1998-2005年分別以博士后、研究科學(xué)家、研究助理教授在美國托馬斯杰弗遜大學(xué)、伊利諾大學(xué)、伯翰姆研究所學(xué)習(xí)和工作，期間設(shè)計(jì)出第一個(gè)Bcl-2小分子抑制劑-HA14-1，該抑制劑發(fā)表于PNAS并獲一項(xiàng)美國專利。2005年入選中國科學(xué)院百人計(jì)劃，受聘于上海藥物研究所，任研究員、課題組長。

采用生物化學(xué)、結(jié)構(gòu)生物學(xué)方法，研究與癌癥、神經(jīng)退行性疾病相關(guān)蛋白質(zhì)的結(jié)構(gòu)與功能。

以這些蛋白質(zhì)為靶標(biāo)，設(shè)計(jì)全新化學(xué)結(jié)構(gòu)的抑制劑或激動(dòng)劑，為藥物研發(fā)提供新的先導(dǎo)化合物。

發(fā)展蛋白質(zhì)結(jié)構(gòu)功能研究、藥物分子設(shè)計(jì)的新方法和新技術(shù)。

研究員；百人計(jì)劃

中科院上海藥物所研究員、博士生導(dǎo)師、課題組長

Zhou Y, Jiang C, Zhang Y, Liang Z, Liu W, Wang L, Luo C, Zhong T, Sun Y, Zhao L, Xie X, Jiang H, Zhou N, Liu D*, Liu H*. Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives as -Amyloid Peptide Aggregation Inhibitors. Journal of Medicinal Chemistry.

Feng Y, Ding X, Chen T, Chen L, Liu F, Jia X, Luo X, Shen X, Chen K, Jiang H, Wang H*, Liu H*, Liu D*. Design, Synthesis and Interaction Study of Quinazoline-2(1H)-Thione Derivatives as Novel Potential Bcl-xL Inhibitors. Journal of Medicinal Chemistry

Jiang C, Feng Y, Huang X, Xu Y, Zhang Y, Zhou N, Shen X, Chen K, Jiang H*, Liu D*. An enzyme-linked immunosorbent assay to compare the affinity of chemical compounds for -amyloid peptide as a monomer. Analytical and Bioanalytical Chemistry

Chen L, Feng Y, Zhou Y, Zhu W, Shen X, Chen K, Jiang H, Liu D*. Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1. Journal of Inorganic Biochemistry

Feng Y, Liu D*, Shen X, Chen K, Jiang H. Structure assembly of Bcl-xL through α5-α5 and α6-α6 interhelix interactions in lipid membranes. Biochimica et Biophysica Acta-Biomembranes

Feng Y, Wu J, Chen L, Luo C, Shen X, Chen K, Jiang H, Liu D*. A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide. Analytical Biochemistry

Feng Y, Zhang L, Hu T, Shen X, Ding J, Chen K, Jiang H, Liu D*. A conserved hydrophobic core at Bcl-xL mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein. Archives of Biochemistry and Biophysics

Feng Y, Shen X, Chen K, Jiang H, Liu D*. A new assay based on fluorescence resonance energy transfer to determine the binding affinity of Bcl-xL inhibitors. Bioscience Biotechnology and Biochemistry

Feng Y, Lin Z, Shen X, Chen K, Jiang H, Liu D*. Bcl-xL forms two distinct homodimers at non-ionic detergents: implications in the dimerization of Bcl-2 family proteins. Journal of Biochemistry.

Li Y*, Liu D*, Cao R, Kumar S, Dong C, An J, Wilson SR, Gao YG, Huang Z. Crystal structure of chemically synthesized vMIP-II. Proteins: Structure, Function, and Bioinformatics

Liu D, Madani N, Li Y, Cao R, Choi WT, Kawatkar SP, Lim MY, Kumar S, Dong CZ, Wang J, Russell JD, Lefebure CR, An J, Wilson S, Gao YG, Pallansch LA, Sodroski JG, Huang Z. Crystal structure and structural mechanism of a novel anti-human immunodeficiency virus and D-amino acid-containing chemokine. Journal of Virology

Liu D*, Xu Y, Feng Y, Liu H, Shen X, Chen K, Ma J, Jiang H*. Inhibitor discovery targeting the intermediate structure of β-amyloid peptide on the conformational transition pathway: implications in the aggregation mechanism of β-amyloid peptide. Biochemistry

Mori M*, Liu D*, Kumar S, Huang Z. NMR structures of anti-HIV D-peptides derived from the N-terminus of viral chemokine vMIP-II. Biochemical And Biophysical Research Communications

Liu D*, Yang B*, Cao R, Huang Z. A chemical strategy to promote helical peptide-protein interactions involved in apoptosis. Bioorganic & Medicinal Chemistry Letters

Yang B*, Liu D*, Huang Z. Identification of Affinity-Enhancing Motifs on Pro-apoptosis peptides derived from the BH3 domain of Bcl-2 family proteins. Bioorganic & Medicinal Chemistry Letters

Liu D*, Huang Z. Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis. Apoptosis

Wang JL*, Liu D*, Zhang ZJ, Shan S, Han X, Srinivasula SM, Croce CM, Alnemri ES, Huang Z. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proceedings of The National Academy of Sciences of The United States of America