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  • 崔京南

    崔京南

    崔京南,男,畢業(yè)于日本岡山大學,是大連理工大學博士生導師。


    人物經(jīng)歷

    1978-1982年:畢業(yè)于東北電力學院、電廠化學專業(yè),學士學位;

    1992-1995年:畢業(yè)于日本岡山大學、應用化學專業(yè),碩士學位;

    1995-1998年:畢業(yè)于日本岡山大學、合成有機化學專業(yè),博士學位;

    1999-2006年:大連理工大學、精細化工國家重點實驗室,副教授;

    2006-2007年:瑞典皇家工學院,化學系,訪問學者;

    崔京南

    2007年--至今:大連理工大學、精細化工國家重點實驗室,教授,博士生導師

    研究方向

    熒光分析技術在食品安全和環(huán)境污染中微量有害物質(zhì)快速檢測方法研究熒光探針設計、合成及生物酶活性檢測

    社會兼職

    (1)J. Org. Chem.; (2)Tetrahedron Lett.; (3)Bioorg. Med. Chem.; (4)Int. J. Mol. Sci. 等學術期刊審稿人。

    著作論文

    [1]Feng, Lei,Ma, Xiaochi,Tian, Xiangge,Yu, Zhenlong,Zhao, Xinyu,Sun, Chengpeng,Cui, Jingnan,Ning, Jing,Wang, Chao,Zhang, Baojing.A two-photon ratiometric fluorescent probe for imaging and quantitative analysis of botanic glucosyltransferase: A key enzyme for the biosynthesis of bioactive glycosides[J],SENSORS AND ACTUATORS B-CHEMICAL,2019,282:112-121

    [2]Ning, Jing,Huo, Xiaokui,Feng, Lei,Wang, Chao,Sun, Chengpeng,Cui, Jingnan,James, Tony D.,Ma, Xiaochi,Liu, Tao,Dong, Peipei,Wang, Wei,Ge, Guangbo,Wang, Bo,Yu, Zhenlong,Shi, Lei,Tian, Xiangge.Molecular Design Strategy to Construct the Near-Infrared Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2J2[J],JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2019,141(2):1126-1134

    [3]Tian, Xiangge,Zhou, Dayong,Wang, Chao,Sun, Chengpeng,Ning, Jing,Ma, Xiaochi,Tian, Zhenhao,Wang, Yan,Hou, Jie,Feng, Lei,Song, Liang,Cui, Jingnan,Huo, Xiaokui,Zhao, Xinyu.A highly selective fluorescent probe for detecting glutathione transferases to reveal anticancer-activity sensitivity of cisplatin in cancer cells and tumor tissues[J],SENSORS AND ACTUATORS B-CHEMICAL,2018,277:423-430

    [4]Feng, Lei,Ning, Jing,Ma, Xiao-Chi,Li, Ping,Hou, Jie,Cui, Yong-Lei,Tian, Xiang-Ge,Yu, Zhen-Long,Cui, Jing-Nan,Wang, Chao,Huo, Xiao-Kui.Identification and Isolation of Glucosytransferases (GT) Expressed Fungi Using a Two-Photon Ratiometric Fluorescent Probe Activated by GT[J],ANALYTICAL CHEMISTRY,2018,90(22):13341-13347

    [5]Jiao, Long,Song, Fengling,Cui, Jingnan,Peng, Xiaojun.A near-infrared heptamethine aminocyanine dye with a long-lived excited triplet state for photodynamic therapy[J],CHEMICAL COMMUNICATIONS,2018,54(66):9198-9201

    [6]Liu, Tao,Wang, Chao,Cui, Jing-Nan,Yan, Qu-Long,Feng, Lei,Ma, Xiao-Chi,Tian, Xiang-Ge,Yu, Zhen-Long,Ning, Jing,Huo, Xiao-Kui,Sun, Cheng-Peng.Isolation of gamma-Glutamyl-Transferase Rich-Bacteria from Mouse Gut by a Near-Infrared Fluorescent Probe with Large Stokes Shift[J],ANALYTICAL CHEMISTRY,2018,90(16):9921-9928

