1998.9—2002.6華南師范大學(xué)化學(xué)與環(huán)境學(xué)院，學(xué)士；?

2002.9—2008.6中山大學(xué)化學(xué)與化學(xué)工程學(xué)院，博士。

2008.03—2011.03 ? 中山大學(xué)生命科學(xué)學(xué)院，博士后；?

2011.04—2016.1 中山大學(xué)化學(xué)與化學(xué)工程學(xué)院，講師；

2016.1—至今 ?中山大學(xué)化學(xué)與化學(xué)工程學(xué)院，副教授。

本科生課程《無機(jī)化學(xué)》、《化學(xué)生物學(xué)綜合實(shí)驗(yàn)》、《現(xiàn)代無機(jī)化學(xué)進(jìn)展》、《基礎(chǔ)化學(xué)實(shí)驗(yàn)》、《普通化學(xué)》。

? 從事的學(xué)科領(lǐng)域?yàn)樯�物無機(jī)化學(xué)。研究興趣包括靶向性金屬抗腫瘤藥物的設(shè)計(jì)、抗腫瘤活性及機(jī)制研究。近兩年，以與腫瘤發(fā)生、發(fā)展的關(guān)鍵的蛋白分子為靶點(diǎn)，設(shè)計(jì)了系列的金屬配合物作為新穎的抑制劑，并研究了它們的抗腫瘤作用機(jī)制。主要研究的靶點(diǎn)包括組蛋白去乙�；�酶（Histone deacetylases, HDACs）和細(xì)胞周期素依賴性激酶（Cyclin-dependent kinases, CDKs）等。

1. 廣東省“百千萬工程青年拔尖人才”，2016.08-2019.08，10萬元。?

2.高校基本科研業(yè)務(wù)費(fèi)青年教師重點(diǎn)培育項(xiàng)目，2016.01-2017.12，30萬元。?

3. 廣東省自然科學(xué)基金（杰出青年基金），2015.08-2019.08，100萬元。?

4. 國家自然科學(xué)基金（面上項(xiàng)目），2016.01-2019.12，77.6萬元。?

5. 國家高技術(shù)研究發(fā)展計(jì)劃(863計(jì)劃)子課題，2012.01-2015.12，92.5萬元。?

6. 國家自然科學(xué)基金 (青年科學(xué)基金項(xiàng)目)，2013.01-2015.012，25萬元。?

7. 廣州市科技計(jì)劃項(xiàng)目，2014.01-2016.12，8萬元。?

8. 高�；�本科研業(yè)務(wù)費(fèi)青年教師培育項(xiàng)目，2013.01-2015.12，10萬元。?

9. 第四十四批中國博士后科學(xué)基金，2008.03-2010.03，3萬元。?

? 1. Zhang, D. Y., Zheng, Y., Tan, C. P.*, Sun, J. H., Zhang, W., Ji, L. N. and Mao, Z. W.* Graphene Oxide Decorated with Ru(II)u2013Polyethylene Glycol Complex for Lysosome-Targeted Imaging and Photodynamic/Photothermal Therapy. ACS Applied Materials & Interfaces 2017 DOI: 10.1021/acsami.6b13808. IF: 7.145

? 2. Cao, J. J., Tan, C. P.*, Chen, M. H., Wu, N., Yao, D. Y., Liu, X. G., Ji, L.-N., Mao, Z. W.* Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium (III) complexes. Chemical Science 2017, 8, 631-640. IF: 9.144

? 3. Xue, S. S., Tan, C. P.*, Chen, M. H., Cao, J. J., Zhang, D. Y., Ye, R. R., Ji, L. N. and Mao, Z. W.* Tumor-targeted supramolecular nanoparticles self-assembled from a ruthenium-beta-cyclodextrin complex and an adamantane-functionalized peptide. Chemical Communications 2017, 53 (5), 842-845. IF: 6.567 (Front Cover)

