2006年畢業(yè)于蘭州大學(xué)生命科學(xué)學(xué)院，多肽生物化學(xué)與藥物化學(xué)研究方向，獲理學(xué)博士學(xué)位。2006-2010年，在中科院上海生命科學(xué)研究院神經(jīng)科學(xué)研究所做博士后，離子通道結(jié)構(gòu)與功能研究方向；2011年加入上海交通大學(xué)醫(yī)學(xué)院研究團(tuán)隊(duì)，任醫(yī)學(xué)科學(xué)研究院“蛋白質(zhì)結(jié)構(gòu)與功能研究組”組長(zhǎng)。

近年來一直從事蛋白質(zhì)/多肽的結(jié)構(gòu)和功能研究，擅長(zhǎng)利用化學(xué)生物學(xué)、生物物理、分子藥理、分子生物學(xué)、計(jì)算生物學(xué)等多學(xué)科交叉的技術(shù)研究蛋白的結(jié)構(gòu)與功能的關(guān)系及其相關(guān)的分子發(fā)現(xiàn)，取得了一系列較為重要的成果。

現(xiàn)階段的研究方向是具有重要醫(yī)學(xué)價(jià)值蛋白質(zhì)的結(jié)構(gòu)功能和活性分子發(fā)現(xiàn)研究，其中包括：1）膜受體激活過程中的動(dòng)態(tài)變構(gòu)機(jī)制與關(guān)鍵結(jié)構(gòu)域鑒定；2）膜受體內(nèi)源性調(diào)控分子的發(fā)現(xiàn)與生理病理功能研究；3）基于受體蛋白三維結(jié)構(gòu)的藥物設(shè)計(jì)；4). 具有重要藥用價(jià)值的毒素蛋白靶受體的發(fā)現(xiàn)與藥物設(shè)計(jì)。主要采用化學(xué)生物學(xué)、生物物理、分子藥理、分子生物學(xué)、計(jì)算生物學(xué)等多學(xué)科交叉的技術(shù)研究這些蛋白的結(jié)構(gòu)與功能的關(guān)系及其相關(guān)的分子發(fā)現(xiàn)。

近年發(fā)表研究論文

1. Yang,Y*., Yu, Y.*, Cheng, J., Liu. Y,. Liu. D.S., Wang, J., Zhu, M.X., Wang,R., Xu, T.L. (2012). (Co-first author). Highly conserved salt bridge stabilizes a rigid signal patch at the extracellular loop critical for surface expression of acid-sensing ion channel. J Biol Chem, 287(18):14443-55，(IF2010: 5.328 )