    [7]Huo, Xiaokui,Ma, Xiaochi,Tian, Xiangge,Li, Yannan,Feng, Lei,Cui, Yonglei,Wang, Chao,Cui, Jingnan,Sun, Chengpeng,Liu, Kexin.highly selective ratiometric fluorescent probe for real-time imaging of beta-glucuronidase in living cells and zebrafish[J],SENSORS AND ACTUATORS B-CHEMICAL,2018,262:508-515

    [8]Li, Pengbo,Wang, Yiru,Zhang, Shufang,Xu, Liang,Wang, Gongchen,Cui, Jingnan.An ultrasensitive rapid-response fluorescent probe for highly selective detection of HSA[J],TETRAHEDRON LETTERS,2018,59(14):1390-1393

    [9]Liu, Tao,Zhao, Xinyu,Huo, Xiaokui,Sun, Chengpeng,Cui, Jingnan,Feng, Lei,Ma, Xiaochi,Ning, Jing,Wang, Bo,Dong, Bin,Li, Song,Tian, Xiangge,Yu, Zhenlong,Peng, Yulin,Wang, Chao.Activatable Near-Infrared Fluorescent Probe for Dipeptidyl Peptidase IV and Its Bioimaging Applications in Living Cells and Animals[J],ANALYTICAL CHEMISTRY,2018,90(6):3965-3973

    [10]Jin, Yinzhu,Wang, Chao,Ning, Jing,Zhang, Baojing,Feng, Lei,Ma, Xiaochi,Tian, Xiangge,Jin, Lingling,Cui, Yonglei,Liu, Tao,Yu, Zhenlong,Huo, Xiaokui,Cui, Jingnan,Sun, Chengpeng.Highly Specific near-Infrared Fluorescent Probe for the Real-Time Detection of beta-Glucuronidase in Various Living Cells and Animals[J],ANALYTICAL CHEMISTRY,2018,90(5):3276-3283

    [11]Zhang Chuanmin,Zhang Shubiao,Zhi Defu,Cui Jingnan.Cancer Treatment with Liposomes Based Drugs and Genes Co-delivery Systems.[J],Current medicinal chemistry,2018,25(28):3319-3332

    [12]焦龍,宋鋒玲,崔京南,彭孝軍.A near infrared heptamethine aminocyanine dye with a long-living excited triplet state for photodynamic therapy[J],Chemical Communications, 2018, 54, 9198 u2013 9201.,2018,54:9198-9201

    [13]Lv, Xia,Yang, Ling,Feng, Lei,Ai, Chun-Zhi,Hou, Jie,Wang, Ping,Zou, Li-Wei,Cheng, Jie,Ge, Guang-Bo,Cui, Jing-Nan.A Practical and High-Affinity Fluorescent Probe for Uridine Diphosphate Glucuronosyltransferase 1A1: A Good Surrogate for Bilirubin[J],JOURNAL OF MEDICINAL CHEMISTRY,2017,60(23):9664-9675

    [14]Qiao, Qinglong,Liu, Wenjuan,Chen, Jie,Zhou, Wei,Yin, Wenting,Miao, Lu,Cui, Jingnan,Xu, Zhaochao.A naphthalimide-derived fluorogenic probe for SNAP-tag with a fast record labeling rate[J],DYES AND PIGMENTS,2017,147:327-333

    [15]Ge, Guang-Bo,Yang, Ling,Feng, Lei,Jin, Qiang,Wang, Yi-Ru,Liu, Zhao-Ming,Zhu, Xin-Yue,Wang, Ping,Hou, Jie,Cui, Jing-Nan.A novel substrate-inspired fluorescent probe to monitor native albumin in human plasma and living cells[J],ANALYTICA CHIMICA ACTA,2017,989:71-79

