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  • 帥心濤

    帥心濤

    帥心濤,化學(xué)與化工學(xué)院教授,中山醫(yī)學(xué)院雙聘教授,中山醫(yī)學(xué)院生物醫(yī)學(xué)工程中心負(fù)責(zé)人,光電及功能復(fù)合材料研究院“納米生物技術(shù)”平臺(tái)PI。以納米醫(yī)學(xué)技術(shù)為平臺(tái)的腫瘤診斷及治療研究,主要涉及腫瘤顯像納米探針、抗癌藥物和核酸(例如:基因及RNAi等)的高效靶向傳輸?shù)取?

    工作經(jīng)歷

    2005年6月開(kāi)始:中山大學(xué)化學(xué)與化工學(xué)院高分子所教授。

    2003年6月-2005年5月:美國(guó)凱斯西儲(chǔ)大學(xué)研究員(研究助教授級(jí))。

    2002年1月-2003年5月:德國(guó)馬爾堡大學(xué)洪堡學(xué)者。

    2001年1月-2001年12月:美國(guó)北卡州立大學(xué)訪問(wèn)學(xué)者。

    2000年10月-2000年12月:中國(guó)科學(xué)院工程塑料國(guó)家工程研究中心,任研究三室主任。

    帥心濤

    1998年2月-2000年9月:中國(guó)科學(xué)院化學(xué)研究所,任副研究員及研究組長(zhǎng)。其間赴日本名古屋大學(xué)及東京工業(yè)大學(xué)做訪問(wèn)研究一年。

    1996年10月-1997年12月:波蘭科學(xué)院聚合物化學(xué)研究所博士后。

    教育背景

    1993年3月-1996年10月:北京理工大學(xué)化工與材料學(xué)院學(xué)習(xí),獲博士學(xué)位。

    1986年9月-1993年2月:北京理工大學(xué)化工與材料學(xué)院學(xué)習(xí),獲學(xué)士及碩士學(xué)位。

    學(xué)術(shù)積累

    一直從事新型生物降解及生物相容聚合物的合成及應(yīng)用研究,近年來(lái)主要從事聚合物納米醫(yī)用材料的研究,在抗癌藥物和核酸的傳輸以及腫瘤顯像等方面取得一系列研究成果。

    在包括《Macromolecules》、《Bioconjugate Chem.》、《Biomacromolecules》、《Chem. Mater.》、《Angew. Chem.》、《Chem. Commun.》、《Adv. Mater.》、《J. Controlled Release》、《Biomaterials》、《J. Biomed. Mater. Res.》等學(xué)術(shù)刊物上發(fā)表論文40多篇(其中,SCI收錄論文35篇),被國(guó)內(nèi)外同行在SCI刊物上引用100多篇次(扣除自引)。

    現(xiàn)為J. Controlled Release等7個(gè)國(guó)際學(xué)術(shù)期刊的審稿人。與歐、美、日等國(guó)家高水平研究室建立了穩(wěn)固的學(xué)術(shù)聯(lián)系,為開(kāi)展高水平的國(guó)際合作奠定了堅(jiān)實(shí)的基礎(chǔ)。

    近5年來(lái),作為負(fù)責(zé)人承擔(dān)2項(xiàng)納米醫(yī)學(xué)研究領(lǐng)域的國(guó)家自然科學(xué)基金項(xiàng)目。目前除了一項(xiàng)國(guó)家自然科學(xué)基金項(xiàng)目在研外,還承擔(dān)一項(xiàng)中山大學(xué)高層次引進(jìn)人才基金項(xiàng)目。

    近5年來(lái)主要論著

    近5年來(lái)主要論著(SCI影響因子4以上的論文):

    1.D. Cheng,G. Hong,W. Wang,R. Yuan,H. Ai,J. Shen*,B. Liang,J. Gao,X. Shuai*,“Nonclustered magnetite nanoparticle encapsulated biodegradable polymeric micelles with enhanced properties for in vivo tumor imaging”,J. Mater. Chem.,DOI:10.1039/C0JM03783D.(IF=4.795)

    2.N. Cao,D. Cheng,S. Zou,H. Ai,J. Gao,X. Shuai*,“The synergistic effect of hierarchical assemblies of siRNA and chemotherapeutic drugs co-delivered into hepatic cancer cells”,Biomaterials,Doi:10.1016/j.biomaterials.2010.11.061.(IF=7.365)

