成就及榮譽(yù)
1997年6月 在 中山醫(yī)科大學(xué)獲得醫(yī)學(xué)(生物化學(xué)專業(yè))博士學(xué)位;1999年晉升副教授;2004年晉升教授、博士生導(dǎo)師并獲中山大學(xué)教師特別津貼,入選教育部首屆“新世紀(jì)優(yōu)秀人才”(2004年),入選廣東省高等學(xué)校“ 千百十工程”培養(yǎng)對(duì)象(2006年),入選2009年 寶鋼優(yōu)秀教師。
主編 人民衛(wèi)生出版社規(guī)劃教材護(hù)理本科《生物化學(xué)》、參加人民衛(wèi)生出版社規(guī)劃教材《醫(yī)學(xué)分子生物學(xué)》的編寫;負(fù)責(zé)國(guó)家級(jí)繼續(xù)醫(yī)學(xué)項(xiàng)目“疾病的分子生物學(xué)基礎(chǔ)”;中山大學(xué)精品課程“生物化學(xué)與分子生物學(xué)”負(fù)責(zé)人。
1999.1-2002.5期間,在美國(guó)進(jìn)行博士后研究工作并晉升為研究助理教授,研究糖尿病視網(wǎng)膜病的分子機(jī)制和治療,成果發(fā)表在國(guó)際著名雜志上,如Diabetes,Journal of Biological Chemistry,F(xiàn)ASEB Journal 等。
研究方向
2002年6月回國(guó)后,先后獲得中山大學(xué)985學(xué)科建設(shè)基金200萬元,組建了先進(jìn)的分子生物學(xué)實(shí)驗(yàn)室,建立了一支結(jié)構(gòu)合理、基礎(chǔ)扎實(shí)、積極進(jìn)取的科研隊(duì)伍。研究方向?yàn)椋翰±硇匝茉錾纳淖、分子機(jī)制及血管增生性疾病的生物治療。課題組成員包括副教授1名,副主任技師1名,講師3名,在讀博士生9名、碩士生6名。已畢業(yè)博士2名、碩士3名。截至目前已獲得國(guó)家自然科學(xué)基金(3項(xiàng),70萬)、CMB學(xué)者項(xiàng)目(5萬美元)、教育部新世紀(jì)優(yōu)秀人才支持計(jì)劃(50萬)、廣東省科技攻關(guān)重大專項(xiàng)(2項(xiàng),40萬)、 廣東省自然科學(xué)基金團(tuán)隊(duì)項(xiàng)目(150萬,核心成員)、廣東省自然科學(xué)基金面上項(xiàng)目(10萬,2項(xiàng))、廣州市科技攻關(guān)重點(diǎn)項(xiàng)目(2項(xiàng),50萬)、廣東省醫(yī)學(xué)科學(xué)基金(3.5萬,4項(xiàng))等基金近300萬元的資助,研究工作進(jìn)展順利,已發(fā)表SCI論文25篇(通訊作者12篇,第一作者1篇),中文論文10篇,發(fā)表論文被國(guó)際同行引用總次數(shù)為368次,最高單篇他引106次,研究成果作為第一完成人獲得教育部、廣東省自然科學(xué)二等獎(jiǎng)各一項(xiàng)。
人生格言
人生最好的朋友和最大的敵人都是自己,能夠駕馭自己就能駕馭人生。
給學(xué)生的一句話:勤奮和思考是從事科學(xué)研究必備的條件。
近五年SCI論文
⒈ Xia Yang,Rui Cheng,Chaoyang Li,Weibin Cai,Jian-xing Ma,Qianping Liu,Zhonghan Yang,Zhihong Song,Zuguo Liu,and Guoquan Gao (corresponding author). Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity. Cancer Biology & Therapy,5⑷:399-405,2006. (Impact factor 3.3)
⒉ Qingsong Wang,Xia Yang,Zhonghan Yang,Guoquan Gao (corresponding author). A novel method for expression and purification of human Pigment Epithelium-derived Factor with biological activities in Escherichia coli. Preparative Biochemistry & Biotechnology,36⑵:127-138,2006. (Impact factor 1.0)
⒊ Weibin Cai,Jianfang Ma,Chaoyang Li,Zhonghan Yang,Xia Yang,Wei Liu,Zuguo Liu,Mintao Li,and Guoquan Gao (corresponding author). Enhanced anti-angiogenic effect of a deletion mutant of plasminogen kringle 5 on neovascularization. J Cell Biochem,96⑹:1254-1261,2005. (Impact factor 3.5)
⒋ Gao G,Shao C.,Zhang S.X.,Dudley A.,Fant J,and Ma J-x. Kallikrein-binding protein inhibits retinal neovascularization and decreases vascular leakage. Diabetologia,46,689-698,2003. (Impact factor 5.7)
⒌ Gao G,Li Y,Fant J,Becerra SP,Crosson C and Ma J-x. Difference in ischemic regulation of vascular endothelial growth factor and pigment epithelium--derived factor in brown norway and sprague dawley rats contributing to different susceptibilities to retinal neovascularization. Diabetes,51⑷,1218-1225,2002. (Impact factor 9.1)