    [16]Jin, Qiang,Yang, Ling,Feng, Lei,Zhang, Shui-Jun,Wang, Dan-Dan,Wang, Fang-Jun,Zhang, Yi,Cui, Jing-Nan,Guo, Wen-Zhi,Ge, Guang-Bo.Real-Time Tracking the Synthesis and Degradation of Albumin in Complex Biological Systems with a near-Infrared Fluorescent Probe[J],ANALYTICAL CHEMISTRY,2017,89(18):9884-9891

    [17]Jiao, Long,Song, Fengling,Zhang, Biyou,Ning, Houfu,Cui, Jingnan,Peng, Xiaojun.Improving the brightness and photostability of NIR fluorescent silica nanoparticles through rational fine-tuning of the covalent encapsulation methods[J],JOURNAL OF MATERIALS CHEMISTRY B,2017,5(26):5278-5283

    [18]Wang, Yi-Ru,Feng, Lei,Xu, Liang,Hou, Jie,Jin, Qiang,Zhou, Nan,Lin, Yuan,Cui, Jing-Nan,Ge, Guang-Bo.An ultrasensitive and conformation sensitive fluorescent probe for sensing human albumin in complex biological samples[J],SENSORS AND ACTUATORS B-CHEMICAL,2017,245:923-931

    [19]Dai, Ziru,Ge, Guang-Bo,Yang, Ling,Feng, Lei,Cui, Jing-Nan,Jin, Qiang.A HIGHLY SELECTIVE RATIOMETRIC TWO-PHOTON FLUORESCENT PROBE FOR HUMAN CYTOCHROME P450 1A1 AND ITS APPLICATION[J],DRUG METABOLISM AND PHARMACOKINETICS,2017,32(1):S37-S37

    [20]Jin, Qiang,Feng, Lei,Wang, Dandan,Ge, Guang-Bo,Cui, Jing-Nan,Ling, Yang.A HIGHLY SELECTIVE NEAR-INFRARED FLUORESCENT PROBE FOR CARBOXYLESTERASE 2 AND ITS BIOIMAGING APPLICATIONS IN LIVING SYSTEMS[J],DRUG METABOLISM AND PHARMACOKINETICS,2017,32(1):S22-S22

    [21]Lv, Xia,Feng, Lei,Cui, Jing-Nan,Yang, Ling,Ge, Guang-Bo.A TURN ON FLUORESCENT PROBE FOR HUMAN UDP-GLUCURONOSYL TRANSFERASE 1A1 AND BILIRUBIN METABOLISM EVALUATION[J],DRUG METABOLISM AND PHARMACOKINETICS,2017,32(1):S35-S35

    [22]宋鋒玲,崔京南,彭孝軍.Improving brightness and photostability of NIR fluorescent silica nanoparticles through rational fine-tuning of the covalent encapsulation methods[J],Journal of Materials Chemistry B,2017,5:5278-5283

    [23]Dai, Zi-Ru,Yang, Ling,Feng, Lei,Jin, Qiang,Cheng, Hailing,Li, Yan,Ning, Jing,Yu, Yang,Ge, Guang-Bo,Cui, Jing-Nan.A practical strategy to design and develop an isoform-specific fluorescent probe for a target enzyme: CYP1A1 as a case study[J],CHEMICAL SCIENCE,2017,8(4):2795-2803

    [24]丁樂樂,田鎮(zhèn)豪,侯潔,翁仔淼,崔京南,楊凌,葛廣波.基于BODIPY母核的羧酸酯酶1特異性熒光探針底物的設計研發(fā)[J],藥學學報,2017,52(1):58-65

    [25]Jin, Qiang,Cui, Jing-Nan,Yang, Ling,Feng, Lei,Wang, Dan-Dan,Wu, Jing-Jing,Hou, Jie,Dai, Zi-Ru,Sun, Shi-Guo,Wang, Jia-Yue,Ge, Guang-Bo.A highly selective near-infrared fluorescent probe for carboxylesterase 2 and its bioimaging applications in living cells and animals[J],BIOSENSORS & BIOELECTRONICS,2016,83:193-199

    [26]Cui, Jing-Nan,Xu, Liang.A rapid-response fluorescent probe for the sensitive and selective detection of human albumin in plasma and cell culture supernatants[J],CHEMICAL COMMUNICATIONS,2016,52(36):6064-6067

