2012-至今天然藥物及仿生藥物國家重點(diǎn)實(shí)驗(yàn)室副主任

2010-至今 教授，北京大學(xué)藥學(xué)院，課題組長

2007-2010 副教授，北京大學(xué)藥學(xué)院，課題組長

2004-2006 化學(xué)生物學(xué)博士后，洪堡獎(jiǎng)學(xué)金，德國馬普煤炭研究所，導(dǎo)師：Manfred T. Reetz教授

1999-2004 有機(jī)化學(xué)博士，中科院上海有機(jī)化學(xué)研究所，導(dǎo)師：麻生明院士

1995-1999 化學(xué)學(xué)士，山東大學(xué)

1）綠色化學(xué)：氧氣氧化與活化，氧合反應(yīng)（Oxygenation Reactions），氮合反應(yīng)（Nitrogenation Reactions）；

2）地球豐產(chǎn)過渡金屬催化；

3）基于內(nèi)源性物質(zhì)進(jìn)行先導(dǎo)藥物發(fā)現(xiàn)，通過可控自由基反應(yīng)、惰性鍵活化、串聯(lián)催化等過程尋求生物活性分子合成新途徑、新方法，利用簡單原料以簡潔、高效的合成方法為先導(dǎo)藥物發(fā)現(xiàn)及構(gòu)效關(guān)系研究服務(wù)。

1. Xiaoqiang Huang, Xinyao Li, Miancheng Zou, Song Song, Conghui Tang, Yizhi Yuan, andNing Jiao*, From Ketones to Esters by a Cu-Catalyzed Highly Selective C(CO)-C(alkyl) Bond Cleavage: Aerobic Oxidation and Oxygenation with Air,J. Am. Chem. Soc.2014,136, 14858-14865.

2. Feng Chen, Xiaoqiang Huang, Xinyao Li, Tao Shen, Miancheng Zou, andNing Jiao*, Dehydrogenative N-Incorporation: A Direct Approach to Quinoxaline N-Oxides under Mild Conditions,Angew. Chem. Int. Ed.2014, 53,10495-10499.

3. Conghui Tang andNing Jiao*, Copper-Catalyzed Aerobic Oxidative C?C bond Cleavage for C?N Bond Formation: From Ketones to Amides,Angew. Chem. Int. Ed.2014,53,6528-6532. (Hot Paper).

4. Yu-Feng Liang andNing Jiao*,Transition-Metal Free Highly Efficient C-H Hydroxylation of Carbonyls with Molecular Oxygen Under Mild Conditions,Angew. Chem. Int. Ed.2014,53, 548.

5. Chun Zhang, Peng Feng andNing Jiao*, Cu-Catalyzed Esterification Reaction via Aerobic Oxygenation and C-C Bond Cleavage: An Approach toα-Ketoesters,J. Am.Chem. Soc.2013,135, 15257u201315262.

6. Teng Wang andNing Jiao*, TEMPO-catalyzed Aerobic Oxygenation and Nitrogenation of Olefins via C=C Double Bond Cleavage,J. Am. Chem. Soc.2013,135, 11692-11695.

7. Yijin Su, Xiang Sun, Guolin Wu, andNing Jiao*, Catalyst-controlled Highly Selective Coupling and Oxygenation of Olefins: A Direct Approach to Alcohols, Ketones and Diketones,Angew. Chem. Int. Ed.2013,52, 9808-9812 (10.1021/anie.201303917).

8. Chong Qin, Peng Feng, Yang Ou,Tao Shen, Teng Wang andNing Jiao*,Highly Selective Csp-Csp Bond Cleavage:The Nitrogenation of Alkynes to Amides,Angew. Chem. Int. Ed.2013,52, 7850-7854. (Hot Paper).

9. Tao Shen, Teng Wang, Chong Qin, andNing Jiao*, Ag-catalyzed Nitrogenation of Alkynes: A Direct Approach to Nitriles via C-C Triple Bond Cleavage,Angew. Chem. Int. Ed.2013,52, 6677-6680. (Hot Paper) (Highlighted bySynfact(2013, 9(9), 0949).

10. Yuepeng Yan, Peng Feng, Qing-Zhong Zheng,Yu-FengLiang,Jingfen Lu, andNing Jiao*, PdCl2and NHPI Cocatalyzed Csp-H HydroxylationviaDioxygen Activation,Angew. Chem. Int. Ed.2013,52, 5827-5831.

11. Conghui Tang andNing Jiao*, Copper-catalyzed C-H Azidation of Anilines under Mild Conditions,J. Am. Chem. Soc.2012,134, 18924-18927.(Highlighted bySynform(2013, 02, A21) andSynfact(2013,9(2), 0207), Highlighted byAngew. Chem. Int. Ed. 10.1002/anie.201302015)

12. Xejun Xu, Chun Zhang, (These two authors contributed equally to this work) andNing Jiao*, Cu-mediated Aerobic Oxidative Dehydrogenative Annulation and Oxygenation of Aldehydes and Amines for Oxazoles via C-H Functionalization and Dioxygen Activation,Angew. Chem. Int. Ed.2012,51, 11367u201311370(Hot Paper).

