人物經(jīng)歷
1990 年畢業(yè)于上海醫(yī)科大學(xué);
1995 年于中國科學(xué)院上海藥物研究所獲博士學(xué)位,留所任助理研究員;
1996 年赴日本九州大學(xué)藥學(xué)部生藥學(xué)教室進(jìn)行博士后工作;
1998 年回所工作,期間曾赴美國加州大學(xué)圣地亞哥分校 Scripps 海洋學(xué)研究所訪問研究。
社會任職
中科院上海藥物所研究員、博士生導(dǎo)師、研究組長。
科學(xué)研究
研究方向
以產(chǎn)業(yè)化為目標(biāo),以天然藥用資源的水溶性成分研究為基礎(chǔ),探索中藥的作用機理和物質(zhì)基礎(chǔ),尋找和發(fā)現(xiàn)結(jié)構(gòu)新穎的天然活性化合物及先導(dǎo)化合物,并在此基礎(chǔ)上開展新藥創(chuàng)制和中藥現(xiàn)代化的研究。
研究項目
承擔(dān)“重大新藥創(chuàng)制”國家科技重大專項,上海市重大產(chǎn)業(yè)科技攻關(guān)項目等多個課題。
榮譽記錄
2011年獲國家技術(shù)發(fā)明二等獎2011年獲中國藥學(xué)發(fā)展獎杰出青年學(xué)者獎2007年獲上海市技術(shù)發(fā)明一等獎2006年獲中國國際工業(yè)博覽會創(chuàng)新獎2006年獲上海市科教黨委系統(tǒng)青年科技創(chuàng)新人才獎2005年獲中國科學(xué)院先進(jìn)集體2004年獲上海藥學(xué)會藥學(xué)科技獎2003年上;瘜W(xué)化工學(xué)會吳蘊初專項獎提名獎2020年5月,入選2020年上海市全國勞動模范和先進(jìn)工作者候選人。
2020年11月,榮獲2020年全國先進(jìn)工作者稱號。
主要論著
Xiao-Ping Hu, Shu-Wei Zhang, Shan-Shan Liu, and Li-Jiang Xuan. New Anthraquinone and Iridoid Glycosides from the Stems of Hedyotis hedyotidea. Helvetica Chimica Acta
Zhou Tong; Zhang Xiao-Hui; Zhang Shu-Wei; Liu Shan-Shan; Xuan Li-Jiang. New Phenylpropanoids and In Vitro α-Glucosidase Inhibitors from Balanophora japonica. Planta medica
Zhou, Tong; Zhang, Shu-wei; Liu, Shan-shan; Cong, Hai-jian; Xuan, Li-jiang. Daphnodorin dimers from Edgeworthia chrysantha with α-glucosidase inhibitory activity. Phytochemistry Letter
Chen, Li; Xuan, Li-Jiang; Wang, Yi-Ping. Effects of magnesium lithospermate B and its analogues on Ca2+ homeostasis in cultured rat thoracic aorta vascular smooth muscle cells. Planta Medica
Yu, Juan; Zhang, Hao-Hao; Yu, Qiang; Xuan, Li-Jiang. Prenylated Phenols from Sabia japonica. Helvetica Chimica Acta
Liu, Shan-Shan; Zhou, Tong; Zhang, Shu-Wei; Xuan, Li-Jiang. Chemical Constituents from Clerodendrum bungei and Their Cytotoxic Activities. Helvetica Chimica Acta
Zhang, Xiao-Hui; Liu, Shan-Shan; Xuan, Li-Jiang. Cyclopentenylglycines and other constituents from Alangium chinense. Biochemical Systematics and Ecology
Wu, Jun; Zhou, Tong; Zhang, Shu-wei; Zhang, Xiao-hui; Xuan, Li-jiang. Cytotoxic terpenoids from the fruits of Vitex trifolia L. Planta Medica
Xiao Kai, Zhang Hongjun, Xuan Lijiang, Zhang Juan, Xu Yaming, Bai Donglu. Stilbenoids: chemistry and bioactivities. Studies in natural chemistry
Xiaohui Zhang, Shuwei Zhang, Lijiang Xuan. Three new furannosesquiterpenoids from Bombax malabaricum and revised NMR assignment of Hibiscone C. Heterocycles
Shanshan Liu, Huilin Zhu, Shuwei Zhang, Xiaohui Zhang, Qiang Yu, and Lijiang Xuan. Abietane diterpenoids from Clerodendrum bungei. J. Nat. Prod
Jun Wu, Xiaohui Zhang, Shuwei Zhang, Lijiang Xuan. Three novel compounds from the flowers of Bombax malabaricum. Helvertica Chimica Act
Wang, Li; Zhang, Qiang; Li, Xiaochuan; Lu, Youli; Xue, Zhimou; Xuan, Lijiang; Wang, Yiping. Pharmacokinetics and metabolism of lithospermic acid by LC/MS/MS in rats. International Journal of Pharmaceutics
Shuwei Zhang, Lijiang Xuan. Cyclopentenone and furan derivative from mycelia of Cordyceps cicadae. The Journal of Antibiotics
Zhang, Xiao-Hui; Zhu, Hui-Lin; Yu, Qiang; Xuan, Li-Jiang. Cytotoxic cardenolides from Streptocaulon griffithii. Chemistry & Biodiversity
Zhang, Shu-Wei; Xuan, Li-Jiang. Five aromatics bearing a 4-O-methylglucose unit from Cordyceps cicadae. Helvetica Chimica Acta,
Jiang, Lili; Zhang, Shuwei; Xuan, Lijiang. Oxanthrone C-glycosides and epoxynaphthoquinol from the roots of Rumex japonicus. Phytochemistry
Zhang, Xiaohui; Zhu, Huilin; Zhang, Shuwei; Yu, Qiang; Xuan, Lijiang. Sesquiterpenoids from Bombax malabaricum. Journal of Natural Products,
Li, Xiaochuan; Yu, Chen; Wang, Li; Lu, Youli; Wang, Wenyi; Xuan, Lijiang; Wang, Yiping. Simultaneous determination of lithospermic acid B and its three metabolites by liquid chromatography/tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis
Li, Xiaochuan; Yu, Chen; Lu, Youli; Gu, Yunlong; Lu, Jie; Xu, Wei; Xuan, Lijiang; Wang, Yiping. Pharmacokinetics, tissue distribution, metabolism, and excretion of depside salts from Salvia miltiorrhiza in rats. Drug Metabolism and Disposition