人物經(jīng)歷
清華大學(xué)教授，博士生導(dǎo)師 。1962年5月生于陜西。1978-1989就讀于西北農(nóng)業(yè)大學(xué)并獲博士學(xué)位， 1995-1998在美國(guó)圣路易斯大學(xué)、華盛頓大學(xué)和阿拉巴馬大學(xué)等醫(yī)學(xué)院從事訪問學(xué) 者和博士后研究。1990-1995受聘西北農(nóng)業(yè)大學(xué)副教授，1998-2005受聘清華大學(xué)副教授， 2005年受聘清華大學(xué)教授。
2016年6月12日，常智杰當(dāng)選第五屆農(nóng)業(yè)轉(zhuǎn)基因生物安全委員會(huì)委員。
研究方向
1．細(xì)胞信號(hào)傳導(dǎo)(包括TGF-beta,FGF,Wnt及STAT)的分子機(jī)理
2．腫瘤發(fā)生的分子機(jī)理
3．泛素化修飾對(duì)細(xì)胞增殖與分化的影響。
主要作品
Yu Rong, Long Cheng, Hongxiu Ning, Jizhen Zou, Yuanjiang Zhang, Fang Xu, Li Liu, Zhijie Chang*, and Xin-Yuan Fu*. WT1 and STAT3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms’ tumor. Cancer Research 66: 8049-8057, 2006. (co-corresponding authors)
Xinjun Zhang, Xi He, Xin-Yuan Fu*, Zhijie Chang*. Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics. Journal of Cell Science 119: 1053-62, 2006. (co-corresponding authors)
Hong Xin, Xialian Xu, Linyu Li, Hongxiu Ning, Yu Rong, Yu Shang, Yinyin Wang, Xin-Yuan Fu, and Zhijie Chang*. CHIP controls the sensitivity of TGF-β signaling by maintaining the basal level of Smad3 through ubiquitin-mediated degradation. J. Biol. Chem. 280: 20842-20850, 2005.
Linyu Li, Hong Xin, Xialian Xu, Mei Huang, Xinjun Zhang, Yue Chen, Shuping Zhang, Xin-Yuan Fu* and Zhijie Chang*. CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription. Mol. Cell. Biol. 24: 856-864, 2004. (co-corresponding authors).
Shiqin Xiong, Qiuhui Zhao, Zhili Rong, Guanrong Huang, Yiling Huang, Peila Chen, Shuping Zhang, Li Liu, and Zhijie Chang*. hSef inhibits PC12 cell differentiation by interfering with Ras-Mitogen-activated MAPK signaling. J. Biol. Chem. 278: 50273-50282, 2003.
