人物經(jīng)歷
2016年至今,任四川大學(xué)生物治療國家重點實驗室研究員
2014年-2016年,美國哈佛大學(xué)醫(yī)學(xué)院貝以迪醫(yī)學(xué)中心訪問學(xué)者
2010年,任四川大學(xué)生物治療國家重點實驗室副研究員
2008年,任四川大學(xué)生物治療國家重點實驗室助理研究員
2008年,獲四川大學(xué)博士學(xué)位
2004年,獲西南大學(xué)碩士學(xué)位
2000年,畢業(yè)于河南科技學(xué)院獲學(xué)士學(xué)位
研究方向
作為項目負責(zé)人,先后承擔(dān)國家自然科學(xué)基金3項,國家重大專項1項。同時參與國家973,863,重點研發(fā)計劃等多項課題的研究工作。
主要研究方向包括以下方面:
1) 腫瘤免疫治療分子機理與應(yīng)用開發(fā)。包括免疫治療新靶點的發(fā)現(xiàn),新型抗體的研發(fā),利用CRISPR等技術(shù)進行基因工程細胞(如T細胞)的遺傳改造與抗腫瘤研發(fā),腫瘤疫苗的抗腫瘤機理與新型疫苗的研發(fā)。
2) 中樞神經(jīng)系統(tǒng)惡性腫瘤的發(fā)生分子機理與治療。
3) 細胞增生,分化,衰老,死亡等的基本生物學(xué)分子機制研究。
著述成果
1) Tang M, Wei H, Han L, Deng J, Wang Y, Yang M, Tang Y, Guo G, Zhou L*, Tong A*. Whole-genome sequencing identifies new genetic alterations in meningiomas. Oncotarget. 2017 Feb 3. doi: 10.18632/oncotarget.15043.(*并列通訊)
2) Wang Y, Deng J, Guo G, Tong A*, Peng X, Chen H, Xu J, Liu Y, You C, Zhou L*. Clinical and prognostic role of annexin A2 in adamantinomatous craniopharyngioma. J Neurooncol. 2017 Jan;131(1):21-29. (*并列通訊)
3) Yang Y, He L, Liu Y, Xia S, Fang A, Xie Y, Gan L, He Z, Tan X, Jiang C, Tong A*, Song X*. Promising Nanocarriers for PEDF Gene Targeting Delivery to Cervical Cancer Cells Mediated by the Over-expressing FRα. Sci Rep. 2016 Aug 31;6:32427. (*并列通訊)
4) Yuan Z*, Guo W, Yang J, Li L, Wang M, Lei Y, Wan Y, Zhao X, Luo N, Cheng P, Liu X, Nie C, Peng Y, Tong A*, Wei Y. PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells. J Biol Chem. 2015 Jun 12;290(24):14927-44. (*并列通訊)
5) Yang M, Tang M, Ma X, Yang L, He J, Peng X, Guo G, Zhou L, Luo N, Yuan Z*, Tong A*. AP-57/C10orf99 is a new type of multifunctional antimicrobial peptide. Biochem Biophys Res Commun. 2015 Feb 13;457(3):347-52. (*并列通訊)
6) Liu S, Zhou R, Zhong J, Nie C, Yuan Z, Zhou L, Luo N, Wang C*, Tong A*. HepG2.2.15 as a model for studying cell protrusion and migration regulated by S100 proteins. Biochem Biophys Res Commun. 2014 Jun 20;449(1):175-81. (*并列通訊)
7) Li Z, Tang M, Ling B, Liu S, Zheng Y, Nie C, Yuan Z, Zhou L, Guo G, Tong A*, Wei Y. Increased expression of S100A6 promotes cell proliferation and migration in human hepatocellular carcinoma. J Mol Med (Berl). 2014 Mar;92(3):291-303. (通訊作者)
8) Wu DM, Zhang P, Liu RY, Sang YX, Zhou C, Xu GC, Yang JL, Tong AP*, Wang CT*. Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma. FEBS Lett. 2014 May 21;588(10):1921-9. (*并列通訊)
9) Gong F, Peng X, Sang Y, Qiu M, Luo C, He Z, Zhao X, Tong A*. Dichloroacetate induces protective autophagy in LoVo cells: involvement of cathepsin D/thioredoxin-like protein 1 and Akt-mTOR-mediated signaling. Cell Death Dis. 2013 Nov 7;4:e913(通訊作者)
10) Zhou R, Huang W, Yao Y, Wang Y, Li Z, Shao B, Zhong J, Tang M, Liang S, Zhao X, Tong A*, Yang J*. CA II, a potential biomarker by proteomic analysis, exerts significant inhibitory effect on the growth of colorectal cancer cells. Int J Oncol. 2013 Aug;43(2):611-21(*并列通訊)
11) Zhang D, Tong A*, Zhou L, Fang F, Guo G*. Osteogenic differentiation of human placenta-derived mesenchymal stem cells (PMSCs) on electrospun nanofiber meshes. Cytotechnology. 2012 Dec;64(6):701-10. (*并列通訊)
12) Shao B, Tang M, Li Z, Zhou R, Deng Y, Nie C, Yuan Z, Zhou L, Tang M, Tong A*, Wei Y. Proteomics analysis of human umbilical vein endothelial cells treated with resveratrol. Amino Acids. 2012 Oct;43(4):1671-8. (通訊作者)
13) Peng XC, Gong FM, Zhao YW, Zhou LX, Xie YW, Liao HL, Lin HJ, Li ZY, Tang MH, Tong AP*. Comparative proteomic approach identifies PKM2 and cofilin-1 as potential diagnostic, prognostic and therapeutic targets for pulmonary adenocarcinoma. PLoS One. 2011;6(11):e27309. (通訊作者)
14) Tong A, Gou L, Lau QC, Chen B, Zhao X, Li J, Tang H, Chen L, Tang M, Huang C, Wei YQ. Proteomic profiling identifies aberrant epigenetic modifications induced by hepatitis B virus X protein. J Proteome Res. 2009 Feb;8(2):1037-46. doi: 10.1021/pr8008622.
15) Tong A, Wu L, Lin Q, Lau QC, Zhao X, Li J, Chen P, Chen L, Tang H, Huang C, Wei YQ. Proteomic analysis of cellular protein alterations using a hepatitis B virus-producing cellular model. Proteomics. 2008 May;8(10):2012-23.
16) Tong A, Zhang H, Li Z, Gou L, Wang Z, Wei H, Tang M, Liang S, Chen L, Huang C, Wei Y. Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid. Cancer Chemother Pharmacol. 2008 Apr;61(5):791-802.