研究方向
長(zhǎng)期從事有關(guān)白血病發(fā)病及治療分子機(jī)制的基礎(chǔ)研究，參加了血研所一系列重大的科研項(xiàng)目，在維甲酸誘導(dǎo)分化治療APL的基礎(chǔ)理論研究方面取得了可喜的成績(jī)。他主要針對(duì)髓系白血病細(xì)胞分化和凋亡過程中的信號(hào)轉(zhuǎn)導(dǎo)途徑以及相關(guān)基因的功能進(jìn)行深入研究，曾在國(guó)際上率先報(bào)道了環(huán)腺苷酸具有參與介導(dǎo)As2O3誘導(dǎo)分化APL細(xì)胞的功能，為闡明As2O3誘導(dǎo)緩解治療APL的作用機(jī)制提供了依據(jù)。這些年來，童建華先后承擔(dān)了多項(xiàng)國(guó)家自然科學(xué)基金項(xiàng)目和國(guó)家科技部863計(jì)劃，并先后獲得了上海市科委啟明星計(jì)劃和上海市教委曙光計(jì)劃的資助。
代表性論文
1.Tong J-H（corresponding author）. Rig-G as a key mediator of the anti-proliferative activity of interferon-related pathways through enhancing p21 and p27 proteins. Proc. Natl. Acad. Sci. USA, 2006, in press
2.Tong J-H（corresponding author）. Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyalocytic leukemia cell differentiation. Leukemia,2004, 18, 285-292
3.Tong J-H（corresponding author）. Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk. Blood, 2002,99,1014-1022
4.Tong J-H (first author), Genomic organization of the JEM-1 (BLZF1) gene on human chromosome 1q24: Molecular cloning and analysis of its promoter region. Genomics, 2000, 69, 380-390.
5.Tong J-H (first author), Jem-1, a novel nuclear co-factor: localization and functional interaction with AP-1. Leukemia, 1999, 13, pp1982-1992.
6.Tong J-H (first author), Fant X, Duprez E, Benoit G, Uphoff C-C, Drexler H-G, Pla J-C, Lofvenberg E and Lanotte M.Expression patterns of the JEM-1 gene in normal and tumor cells:ubiquity contrasting with a faint, but retinoid-induced, mRNA expression in promyelocytic NB4 cells. Leukemia,1998,12,pp1733.
7.Tong J-H (co-first author), Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes.Proc. Natl. Acad. Sci. USA, 1997, 94, 7406-7411
8.Tong J-H (co-first author), JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated by retinoids during t(15;17) promyelocytic leukaemia maturation.Oncogene, 1997, 14, 1563-1570
9.Tong J-H (first author), Molecular rearrangements of the MYL gene in acute promyelocytic leukemia (APL, M3) define a breakpoint cluster region as well as some molecular variants. Oncogene, 1992, 7, 311
其他相關(guān)
招生要求：生物類、醫(yī)學(xué)類、醫(yī)學(xué)檢驗(yàn)類專業(yè)畢業(yè)生，有工作經(jīng)驗(yàn)者更佳。
聯(lián)系方式：上海瑞金醫(yī)院血液學(xué)研究所，郵編: 200025，
