2002年畢業(yè)于天津大學(xué)，獲生物醫(yī)學(xué)工程學(xué)博士學(xué)位。

2002-2005年在德國(guó)Friedrich-Schiller-University Jena從事博士后研究。

Advanced Engineering Materials客座編輯，AIMS Materials Sciences、World Journal of Stem Cells、Advanced Biomaterials 國(guó)際編委。中國(guó)生物材料學(xué)會(huì)-骨修復(fù)材料與器械分會(huì)、中國(guó)機(jī)械工程學(xué)會(huì)-生物材料表面工程專業(yè)委員會(huì)委員。

兼任Advanced Materials, J Am Chem Soc, Angew Chem Int Ed, ACS Nano, Biomaterials等60余種國(guó)際期刊審稿人。

醫(yī)用鈦/鈦合金、納米藥物控釋系統(tǒng)。

1、鈦及鈦合金表/界面及其與細(xì)胞相互作用: 從天然骨多級(jí)微/納結(jié)構(gòu)生物仿生角度出發(fā)，構(gòu)筑鈦基材多尺度微/納復(fù)合結(jié)構(gòu)界面及生物誘導(dǎo)性界面。探究鈦基材表/界面介導(dǎo)特異蛋白吸附、細(xì)胞粘附/增殖/分化及組織形成的基本規(guī)律及分子機(jī)制。

2、響應(yīng)性納米藥物控釋系統(tǒng)及微裝置: 利用鐵磁納米顆粒及介孔硅納米顆粒，發(fā)展對(duì)不同外界刺激（如熱、光、磁場(chǎng)、pH、氧化還原等）產(chǎn)生反應(yīng)的響應(yīng)性納米藥物遞送系統(tǒng)，在分子、細(xì)胞和動(dòng)物水平探究各系統(tǒng)載體的分解、代謝及分布，為臨床腫瘤治療提供潛在的載體及科學(xué)依據(jù)。

3、功能性鈦合金植入體研發(fā)關(guān)鍵技術(shù): 針對(duì)臨床硬組織修復(fù)植入體（人工關(guān)節(jié)、種植牙等）潛在的炎癥、細(xì)菌感染，骨質(zhì)疏松病患固定等實(shí)際需求開展研究，發(fā)展抗菌/炎癥及原位骨質(zhì)疏松治療新技術(shù)，為研發(fā)相關(guān)功能性鈦合金植入體提供技術(shù)支撐。

中國(guó)青年科技獎(jiǎng)（2011）、重慶市杰出青年科學(xué)基金（2011）、教育部“新世紀(jì)優(yōu)秀人才”（2007）、霍英東青年教師基金（基礎(chǔ)研究）獲得者（2010）。

2018年8月3日，國(guó)家自然科學(xué)基金委員會(huì)公布2018年度國(guó)家杰出青年科學(xué)基金建議資助項(xiàng)目申請(qǐng)人名單，其中蔡開勇研究領(lǐng)域的《生物醫(yī)用材料表界面》項(xiàng)目在2018年度國(guó)家杰出青年科學(xué)基金建議資助項(xiàng)目申請(qǐng)人名單內(nèi)。

主持或參與973、科技部支撐計(jì)劃、國(guó)家自然科學(xué)基金重點(diǎn)/面上項(xiàng)目等20余項(xiàng)。在Angew Chem Int Ed, Advanced Materials, ACS Nano，Small, Biomaterials, Acta Biomaterialia等核心期刊發(fā)表SCI論文70余篇，IF>5的20篇，其中IF>10的6篇。獲權(quán)國(guó)家發(fā)明專利8項(xiàng)。

承擔(dān)或參與國(guó)家科技支撐計(jì)劃、國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目、面上項(xiàng)目以及省部級(jí)課題10余項(xiàng)，參編專著2部。

1.Zhong Luo, Kaiyong Cai*, Yan Hu, Jinghua Li, Xingwei Ding, Beilu Zhang, Dawei Xu, Weihu Yang, Peng Liu. Redox-responsive molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles. Advanced Materials, 2011, 24（3）：431-435.

