人物經(jīng)歷
2002.9u20132011.6,蘭州大學(xué) 本碩博,獲理學(xué)博士學(xué)位,導(dǎo)師周波教授;
2011.12u20132014.12,西北農(nóng)林科技大學(xué)化學(xué)生物學(xué),博士后,合作導(dǎo)師 高錦明教授。
2015.01副教授,2011.07碩士生導(dǎo)師。
科研課題
先后主持(時間順序):
南開大學(xué)元素有機化學(xué)國家重點實驗室開放基金1項;
國家自然科學(xué)基金青年項目1項,應(yīng)急管理項目1項;
陜西省自然科學(xué)基金青年人才項目1項.
研究領(lǐng)域
1. 天然活性萜類物質(zhì)的多樣性合成、構(gòu)效關(guān)系和靶點識別;
2. 基于作用機制(靶點)明晰的藥物設(shè)計與合成。
開設(shè)課程
《有機化學(xué)》、《有機化學(xué)(雙語)》、《有機化學(xué)實驗》。
學(xué)術(shù)論文
15. HanYu, GuoyongDai, Qiu-RuiHe, Tang, J. J., Enantioselective synthesis and evaluation of 4-styryldihydropyrimidin-2-thiones as anti-proliferative agents. Med. Chem. Res. 2017, doi:10.1007/s00044-017-1790-4. (IF2015: 1.436)
14. Han Y. Y.; Tang J. J.; Gao R. F.; Guo X.; Lei M.; Gao J. M.,A new semisynthetic 1-O-acetyl-6-O-lauroylbritannilactone induces apoptosis of human laryngocarcinoma cells through p53-dependent pathway.Toxicol. In Vitro 2016, 35 : 112-120.(IF2015: 3.338)
13. Fan N.-J.; He Q.-R.; Duan M.; Bai Y.-B.; Tang J.-J., Synthesis and antiproliferative activity of D-ring substituted steroidal benzamidothiazoles. Steroids 2016, 112 : 103-108. (IF2015: 2.513)
12. Mu H.; Liu Q.; Niu H.; Wang D.; Tang J.; Duan J.Autophagy Promotes DNA-protein Crosslink Clearance. Mutat. Res-Gen. Tox. En. 2016, 797 : 21-25. (IF2015: 2.254)
11. Xiang P.; Guo X.; Han Y.-Y.; Gao J.-M.; Tang J.-J.Cytotoxic and Pro-apoptotic Activities ofSesquiterpene Lactones fromInula Britannica.Nat. Prod. Commun. 2016,11: 7-10. (IF2015: 0.884)
10. Guo X.; Gao J.-M.; Tang J. J.( S )-4-[(3a R ,4 S ,7a R )-4-Methoxy-6-methyl-3-methylene- 2-oxo-2,3,3a,4,7,7a-hexahydrobenzofuran-5-yl]pentyl Acetate. Molbank 2016, 2016, M890.
9. Tang J.-J.; Li G.; Gao J.-M.Synthesis and cytotoxicity of novel steroidal C-20 oxime ester derivatives from 16-DPA. Ar. J. Chem. 2015, DOI:10.1016/j.arabjc.2014.12.032. (IF2014: 3.725)
8. Fan N.-J.; Wei S.-P.; Gao J.-M.; Tang J.-J.Potential Insecticidal Activity of Steroidal C-17 Pyrazolinyl Derivatives. J. Braz. Chem. Soc. 2015, 26: 389-392.(IF2014: 1.129)
7. Dong S.;Tang J.-J.; Chang C.-C.; Tian J.-M.; Guo J.-T.; Zhang Q.; Li H.;Gao J.-M.Semisynthesis and in vitro cytotoxic evaluation of new analogues of 1- O -acetylbritannilactone, a sesquiterpene from Inula Britannica .Eur. J. Med. Chem. 2014, 80: 71-82.(IF2015: 3.902)
6. Tang J.-J.; Dong S.;Han Y.-Y.; Lei M.; Gao J.-M.Synthesis of 1- O -acetylbritannilactone Analogues from Inula britannica and in vitro Evaluation of their Anticancer Potential.MedChemComm . 2014, 10: 1584-1589. (IF2014: 2.495, co-first author)
5. Tang J.-J.; Zhang F.-Y.; Wang D.-M.; Tian J.-M.; Dong S.; Gao J.-M.Semisynthesis and Antifeedant Activity of New Derivatives of Dihydro-b-Agarofuran, a Sesquiterpene from Parnassia wightiana .Int. J. Mol. Sci.2013 , 14: 19484-19493. (IF2014: 2.862, co-first author)
4. Fan N.-J.; Tang J.-J.; Zhang Q.-Z.; Gao J.-M.Synthesis and cytotoxic activity of some novel steroidal C-17 pyrazolinyl derivatives. Eur. J. Med. Chem. 2013, 69: 182-190. (IF2014: 3.447, co-first author)
3. Tang J.-J.; Fan G.-J.; Dai F.; Ding D.-J.; Wang Q.; Lu D.-L.; Li R.-R.; Li X.-Z.; Hu L.-M.; Jin X.-L.; Zhou B.Finding more active antioxidants and cancer chemoprevention agents by elongating the conjugated links of resveratrol.Free Radic. Biol. Med. 2011, 55: 1447-1457. (IF2014: 5.736)
2. 范寧娟, 湯江江. 4-酰氧基黃體酮衍生物的合成及其細胞毒活性研究. 合成化學(xué) 2016, 24(9): 763-767. (核心)
1. 范寧娟, 王長如, 湯江江, 高錦明. 氯化亞錫還原法合成4u2019-氨基黃體酮類苯亞甲基衍生物. 應(yīng)用化學(xué) 2014, 31: 520-523. (核心)