數字圖像處理、光學微納成像及應用、信息光學、計算機程序設計。

1.國家自然科學研究基金項目：針尖增強拉曼光譜用于T細胞特異性受體結構表征的研究，項目編號：61575069

2.國家自然科學研究基金項目：多波長、熒光數字全息顯微術及在T細胞活化定量表征中的研究，項目編號：61275015

3.國家自然科學研究基金項目：多道偏振近場光學顯微鏡及在多色量子點標記TCR/CD3納米微域構成，項目編號：61078064

4.國家自然科學研究基金項目：多道偏振掃描近場光學顯微成像系統(tǒng)結合量子點標記研究TCR/CD3 特異性識別及信號傳導分子機制，項目編號： 60978065

近年來發(fā)表的代表性論文：

1.Qinnan Zhang, Xiaoxu Lu, Yingjie Yuan, Daosen Zhang, Jiaosheng Li, Liyun Zhong*. “Concurrent scanning double-tip enhanced Raman scattering by near-field coupling effect”. Plasmonics, DOI: 10.1007/s11468-015-0037-9 (2015)

2.Daosen Zhang, Yanyan Feng, Qinnan Zhang, Xin Su, Xiaoxu Lu, Shengde Liu, LiyunZhong*. “Raman spectrum reveals the cell cycle arrest of Triptolide-induced leukemic T-lymphocytes apoptosis”. Spectrochimica Acta Part A , 141(15 ): 216u2013222(2015)

3.Xin Su, Daosen Zhang, Yingtian He, Xiaoxu Lu, Qinnan Zhang, Shengde Liu, Liyun Zhong*.“Raman micro-spectrum reveals the biochemical changes of Mesenchymal stem cells differentiation into Islet-like cells”. Journal of Biomedical Optics, DOI: 10.1117/1.JBO.20.11.110621

4.Fan? Jinping, Lu? Xiaoxu, Liu? Shengde, Zhong? Liyun*. “Nanoscale Relationship Between CD4 and CD25 of T Cells Visualized with NSOM/QD-Based Dual-Color Imaging System” Nanoscale Research Letters. DOI: 10.1186/s11671-015-1130-x(2015)

5.Wangping Zhang, Xiaoxu Lu, Chunshu Luo, Liyun Zhong*, Javier Vargas. “Principal component analysis based simultaneous dual-wavelength phase-shifting interferometry”. Optics Communications,? 341: 276-283(2015)

6.Shufang Hu, Yanyan Feng , Daosen Zhang , Xiaoxu Lu , Jindong Tian , Jinping Fan, Liyun Zhong*. “Raman spectral change of Artemisinin-induced Raji cells apoptosis”. Vibrational Spectroscopy, DOI: 10.1016/j.vibspec.2015.10.006

7.Fanchuang Zeng, Jinping Fan, Hui Zhao,Xiaoxu Lu, Shuzhen Ma, Liyun Zhong*. “Visual evaluation of the finch recording quality”. Microwave and Optical Technology Letters. 57( 6): 1403u20131406(2015)

8.Wangping Zhang, Xiaoxu Lu, Leihuan Fei, Hui Zhao, Hanling Wang, Liyun Zhong*.“Simultaneous phase-shifting dual-wavelength interferometry based on two-step demodulation algorithm” Optics Letters, 39(18):5375-5378 (2014)

9.Leihuan Fei, Xiaoxu Lu, Hanling Wang, Wangping Zhang, Jindong Tian, Liyun Zhong*. “Single-wavelength phase retrieval method from simultaneous multi-wavelength in-line phase-shifting interferograms”, Optics Express, 22(25):30910-30923 (2014)

10.Tao Tao, Qi Shen, Xiaoxu Lu, Yingtian He, Liyun Zhong*, “Raman spectroscopyu2013based multivariate statistical analysis reveals the molecular mechanism of K562 Cell apoptosis induced by Adriamycin”. Spectroscopy Letters. 47(4):301-305(2014)

11.Li Mingxing, Yang Kai, Zhong Liyun*. “Wavefront phase reconstruction approach of imaging interferometry based on shearography and the integrated unwrapping algorithm”. Optical and Quantum Electronics. 47(3):545-559 (2015)

12.Yintian He, Desi Zhang, Tao Tao, Qi Shen, Xiaoxu Lu, Shende Liu,? Liyun Zhong*. “Raman spectroscopy and AFM imaging directly reveals the activation-dependent characteristic of T cells”. Laser Physics, 24(8): 085701. DOI:10.1088/1054-660X/24/8/085701(2014)

13.Liyun Zhong*, Zhun Zhang,Xiaoxu Lu, Shengde Liu, Crystal Y. Chen, Zheng W. Chen. “NSOM/QD-Based Visualization of GM1 Serving as Platforms for TCR/CD3 Mediated T-Cell Activation”. BioMed Research International. 2013:276498 (2013)

14.Jian Deng, Hankun Wang, Desi Zhang, Liyun Zhong, Jinping Fan, Xiaoxu Lu. “Phase shiftextraction algorithm based on Euclidean matrix norm”.Optics Letters, 38(9):1506-1508 (2013)

15.Jian Deng, Hankun Wang, Fengjie Zhang, Desi Zhang, Liyun Zhong, Xiaoxu Lu. “Two-step phase demodulation algorithm based on the extreme value of interference”. Optics Letters, 37(22):4669-4671(2012）

16.Xiaoxu Lu, Jianpei Chen, Shengde, Liu, Zhijian Ma, Zhun, Zhang, Liyun Zhong*. “3D profile reconstruction of biological sample by in-line image-plane phase-shifting digital microscopic holography”. Optics and Lasers In Engineering 50(10): 1431-1435, 2012

17.Liyun Zhong*, Zhun Zhang Xiaoxu,Lu, Dan Huang, Ying Chen CY, Richard Wang,Zheng W Chen. “NSOM/QD-based fluorescence-topographic image fusion directly reveals nano-spatial peak-valley polarities of CD69 and CD71 activation molecules on cell-membrane fluctuations during T-cell activation”. Immunology Letters,? 2011,140(1-2):44-51

18.Liyun Zhong*, Zhuan, Zhuang, Xiaoxu Lu. “Detail displaying difference of the digital holographic reconstructed image between the convolution algorithm and Fresnel algorithm”. Optics Express, 19(23):23621-23630（2011）

19.Liyun Zhong, Gucheng Zeng, Xiaoxu Lu, Richard Wang, Guangming Gong, Dan Huang,Zheng W. Chen. “NSOM/QD-based nanoscale imaging directly visualizes CD3-induced and CD28-enhanced nano-spatial co-clustering of T cell receptor and co-receptor in nano-domains during T-cell activation”. PLoS ONE, 4(6): e5945(2009)

20.Zeng G，Chen J，Zhong L*, Wang R, Jiang, L, Cai J, Yan L, Huang D，Chen Z W. “NSOM- and AFM-based nanotechnology elucidates nano-structural and atomic-force features of a Y.pestis V immunogen-containing particle vaccine capable of eliciting robust response”. Proteomics, 9(6):1538-47 (2009)。