13. Teng Wang, Wang Zhou, Hang Yin, Jun-An Ma, andNing Jiao*, Iron-Facilitated Oxidative Dehydrogenative C-O Bond Formation via Propargyl Csp3u2013H FunctionalizationAngew. Chem. Int. Ed.2012,51, 10823-10826.

14. Chong Qin, Tao Shen, Conghui Tang, andNing Jiao*, FeCl2-promoted Unactivated C-C Bond Cleavage of Alkylarenes and Polystyrene: Direct Synthesis of Versatile Arylamines,Angew. Chem. Int. Ed.2012,51, 6971-6975(Hot Paper).

15. Shengtao Ding, andNing Jiao*, N,N-Dimethylformamide: A Multipurpose Building Block,Angew. Chem. Int. Ed.2012,51, 9226-9237. (review, invited contribution).

16. Chong Qin, Wang Zhou, Feng Chen, Yang Ou, andNing Jiao*, Iron-catalyzed C-H and C-C Bond Cleavage: A Direct Approach to Amides from Simple Hydrocarbon Molecules,Angew. Chem. Int. Ed.2011,50, 12595-12599.

17. Feng Chen, Chong Qin, Yuxin Cui, andNing Jiao*, Implanting Nitrogen into Hydrocarbon Molecules via C-H/C-C Bonds Cleavage: The Direct Approach to Tetrazoles.Angew. Chem. Int. Ed.2011,50, 11487-11491. (Highlighted bySynfacts(Synfacts,2012,8, 0144.).

18. Chun Zhang, Zejun Xu, Liangren Zhang, andNing Jiao*, Copper-catalyzed Aerobic Oxidative Coupling of Aryl Acetaldehydes with Anilines Leading to α-Ketoamides.Angew. Chem. Int. Ed.2011,50, 11088-11092. (VIP articles, Frontispiece Paper, Highlighted byChemCatChem(ChemCatChem,2012,4, 175-176)

19. Shengtao Ding, andNing Jiao*, The Direct Transformation of DMF (N,N-Dimethylformamide) to -CN: Pd-catalyzed Cyanation of Heteroarenes via C-H Functionalization.J. Am. Chem. Soc.2011,133(32), 12374-12377. (Highlighted byOrg. Process Res. Dev.2011,15, 1216u20131221).

20. Chong Qin, andNing Jiao*, Iron-Facilitated Direct Oxidative C?H Transformation of Allylarenes or Alkenes to Alkenyl Nitriles.J. Am. Chem. Soc.2010,132, 15893-15895. (Most accessed articles, Highlighted bySynfacts(Synfacts,2011,2, 203))

21. Chun Zhang, andNing Jiao*, Cu-catalyzed Aerobic Oxidative Dehydrogenative Coupling of Anilines Leading to Aromatic Azo Compounds using Dioxygen as Oxidant.Angew. Chem. Int. Ed.2010,49, 6174-6177. (Most accessed articles)

22. Zhuangzhi Shi,Bo Zhang, Yuxin Cui, andNing Jiao*, Palladium-Catalyzed Ring-expansion Reaction of Indoles with Alkynes: From Indoles to Tetrahydroquinoline Derivatives Under Mild Conditions.Angew. Chem. Int. Ed.2010,49, 4036-4041. (Frontispiece Paper, Most accessed articles)

23. Chun Zhang, andNing Jiao*, Dioxygen Activation at Ambient Conditions: Cu-catalyzed Oxidative Amidation-Diketonization of Terminal Alkynes Leading to α-Ketoamides.J. Am. Chem. Soc.2010,132, 28-29. (Highlighted byOrg. Chem.)

24. Zhuangzhi Shi,Shengtao Ding, Yuxin Cui, andNing Jiao*, Pd-catalyzed Oxidative Cycloaromatization of Biaryls with Alkynes Using Dioxygen as Oxidant.Angew. Chem. Int. Ed.2009,48, 7895-7898.

25. Wang Zhou, Liangren Zhang, andNing Jiao*, Direct Transformation of Methyl Aromatics to Aryl Nitriles at Room Temperature.Angew. Chem. Int. Ed.2009,48, 7094-7097. (Hot Paper) (Highlighted by “Synform,2009,A71”, “Org. Chem. Highlights” (2010, September 27), and “Nature China ”.

26. Zhuangzhi Shi, Chun Zhang, Si Li, Delin Pan, Sengtao Ding, Yuxin Cui, andNing Jiao*, Indoles from Simple Anilines and Alkynes: Palladium-Catalyzed C-H Activation Using Dioxygen as the Oxidant.Angew. Chem. Int. Ed.2009,48, 4572-4576. (Hot Paper, Highlighted bySynfacts(Synfacts,2009,8, 846)，and“Nature China ”, Most accessed articles).

27. Delin Pan, Anjun Chen, Yijin Su, Wang Zhou, Si Li, Wei Jia, Juan Xiao, Qingjian Liu, Liangren Zhang, andNing Jiao*,Ligand Free Pd-Catalyzed Highly Selective Arylation of Allylic Esters with Retention of the Traditional Leaving Group.Angew. Chem. Int. Ed.2008,47, 4729-4732.