學(xué)科專業(yè)：病原生物學(xué)

研究方向：病原生物感染引起的機體天然免疫調(diào)控機制的研究

學(xué)習(xí)經(jīng)歷：

1996.09-2000.07 生物化學(xué) 本科 華中師范大學(xué)

2000.09-2003.07 微生物學(xué) 碩士 華中師范大學(xué)

2003.09-2006.07 病原生物學(xué) 博士 中國疾病預(yù)防控制中心病毒病預(yù)防控制所

工作經(jīng)歷：

2007.05-2011.12病原生物學(xué) 博士后 Creighton University School of Medicine，USA

2012.1-2012.05病原生物學(xué) 研究助理教授 Creighton University School of Medicine，USA

2013.02-至今 教授 武漢大學(xué)基礎(chǔ)醫(yī)學(xué)院

目前主要科學(xué)研究領(lǐng)域和興趣

近年來主要從事病原生物感染引起的機體天然免疫調(diào)控機制的研究，側(cè)重于非編碼RNA在這一過程中起的作用。目前主持國家自然科學(xué)基金2項、教育部博士點基金1項及武漢大學(xué)人才項目1項。在SCI刊物及國內(nèi)核心期刊上發(fā)表學(xué)術(shù)論文二十余篇。

教學(xué)情況

2013年至今在武漢大學(xué)基礎(chǔ)醫(yī)學(xué)院寄生蟲教研室從事教學(xué)科研工作。

近5年代表性論文

1). Zhou R, FengY, Chen XM. Non-coding RNAs in epithelial immunity to Cryptosporidium infection. (2014) Parasitology. 141(10):1233-43.

2). Zhou R, Gong AY, Chen D, Miller RE, Eischeid AN, Chen XM. Histone deacetylases and NF-?B signaling coordinate expression of CX3CL1 in epithelial cells in response to microbial challenge by suppressing miR-424 and miR-503. (2013) PLoS One. 8(5):e65153.

3). Zhou R, Gong AY, Eischeid AN, Chen XM. miR-27b regulates RNA stability to coordinate TLR4/NF-kappaB-mediated epithelial anti-C. parvum defense by targeting KSRP. (2012) ?PLoS Pathogen. 8: e1002702.

4). Zhao J, Gong AY, Zhou R, Liu J, Eischeid A, and Chen XM. Downregulation of PCAF by miR-181s provides feedback regulation to TNF-α-induced transactivation of pro-inflammatory genes in gastrointestinal epithelial cells. (2012) J Immunol. 188(33): 1266-1274.

5). Zhou R, Li X, Hu G, Gong AY, Drescher KM, Chen XM. miR-16 Targets Transcriptional Corepressor SMRT and Modulates NF-kappaB-Regulated Transactivation of Interleukin-8 Gene. (2012) PLoS One. 7(1): e30772.

6). Zhou R, Ou2019Hara SP, Chen XM. MicroRNA regulation of innate immune responses in epithelial cells. (2011) Cell Mol Immunol. 8 (5):371-9.

7). Hu G, Zhou R, Liu J, Gong AY, and Chen XM. MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling-4 in biliary epithelial cells in response to Cryptosporidium parvum infection. (2010) J Infect Dis. 202(1): 125-135.

8). Zhou R, Hu G, Gong AY, and Chen XM. Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells. (2010) Nucleic Acids Research. 38(10): 3222-32.

9). Li X, Liu J, Zhou R, Huang S, Huang S, Chen XM. Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation. （2010）Br J Haematol. 148(1): 69-79.

10). Gong AY, Zhou R, Hu G, Liu J, Sosnowska D, Drescher KM, Dong H, Chen XM. Cryptosporidium parvum induces B7-H1 expression in cholangiocytes by down-regulating microRNA-513. (2010) J Infect Dis. 201(1): 160-169.

11). Zhou R, Hu G, Liu J, Gong AY, Drescher KM, and Chen XM. NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses. (2009) PLoS Pathog. 5(12): e1000681.

12). Hu G, Zhou R, Liu J, Gong AY, Eischeid AN, Dittman JW, and Chen XM. MicroRNA-98 and let-7 confer cholangiocyte expression of cytokine-inducible Src homology 2-containing protein in response to microbial challenge.（2009）J Immunol. 183(3): 1617-1624.

13). Gong AY, Zhou R, Hu G, Li X, Splinter PL, Ou2019Hara SP, LaRusso NF, Soukup GA, Dong H, and Chen XM. MicroRNA-513 regulates B7-H1 translation and is involved in IFN-gamma-induced B7-H1 expression in cholangiocytes.（2009）J Immunol. 182: 1325-33.