使用包括線蟲(chóng)和小鼠等多個(gè)模式生物，本實(shí)驗(yàn)室致力于闡明調(diào)控衰老的分子機(jī)制，目前的主要研究?jī)?nèi)容包括：

(1) 篩選衰老相關(guān)的重要基因并研究其作用機(jī)理：

我們利用線蟲(chóng)壽命短（約3-4周），分子機(jī)理保守的特點(diǎn)，以其為模式生物分析衰老相關(guān)基因的表達(dá)并篩選出確實(shí)影響衰老的基因。除了蛋白編碼基因外，我們也關(guān)注microRNA，這一類(lèi)非編碼的小RNA在衰老中的作用。

(2) 探索長(zhǎng)壽基因與衰老相關(guān)疾�。ㄈ缟窠�(jīng)退行性疾病等）之間的關(guān)系：

長(zhǎng)壽的個(gè)體一般較少罹患衰老相關(guān)疾病。這就為應(yīng)對(duì)相關(guān)疾病提供了一條嶄新的思路，即通過(guò)調(diào)控長(zhǎng)壽通路來(lái)預(yù)防或治療包括神經(jīng)退行性疾病等衰老相關(guān)疾病。本實(shí)驗(yàn)室使用包括線蟲(chóng)、培養(yǎng)細(xì)胞、以及小鼠等多種模型來(lái)檢驗(yàn)我們篩選得到的長(zhǎng)壽基因在衰老相關(guān)疾病中的作用及機(jī)理，以期為這些疾病的防治尋找新的方法。

Shen, Y., Wollam, J., Magner, D., Karalay, O., and Antebi, A. (2012). A steroid receptor-microRNA switch regulates life span in response to signals from the gonad.Science338, 1472-1476.Cao, J.*,Shen, Y.*, Zhu, L., Xu, Y., Zhou, Y., Wu, Z., Li, Y., Yan, X., and Zhu, X. (2012). miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.Nat Cell Biol14, 697-706.Shen, Y.*, Li, N.*, Wu, S., Zhou, Y., Shan, Y., Zhang, Q., Ding, C., Yuan, Q., Zhao, F., Zeng, R., et al. (2008). Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells.Dev Cell14, 342-353.Magner, D.B., Wollam, J.,Shen, Y., Hoppe, C., Li, D., Latza, C., Rottiers, V., Hutter, H., and Antebi, A. (2013). The NHR-8 nuclear receptor regulates cholesterol and bile acid homeostasis in C. elegans.Cell Metab18, 212-224.Heestand, B.N.,Shen, Y., Liu, W., Magner, D.B., Storm, N., Meharg, C., Haberman, B., Antebi, A. (2013). Dietary Restriction Induced Longevity Is Mediated by Nuclear Receptor NHR-62 in Caenorhabditis elegans.PLoS Genet9(7): e1003651.Wollam, J., Magner, D.B., Magomedova, L., Rass, E.,Shen, Y., Rottiers, V., Habermann, B., Cummins, C.L., and Antebi, A. (2012). A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.PLoS Biol10, e1001305.Wollam, J., Magomedova, L., Magner, D.B.,Shen, Y., Rottiers, V., Motola, D.L., Mangelsdorf, D.J., Cummins, C.L., and Antebi, A. (2011). The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.Aging Cell10, 879-884.Yan, X.,Shen, Y., and Zhu, X. (2010). Live show of Rho GTPases in cell migration.J Mol Cell Biol2, 68-69.Zhang, Q., Wang, F., Cao, J.,Shen, Y., Huang, Q., Bao, L., and Zhu, X. (2009). Nudel promotes axonal lysosome clearance and endo-lysosome formation via dynein-mediated transport.Traffic10, 1337-1349.Yan, X., Li, F., Liang, Y.,Shen, Y., Zhao, X., Huang, Q., and Zhu, X. (2003). Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.Mol Cell Biol23, 1239-1250.