1996年7月畢業(yè)于吉林大學(xué)化學(xué)系，獲學(xué)士學(xué)位。

1999年7月畢業(yè)于中國(guó)科學(xué)院上海藥物研究所，從事天然產(chǎn)物分離純化和結(jié)構(gòu)鑒定，獲有機(jī)化學(xué)碩士學(xué)位。

2002年7月畢業(yè)于中國(guó)科學(xué)院化學(xué)所，從事生物轉(zhuǎn)化和生物催化研究，獲有機(jī)化學(xué)博士學(xué)位。?

2002年12月至2005年8月在加拿大的埃爾伯塔大學(xué)化學(xué)系從事博士后研究，主要從事糖轉(zhuǎn)移酶的生化表征和糖轉(zhuǎn)移酶在寡糖合成中的應(yīng)用，以及寡糖的化學(xué)合成。

2005年9月任威斯康星大學(xué)麥迪遜分校藥學(xué)院研究助理，主要從事烯二炔類(lèi)抗生素的生物合成研究。

2008年9月回國(guó)，受聘于上海交通大學(xué)任特別研究員，現(xiàn)任職于上海交通大學(xué)微生物代謝教育部重點(diǎn)實(shí)驗(yàn)室。共發(fā)表21篇SCI研究論文，其中JACS 3篇、 PNAS 2篇、Nature Structural & Molecular Biology 1 篇，以及有機(jī)化學(xué)專(zhuān)業(yè)雜志JOC 2篇。

　1. 抗菌和抗腫瘤的微生物次級(jí)代謝產(chǎn)物的生物合成和組合生物合成 　　微生物次代謝物是由微生物產(chǎn)生的天然產(chǎn)物，通常結(jié)構(gòu)復(fù)雜、活性官能團(tuán)較多。這些天然產(chǎn)物的合成通常是以小分子為原料，經(jīng)過(guò)一系列連續(xù)的酶催化反應(yīng)組裝合成的。通過(guò)克隆負(fù)責(zé)目標(biāo)天然產(chǎn)物的生物合成基因簇，闡明天然產(chǎn)物在生物體內(nèi)的生物合成途徑，闡述酶催化反應(yīng)的機(jī)理。再通過(guò)對(duì)目標(biāo)天然產(chǎn)物合成途徑中的合成基因或調(diào)控基因做合理的修飾，以期產(chǎn)生結(jié)構(gòu)類(lèi)似的“非天然”的天然產(chǎn)物，豐富可供生理活性化合物篩選的物質(zhì)基礎(chǔ)。 　

　2. 微生物來(lái)源的生理活性天然產(chǎn)物的篩選和鑒定 　　自20世紀(jì)20年代末青霉素的發(fā)現(xiàn)至今，微生物仍然是藥物和藥物先導(dǎo)化合物的重要來(lái)源�；�于極端環(huán)境微生物包括深海微生物、嗜熱、嗜鹽、嗜壓微生物以及共生微生物產(chǎn)生的結(jié)構(gòu)新穎的化合物的高幾率，應(yīng)用主要疾病如腫瘤、心血管疾病、糖尿病和感染性疾病作為靶標(biāo)，對(duì)微生物的代謝物進(jìn)行篩選、分離純化和結(jié)構(gòu)鑒定。 　　3. 酶作為生物催化劑在有機(jī)合成中的應(yīng)用 　　酶作為重要的生物催化劑，具有優(yōu)異的化學(xué)選擇性、區(qū)域選擇性和立體選擇性。在理解生物合成途徑中催化天然產(chǎn)物生物合成的酶的催化機(jī)理的基礎(chǔ)上，拓展酶催化在有機(jī)合成中的應(yīng)用，豐富有機(jī)合成方法學(xué)的研究。