    [27]Cui, Jing-Nan.A highly selective marker reaction for measuring the activity of human carboxylesterase 1 in complex biological samples[J],RSC ADVANCES,2016,6(6):4302-4309

    [28]Cui, Jing-Nan.A Two-Photon Ratiometric Fluorescent Probe for Imaging Carboxylesterase 2 in Living Cells and Tissues[J],ACS APPLIED MATERIALS & INTERFACES,2015,7(51):28474-28481

    [29]Cui, Jing-Nan.A Highly Selective Ratiometric Two-Photon Fluorescent Probe for Human Cytochrome P450 1A[J],JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2015,137(45):14488-14495

    [30]Cui, Jing-Nan.An optimized ratiometric fluorescent probe for sensing human UDP-glucuronosyltransferase 1A1 and its biological applications[J],BIOSENSORS & BIOELECTRONICS,2015,72:261-267

    [31]Cui, Jing-Nan.A highly selective fluorescent ESIPT probe for the detection of Human carboxylesterase 2 and its biological applications[J],BIOSENSORS & BIOELECTRONICS,2015,65:9-15

    [32]Cui, Jingnan.Coumarin 545: an emission reference dye with a record-low temperature coefficient for ratiometric fluorescence based temperature measurements[J],ANALYST,2015,140(4):1008-1013

    [33]Cui, Jing-Nan.A ratiometric fluorescent sensor for highly selective detection of human carboxylesterase 2 and its application in living cells[J],SENSORS AND ACTUATORS B-CHEMICAL,2014,205:151-157

    [34]Feng, Lei,Liu, Zhao-Ming,Xu, Liang,Lv, Xia,Ning, Jing,Hou, Jie,Ge, Guang-Bo,Cui, Jing-Nan,Yang, Ling.A highly selective long-wavelength fluorescent probe for the detection of human carboxylesterase 2 and its biomedical applications[J],CHEMICAL COMMUNICATIONS,2014,50(93):14519-14522

    [35]Cui, Jingnan.A fluorescent probe based on N-butylbenzene-1,2-diamine for Cu(II) and its imaging in living cells[J],JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY,2014,80(3-4):383-390

    [36]Liu, Zhao-Ming,Feng, Lei,Ge, Guang-Bo,Lv, Xia,Hou, Jie,Cao, Yun-Feng,Cui, Jing-Nan,Yang, Ling.A highly selective ratiometric fluorescent probe for in vitro monitoring and cellular imaging of human carboxylesterase 1[J],BIOSENSORS & BIOELECTRONICS,2014,57:30-35

    [37]Liu, Tianyu,Liu, Xiaogang,Spring, David R.,Qian, Xuhong,Cui, Jingnan,Xu, Zhaochao.Quantitatively Mapping Cellular Viscosity with Detailed Organelle Information via a Designed PET Fluorescent Probe[J],SCIENTIFIC REPORTS,2014,4:5418

    [38]崔京南.A highly selective ratiometric fluorescent probe for in vitro monitoring and cellular imaging of human carboxylesterase1[J],Biosensors & Bioelectronics,2014,57(1):30-35

    [39]崔京南.A highly selective long-wavelength fluorescent probe for human carboxylesterase 2 and its biomedical applications[J],Chem. Commun,2014,50(50):14519-14522

    [40]崔京南.Quantitatively Mapping Cellular Viscosity with Detailed OrganelleInformation via a Designed PET Fluorescent Probe[J],SCIENTIFIC REPORTS,2014,4(5418):1-7

    [41]Zou, Chunyan,Qiao, Qinglong,Zhao, Miao,Mao, Deqi,Wang, Danfeng,Feng, Lei,Cui, Jingnan,Xu, Zhaochao.A ratiometric fluorescent probe for fluoride ion based on naphthoimidazolium receptor[J],RSC ADVANCES,2014,4(82):43746-43751