2016

4. ?Wang, F. X., Chen, M. H., Hu, X. Y., Ye, R. R., Tan, C. P.*, Ji, L. N. and Mao, Z. W. Ester-Modified Cyclometalated Iridium(III) Complexes as Mitochondria-Targeting Anticancer Agents. Scientific Reports 2016, 6, 38954. IF: 5.228

? 5. Ye, R. R., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Coumarin-appended phosphorescent cyclometalated iridium(III) complexes as mitochondria-targeted theranostic anticancer agents. Dalton Transactions 2016, 45(33), 13042-13051. IF: 4.177 (Front Cover)

? 6. Ye, R. R., Tan, C. P.*, Chen, M. H., Hao, L., Ji, L. N. and Mao, Z. W.* Mono- and dinuclear phosphorescent rhenium(I) complexes: impact of subcellular localization on anticancer mechanisms. Chemistry-A European Journal 2016, 22(23), 7800-7809. IF: 5.771

7. Zhang, W., Shen, J., Su, H., Mu, G., Sun, J. H., Tan, C. P., Liang, X. J., Ji, L. N., Mao, Z. W.* Co-delivery of cisplatin prodrug and chlorin e6 by mesoporous silica nanoparticles for chemo-photodynamic combination therapy to combat drug resistance. ACS Applied Materials & Interfaces 2016, 8(21), 13332-13340. IF: 7.145

8. He, L., Li, Y., Tan, C. P.*, Ye, R. R., Chen, M. H., Cao, J. J., Ji, L. N. and Mao, Z. W.* Cyclometalated iridium(III) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents. Chemical Science 2015, 6, 5409-5418. IF: 9.144 (Back Cover)

9. Ye, R. R., Tan, C. P.*, Lin, Y. N., Ji, L. N., Mao, Z. W.* A phosphorescent rhenium(I) histone deacetylase inhibitor: mitochondrial targeting and paraptosis induction. Chemical Communications 2015, 51(39),8353-8356. IF: 6.567

10. Li, Y., Tan, C. P. (Co-first author), He, L., Ji, L. N., Mao, Z. W.* Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents. Biomaterials 2015, 39, 95-104. IF: 8.387

? 11. Zhang, W., Li, Y., Sun, J. H., Tan, C. P., Ji, L. N., Mao, Z. W.* Supramolecular self-assembled nanoparticles for chemo-photodynamic dual therapy against cisplatin resistant cancer cells. Chemical Communications 2015, 51(10), 1807-1810. IF: 6.567

12. Li, J. M., Zhang, W., Su, H., Wang, Y. Y., Tan, C. P., Ji, L. N., Mao, Z. W.* Reversal of multidrug resistance in MCF-7/ADR cells by codelivery of doxorubicin and BCL2 siRNA using a folic acid-conjugated polyethylenimine hydroxypropyl-beta-cyclodextrin nanocarrier. International Journal of Nanomedicine 2015, 10, 3147-3162. IF: 4.32

13. ?He, L., Tan, C. P.*, Ye, R. R., Zhao, Y. Z., Liu, Y. H., Zhao, Q., Ji, L. N., Mao, Z. W.* Theranostic iridium(III) complexes as one- and two-photon phosphorescent trackers to monitor autophagic lysosomes. Angewandte Chemie International Edition 2014, 53(45), 12137-12141. IF: 11.709

14. ?Ye, R. R., Tan, C. P.*, He, L., Chen, M. H., Ji, L. N., Mao, Z. W.* Cyclometalated Ir(III) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy. Chemical Communications 2014, 50(75), 10945-10948. IF: 6.567

15. ?He, L., Liao, S. Y., Tan, C. P.*, Lu, Y. Y., Xu, C. X., Ji, L. N., Mao, Z. W.* Cyclometalated iridium(III)-beta-carboline complexes as potent autophagy-inducing agents. Chemical Communications 2014, 50(42), 5611-5614. IF: 6.567

16. ?Tan, C. P., Lu, Y. Y., Ji, L. N., Mao, Z. W.* Metallomics insights into the programmed cell death induced by metal-based anticancer compounds. Metallomics 2014, 6(5), 978-995. IF: 3.54 (Front Cover)