主要代表性論文： 　　1. Lin SJ, Van Lanen SG and Shen B*, “A Free-Standing Condensation Enzyme Catalyzing Ester Bond Formation in C-1027 Biosynthesis”. Proc. Natl. Acad. Sci. U.S.A. 2009,106, 4183-4188. 　　2. Lin SJ, Van Lanen SG and Shen B*, “Characterization of the Two-Component, FAD-Dependent Monooxygenase SgcC that Requires Carrier Protein-Tethered Substrates for the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027”. J. Am. Chem. Soc. 2008, 130, 6616-6623. 　　3. Lin SJ, Van Lanen SG and Shen B*, “Regiospecific Chlorination of (S)-?-Tyrosyl-S-Carrier Protein Catalyzed by SgcC3 in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027”. J. Am. Chem. Soc. 2007, 129, 12432-8. 　　4. Van Lanen SG, Lin SJ and Shen B*, “The Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 Involves a New Branching Point in Chorismate Metabolism” Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 494-499.( Featured in C & E News, January 14, 2008, p36) 　　5. Luo Y, Lin SJ, Zhang J, Cooke HA, Bruner SD and Shen B*, “Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor abtibiotic neocarzinastatin”. J. Biol. Chem. 2008, 283, 14694-14702. 　　6. Van Lanen SG, Lin SJ, Dorrestein PC, Kelleher NL, Shen B*, “Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027” J. Biol. Chem. 2006, 281, 29633-29640. 　　7. Rose NL, Completo GC, Lin SJ, McNeil M, Palcic MM*, Lowary TL*. “Expression, Purification, and Characterization of a Galactofuranosyltransferase Involved in Mycobacterium tuberculosis Arabinogalactan Biosynthesis” J. Am. Chem. Soc. 2006, 128, 6721-6729. 　　8. Greco A, Ho JGS, Lin SJ, Palcic MM, Rupnik M, Ng KKS*, “Carbohydrate Recognition by Clostridium difficile Toxin A” Nature Structural & Molecular Biology 2006, 13, 460-461. 　　9. Ma B, Audette GF, Lin SJ, Palcic MM, Hazes B, and Taylor DE*, “Purification, kinetic characterization, and mapping of the minimal catalytic domain and the key polar groups of Helicobacter pylori alpha-(1,3/1,4)-fucosyltransferases” J. Biol. Chem. 2006, 281, 6385-6395. 　　10. Lin SJ, Tan CH, Jiang SH, Li YM and Zhu DY*, “C9-iridoids from Scrophularia buergeriana” Helvetica Chimica Acta 2006, 89, 2789-2793. 　　11. Bai Y, Lin SJ, Qi GZ, Palcic MM and Lowary TL*, “Synthesis of n-octyl 2,6-dideoxy-alpha-L-lyxo-hexopyranosyl-(1-2)-3-amino-3-deoxy-?-D-galacto-pyranoside, an analog of the H-disaccharide antigen” Carbohydrate Research 2006, 341, 1702-1707. 　　12. Ridgway KM, Shi W, Lin SJ, Palcic MM and Lowary TL*, “Chemical and chemoenzymatic synthesis of a trisaccharide fragment of Tsukamurella paurometabola lipoarabinomannan”. Canadian Journal of Chemistry 2006, 84, 642-649. 　　13. Wang MX*, Lin SJ, Liu J and Zheng QY. “Efficient biocatalytic synthesis of highly enantiopure ?-alkylated arylglycines and amides” Advanced Synthesis & Catalysis 2004,346, 439-445. 　　14. Wang MX*, Lin SJ, Liu CS, Zheng QY and Li JS, “Nitrile biotransformations for highly efficient and enantioselective syntheses of electrophilic oxiranecarboxamides” J. Org. Chem. 2003, 68, 4570-4573. 　　15. Wang MX* and Lin SJ “Practical and convenient enzymatic synthesis of enantio-pure alpha-amino acids and amides” J. Org. Chem. 2002, 67, 6542-6545. 　　16. Wang MX* and Lin SJ, “Highly efficient and enantioselective synthesis of L-arylglycines and D-arylglycine amides from biotransformation of nitriles”. Tetrahedron Letters 2001, 42, 6925-6927. 　　17. Guo L, Lin SJ, Yang YF, Qi L, Wang MX and Chen Y*, “Fast enantioseperation of aryglycine amides by capillary eletrophoresis with highly sulfated-?-cyclodextrin as a chiral selector”. Journal of Chromatography A 2003, 998 (1-2): 221-228. 　　18. Guo L, Lin SJ, Dai DS, Yang YF, Qi L, Wang MX and Chen Y*, “Enantio-separation of ?-quaternary arylglycine amides by capillary electropherosis with human serum albumin” Analytical Letters 2003, 36 (7): 1451-1462. 　　19. Lin SJ, Jiang SH, Li YM, Zeng JF and Zhu DY*, “Two novel iridoids from Scrophularia buergeriana” Tetradron Letters 2000, 41, 1069-1071. 　　20. Dingle T, Wee S, Mulvey GL, Greco A, Kitova EN, Sun J, Lin SJ, Klassen JS, Palcic MM, Ng KK, Armstrong GD*, “Functional properties of the carboxy-terminal host cell-binding domains of the two toxins, TcdA and TcdB, expressed by Clostridium difficile”. Glycobiology 2008, 18, 698-706. 　　21. Jiang SH, Wang HQ, Li YM, Lin SJ, Tan JJ, Zhu DY*. “Two new C18-norditerpenoid alkaloids from Aconitum delavayi” Chinese Chemical letters, 2007, 18, 409-411。