1、 ?198301-198601：哈爾濱醫(yī)科大學(xué) ?基礎(chǔ)醫(yī)學(xué)系，助教

2、 ?198901-199101：哈爾濱醫(yī)科大學(xué) ?附屬第一醫(yī)院研究部，主管

3、 ?199101-199301：東京醫(yī)科齒科大學(xué) ?醫(yī)學(xué)部，研究員

4、 ?199701-199801：東京醫(yī)科齒科大學(xué) ?醫(yī)學(xué)部，講師

5、 ?199801-200701：哈佛醫(yī)學(xué)院 ?布里根醫(yī)院血液腫瘤科，研究員，講師

6、 ?200701-：·哈爾濱醫(yī)科大學(xué) ?附屬第一醫(yī)院血液內(nèi)科，教授，博士生導(dǎo)師

成果論文

1、 ?Apoptosis of Neutrophils and Their Elimination by Kupffer Cell in Rat Liver.,Hepatology,1996; 24(5),第一作者

2、 ?Expression of P-selectin on hepatic endothelia and platelets promoting neutrophil removal by liver macrophages.,Blood,1998; 92(2),第一作者

3、 ?Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride.,Am J Pathol,1998; 153(2),第一作者

4、 ?Role of the liver in regulating numbers of circulating neutrophils.,Blood,2001; 98(4),第一作者

5、 ?Lactadherin inhibits enzyme complexes of blood coagulation by completing for phospholipid binding sites.,Blood,2003; 101(7),第一作者

6、 ?Lactadherin binds selectively to membranes containing phosphatidyl-L-serine and increased curvature.,Biochim Biophys Acta,2004; 1667(1),第一作者

7、 ?Lactadherin detects early phosphatidylserine exposure on immortalized leukemia cells undergoing programmed cell death.,Cytometry A,2006; 69(12),第一作者

8、 ?Platelet phosphatidylserine exposure during thrombosis is predominantly partial rather than complete:in vitro and in vivo detection utilizing lactadherin.,J Thromb Haemost,2008; 6(7),第一作者

9、 ?Procoagulant activity and phosphatidylserine of amniotic fluid cells.,Thromb Haemost,2009; 101(5),通訊作者

10、 ? Daunorubicin induces procoagulant activity of cultured endothelial cells through phosphatidylserine.,Thromb Haemost,2010;104(6),通訊作者

11、 ?Lactadherin functions as a probe for phosphatidylserine exposure and as an anticoagulant in the study of stored platelets.,Vox Sang,2011; 100(2),通訊作者

12、 ?Phagocytosis by macrophages and endothelial cells inhibits procoagulant and fibrinolytic activity of acute promyelocytic leukemia cells.,Blood,2012;119(10),通訊作者

13、 ?Homocysteine enhances clot-promoting activity of endothelial cells via phosphatidylserine externalization and microparticles formation.,Amino Acids,2012;43(3),通訊作者

14、 ? Effect of arsenic trioxide and daunorubicin on procoagulant activity of acute promyelocytic leukemia cells., Zhonghua Yi Xue Za Zhi,2012;92(16),通訊作者

15、 ?Procoagulant activity of erythrocytes and platelets through phosphatidylserine exposure and microparticles release in patients with nephrotic syndrome.,Thromb Haemost,2012；107(4),通訊作者

16、 ?Endothelial cell phagocytosis of senescent neutrophils decreases procoagulant activity.,Thromb Haemost,2013;109(6),通訊作者

17、 ?Role of erythrocytes and platelets in the prothrombotic status in polycythemia vera through phosphatidylserine exposure and microparticle generation.,Thromb Haemost,2013;109(6),并列一作

18、 ?Extracellular DNA traps released by acute promyelocytic leukemia cells through autophagy. ,Cell Death and Disease,2016;7(6),通訊作者

19、 ?Phosphotidylserine exposure and neutrophil extracellular traps enhance procoagulant activity in patients with inflammatory bowel disease.,Thromb Haemost,2016;115(4),通訊作者

20、 ?Promyelocytic extracellular chromatin exacerbates coagulation and fibrinolysis in acute promyelocytic leukemia.,Blood,2017;129(13),通訊作者

21、 ?Microparticles and blood cells induce procoagulant activity via phosphatidylserine exposure in NSTEMI patients following stent implantation.,International Journal of Cardiology,2016;223,通訊作者

22、 ?Enhanced Procoagulant Activity on Blood Cells after Acute Ischemic Stroke.,Translational stroke research,2017;8(1),通訊作者

23、 ?Phosphatidylserine on blood cells and endothelial cells contributes to the hypercoagulable state in cirrhosis.,Liver Int ,2016;36(12),通訊作者

24、 ?Circulating microparticles, blood cells and endothelium induce procoagulant activity in sepsis through phosphatidylserine exposure.,Shock,2016;45(3),通訊作者

25、 ?Procoagulant activity induced by transcatheter closure of atrial septal defects is associated with exposure of phosphatidylserine on microparticles, platelets and red blood cells.,Thrombosis research,2015;136(2),通訊作者

主要研究方向: 白細(xì)胞及血小板生物學(xué)及其體內(nèi)平衡 細(xì)胞成熟和凋亡過程細(xì)胞膜磷脂分析 乳粘素的功能和作用機(jī)制 APL凝血異常的分子病理 心血管疾病血栓形成機(jī)制。

1、 ?體外LAK細(xì)胞殺傷人肺癌細(xì)胞的研究,黑龍江省科學(xué)技術(shù)進(jìn)步獎(jiǎng),三等獎(jiǎng),199101。