    3. J. Dai,S. Zou,Y. Pei,D. Cheng,H. Ai,X. Shuai*,“Polyethylenimine-grafted Copolymer of Poly(L-lysine) and Poly(ethylene glycol) for Gene Delivery”,Biomaterials,Doi:10.1016/j.biomaterials.2010.10.044.(IF=7.365)

    4. G. Liu,Z. Wang,J. Lu,C. Xia,F. Gao,Q. Gong,B. Song,X. Zhao,X. Shuai,X. Chen,H. Ai,Z. Gu,“Low molecular weight alkyl-polycation wrapped magnetite nanoparticle clusters as MRI probes for stem cell labeling and in vivo imaging”,Biomaterials,2011,2,528-537. (IF=7.365)

    5. W. Zhang,Y. Li,L. Liu*,Q. Sun,X. Shuai*,W. Zhu,Y Chen*,“Amphiphilic Toothbrushlike Copolymers Based on Poly(ethylene glycol) and Poly(ε-caprolactone) as Drug Carriers with Enhanced Properties”,Biomacromolecules,2010,111331-1338.(IF=4.502)

    6. B. Liang,M. He,C. Chan,Y. Chen,X. Li,Y. Li,D. Zheng,M. Lin,H. Kung,X. Shuai*,Ying Peng*,“The Use of Folate-PEG-grafted-hybranched-PEI Nonviral Vector for the Inhibition of Glioma Growth In The Rat”,Biomaterials 2009,30,4014-4020.(IF=7.365)

    7. J. Lu,S. Ma,J. Sun,C. Xia,C. Liu,Z. Wang,X. Zhao,F. Gao,Q. Gong,B. Song,X. Shuai,Hua Ai,Zhongwei Gu,“Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging”,Biomaterials 2009,30,2919-2928.(IF=7.365)

    8. G. Chen*,W. Chen,Z. Wu,R. Yuan,Hua Li,J. Gao,X. Shuai*,“MRI-visible polymeric vector bearing CD3 single chain antibody for gene delivery to T cells for immunosuppression”,Biomaterials 2009,30,1962-1970.(IF=7.365)

    9. H. Ai,C. Flask,B. Weinberg,X. Shuai,M. D. Pagel,D. Farrell,J. Duerk,J. Gao,“Magnetite-loaded polymeric micelles as novel magnetic resonance probe”,Adv. Mater. 2005,17,1949-1952.(IF=8.379)

    10. S. Mao,X. Shuai,F. Unger,and T. Kissel,“Synthesis and characterization of water-soluble poly (ethylene glycol)-graft-trimethyl chitosan block copolymers and their application as insulin delivery carriers”,Biomaterials 2005,26,6343-6356.(IF=7.365)

    11. X. Shuai,T. Merdan,F. Unger,T. Kissel,“Biodegradable Supra-molecular Vehicle Showing Combined Good Biocompatibility and High Gene Transfection Efficiency”,Bioconjugate Chem. 2005,16,322-329.(IF=4.35)

    12. N. Nasongklau2020,X. Shuaiu2020,H. Ai,J. Gao,“cRGD-functionalized micelle (cRGD-PEG-PCL) for targeted doxorubicin delivery to tumor neovasculature”,Angew. Chem. Int. Edi. 2004,43,6323-6327.(共同第1,IF=11.829)

    13. Y. Zhao,X. Shuai,C. Chen,F. Xi,“Synthesis of star block copolymers from dendrimer initiators by combing ring-opening polymerization and atom transfer radical polymerization”,Macromolecules 2004,37,8854-8862.(IF=4.539)

    14. X. Shuai,H. Ai,N. Nasongkla,S. Kim,and J. Gao,“Micellar Carriers Based on Block Copolymers of Poly(e-caprolactone) and Poly(ethylene glycol) for Doxorubicin Delivery”,J. Controlled Release 2004,98,415-426.(IF=5.949)

    15. X. Shuai,T. Merdan,and T. Kissel,“Core-crosslinked Polymeric Micelles as Paclitaxel carriers”,Bioconjugate Chem. 2004,15,441-448.(IF=4.35)

