天津醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院教授，入選天津市“131”創(chuàng)新型人才，獨(dú)立支配經(jīng)費(fèi) 295萬(wàn)元。王峰教授，致力于研究端粒與細(xì)胞衰老的關(guān)系以及端粒酶在腫瘤發(fā)生發(fā)展中的關(guān)鍵作用。相關(guān)工作在PNAS，EMBO.J以及Cell Reports等科研雜志發(fā)表。
工作經(jīng)歷
2014年6月~今 天津醫(yī)科大學(xué) 醫(yī)用生物學(xué)教研室 教授
研究方向
王峰老師課題組主要研究方向包括：
1）端粒DNA復(fù)制的分子機(jī)制；
2） 端粒DNA高級(jí)結(jié)構(gòu)形成對(duì)復(fù)制性衰老的影響；
3）環(huán)境污染引發(fā)DNA損傷以及復(fù)制性衰老的作用機(jī)制；
4）端粒長(zhǎng)度縮短對(duì)智力發(fā)育以及認(rèn)知水平的影響及機(jī)制。
發(fā)表文章
Wang F*, Steward J, Carolyn PM. (2014) Human CST Abundance Determines Recovery from Diverse Forms of DNA Damage and Replication Stress.Cell Cycle;15;13(22):3488-3498
Kasbek,C., Wang,F., Price,C.M. (2013) Human TEN1 maintains telomere integrity and functions in genome-wide replication restart.Journal of Biological Chemistry; 288(42): 30139-50
Wang, F., Tang, M.L., Zeng, Z.X., Wu. R.Y., Xue, Y., Hao, Y.H., Pang, D.W., Zhao, Y., Tan, Z. (2012) Telomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cells.Proc Natl Acad Sci U S A109: 20413-20418
Wang, F., Stewart, J.A., Kasbek, C., Zhao, Y., Wright, W.E., Price, C.M. (2012) Human CST has independent functions during telomere duplex replication and C-strand fill-in.Cell Rep.2:1096-1103
Stewart, J.A.,Wang, F., Chaiken, M.F., Kasbek, C., Chastain, P.D., Wright, W.E., Price, C.M. (2012) Human CST promotes telomere duplex replication and general replication restart after fork stalling.EMBO J.31:3537-3549
Stewart, J.A., Chaiken, M.F., Wang, F., Price, C.M. (2012) Maintaining the end: Roles of telomere proteins in end-protection, telomere replication and length regulation.Mutation Research. 730:12-19
Wang, F., Zhao, Y., Hao, Y., Tan, Z. (2008) Identification of low-abundance alternatively spliced mRNA variants by exon exclusive reverse transcriptase polymerase chain reaction.Anal Biochem383: 307-310
Kan, ZY., Lin, Y.,Wang, F., Zhuang, X.Y., Zhao, Y., Pang, D.W., Hao, Y.H., Tan, Z. (2007) G-quadruplex formation in human telomeric (TTAGGG)4 sequence with complementary strand in close vicinity under molecularly crowded condition.Nucleic Acids. Res.35: 3646-3653
