肖智雄
人物簡(jiǎn)介
美國(guó)波士頓大學(xué)醫(yī)學(xué)院教授、四川大學(xué)生命科學(xué)學(xué)院院長(zhǎng)
研究方向
腫瘤分子生物學(xué)，信號(hào)傳遞，細(xì)胞生長(zhǎng)代謝與衰老，轉(zhuǎn)化醫(yī)學(xué)。
研究?jī)?nèi)容
抗腫瘤基因p53 和Rb 及家族成員的功能和調(diào)控
DNA 損傷和細(xì)胞脅迫對(duì)細(xì)胞生長(zhǎng)，調(diào)控，代謝和衰老的調(diào)控及信號(hào)傳導(dǎo)通路
蛋白質(zhì)磷酸化，乙�；�，泛素化及甲基化對(duì)腫瘤發(fā)生重要蛋白的調(diào)控
基因表達(dá)調(diào)控，計(jì)算機(jī)生物模型及其運(yùn)用
抗癌藥物篩選和鑒定以及轉(zhuǎn)化醫(yī)學(xué)應(yīng)用研究
工作經(jīng)歷
簡(jiǎn)歷
四川大學(xué)生物系生物化學(xué)專業(yè)獲理學(xué)學(xué)士學(xué)位(1982年)和理學(xué)碩士學(xué)位（1985年）。四川大學(xué)生物系助教(1985)教育部中美生化和分子生物學(xué)留美項(xiàng)目（CUSBMBEA）選拔獲選，留學(xué)美國(guó)（1986）獲美國(guó)麻省大學(xué)（University of Massachusetts at Amherst）分子生物學(xué)博士學(xué)位（1990）哈佛大學(xué)博士后（1991-1995）美國(guó)波士頓大學(xué)醫(yī)學(xué)院生化系和醫(yī)學(xué)系助理教授（1996），副教授（2001），正教授（2007）。第四軍醫(yī)大學(xué)客座教授（1998-2002）中國(guó)協(xié)和醫(yī)科大學(xué)客座教授(1999-2004)四川大學(xué)客座教授（1998-2004）。
代表性論文
1、Hiroyuki Inuzuka,Alan Tseng,Daming Gao,Bo Zhai,Qing Zhang,Shavali Shaik,Lixin Wan,Xiaolu L. Ang,Caroline Mock,Haoqiang Yin,Jayne M. Stommel,Steven Gygi,Galit Lahav,John Asara,Zhi-Xiong Jim Xiao,William G. Kaelin, Jr.,J. Wade Harper and Wenyi Wei. Phosphorylation by Casein Kinase I Promotesthe Turnover of the Mdm2 Oncoprotein via the SCFb-TRCP Ubiquitin Ligase. Cancer Cell,in press.
2、Du, W., Wu, J., Walsh, EM., Zhang, Y., Chen, CY., and Xiao ZX, Nutlin-3aaffects expression and function of retinoblastoma protein: a role of retinoblastoma protein in cellular response to nutlin-3a. J. Biol. Chem. 284: 26315-26321, 2009.
3、Qiu, W., Wu, J., Walsh, W. M., Zhang, Y., Chang, C-Y., Fujita, J., and Xiao ZX.Retinoblastoma protein modulates gankyri-MDM2 inregulation of p53 stability and chemosensitivity in cancer cells. Oncogene27:4034-4043, 2008.
4、Jin Y, Zeng SX, Sun XX, Lee H, Blattner C, Xiao Z,Lu H.MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with MDM2. Mol. Cell. Biol. 28:1218-1229, 2008.
5、Chang, DLF., Qiu, W.. Ying, H., Zhang, Y., Chen, CY., and Xiao ZX.ARF promotes accumulation of retinoblastoma protein through inhibition of MDM2.Oncogene26: 4627-4634, 2007.
6、Ying, H. and Xiao, ZX.Targeting retinoblastoma protein for degradation by proteasomes. Cell Cycle5:506-508, 2006.Ying,H., Chang,DL., Zheng, H.,McKeon, F., and Xiao, Z.X.The DNA-binding and transactivation activities are essential for TAp63 protein degradation. Mol. Cell. Biol.25:6154-6164, 2005.
7、Sdek, P., Ying, H., Chang,DL., Qiu, W.,Zheng, H.,Allday, MJ and Xiao, Z.X.-independent degradation of retinoblastoma protein. Mol. Cell20:699-708, 2005.
8、Sdek, P., Ying, H., Zheng, H., Margulis, A., Tang, X., Tian, K. and Xiao. Z.X.The central acidic domain of MDM2 is critical in inhibition of retinoblastoma -mediated suppression of E2Fand cell growth. J. Biol. Chem. 279: 53317-22. 2004
9、Murray, S.A., Zheng, H., Gu, L. and Xiao, Z.X. IGF-1 activates p21 to inhibit UV-induced cell death. Oncogene22: 1703-1711, 2003.
10、Zheng, H., You, H., Zhou, X. Z., Murray, S.A., Uchida, T., Wulf, G., Gu, L., Tang, X., Lu, K.P. and Xiao, Z.X.The Prolyl isomerase Pin1 is a novel regulator of p53 ingenotoxic response. Nature419: 849-853 (with News and Views 419:795-797), 2002.
11、Xiao, Z.X.,Chen, J., Levine, A. J., Modjtahedi, N., Xing, J., Sellers, W. R. and Livingston, D. M.Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature, 375, 694-698, 1995.
12、Xiao, Z.X.Ginsberg, D., Ewen, M. and Livingston, D. M.Regulation of the Grossman, S.R., Perez, M., Joseph, M., Mansur, C.,Xiao, Z.X., Kumar, S., Howley, P.M. and Livingston, D.M.p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol. Cell2: 405-415, 1998.
13、Xiao, Z.X.Ginsberg, D., Ewen, M. and Livingston, D. M.Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. Proc. Natl. Acad. Sci. USA. 93, 4633-4637, 1996.