    [42]Qiao, Qinglong,Zhao, Miao,Lang, Haijing,Mao, Deqi,Cui, Jingnan,Xu, Zhaochao.A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells[J],RSC ADVANCES,2014,4(49):25790-25794

    [43]Song, Xinwei,Liu, Fengyu,Sun, Shiguo,Wang, Jingyun,Cui, Jingnan,Peng, Xiaojun.An NIR dye encapsulated by a supramolecular assembly for imaging mitochondria in living cells with ultrastable photostability[J],RSC ADVANCES,2014,4(18):9326-9329

    [44]Liu, Tianyu,Zhang, Xinfu,Qiao, Qinglong,Zou, Chunyan,Feng, Lei,Cui, Jingnan,Xu, Zhaochao.A two-photon fluorescent probe for imaging hydrogen sulfide in living cells[J],DYES AND PIGMENTS,2013,99(3):537-542

    [45]Song, Xinwei,Liu, Fengyu,Sun, Shiguo,Cui, Jingnan,Fan, Jiangli,Song, Fengling,Peng, Xiaojun.O-atom effect on the dynamic balance between redox-induced viologen derivative radical and its dimer modulated by cucurbit[8]uril[J],SUPRAMOLECULAR CHEMISTRY,2013,25(7):401-408

    [46]Chen, Tao,Zheng, Yi,Xu, Zhaochao,Zhao, Miao,Xu, Yongnan,Cui, Jingnan.A red emission fluorescent probe for hydrogen sulfide and its application in living cells imaging[J],TETRAHEDRON LETTERS,2013,54(23):2980-2982

    [47]Wu, Zhiyong,Cui, Jingnan,Qian, Xuhong.Rational design of fluorescent viscosity sensors by the principle of photoinduced electron transfer[J],TETRAHEDRON LETTERS,2013,54(21):2575-2578

    [48]Liu, Tianyu,Xu, Zhaochao,Spring, David R.,Cui, Jingnan.A Lysosome-Targetable Fluorescent Probe for Imaging Hydrogen Sulfide in Living Cells[J],ORGANIC LETTERS,2013,15(9):2310-2313

    [49]Wu, Zhi-Yong,Cui, Jing-Nan,Qian, Xu-Hong,Liu, Tian-Yu.A 4-aminonaphthalimide based environmentally sensitive fluorescence probe[J],CHINESE CHEMICAL LETTERS,2013,24(5):359-361

    [50]王專,崔京南,歐其,吳祖望.三苯二嗪型藍色活性染料研究進展[J],染料與染色,2013,50(1):10-13

    [51]Wang, Min,Xu, Zhaochao,Wang, Xu,Cui, Jingnan.A fluorescent and colorimetric chemosensor for nitric oxide based on 1,8-naphthalimide[J],DYES AND PIGMENTS,2013,96(2):333-337

    [52]王專,崔京南,歐其,吳祖望.三苯二噁嗪型藍色活性染料研究進展[A],第十二屆全國染料與染色學術研討會暨信息發(fā)布會,2012,16-20

    [53]王靜,程耀邦,邊悅玲,徐兆超,崔京南.苯萘體系普朔爾環(huán)化反應中橋原子與取代基對芳香自由基誘導分子內(nèi)1,5-氫轉移的影響[J],中國科技論文,2012,6:454-461

    [54]Xing, Junling,Cui, Jingnan,Wang, Shuang,Gao, Jin,Zhang, Zhichao.Novel acenaphthopyrazine derivatives as antitumor agents against MCF-7 cells: molecular synthesis, optical properties, and DNA-binding studies[J],MONATSHEFTE FUR CHEMIE,2012,143(2):243-250

    [55]Chen, Xiufu,Wang, Jingyun,Cui, Jingnan,Xu, Zhaochao,Peng, Xiaojun.A ratiometric and exclusively selective Cu-II fluorescent probe based on internal charge transfer (ICT)[J],TETRAHEDRON,2011,67(26):4869-4873

    [56]Miao, Qingqing,Wu, Liqiong,Cui, Jingnan,Huang, Mingdong,Ma, Tingli.A New Type of Dye-Sensitized Solar Cell with a Multilayered Photoanode Prepared by a Film-Transfer Technique[J],ADVANCED MATERIALS,2011,23(24):2764-2768