    16. Y. Zhao,X. Shuai,C. Chen,F. Xi,“Synthesis of novel dendrimer-like star block copolymers with definite number of arms by combination of ROP and ATRP”,Chem. Commun. 2004,14,1608-1609.(IF=5.504)

    17. X. Shuai,T. Merdan,F. Unger,W. Matthias,and T. Kissel,“Novel Biodegradable Ternary Copolymers -PEI-g-PCL-b-PEG: Synthesis,Characterization and Potential as Efficient Non-viral Gene Delivery Vectors”,Macromolecules 2003,36,5751-5759.(IF=4.539)

    18. Y. Zhao,X. Shuai,C. Chen,F. Xi,“Synthesis and Characterization of Star-Shaped Poly(L-lactide)s Initiated with Hydroxyl-Terminated Poly(Amidoamine) (PAMAM-OH) Dendrimers”,Chem. Mater. 2003,15,2836-2843.(IF=5.368)

    19. M. Wei,X. Shuai, A. E. Tonelli,“Melting and Crystallizatioin Behavior of Biodegradable Polymers Enzymatically Coalesced from Their Cyclodextrin Inclusion Complexes”,Biomacromolecules 2003,4,783-792.(IF=4.502)

    20. X. Shuai,F. Porbeni,M. Wei,T. Bullions,A. E. Tonelli,“Stereo-selectivity in the Formation of Inclusion Complexes of Poly(3-hydroxybutyrate)s with Cyclodextrins”,Macromolecules 2002,35,3778-3780.(IF=4.539)

    21. Y. Na,Y. He,X. Shuai,Y. Kikkawa,Y. Doi,and Y. Inoue,“Compatibilization Effect of Poly(e-caprolactone)--Poly(ethylene glycol) Block Copolymers and Phase Morphology Analysis in Immiscible Poly(lactide)/ Poly(e-caprolactone) Blends”,Biomacromolecules 2002,3,1179-1186.(IF=4.502)

    22. X. Shuai,F. Porbeni,M. Wei,T. Bullions,A. E. Tonelli,“Formation of Inclusion Complexes of Poly(3-hydroxybutyrate)s with Cyclodextrins 1: Immobilization of Atactic Poly(R,S-3-hydroxybutyrate) and Miscibility Enhancement between Poly(R,S-3-hydroxy butyrate) and Poly(e-caprolactone)”,Macromolecules 2002,35,3126-3132.(IF=4.539)

    23. X. Shuai,F. Porbeni,M. Wei,T. Bullions,A. E. Tonelli,“Inclusion Complex Formation between α,γ-Cyclodextrins and a Triblock Copolymer and the Cyclodextrin Type-Dependent Microphase Structures of their Coalesced Samples”,Macromolecules 2002,35,2401-2405. (IF=4.539)

    24. X. Shuai,M. Wei,F. Porbeni,A. E. Tonelli,“Formation of and coalescence from the inclusion complex of a biodegradable block copolymer and a-cyclodextrin2: A novel means to modify the biodegradation behavor of biodegradable block copolymers”,Biomacromolecules 2002,3,201-207.(IF=4.502)

    25. X. Shuai,F. Porbeni,M. Wei,I. Shin & A. E. Tonelli,“Formation of and coalescence from the inclusion complex of a biodegradable block copolymer and a-cyclodextrin: A novel means to modify the phase structure of biodegradable block copolymers”,Macromolecules 2001,34,7355-7361.(IF=4.539)

    26. Y. He,J. Li,X. Shuai,Y. Inoue,“Reversible thinning/thickening phenomenon of polymer blends in aqueous media”,Macromolecules 2001,34,8166-8172.(IF=4.539)

    27. Y. He,X. Shuai,A. Cao,K. Kasuya,Y. Doi,Y. Inoue,“Enzymatic biodegradation of synthetic atactic P(R,S-hydroxybutyrate) induced by amorphous polymer and the enzymatic degradation temperature window of amorphous systems”,Biomacromolecules 2001,2,1045-1051.(IF=4.502)

    28. Y. He,He,X. Shuai,A. Cao,K. Kasuya,Y. Doi,Y. Inoue,"Enzymatic biodegradation of chemosynthetic atactic P(3HB) enhanced by an amorphous non-biodegradable polymer: blend of atactic P(3HB) with PMMA",Macromol. Rapid Comm., 2000,21: 1277-1281.(IF= 4.146)

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