17. ? Zhao, M. X., Zhao, M., Zeng, E. Z., Li, Y., Li, J. M., Cao, Q., Tan, C. P., Ji, L. N., Mao, Z. W.* Enhanced anti-cancer efficacy to cancer cells by doxorubicin loaded water-soluble amino acid-modified beta-cyclodextrin platinum complexes. Journal of Inorganic Biochemistry 2014, 137, 31-39. IF: 3.205

18. ? Li, Y., Liu, G. F.*, Tan, C. P., Ji, L. N., Mao, Z. W.* Antitumor properties and mechanisms of mitochondria-targeted Ag(I) and Au(I) complexes containing N-heterocyclic carbenes derived from cyclophanes. Metallomics 2014, 6(8), 1460-1468. IF: 3.54

19. ?Ye, R. R., Ke, Z. F., Tan, C. P.*, He, L., Ji, L. N., Mao, Z. W.* Histone-deacetylase-targeted fluorescent ruthenium(II) polypyridyl complexes as potent anticancer agents. Chemistry-A European Journal 2013, 19(31), 10160-10169. IF: 5.771 (Front Cover)

?20. ?He, L., Liao, S. Y., Tan, C. P.*, Ye, R. R., Xu, Y. W., Zhao, M., Ji, L. N., Mao, Z. W.* Ruthenium-arene-carboline complexes as potent inhibitors of cyclin-dependent kinase 1: synthesis, characterization and anticancer mechanism studies. Chemistry-A European Journal 2013, 19(36), 12152-12160. IF: 5.771

21. ? Zheng, X. H., Zhong, Y. F., Tan, C. P., Ji, L. N., Mao, Z. W.* Pt(II) squares as selective and effective human telomeric G-quadruplex binders and potential cancer therapeutics. Dalton Transactions 2012, 41(38), 11807-11812. IF: 4.177

22. ? Wang, H. L., De Yonker, N. J., Gao, H., Tan, C. P., Zhang, X. T., Ji, L. N., Zhao, C. Y.*, Mao, Z. W.* Aquation and dimerization of osmium(II) anticancer complexes: a density functional theory study. Rsc Advances 2012, 2(2), 436-446. IF: 3.289

23. ? Li, J. M., Wang, Y. Y., Zhao, M. X., Tan, C. P., Li, Y. Q., Le, X. Y., Ji, L. N., Mao, Z. W.* Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking. Biomaterials 2012, 33(9), 2780-2790. IF: 8.387

24. ?Tan, C. P., Wu, S. H., Lai, S. S., Wang, M. X., Chen, Y., Zhou, L. J., Zhu, Y. P., Lian, W., Peng, W. L., Ji, L. N., Xu, A. L.* Synthesis, structures, cellular uptake and apoptosis-inducing properties of highly cytotoxic ruthenium-Norharman complexes. Dalton Transactions 2011, 40(34), 8611-8621. IF: 4.177

25. ?Tan, C. P., Hu, S., Liu, J.*, Ji, L. N.* Synthesis, characterization, antiproliferative and anti-metastatic properties of two ruthenium-DMSO complexes containing 2,2’-biimidazole. European Journal of Medicinal Chemistry 2011, 46(5), 1555-1563. IF: 3.902

26. ? Zhao, M. X., Li, J. M., Du, L. Y., Tan, C. P., Xia, Q.*, Mao, Z. W.*, Ji, L. N. Targeted cellular uptake and sirna silencing by quantum-dot nanoparticles coated with beta-cyclodextrin coupled to amino acids. Chemistry-A European Journal 2011, 17(18), 5171-5179. IF: 5.771

27. ? Li, J. M., Zhao, M. X., Su, H., Wang, Y. Y., Tan, C. P., Ji, L. N., Mao, Z. W.* Multifunctional quantum-dot-based siRNA delivery for HPV18 E6 gene silence and intracellular imaging. Biomaterials 2011, 32(31), 7978-

