人物簡介
陳 泉，女，博士，副教授。2007年畢業(yè)于 中國科學技術大學生物化學與分子生物學系，獲理學博士學位。2007至2009年赴美國梅奧醫(yī)學院(Mayo Clinic)從事博士后工作，研究G蛋白偶聯(lián)受體的結構和功能。2009至2011年赴 南加州大學從事鋅指蛋白的設計與篩選相關研究。2011年3月作為中國科技大學優(yōu)秀人才引進，現(xiàn)任生命科學學院副教授。2009年獲17多肽調(diào)控國際會議優(yōu)秀博士后獎。主要研究成果發(fā)表于Journal of Biological Chemistry, Am. J. Physiol. Endocrinol. Metab, Protein Science等相關領域國際重要期刊。
研究領域
1）工程改造轉錄因子并探究其在合成生物學中的應用
2）開發(fā)設計生物網(wǎng)絡適配的生物功能器件
代表論文
1、Miller, L.J., Chen, Q., Lam, P.C., Pinon, D.I., Sexton, P.M., Abagyan, R. and Dong, M.Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling. Journal of Biological Chemistry, 2011, In press
2、 Chen, Q., Pinon, D.I., Miller, L.J., and Dong, M. Spatial approximations between residues 6 and 12 in the amino-terminal region of glucagon-Like peptide 1 and its receptor. a region critical for biological activity. , 2010, 285:
3、 Chen, Q., Miller, L.J., and Dong, M. Role of N-linked glycosylation in biosynthesis, trafficking, and function of the human glucagon-like peptide 1 receptor. . 2010, 299(1): E62-8
4、 Chen, Q., Pinon, D.I., Miller, L.J., and Dong, M. Molecular basis of glucagon-like peptide 1 docking to its intact receptor studied with carboxyl-terminal photolabile probes. Journal of Biological Chemistry, 2009, 284:
5、 Chen, Q., Niu, X., Xu, Y., Wu, J., and Shi, Y. Solution Structure and Backbone Dynamics of AF-6 PDZ domain/Bcr Peptide Complex. , 2007, 16:
6、Niu, X., Chen, Q., Zhang, J., Shen, W., Shi, Y., and Wu, J. Interesting structural and dynamical behaviors exhibited by the AF-6 PDZ domain upon Bcr peptide binding. , 2007, 46(51):
7、Ding, H., Xu, Y., Chen, Q., Dai, H., Tang, Y., Wu, J., and Shi, Y. Solution structure of human SUMO-3 C47S and its binding surface for Ubc9. , 2005, 44(8):
8、Zhang, X., Zhang, J., Li, X., Xu, J., Huang, H., Chen, Q., Wu, J., and Shi, Y. Compact molten globule-like state of hUBF HMG Box1 at extremely low pH. , 2005, 1748: 66u201373
9、 Chen, Q. and Shi, Y. Progress in SUMO modification research. , 2004, 16: 1-6
10.Xiao, Y., Chen, Q., Hang, J., Shi, Y., Wu, J., Hong, Y. and Wang, Y. Selective induction, purification and characterization of a laccase isozyme from the basidiomycete Trametes sp. AH28-2. , 2004, 96(1):26-35