人物經(jīng)歷
1999-2003年，北京大學(xué)生命科學(xué)學(xué)院 生物科學(xué) 學(xué)士
2003-2008年，美國(guó)加州大學(xué)洛杉磯分校 分子生物學(xué) 博士
2006-2008年，美國(guó)加州大學(xué)洛杉磯分校 統(tǒng)計(jì)學(xué) 碩士
2008-2009年，美國(guó)加州大學(xué)洛杉磯分校 博士后
2009-2013年，美國(guó)圣地亞哥Ludwig腫瘤研究所，加州大學(xué)圣地亞哥分校 博士后
2013年-， 清華大學(xué)生命科學(xué)學(xué)院 研究員
科研方向
主要科研領(lǐng)域與方向:?
研究興趣包括表觀(guān)遺傳學(xué)，基因組學(xué)和發(fā)育生物學(xué)。同時(shí)利用分子生物學(xué)、發(fā)育生物學(xué)和計(jì)算生物學(xué)的方法，采用干濕實(shí)驗(yàn)結(jié)合的方式，研究干細(xì)胞分化和個(gè)體發(fā)育以及人類(lèi)疾病中的表觀(guān)遺傳調(diào)控機(jī)制。本實(shí)驗(yàn)室將致力于：（1）動(dòng)物胚胎早期發(fā)育過(guò)程中的表觀(guān)遺傳調(diào)控；（2）干細(xì)胞分化過(guò)程中的表觀(guān)遺傳調(diào)控；（3）調(diào)控序列如啟動(dòng)子、增強(qiáng)子、絕緣子以及三維基因組在發(fā)育和細(xì)胞命運(yùn)決定過(guò)程中的功能；（4）表觀(guān)遺傳相關(guān)人類(lèi)疾病的調(diào)控機(jī)理。
著述成果
代表性論文:
# Correspondence author * First author
Zhenhai Du, Hui Zheng, Bo Huang, Rui Ma, Jingyi Wu, Xianglin Zhang, Jing He, Yunlong Xiang, Qiujun Wang, Yuanyuan Li, Jing Ma, Xu Zhang, Ke Zhang, Michael Q. Zhang, Juntao Gao, Jesse R. Dixon, Xiaowo Wang, Jianyang Zeng, Wei Xie,# (2017) Allelic reprogramming of 3D chromatin architecture during early mammalian development. Nature 547 (232-235).Yuwen Ke,* Yanan Xu,* Xuepeng Chen,* Songjie Feng,* Zhenbo Liu, Yaoyu Sun, Xuelong Yao, Fangzhen Li, Wei Zhu, Lei Gao, Haojie Chen, Zhenhai Du, Wei Xie, Xiaocui Xu, Xingxu Huang,# and Jiang Liu# (2017) 3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis. Cell 170 (357-381).Reinhard Brunmeir*, Jingyi Wu*, Xu Peng, Sun-Yee Kim, Sofi G. Julien, Qiongyi Zhang, Wei Xie# and Feng Xu# (2016) Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. PLoS Genetics 12(12): e1006474.Wenhao Zhang,* Weikun Xia,* Qiujun Wang, Aaron Towers, Jiayu Chen, Rui Gao, Yu Zhang, Chia-an Yen, Ah Young Lee, Yuanyuan Li, Chen Zhou, Kaili Liu, Jing Zhang, Xiuqi Chen, Zai Chang, Danny Leung,? Shaorong Gao, Yong-hui Jiang, Wei Xie# (2016) Isoform switch of TET1 regulates demethylation and mouse development. Molecular Cell 64 (1-12). Xiaozhe Xiong, Tatyana Panchenko, Shuang Yang, Shuai Zhao, Peiqiang Yan, Wenhao Zhang, Wei Xie, Yuanyuan Li, Yingming Zhao, C David Allis & Haitao Li (2016) Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2. Nature Chemical Biology 12, (1111u20131118).Bingjie Zhang,* Hui Zheng,* Bo Huang,* Wenzhi Li,* Yunlong Xiang, Xu Peng, Jia Ming, Xiaotong Wu, Yu Zhang, Qianhua Xu, Wenqiang Liu, Xiaochen Kou, Yanhong Zhao, Wenteng He, Chong Li,? Bo Chen, Yuanyuan Li, Qiujun Wang, Jing Ma, Qiangzong Yin, Zai Chang, Kehkooi Kee, Anming Meng, Shaorong Gao, Feng Xu, Jie Na,# Wei Xie# (2016). Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature 537 (553-557). Hui Zheng,* Bo Huang,* Bingjie Zhang,* Yunlong Xiang, Zhenhai Du, Qiujun Wang, Yuanyuan Li, Jing Ma, Xu Peng, Zai Chang, Feng Xu, Wei Xie# (2016). Resetting epigenetic memory by reprogramming of histone modifications in mammals. Molecular Cell 63 (1066-1079).Jingyi Wu,* Bo Huang,* He Chen, Qiangzong Yin, Yang Liu, Yunlong Xiang, Bingjie Zhang, Bofeng Liu, Qiujun Wang, Weikun Xia, Wenzhi Li, Yuanyuan Li, Jing Ma, Xu Peng, Hui Zheng, Jia Ming, Wenhao Zhang, Jing Zhang, Geng Tian, Feng Xu, Zai Chang, Jie Na, Xuerui Yang, Wei Xie# (2016). The landscape of accessible chromatin in mammalian preimplantation embryos. Nature 534 (652-657).Bo Xia, Dali Han, Xingyu Lu, Zhaozhu Sun, Ankun Zhou, Qiangzong Yin, Hu Zeng, Menghao Liu, Xiang Jiang, Wei Xie, Chuan He & Chengqi Yi (2015). Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale. Nature Methods 12,1047u20131050.Danny Leung*, Inkyung Jung*, Nisha Rajagopal*, Anthony Schmitt, Siddarth Selvaraj, Ah Young Lee, Chia-An Yen, Shin Lin, Yiing Lin, Yunjiang Qiu, Wei Xie, Feng Yue, Manoj Hariharan, Pradipta Ray, Samantha Kuan, Lee Edsall, Hongbo Yang, Neil C. Chi, Michael Q. Zhang, Joseph R. Ecker & Bing Ren (2015). Integrative analysis of haplotype-resolved epigenomes across human tissues.?Nature?518, 350-354.Jesse R. Dixon*, Inkyung Jung*, Siddarth Selvaraj*, Yin Shen, Jessica E. Antosiewicz-Bourget, Ah Young Lee, Zhen Ye, Audrey Kim, Nisha Rajagopal,?Wei Xie, Yarui Diao, Jing Liang, Huimin Zhao, Victor V. Lobanenkov, Joseph R. Ecker, James A. Thomson & Bing Ren (2015). Chromatin architecture reorganization during stem cell differentiation.?Nature?518, 331-336.Wei Xie#,?Bing Ren#?(2013) Enhancing Pluripotency and Lineage Specification,?Science?341:245-7Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal, Pradipta Ray, John W. Whitaker, Shulan Tian, R. David Hawkins, Danny Leung, Hongbo Yang, Tao Wang, Ah Young Lee, Scott A. Swanson, Jiuchun Zhang, Yun Zhu, Audrey Kim, Joseph R. Nery, Mark A. Urich, Samantha Kuan, Chia-an Yen, Sarit Klugman, Pengzhi Yu, Kran Suknuntha, Nicholas E. Propson, Huaming Chen, Lee E. Edsall, Ulrich Wagner, Yan Li, Zhen Ye, Ashwinikumar Kulkarni, Zhenyu Xuan, Wen-Yu Chung, Neil C. Chi, Jessica E. Antosiewicz-Bourget, Igor Slukvin, Ron Stewart, Michael Q. Zhang, Wei Wang, James A. Thomson,? Joseph R. Ecker, and Bing Ren (2013) Epigenomic Analysis of Multi-lineage Differentiation of Human Embryonic Stem Cells,?Cell?153:?1134-1148).Wei Xie, Cathy L Barr, Audrey Kim, Feng Yue, Ah Young Lee, James Eubanks, Emma L Dempster and Bing Ren (2012) Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome,?Cell?148: 816-831.Hao Wu, Volkan Coskun, Jifang Tao,?Wei Xie, Weihong Ge, Kazuaki Yoshikawa, En Li, Yi Zhang and Yi Eve Sun (2010) Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes,?Science?329 (5990): 444-448.Mark H. Chin, Mike J. Mason,?Wei Xie, Stefano Volinia, Mike Singer, Cory Peterson, Gayane Ambartsumyan, Otaren Aimiuwu, Laura Richter, Jin Zhang, Ivan Khvorostov, Vanessa Ott, Michael Grunstein, Neta Lavon, Nissim Benvenisty, Carlo M. Croce, Amander T. Clark, Tim Baxter, April D. Pyle, Mike A. Teitell, Matteo Pelegrini, Kathrin Plath and William E. Lowry (2009) Induced Pluripotent Stem Cells and Embryonic Stem Cells Are Distinguished by Gene Expression Signatures,?Cell Stem Cell?5(1): 111-123.Wei Xie, Chunying Song, Nicolas L. Young, Adam Sperling, Feng Xu, Rupa Sridharan, Anne Conway, Benjamin A. Garcia, Kathrin Plath, Amander Clark and Michael Grunstein (2009) Histone H3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells,?Molecular Cell, 33(4):417-427.Roberto Ferrari, Matteo Pellegrini, Gregory A. Horwitz,?Wei Xie, Arnold J. Berk and Siavash K. Kurdistani (2008) Epigenetic reprogramming by adenovirus e1a,?Science?321, 1086-1088.Nimet?Maherali*, Rupa?Sridharan*,?Wei?Xie, Jochen?Utikal, Sarah?Eminli, Katrin?Arnold, Matthias?Stadtfeld, Robin?Yachechko, Jason?Tchieu, Rudolf?Jaenisch, Kathrin?Plath and Konrad?Hochedlinger (2007) Directly reprogrammed fibroblasts show?global?epigenetic?remodeling and?widespread?tissue?contribution,?Cell Stem Cell, 1(1): 55-70.Feng Xu, Qiongyi Zhang, Kangling Zhang,?Wei Xie?and Michael Grunstein (2007) Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast,?Molecular Cell, 27(6): 890-900.?榮譽(yù)記錄
2019年9月20日，“科學(xué)探索獎(jiǎng)”評(píng)審委員會(huì)公布2019年“科學(xué)探索獎(jiǎng)”獲獎(jiǎng)名單，頡偉在列。
