1987年畢業(yè)于武漢大學生物系微生物專業(yè)，獲學士學位。?

1992年畢業(yè)于華中農(nóng)業(yè)大學微生物系，獲博士學位。 1994年被破格提拔為副教授。主持國家自然科學青年基金和湖北省自然科學基金各一項。

1994年，覃重軍確立了自己的5個科學夢想：要在重大基礎(chǔ)研究、原創(chuàng)技術(shù)、產(chǎn)業(yè)化、解決人類疾病、新理論上有所突破。

1995年至2000年在美國斯坦福大學基因工程創(chuàng)始人之一Stanley N. Cohen教授實驗室作博士后, 從事鏈霉菌線型質(zhì)粒的復制、重組、修復、 接合轉(zhuǎn)移、端�；�因、異常DNA結(jié)構(gòu)等方面的研究。

2001年通過“引進國外杰出人才計劃”答辯, 被中國科學院上海植物生理研究所聘為研究員、博士生導師。?

2001年回國后主持國家“863”項目和國家自然科學基金共4項，主持上海市、科學院、所基金共5項。

2002年任微生物次生代謝分子調(diào)控研究開放實驗室主任。?

2003年獲國家杰出青年科學基金資助。?

2013年5月8日，覃重軍瞄準了真核單細胞生物的模式材料——釀酒酵母，花了5年時間，用基因編輯的方法，將釀酒酵母中16條天然染色體合成為1條，創(chuàng)建出了國際首例人造單染色體真核細胞，實現(xiàn)“人造生命”里程碑式的重大突破。該成果于2018年8月2日在線發(fā)表在《自然》雜志上。

分子微生物學和分子微生物組學

從事分子微生物學、分子微生物組學和微生物藥物代謝工程的研究，主要內(nèi)容包括：（1）放線菌線型染色體和線型質(zhì)粒的生物學功能。（2）中草藥植物內(nèi)生放線菌。（3）放線菌基因組工程。（4）微生物藥物工業(yè)生產(chǎn)菌種的遺傳改良。?

2019年6月28日，被評為科學中國人（2018）年度人物。

博士畢業(yè)論文發(fā)表在國際知名專業(yè)期刊《細菌學雜志》上，這也是華中農(nóng)大在該本雜志上發(fā)表的第一篇學術(shù)文章。

兩年前，覃重軍帶領(lǐng)團隊將釀酒酵母中16條天然染色體合成為1條，創(chuàng)建出了國際首例人造單染色體真核細胞。這一成果在線發(fā)表在《自然》雜志上，被業(yè)界認為是合成生物學具有里程碑意義的重大突破。

帶領(lǐng)團隊首次在粘細菌中發(fā)現(xiàn)質(zhì)粒并建立遺傳操作系統(tǒng)，全世界有20多個實驗室來函索取質(zhì)粒載體;對大腸桿菌的基因組進行了“刪減、重組、優(yōu)化、合成”等操作，做了大量有益的探索。他的團隊與國內(nèi)制藥企業(yè)合作改良了抗寄生蟲藥物多拉菌素，打破了國外在該領(lǐng)域的壟斷，藥品銷售額超過億元。

1. Yangyang Shao, Ning Lu, Zhenfang Wu, Chen Cai, Shanshan Wang, Ling-Li Zhang, Fan Zhou, Shijun Xiao, Lin Liu, Xiaofei Zeng, Huajun Zheng, Chen Yang, Zhihu Zhao, Guoping Zhao*, Jinqiu Zhou*, Xiaoli Xue* and Zhongjun Qin* (2018) Creating a functional single chromosome yeast. Nature (article). 560:331u2013335.

2. Yangyang Shao, Ning Lu, Chen Cai, Fan Zhou, Shanshan Wang, Zhihu Zhao*, Guoping Zhao*, Jinqiu Zhou*, Xiaoli Xue* and Zhongjun Qin* (2018). A single circular chromosome yeast. Cell Research. 10.1038/s41422-018-0110-y.

3. Yangyang Shao, Ning Lu, Zhongjun Qin* and Xiaoli Xue* (2018). CRISPR-Cas9 facilitated multiple-chromosome fusion in Saccharomyces cerevisiae. ACS Synthetic Biology. 10.1021/acssynbio.8b00397.

4. Yangyang Shao, Ning Lu, Xiaoli Xue* and Zhongjun Qin* (2018). CRISPR-Cas9 facilitated multiple-chromosome fusion in Saccharomyces cerevisiae. Nature Protocol. Invited.

5. Jianting Zhou, Ronghai Wu, Xiaoli Xue* and Zhongjun Qin* (2016) CasHRA (Cas9-facilitated Homologous Recombination Assembly) method of constructing megabase-sized DNA. Nucleic Acids Research. 4(14):e124.