7987. IF: 8.387

28. ? Tan, C. P., Lai, S. S., Wu, S. H., Hu, S., Zhou, L. J., Chen, Y., Wang, M. X., Zhu, Y. P., Lian, W., Peng, W. L., Ji, L. N., Xu, A. L.* Nuclear permeable ruthenium(II) beta-carboline complexes induce autophagy to antagonize mitochondrial-mediated apoptosis. Journal of Medicinal Chemistry 2010, 53(21), 7613-7624. IF: 5.589

29. ? Tan, C. P., Liu, J.*, Li, H., Zheng, W. J., Shi, S., Chen, L. M., Ji, L. N.* Differences in structure, physiological stability, electrochemistry, cytotoxicity, DNA and protein binding properties between two Ru(III) complexes. Journal of Inorganic Biochemistry 2008, 102(2), 347-358. IF: 3.205

?30. ? Tan, C. P., Liu, J.*, Chen, L. M., Shi, S., Ji, L. N.* Synthesis, structural characteristics, DNA binding properties and cytotoxicity studies of a series of Ru(III) complexes. Journal of Inorganic Biochemistry 2008, 102(8), 1644-1653. IF: 3.205

?31. ? Liu, Y. N., Shi, S., Mei, W. J., Tan, C. P., Chen, L. M., Liu, J.*, Zheng, W. J.*, Ji, L. N. In vitro and in vivo investigations on the antiviral activity of a series of mixed-valence rare earth borotungstate heteropoly blues. European Journal of Medicinal Chemistry 2008, 43(9), 1963-1970. IF: 3.902

?32. ? Liu, J.*, Zheng, W. J.*, Shi, S., Tan, C. P., Chen, J. C., Zheng, K. C., Ji, L. N. Synthesis, antitumor activity and structure-activity relationships of a series of Ru(II) complexes. Journal of Inorganic Biochemistry 2008, 102(2), 193-202. IF: 3.205

33. ? Chen, L. M., Liu, J.*, Chen, J. C., Tan, C. P., Shi, S., Zheng, K. C., Ji, L. N.* Synthesis, characterization, DNA-binding and spectral properties of complexes [Ru(L)(4)(dppz)](2+) (L = Im and MeIm). Journal of Inorganic Biochemistry 2008, 102(2), 330-341. IF: 3.205

34. ? Chen, L. M., Liu, J.*, Chen, J. C., Shi, S., Tan, C. P., Zheng, K. C., Ji, L. N.* Experimental and theoretical studies on the DNA-binding and spectral properties of water-soluble complex [Ru(MeIm)(4)(dpq)](2+). Journal of Molecular Structure 2008, 881(1-3), 156-166. IF: 1.78

35. ? Shi, S., Liu, J.*, Li, J., Zheng, K. C., Huang, X. M., Tan, C. P., Chen, L. M., Ji, L. N.* Synthesis, characterization and DNA-binding of novel chiral complexes Delta- and Lambda-[Ru(bpy)(2)L](2+) (L = o-mopip and p-mopip). Journal of Inorganic Biochemistry 2006, 100(3), 385-395. IF: 3.205

36. ? Shi, S., Liu, J.*, Li, J., Zheng, K. C., Tan, C. P., Chen, L. M., Ji, L. N.* Electronic effect of different positions of the -NO2 group on the DNA-intercalator of chiral complexes [Ru(bpy)(2)L](2+) (L = o-npip, m-npip and p-npip). Dalton Transactions 2005, 11), 2038-2046. IF: 4.177

37. ? Liu, J.*, Mei, W. J., Xu, A. W., Tan, C. P., Shi, S., Ji, L. N. Synthesis, characterization and antiviral activity against influenza virus of a series of novel manganese-substituted rare earth borotungstates heteropolyoxometalates. Antiviral Research 2004, 62(1), 65-71. IF: 4.909

38. ? Liu, J.*, Mei, W. J., Xu, A. W., Tan, C. P., Ji, L. N. Synthesis, characterization and antiviral activity of nickel-substituted rare earth molybdosilicic heteropoly blues. Transition Metal Chemistry 2003, 28(5), 500-505. IF: 1.465