    [57]楊翠翠,孔志霞,崔京南.用于染料敏化太陽能電池的苊并吡嗪類染料的合成[J],精細化工,2011,28(7):633-638

    [58]Xie, Lijuan,Cui, Jingnan,Qian, Xuhong,Xu, Yufang,Liu, Jianwen,Xu, Ruian.5-Non-amino aromatic substituted naphthalimides as potential antitumor agents: Synthesis via Suzuki reaction, antiproliferative activity, and DNA-binding behavior[J],BIOORGANIC & MEDICINAL CHEMISTRY,2011,19(2):961-967

    [59]崔京南.Design and synthesis of organic dyes based on acenaphthopyrazine for dye-sensitized solar cells[J],Jingxi Huagong (2011), 28(7), 633-638,2011,28(7):633-638

    [60]Wang Xing-yong,Cui Jing-nan,Ren Wei-min,Zhao Guo-quan,Li Feng,Qian Xu-hong.Reductive Metabolism of Nitroaromatic Compounds by Various Liver Microsomes[J],CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2010,26(6):981-985

    [61]Wang, Kewei,Qian, Xuhong,Cui, Jingnan.Design, synthesis, and bioactivity of cyanonitrovinyl neonicotinoids as potential insecticides[J],MONATSHEFTE FUR CHEMIE,2010,141(10):1117-1122

    [62]Kong, Zhixia,Zhou, Huizhi,Cui, Jingnan,Ma, Tingli,Yang, Xichuan,Sun, Licheng.A new class of organic dyes based on acenaphthopyrazine for dye-sensitized solar cells[J],JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,2010,213(2-3):152-157

    [63]Li, Xiaolian,Wang, Qianqian,Qing, Yang,Lin, Yanjie,Zhang, Yingli,Qian, Xuhong,Cui, Jingnan.Novel DNA intercalators without basic side chains as efficient antitumor agents: Design, synthesis and evaluation of benzo-[c,d]-indol-malononitrile derivatives[J],BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(9):3279-3284

    [64]Wang, Lixiao,Wang, Xingyong,Cui, Jingnan,Ren, Weimin,Meng, Nan,Wang, Jingyun,Qian, Xuhong.Preparation of chiral trans-5-substituted-acenaphthene-1,2-diols by baker’s yeast-mediated reduction of 5-substituted-acenaphthylene-1,2-diones[J],TETRAHEDRON-ASYMMETRY,2010,21(7):825-830

    [65]Xu, Zhaochao,Pan, Jie,Spring, David R.,Cui, Jingnan,Yoon, Juyoung.Ratiometric fluorescent and colorimetric sensors for Cu2+ based on 4,5-disubstituted-1,8-naphthalimide and sensing cyanide via Cu2+ displacement approach[J],TETRAHEDRON,2010,66(9):1678-1683

    [66]Xu, Zhaochao,Baek, Kyung-Hwa,Kim, Ha Na,Cui, Jingnan,Qian, Xuhong,Spring, David R.,Shin, Injae,Yoon, Juyoung.Zn2+-Triggered Amide Tautomerization Produces a Highly Zn2+-Selective, Cell-Permeable, and Ratiometric Fluorescent Sensor[J],JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2010,132(2):601-610

    [67]崔京南.Design, Synthesis and Bioactivity of Vinylnitro-cyano Neonicotinoids as Potential Insecticides[J],Monatsh. Chem.,2010,141:1117-1120

    [68]吳志勇,崔京南.Polarity Sensors Based on Photoinduced Electron Transfer Mechamism[A],The 2nd Workshop on Fluorescence Chemsensors and Bio-imagings,2010,88-89

    [69]Wang, Kewei,Qian, Xuhong,Cui, Jingnan.One step from nitro to oxime: a convenient preparation of unsaturated oximes by the reduction of the corresponding vinylnitro compounds[J],TETRAHEDRON,2009,65(50):10377-10382