6. Xiaoli Xue*, Tao Wang, Peng Jiang, Yangyang Shao, Min Zhou, Li Zhong, Ronghai Wu, Jianting Zhou, Haiyang Xia, Guoping Zhao and Zhongjun Qin* (2015) MEGA (Multiple Essential Genes Assembling) deletion and replacement method for genome reduction in Escherichia coli. ACS Synthetic Biology. 4(6):700u2013706.

7. Jian Chen, Haiyang Xia*, Fujun Dang, Qingyu Xu, Wenjun Li and Zhongjun Qin* (2015) Characterization of the chromosomal integration of Saccharopolyspora plasmid pCM32 and its application to improve production of spinosyn in Saccharopolyspora spinosa. Applied Microbiology and Biotechnology. 99:10141u201310149.

8. Yalan Chen, Huarong Tan and Zhongjun Qin* (2013) Characterization of a replication locus and formation of a higher-order complex between RepA protein and two inverted-repeats in Streptomyces plasmid pSV1. FEMS Microbiology Letters. 349: 144u2013152.

9. Shiyuan Peng, Ana Zeng, Li Zhong, Ran Zhang, Min Zhou, Qiuxiang Cheng, Liqian Zhao, Tao Wang, Huarong Tan and Zhongjun Qin* (2013) Three functional replication origins of the linear and artificially-circularized plasmid SCP1 of Streptomyces coelicolor. Microbiology. 159: 2127u20132140.

10. Ran Zhang, Haiyang Xia, Qingyu Xu, Fujun Dang and Zhongjun Qin* (2013) Recombinational cloning of the antibiotic biosynthetic gene clusters in linear plasmid SCP1 of Streptomyces coelicolor A3(2). FEMS Microbiology Letters. 345: 39u201348.

11. Pengfei Xie, Ana Zeng and Zhongjun Qin* (2013) A putative transglycosylase encoded by SCO4132 influences morphological differentiation and actinorhodin production in Streptomyces coelicolor. Acta Biochimica et Biophysica Sinica. 45(4):296u2013302.

12. Tao Wang, Zhenhua Chen, Qiuxiang Cheng, Min Zhou, Xinli Tian, Pengfei Xie, Li Zhong, Meijuan Shen and Zhongjun Qin* (2012) Characterization of replication and conjugation of plasmid pWTY27 from a widely distributed Streptomyces species. BMC Microbiology. 12:253.

13. Zhenhua Chen, Li Zhong, Meijuan Shen, Ping Fang and Zhongjun Qin* (2012) Characterization of Streptomyces plasmid-phage pFP4 and its evolutionary implications. Plasmid. 68:170u2013178.

14. Min Zhou, Xinyun Jing, Pengfei Xie, Weihua Chen, Tao Wang, Haiyang Xia and Zhongjun Qin* (2012) Sequential deletion of all the PKS and NRPS biosynthetic gene clusters and a 900-kb subtelomeric sequence of the linear chromosome of Streptomyces coelicolor. FEMS Microbiology Letters. 333(2):169u2013179.

15. Yun Fan, Yumei Dai, Qiuxiang Cheng, Guangjun Zhang, Dongshu Zhang, Ping Fang*, Hang Wu, Linquan Bai*, Zixin Deng and Zhongjun Qin* (2012) A self-ligation method for PCR-sequencing the telomeres of Streptomyces and Mycobacterium linear replicons. Journal of Microbiological Methods. 90:105u2013107.

16. Weihua Chen and Zhongjun Qin* (2011) Development of a gene cloning system in a fast-growing and moderately thermophilic Streptomyces species and heterologous expression of Streptomyces antibiotic biosynthetic gene clusters. BMC Microbiology. 11(1):243.

17. Ana Zeng, Tao Wang, Haiyang Xia, Shiyuan Peng, Weihua Chen, Chenglin Jiang, Lihua Xu, Li Zhong, Meijuan Shen and Zhongjun Qin* (2011) Development of a vector and host system and characterization of replication of plasmid pSQ10 in moderately halophilic Nocardiopsis. Acta Biochimica et Biophysica Sinica. 43(9):738u2013743.

18. Peng Guo, Qiuxiang Cheng, Pengfei Xie, Yun Fan, Weihong Jiang and Zhongjun Qin* (2011) Characterization of the multiple CRISPR loci on Streptomyces linear plasmid pSHK1. Acta Biochimica et Biophysica Sinica. 43(8):630u2013639.

19. Li Zhong, Qiuxiang Cheng, Xinli Tian, Liqian Zhao and Zhongjun Qin* (2010) Characterization of the replication, transfer and plasmid/lytic phage cycle of the Streptomyces plasmid-phage pZL12. Journal of Bacteriology. 192:3747u20133754.

20. Ran Zhang, Shiyuan Peng and Zhongjun Qin* (2010) Two internal origins of replication on Streptomyces linear plasmid pFRL1. Applied and Environmental Microbiology. 76(17):5676u20135683.