⒍ Gao G,Li Y,Gee S,Dudley A,Fant J,Crosson C and Ma J-x. Down-regulation of endogenous VEGF and up-regulation of PEDF: a possible mechanism for the anti-angiogenic activity of plasminogen kringle 5. J Biol Chem,277⑾,9492-9497,2002. (Impact factor 7.7)
⒎ Gao G and Ma J-x. Tipping the balance for angiogenic disorders. Drug Discovery Today,7⑶,171-172,2002. (Impact factor 4.1)
⒏ Gao G,Li Y,Zhang D,Gee S,Crosson CE and Ma J-x. Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization. FEBS Lett,489,270-276,2001. (Impact factor 3.7)
⒐ Yousufzai SYK,Gao G,and Abdel-Latif AA. Mitogen-activated protein kinase inhibitors suppress prostaglandin F2a-induced myosin-light chain phosphorylation and contraction in iris sphincter smooth muscle. Eur J Pharmacol,407,17-26,2000. (Impact factor 2.2)
⒑Zhang D,Kaufman PL,Gao G,Saunders RA,and Ma J-x. Intravitreal injection of plasminogen kringle 5,an endogenous angiogenic inhibitor,arrests retinal neovascularization in rats. Diabetologia,44,757-765,2001. (Impact factor 5.7)
⒒Jin J,Guan M,Sima J,Gao G,Zhang M,Liu Z,Fant J and Ma J-x. Decreased pigment epithelium-derived factor and increased Vascular endothelial growth factor in pterygia. Cornea,22⑸:473-477,2003. (Impact factor 1.4)
⒓Zhang S.X.,Sima J,Shao C.,Fant J,Chen Y,Rohrer B,Gao G,and Ma J-x. Plasminogen kringle 5 reduces vascular leakage in the retina in rat models of oxygen-induced retinopathy and diabetes. Diabetologia,47⑴,124-131,2004. (Impact factor 5.7)
⒔Xie Y.,Liu Y.,Ma C.,Yuan Z.,Wang W.,Zhu Z.,Gao G.,Liu X.,Yuan H.,Chen Y.,Huang S.,Wang X.,Zhu X.,Wang X.,Mao Z.,and Li M. Indirubin-3u2019-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons. Neuroscience Letters,367:355-359,2004. (Impact factor 2.1)
⒕Zhang Z.,Ma J-x.,Gao G.,Li C.,Luo L.,Zhang M.,Chen J. and Liu,Z. Plasminogen kringle 5 inhibits alkali burn-induced corneal neovascularization. Invest. Ophthalmol. Vis. Sci.,46:4062-4071,2005. (Impact factor 3.58)
⒖Zhang,S.X.,Wang,J.J.,Gao,G.,Shao,C. Mott,R.,Longeras,R. and Ma,J-x. Pigment epithelium-derived factor (PEDF) is an endogenous anti-inflammatory factor. FASEB J.,20⑵:32-35,2006. (Impact factor 6.82)
⒗Zhang,S.X.,Wang,J.J.,Gao,G.,Park,K. and Ma,J-x. Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy. J Mol Endocrinol.,37⑴:1-12,2006. (Impact factor 3.85)
科研成果
⒈ 人纖溶酶原K5及其突變體治療血管增生性疾病的作用及分子機(jī)制。高等學(xué)?茖W(xué)研究?jī)?yōu)秀成果獎(jiǎng)自然科學(xué)二等獎(jiǎng)(2009),第一完成人
⒉ 人纖溶酶原K5及其突變體治療血管增生性疾病的作用及分子機(jī)制。廣東省科學(xué)技術(shù)自然科學(xué)二等獎(jiǎng)(2009),第一完成人