2.Yan Hu, Kaiyong Cai*, Zhong Luo, Dawei Xu, Daichao Xie, Yuran Huang, Weihu Yang, Peng Liu. TiO2 nanotubes as drug nano-reservoir for regulation of the mobility and differentiation of mesenchymal stem cells. Acta Biomaterialia, 2011, 8（1）:439-448.

3.Xiuyong Chen, Kaiyong Cai*, Min Lai, Li Zhao and Liling Tang.Mesenchymal Stem Cells Differentiation on Hierarchically Micro/Nano-Structured Titanium Substrates.Advanced Biomaterials,2011.

4.Kaiyong Cai*, Yanhua Hou, Yan Hu, Li Zhao, Zhong Luo, Yisong Shi, Min Lai, Weihu Yang, Peng Liu. Correlation of cytotoxicity of TiO2 nanoparticles with different particle sizes on a sub-200 nm scale. Small, 2011,7（21）:3026-3031.

5.Kaiyong Cai*, Jinghua Li, Zhong Luo, Yan Hu, Yanhua Hou, Xingwei Ding. β-cyclodextrin conjugated magnetic nanoparticles for diazepam removal from blood. Chem Commun. 2011,47（27）,7719-7721.

6.Min Lai, Kaiyong Cai*, Li Zhao, Xiuyong Chen, Yanhua Hou, Zaixiang Yang. Surface functionalization of TiO2 nanotubes with bone morphogenetic protein 2 and its synergistic effect on the differentiation of mesenchymal stem cells. Biomacromolecules. 2011，12（4）:1097-1105.

7.Weihu Yang, Jiajia Fang, Peng Liu, Junfeng Li and Kaiyong Cai. Theoretical study of the permeation of water through TiO2 nanotube with molecular dynamics simulation. Molecular Physics. 2011,109（6）:969-974.

8.Zhong Luo, Kaiyong Cai*, Yan Hu, Li Zhao, Peng Liu, Weihu Yang. Redox-responsive Nanoreservoirs Based on Collagen End-capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery. Angew Chem Int Ed.2011,50（3）:640-643.

9.Yan Hu, Kaiyong Cai*, Zhong Luo, Klaus D. Jandt. Layer-by-layer assembling β-estradiol loaded mesoporous silica nanoparticles on titanium substrates and its implication for bone homeostasis. Advanced Materials. 2010, 22（37）:4146-4150.

10.Kaiyong Cai, Feng Jiang, Zhong Luo, Xiuyong Chen. Temperature-responsive controlled drug delivery system based on titanium nanotubes. Advanced Biomaterials, 2010 in press.

11.Kaiyong Cai, Min Lai, Ran Hu, Renlong Xin, Qing Liu, K. L. Paul Sung. Surface engineering of titanium with potassium hydroxide and its effects on the growth behaviors of mesenchymal stem cells. Acta Biomerialia. 2010; （6）2314-2321.

12.Kaiyong Cai, Tingting Kong, Lu Wang, Peng Liu, Weihu Yang, Chong Chen. Regulation of endothelial cells migration on poly（D, L-lactic acid） ?lms immobilized with collagen gradients. Colloids and Surface B-Biointerfaces. 2010;79:291-297.

13.Yan Hu, Kaiyong Cai*, Zhong Luo, Ran Hu. Construction of polyethyleneimine -β-cyclodextrin/pDNA multilayer structure for improved in situ gene transfection. Advanced Engineering Materials, 2010:12（1-2）:B18-B25.

14.Kaiyong Cai, Zhong Luo, Yan Hu, Xiuyong Chen, Li Yang, Linhong Deng. Magnetically triggered reversible controlled drug delivery from microfabricated polymeric multi-reservoir device. Advanced Materials. 2009; 21（40）: 4045-4049.

15.Yan Hu, Kaiyong Cai*, Rui Zhang, Zhong Luo, Li Yang, Klaus D. Jandt, Linhong Deng. Surface mediated in situ differentiation of mesenchymal stem cells on gene-functionalized titanium films fabricated by layer-by-layer technique. Biomaterials. 2009; 30（21）:3626-3635.

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