21. Zhiqun Lu, Pengfei Xie and Zhongjun Qin* (2010) Promotion of markerless deletion of the actinorhodin biosynthetic gene cluster in Streptomyces coelicolor. Acta Biochimica et Biophysica Sinica. 42(10):717u2013721.

22. Pengfei Xie, Ana Zeng and Zhongjun Qin* (2009) cmdABCDEF, a cluster of genes encoding membrane proteins for differentiation and antibiotic production in Streptoymyces coelicolor A3(2). BMC Microbiology. 9:157.

23. Yongqiang Tian, Weihong Jiang, Guoping Zhao* and Zhongjun Qin* (2009) In vivo conjugation-coupled recombinational cloning of a Streptomyces lividans chromosomal telomeric DNA using a linear plasmid. Biotechnology Letter. 31(8):1253u20131258.

24. Ran Zhang, Haiyang Xia, Peng Guo and Zhongjun Qin* (2009) Variation in the replication loci of Streptomyces linear plasmids. FEMS Microbiology Letters. 290:209u2013216.

25. Ran Zhang, Ana Zeng, Ping Fang and Zhongjun Qin* (2008) Characterization of the replication and conjugation loci of Streptomyces circular plasmids pFP11 and pFP1 and their ability to propagate in linear mode with artificially attached telomeres. Applied and Environmental Microbiology. 74(11):3368u20133376.

26. Jingyi Zhao, Li Zhong, Meijuan Shen, Zhijie Xia, Qiuxiang Cheng, Xia Sun, Guoping Zhao, Yuezhong Li* and Zhongjun Qin* (2008) Discovery of an autonomously-replicating plasmid pMF1 from Myxococcus fulvus and the development of a gene cloning system in Myxococcus Xanthus. Applied and Environmental Microbiology. 74(7):1980u20131987.

27. Mingxuan Xu, Yingmin Zhu, Ran Zhang, Meijuan Shen, Weihong Jiang, Guoping Zhao* and Zhongjun Qin* (2006) Characterization of the genetic components of Streptomyces lividans linear plasmid SLP2 for replication in circular and linear modes. Journal of Bacteriology.188:6851u20136857.

28. Ran Zhang, YongYang, Ping Fang, Chenglin Jiang, Lihua Xu, Yingmin Zhu, Meijuan Shen, Haiyang Xia, Jianfu Zhao, Tongbing Chen and Zhongjun Qin* (2006) Diversity of telomere palindromic sequences and replication genes among Streptomyces linear plasmids. Applied and Environmental Microbiology. 72(9):5728u20135733.

29. Meijuan Shen, Ping Fang, Deqiang Xu, Yalei Zhang, Weihuan Cao, Yingmin Zhu, JianfuZhao and Zhongjun Qin* (2006) Replication and Inheritance of Nocardia Plasmid pC1. FEMS Microbiology Letters. 261:47u201352.

30. Haiyang Xia, Yongqiang Tian, Ran Zhang, Kaichun Lin and Zhongjun Qin* (2006) Characterization of Nocardia Plasmid pXT107. Acta Biochimica et Biophysica Sinica. 38(9):620u2013624.

31. Mingxuan Xu, Yingmin Zhu, Meijuan Shen, Weihong Jiang, Guoping Zhao* and Zhongjun Qin* (2006) Characterization of the essential genetic components for conjugal transfer of Streptomyces lividans linear plasmid SLP2. Progress in Biochemistry and Biophysics. 33(10):1u20138.

32. Yongqiang Tian, Pei Hao, G.uoping Zhao* and Zhongjun Qin* (2005) Cloning and characterization of the chromosomal replication origin region of Amycolatopsis mediterranei U32. Biochemical and Biophysical Research Communications. 333(1):14-20.

33. Zhongjun Qin, Meijuan Shen and Stanley N. Cohen* (2003) Identification and characterization of a pSLA2 plasmids locus required for linear DNA replication and circular plasmids stable inheritance in Streptomyces lividans. Journal of Bacteriology. 185 (22):6575u20136582.

34. Zhongjun Qin and Stanley N. Cohen* (2002) Survival mechanisms for Streptomyces linear replicons after telomere damage. Molecular Microbiology. 45(3):785u2013794.

35. Zhongjun Qin and Stanley N. Cohen* (2000) Long palindrome formed in Streptomyces by nonrecombinational intra-strand annealing. Genes&Development. 14:1789u20131796.

36. Zhongjun Qin and Stanley N. Cohen* (1998) Replication at the telomeres of Streptomyces linear plasmid pSLA2. Molecular Microbiology. 28:893u2013903.

37. Zhongjun Qin, Kaiman Peng, Xiufen Zhou, Rongfang Liang, Qi Zhou, Huakui Chen, David A. Hopwood, Tobias Kieser and Zixin Deng* (1994) Development of a gene cloning system for Streptomyces hygroscopicus subsp. yingchenggenesis, a producer of the three useful antifungal compounds, by elimination of three barriers to DNA transfer. Journal of Bacteriology. 176:2090u20132095.