    [70]Xie, Lijuan,Xiao, Yi,Wang, Fang,Xu, Yufang,Qian, Xuhong,Zhang, Rong,Cui, Jingnan,Liu, Jianwen.Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: Synthesis, cytotoxicity, DNA-binding and cell cycle evaluation[J],BIOORGANIC & MEDICINAL CHEMISTRY,2009,17(21):7615-7621

    [71]Xie, Lijuan,Xu, Yufang,Wang, Fang,Liu, Jianwen,Qian, Xuhong,Cui, Jingnan.Synthesis of new amonafide analogues via coupling reaction and their cytotoxic evaluation and DNA-binding studies[J],BIOORGANIC & MEDICINAL CHEMISTRY,2009,17(2):804-810

    [72]崔京南.Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: synthesis, cytotoxicity, DNA-binding and cell cycle evaluation[A],Bioorg. Med. Chem,2009,17(21):7615-7621

    [73]Wang, Kewei,Cui, Jingnan,Xie, Lijuan,Qian, Xuhong.Design, synthesis, and Evaluation of Unsymmetrical Difluoro-Boron Complexes with Imidazoline as Potential Fungicides[J],HETEROATOM CHEMISTRY,2009,20(7):418-424

    [74]Tong, Lian Peng,Cui, Jing Nan,Ren, Wei Min,Wang, Xing Yong,Qian, Xu Hong.Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)- and (-)-mono hydroxyacenaphthenones[J],CHINESE CHEMICAL LETTERS,2008,19(10):1179-1182

    [75]Xie, Lijuan,Qian, Xuhong,Cui, Jingnan,Xiao, Yi,Wang, Kewei,Wu, Peichun,Cong, Liying.Novel angular furoquinolinones bearing flexible chain as antitumor agent: Design, synthesis, cytotoxic evaluation, and DNA-binding studies[J],BIOORGANIC & MEDICINAL CHEMISTRY,2008,16(18):8713-8718

    [76]佟連鵬,張建偉,孔志霞,崔京南.一種具有變色效應的可在生理pH下檢測Co~(2+)的熒光探針[A],中國化學會第26屆學術年會光化學分會場,2008,1

    [77]孔志霞,王興涌,張建偉,崔京南.利用動物肝臟質(zhì)粒還原芳香硝基類化合物[A],中國化學會第26屆學術年會有機化學分會場,2008,1

    [78]Li, Gangyue,Qian, Xuhong,Yan, Shenggang,Cui, Jingnan,Zhang, Rong,Xiao, Yi.Synthesis, herbicidal activity, and structure-bioactivity relationship of pyridyl-containing 2-phenyliminothiazolidines[J],MONATSHEFTE FUR CHEMIE,2008,139(2):169-178

    [79]崔京南.一種具有變色效應的可在生理pH下檢測Co2+的熒光探針[A],中國化學會第二十六屆學術年會,2008

    [80]邊悅玲,崔京南,程耀邦,徐兆超.以氮為橋原子的芳香自由基誘導的1,5-芳香氫轉移的研究[A],中國化學會第二十五屆學術年會,2006,1

    [81]盧春亮,崔京南,徐兆超.一種在生理pH下比例熒光檢測Cd_(2+)的水溶性化學傳感器[A],中國化學會第二十五屆學術年會,2006,1

    [82]王興涌,崔京南,李峰,任偉民.生物轉化法制備手性5-溴-1,2-二羥基苊[A],中國化學會第二十五屆學術年會,2006,1

    [83]崔京南,程耀邦,徐兆超,張大奎.芳香自由基誘導的芳香氫轉移:供吸電子取代基的影響[A],中國化學會第四屆有機化學學術會議,2005,Vol.25:1

    [84]崔京南,李峰,任偉民,喬卉瑩.利用生物轉化制備芳香羥胺:反應體系的pH、溫度和時間對反應選擇性的影響[A],中國化工學會;北京化工大學,2005

    [85]張勉,崔京南.1,8-萘酐類水溶性熒光染料的合成[J],精細化工,2004,21(10):782-784

    [86]Qian X.,Cui J.,Zhang R..Intramolecular aromatic 1,5-hydrogen transfer in preparation of oxacyclic naphthalic anhydride via unusual Pschorr cyclisation[J],Chemical Communications,2001,24:2656-2657

