人物經(jīng)歷
南京大學(xué)物理學(xué)院教授， 2010.5至今
2009-2010加拿大不列顛哥倫比亞大學(xué)化學(xué)系博士后。
加拿大不列顛哥倫比亞大學(xué)，化學(xué)系，博士（導(dǎo)師：Hongbin Li教授），2004.9-2009.4
南京大學(xué)，化學(xué)化工學(xué)院，碩士（導(dǎo)師：蔣錫群教授），2001.9-2004.6
南京大學(xué)，化學(xué)化工學(xué)院，本科 （導(dǎo)師：全一武、陳慶民教授），1997.9-2001.6
所授課程
物理生物學(xué)新生研討課;
物理生物學(xué)前沿
研究領(lǐng)域
主要的研究領(lǐng)域包括：?jiǎn)畏肿由镂锢�、蛋白質(zhì)多肽生物材料、生物力學(xué)。本實(shí)驗(yàn)室主要發(fā)展和應(yīng)用多種單分子測(cè)量手段，如原子力顯微鏡，磁鑷，全內(nèi)反射熒光顯微鏡等來(lái)探索生物分子結(jié)構(gòu)與功能之間的關(guān)系，特別是環(huán)境因素對(duì)生物分子結(jié)構(gòu)與功能的調(diào)控。我們還通過(guò)自組裝的方法，設(shè)計(jì)制備有著多種新奇物理和生物特性的蛋白質(zhì)多肽生物材料，用于納米技術(shù)和組織工程。
科研項(xiàng)目
國(guó)家自然科學(xué)基金面上項(xiàng)目：彈性蛋白力學(xué)構(gòu)造的單分子研究 （2011-2013）；蛋白質(zhì)折疊的單分子力譜研究（2012-2014）；新世紀(jì)人才支持計(jì)劃（2011-2013）
代表論文
1. “How Do Proteins Unfold upon Adsorption on Nanoparticle Surfaces?” Pan, H, Qin, M, Meng, W, Cao, Y*, Wang, W* (2012)Langmuir. [Epub ahead of print]
2. “A versatile "multiple fishhooks" approach for the study of ligand-receptor interactions using single molecule atomic force microscopy.” Han, X, Qin, M, Pan, H, Cao, Y*, Wang, W* (2012)Langmuir28:10020-5.
3. “Single-molecule experiments reveal the flexibility of a Per-ARNT-Sim domain and the kinetic partitioning in the unfolding pathway under force” Gao X, Qin, M, Yin, PG, Liang, JY, Wang, J, Cao, Y*, Wang, W* (2012)Biophysical Journal102:2149-57.
4. “Low folding cooperativity of Hp35 revealed by single-molecule force spectroscopy and molecular dynamics simulation” Lv, CM, Tan, C, Qin, M., Zou, DW, Cao, Y*, Wang, W* (2012)Biophysical Journal102:1944-51.
5. “A genetically encoded copper(I) sensor based on engineered structural distortion of EGFP.” Liang, J, Qin, M, Xu, R, Gao, X, Shen, Y, Xu, Q, Cao, Y*, Wang, W* (2012)Chemical Communications48:3890-2
6. “Designed biomaterials to mimic the mechanical properties of muscles” Lv, S, Dudek, DM, Cao, Y, Balamurali, MM, Gosline, J, Li, HB (2010)Nature465: 69-73
7. “Single molecule force spectroscopy reveals engineered metal chelation is a general approach to enhance mechanical stability of proteins” Cao, Y, Yoo, T, Li, HB (2008)Proceedings of the National Academy of Sciences USA105: 11152-11157.
8. “Engineered elastomeric proteins with dual elasticity can be controlled by a molecular regulator” Cao, Y, Li, HB (2008)Nature Nanotechnology3: 512-516.
9. “A functional single-molecule binding assay via force spectroscopy” Cao, Y, Balamurali, MM, Sharma, D, Li, HB (2007)Proceedings of the National Academy of Sciences USA104:15677-15681.
10.“Polyprotein of GB1 is an ideal artificial elastomeric protein” Cao, Y, Li, HB (2007)Nature Materials6: 109-114.
