教育與研究經(jīng)歷
1997年于武漢大學(xué)化學(xué)系獲學(xué)士學(xué)位，2002年于武漢大學(xué)化學(xué)系獲博士學(xué)位。留校在武漢大學(xué)化學(xué)與分子科學(xué)學(xué)院教育部生物醫(yī)用材料重點(diǎn)實(shí)驗(yàn)室任教。
研究領(lǐng)域與興趣
藥物傳遞體系，組織工程材料，功能高分子材料（涂料）
承擔(dān)項(xiàng)目與課題
主持國家自然科學(xué)基金課題“陽離子型基因載體構(gòu)建—基于pH敏感可逆動態(tài)結(jié)合與主客體作用的自組裝體新型模式研究（21374085）”，“多功能化聚陽離子基因載體的設(shè)計(jì)（21174110）”，“新型功能化聚碳酸酯生物醫(yī)用材料的制備和應(yīng)用（20874075）”, “生物可降解碳酸酯的酶促合成及聚磷酸酯的稀土合成研究（20304010）”。參與國家973計(jì)劃課題“生物醫(yī)用材料組織誘導(dǎo)作用的分子機(jī)制與設(shè)計(jì)原理與設(shè)計(jì)原理；誘導(dǎo)組織形成的材料化學(xué)信號及其對細(xì)胞行為調(diào)控的分子機(jī)制” （2011CB606202）、“組織誘導(dǎo)性生物醫(yī)用材料的基礎(chǔ)研究；裝載基因材料的分子設(shè)計(jì)及組織誘導(dǎo)作用和機(jī)理”（2005CB623903）；國家重大科學(xué)研究計(jì)劃“納米技術(shù)改善難溶性藥物功效的應(yīng)用基礎(chǔ)研究；增溶與促透性納米給藥系統(tǒng)的構(gòu)建與表征”（2009CB930301）等項(xiàng)目。
學(xué)術(shù)成果
Self-Assembled Vehicle Construction via Boronic Acid Coupling and Hostu2013Guest Interaction for Serum-Tolerant DNA Transport and pH-Responsive Drug Delivery. Advanced Healthcare Materials(2014), DOI: 10.1002/adhm.201300162，published online.(通訊聯(lián)系人)
Peptide Decoration of Nanovehicles to Achieve Active Targeting and Pathology-Responsive Cellular Uptake for Bone Metastasis Chemotherapy. Biomaterials Science(2014), accepted (通訊聯(lián)系人)
Theranostic GO-Based Nanohybrid for Tumor Induced Imaging and Potential Combinational Tumor Therapy. Small, 2014. 10(3): p. 599-608. (共同一作)
In vivo synergetic effect of in situ sclerotherapy and transient embolotherapy designed for fast-flow vascular malformation treatments with the aid of injectable hydrogel. Journal of Materials Chemistry. B(2013), 1, 2601-2611. (通訊聯(lián)系人)
Graphene-Based Anticancer Nanosystem and Its Biosafety Evaluation Using a Zebrafish Model. Biomacromolecules (2013),14,358-366. (通訊聯(lián)系人)
Construction of functional aliphatic polycarbonates for biomedical applications. Progress in Polymer Science(2012), 37, 211u2013236. （一作）
Extraordinarily enhanced gene transfection and cellular uptake by aromatic hydrophobicization to PEI25K. Journal of Materials Chemistry(2012), 22(45), 24092-24101. (通訊聯(lián)系人)
A smart micellar system with an amine-containing polycarbonate shell. Acta Biomaterialia(2012), 8, 589u2013598. (通訊聯(lián)系人)
A linear-dendritic cationic vector for efficient DNA grasp and delivery. Acta Biomaterialia(2012), 8, 2121u20132132. (通訊聯(lián)系人)
A strategy to improve serum-tolerant transfection activity of polycation vectors by surface hydroxylation. Biomaterials(2011), 32, 9925u20139939. (通訊聯(lián)系人)