    主要成就

    相關研究成果在J. Am. Chem. Soc.; Org. Lett.; Chem. Commun; J. Org.Chem.; Sci. Rep; Biosensors and Bioelectronics等雜志發(fā)表論文50余篇,共被引用700余次;獲得國家專利授權20余項;作為項目負責人獲得資助國家自然科學基金面上項目3項、國家科技支撐計劃、國家自然科學基金重大培育計劃、上海市科委科研項目各1項。

    1、通過把熒光檢測技術引入食品安全領域,將傳統(tǒng)快速檢測儀器的定性檢測提高至定量檢測,特別是將重金屬離子檢測限由10 mg/L降低至0.05 mg/L;已完成便攜式食品安全熒光快速檢測儀開發(fā);

    2、完成數(shù)碼彩色打印專用染料及墨水制備工藝開發(fā),產(chǎn)品打破國外產(chǎn)品壟斷,大幅降低價格,使國外產(chǎn)品基本退出國內(nèi)市場;成果獲得國家科技發(fā)明二等獎(大幅面數(shù)碼噴墨染料及其應用,2006年,第二位獲獎人)。

    3、開發(fā)金屬離子、中性小分子、陰離子、粘度、生物酶(乙酰膽堿酶、羧酸酯酶、人血清蛋白酶和P450酶)等高選擇性、比例檢測的雙通道熒光探針30余種;成果獲得上海市自然科學一等獎(生物功能色素及熒光分子傳感器,2008年,第三位獲獎人)。

    獎勵:

    (1)國家技術發(fā)明二等獎,2006年,大幅面數(shù)碼噴墨染料及其應用,彭孝軍、崔京南、張 蓉、王力成、樊江麗、王力軍;

    (2)上海市自然科學一等獎,2008年,生物功能色素及熒光分子傳感器,錢旭紅、肖 義、崔京南、徐玉芳;

    專利

    一種用于識別硫化氫的特異性熒光探針及其應用

    一種苯并噻唑類識別硫化氫的熒光探針及其應用

    一種用于識別半胱氨酸的特異性熒光探針及其應用

    一種以苊并吡嗪為母體的高靈敏性熒光探針、制備及應用

    芳雜環(huán)基咪唑并萘酰亞胺類化合物及其應用

    一類苊并吡嗪染料及其在染料敏化太陽能電池上的應用

    一類鄰二氰基苊并吡嗪化合物及其抗腫瘤應用

    手性2-羥基苊酮類化合物的制備方法

    一種萘酰亞胺熒光染料及其制備和應用

    一種染料型中性墨水及其制備方法

    科研項目

    當前位置: 崔京南>> 科學研究>> 科研項目

    人源羧酸酯酶1亞型選擇性熒光探針設計、合成與生物學應用, 國家自然科學基金, 2015/08/18, 進行

    制筆行業(yè)關鍵材料及制備技術研發(fā)與產(chǎn)業(yè)化, 國家科技支撐計劃項目, 2011/06/01, 完成

    基于剛性、稠環(huán)芳香醇的手性分子熒光探針設計與合成,高等學校博士學科點專項科研基金項目, 2010/12/02, 完成

    利用生物轉化法制備剛性、稠環(huán)芳香手性醇, 國家自然科學基金, 2008/09/25-2011/12/31, 完成

    利用鎘離子比率熒光探針研究鎘誘導的細胞程序化死亡過程中NO的作用機制, 國家自然科學基金, 2007/09/25-2012/12/31, 完成

    特色精細化學品及工藝共性技術開發(fā)一期項目, 2017/06/13-2021/06/13, 進行

    生物分子檢測及醫(yī)學診斷用菁熒光標記染料, 遼寧省高等學?蒲杏媱濏椖, 2007/01/01-2010/09/17, 完成

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