2. Yang, H.Y., GaoZ.B., Yu, Y., Jiang H.L. et al. (2012). A Theoretical Model for Calculating Voltage Sensitivity of Ion Channels and the Application on Kv1.2 Potassium Channel. Biophys J.102:1815-1825，(IF2010: 4.218)
3. Yu, Y., Li, W.G.,Chen, Z., Jiang, H.L., Xu, T.L. (2011). Atomic Level Characterization of the Nonproton Ligand-sensing Domain of ASIC3 Channel. J Biol Chem, 286(28):24996-5006. (IF2010: 5.328 )
4. Li, W.G.*; Yu, Y.*，Huang，C.;Cao, H.;Xu, T.L. (2011).(*Co first author). Nonproton Ligand Sensing Domain Is Required for Paradoxical Stimulation of Acid-sensing Ion Channel 3 (ASIC3) Channels by Amiloride. J Biol Chem. 286(49):42635-46. (IF2010: 5.328 )
5. Hu R, Duan B, Wang D, Yu Y, Li W, Luo H, Lu P, Lin J, Zhu G, Wan Q, Feng H.(2011). Role of Acid-sensing ion channel 1a in the secondary damage of traumatic spinal cord injury. Ann Surg.254(2): 353-62.(IF2010: 7.474).
6. Duan, B.;Wang, Y.Z.,Yang, T.,Chu, X.P.;Yu, Y., Xu ,T.L.(2011). Extracellular Spermine Exacerbates Ischemic Neuronal Injury through Sensitization of ASIC1a Channels to Extracellular Acidosis. J Neurosci. 31: 2011-12.(IF2010: 7.474).
7. Yu, Y., Chen. Z., Li. W.G. et al. (2010). A non-proton ligand sensor of acid-sensing ion channels. Neuron 68(1):61-72，(IF2010: 14.027).
* Commented in “Small molecule ion channel match making: a natural fit for new ASIC ligands”, Bagriantsev SN and Minor DL Jr. Neuron. 68(1):1-3
8. Li, W.G.*, Yu, Y.*; Zhang, Z.D.;Cao, H.;Xu, T.L. (2010).(*Co-first author).ASIC3 Channels Integrate Agmatine and Multiple Inflammatory Signals through the Nonproton Ligand Sensing Domain. Mol Pain.86 (1):88-99 (IF2010: 4.148).
9. Yang, H.Y.*, Yu, Y.* Hua-liang Jiang, et al. (2009). (*Co-first author). Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism. PLoS Biol. Jul;7(7) ):e1000151. (IF2010: 12.469).
10. Yang, H.Y.*, Yu, Y.*, Hua-liang Jiang, et al. (2009). (*Co-first author). Conformational sampling on acid-sensing ion channel 1 (ASIC1): implication for a symmetric conformation. Cell Res. 19(8):1035-7. (IF2010: 9.471).
11. Wang, C. L. Yao, J.L., Yu, Y., et al. (2008). Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 16(12):6415-22 (IF2010: 2.978).
12. Wang CL, Wang X, Yu Y, Cui Y, Liu HM, Lai LH, Guo C, Liu J, Wang R(2008). Type 1 diabetes attenuates the modulatory effects of endomorphins on mouse colonic motility. Neuropeptides.42(1):69-77. (IF2010: 2.464).
13. Yu, Y., X. Shao, et al. (2007). Structure-activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C-terminus. ChemMedChem 2(3): 309-17. (IF2010: 3.306).
14. Yu, Y., X. Shao, et al. (2007). In vitro and in vivo characterization of opioid activities of endomorphins analogs with novel constrained C-terminus: Evidence for the important role of proper spatial disposition of the third aromatic ring. Peptides ;28(4):859-70.(IF2010: 2.654).
15. Yu, Y., Y. Cui, et al. (2007). In vitro characterization of the effects of endomorphin 1 and 2, endogenous ligands for mu-opioid receptors, on mouse colonic motility. Biochem Pharmacol 73(9):1384-93. (IF2010: 4.889).
16. Wang, C.L*.,Yu.Y*, et al. (2007) (*Co-first author) Cardiovascular responses to intrathecal administration of endomorphins in anesthetized rats. Peptides 28(4):871-7.(IF2010: 2.654).
17. Wang, W., Yu, Y., et al. (2007). Modulation of acid-sensing ion channels by Cu2+ in cultured hypothalamic neurons of the rat. Neuroscience 145(2):631-641.
18. Yu, Y., C. L. Wang, et al. (2006). Cterminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats. Peptides 27(1): 136-43.(IF2010: 2.654).
19. Yu, Y., Y. Cui, et al. (2006). Endomorphin1 and endomorphin2, endogenous potent inhibitors of electrical field stimulation (EFS)-induced cholinergic contractions of rat isolated bronchus. Peptides 27(7): 1846-51. (IF2010: 2.654).
20. Yu, Y., X. Wang, et al. (2006). Abnormal modulation of cholinergic neurotransmission by endomorphin 1 and endomorphin 2 in isolated bronchus of type 1 diabetic rats. Peptides 27(11): 2770-7. (IF2010: 2.654).
21. Fan, Y. Z., H. Chang, Yu, Y., et al. (2006). Thymosin alpha1 suppresses proliferation and induces apoptosis in human leukemia cell lines. Peptides 27(9): 2165-73. (IF2010: 2.654).
22. Fan, Y. Z., H. Chang, Yu, Y., et al. (2006). Thymopentin (TP5), an immunomo- dulatory peptide, suppresses proliferation and induces differentiation in HL-60 cells. Biochim Biophys Acta 1763(10): 1059-66.(IF2010: 4.374).
23. Liu, H. M., X. F. Liu, Yao, J. L. Wang, C.L, Yu, Y., et al. (2006). Utilization of combined chemical modifications to enhance the blood-brain barrier permeability and pharmacological activity of endomorphin-1. J Pharmacol Exp Ther 319(1): 308-16. (IF2010: 4.093).
24. Liu, J*, Yu. Y*, et al. (2005). (*Cofirst author) Cardiovascular effects of endomorphins in alloxan-induced diabetic rats. Peptides 26(4): 607-14. (IF2010: 2.654).
25. Xu, P. H., Cheng, Q., Li, H. F., Yu, Y., et al.(2005) The relaxant effect of dobutamine on porcine coronary arterial ring segments. Pharmazie. 60(5):375-7. (IF2010: 0.812).

近年所獲國家發(fā)明專利

1. Wang, R., Yu, Y., Liu, H.M. C-terminus modified analogs of endomorphin-1 (No. 200410073159.2.).
2. Wang, R., Yu, Y., Liu, H.M. C-terminus modified analogs of endomorphin-2 (No. 200710147468.3.).
3. Wang, R., Fan, Y.Z., Yu, Y., Chang, H. A new usage of polyhexose isolated from pumpkin (200710017285X.)。

近年來，已有26篇SCI論文在Neuron, PLoS Biol., J Biol Chem, Cell Res., J Neurosci., Ann Surg. Mol Pain, Biochem Pharm., ChemMedChem, Peptides, Neurosci., BBA Mol. Res., J Pharmacol Exp. Ther 等國際知名學(xué)術(shù)雜志上發(fā)表，其中第一/并列第一作者SCI論文共15篇，篇均影響因子>5（IF2010）；論文多次被國內(nèi)外同行在Nature, Neuron，Chem Rev, J Neurosci, J Biol Chem等知名雜志上正面引用。主持并完成國家自然科學(xué)基金委青年科學(xué)基金項(xiàng)目、“中國博士后科學(xué)基金”項(xiàng)目、“中國科學(xué)院王寬誠基金”資助項(xiàng)目、中國科學(xué)院上海生命科學(xué)研究院優(yōu)秀青年人才領(lǐng)域前沿項(xiàng)目各1項(xiàng)。曾獲“香港求是基金會(huì)”研究生獎(jiǎng)，中國博士后科學(xué)基金一等獎(jiǎng)，甘肅省科學(xué)技術(shù)發(fā)明獎(jiǎng)一等獎(jiǎng)；中國科學(xué)院上海生命科學(xué)研究院優(yōu)秀青年人才，“Sanofi-Aventis-SIBS”優(yōu)秀青年人才，基金委首批"優(yōu)秀青年"獲得者。