2006.9-至今 嘉興學(xué)院醫(yī)學(xué)院 院長(zhǎng)

2005.8-2006.8揚(yáng)州市第一人民醫(yī)院心內(nèi)科副主任、中心實(shí)驗(yàn)室業(yè)務(wù)指導(dǎo)主任、科教處副主任。

1980.9－1983.3大連醫(yī)學(xué)院心血管系碩士研究生畢業(yè)，1983.4－1987.10在天津市胸科醫(yī)院/心血管研究所心內(nèi)科從事臨床工作

1987.11－1989.12英國(guó)倫敦Brompton皇家國(guó)家心肺醫(yī)院心臟科研究員

1990.1－1994.1英國(guó)倫敦大學(xué)Charing Cross & Westminster 醫(yī)學(xué)院及Westminster 醫(yī)院心臟科研究員

1994.2－1996.12美國(guó)辛辛那提大學(xué)醫(yī)學(xué)院心臟科博士后研究員

1997.1－1998.7美國(guó)辛辛那提大學(xué)醫(yī)學(xué)院心臟科高級(jí)研究員

1998.8－2005年英國(guó)倫敦大學(xué) University College醫(yī)學(xué)院心臟科/生理系高級(jí)研究員、愛(ài)爾蘭皇家圣三一學(xué)院藥理系心血管研究室/St Jameu2019s醫(yī)院心臟科高級(jí)研究員。在國(guó)外工作期間，曾經(jīng)于1999-2001年協(xié)助天津胸科醫(yī)院/心血管病研究所陳樹(shù)勛教授建立天津市分子心臟病學(xué)研究中心，設(shè)計(jì)了探查MMP在心肌梗塞后心室重構(gòu)中的分子機(jī)制等項(xiàng)目。

2002－2005年兼職任中國(guó)山東省立醫(yī)院中心實(shí)驗(yàn)室主任、內(nèi)科副主任、心血管中心副主任，院長(zhǎng)特別助理，為該院建立了分子心臟病學(xué)研究室，設(shè)計(jì)開(kāi)展了在細(xì)胞和分子水平研究病毒性心肌炎的科研和臨床項(xiàng)目。

2003－至今擔(dān)任中國(guó)人民解放軍總醫(yī)院、軍醫(yī)進(jìn)修學(xué)院基礎(chǔ)醫(yī)學(xué)研究所分子生物學(xué)室客座研究員，合作開(kāi)展了小分子熱休克蛋白HSP20基因在心臟病患者中的突變分布及其意義等項(xiàng)目。在國(guó)際國(guó)內(nèi)學(xué)術(shù)期刊發(fā)表論文40余篇，其中收錄SCI期刊12篇。主編《臨床分子心臟病學(xué)現(xiàn)代心臟病學(xué)的新領(lǐng)域》一書(shū)。

1958.9-1964.8 天津市塘沽區(qū)明星路小學(xué) 學(xué)生

1973.9-1977.2 吉林醫(yī)學(xué)院醫(yī)療系 學(xué)生

1980.9-1983.3 大連醫(yī)學(xué)院心血管系 碩士研究生

1990.1-1994.1 英國(guó)倫敦大學(xué)Charing Cross & Westminster 醫(yī)學(xué)院心血管專(zhuān)業(yè) 博士研究生工作經(jīng)歷

1977.3-1980.8 天津市塘沽醫(yī)院內(nèi)科 住院醫(yī)師

1983.4-1987.10 天津市胸科醫(yī)院心內(nèi)科 住院醫(yī)師、總住院醫(yī)師、主治醫(yī)師

1987.11-1989.12 英國(guó)倫敦Brompton醫(yī)院心臟科 研究員

1990.1-1994.1 英國(guó)倫敦大學(xué)Charing Cross & Westminster 醫(yī)學(xué)院心臟科 研究員

1994.2-1997.2 美國(guó)Cincinnati大學(xué)醫(yī)學(xué)院心臟科 博士后研究員

1997.2-1998.7 高級(jí)研究員

1998.8-2003.8 英國(guó)倫敦大學(xué) University College醫(yī)學(xué)院內(nèi)科/生理系 高級(jí)研究員

2003.9-2005.7 愛(ài)爾蘭Dublin大學(xué)TrnityCollege /St Jameu2019s醫(yī)院心臟科 高級(jí)研究員

2005.8-2006.8 揚(yáng)州大學(xué)第二臨床醫(yī)學(xué)院心內(nèi)科 副主任、中心實(shí)驗(yàn)室主任、博士生導(dǎo)師

2006.9-至今 嘉興學(xué)院醫(yī)學(xué)院 院長(zhǎng)

1. 心血管病臨床診斷與治療

2. 心血管病基礎(chǔ)研究

3. 醫(yī)學(xué)心理學(xué)和臨床心理學(xué)的應(yīng)用和教育

專(zhuān)業(yè)學(xué)會(huì)會(huì)員

1. 中華醫(yī)學(xué)會(huì) （1985）

2. 英國(guó)皇家醫(yī)學(xué)會(huì) （1988）

3. 美國(guó)心臟協(xié)會(huì) （1995）

4. 國(guó)際心臟研究學(xué)會(huì) （1995）

1. Continuous observing ECG PTFv1 to determine left ventricular function of patients with AMI. （心電圖PTFv1動(dòng)態(tài)觀察判斷急性心肌梗塞患者左室功能的價(jià)值） 陳樹(shù)勛, 宋國(guó)杰, 梁爽霖 天津醫(yī)藥 1986;15:29

2. An echocardiographic study in AMI patients and an attempt to predict pump failure by ECHO indices （超聲心動(dòng)圖預(yù)判急性心肌梗塞患者泵衰竭） 陳樹(shù)勛, 宋國(guó)杰 中華心血管病雜志 1987;15:316

3. Using ECG Q-Tc and R wave changes to diagnose coronary artery disease （使用心電圖校正Q-T間期和R波改變?cè)\斷冠心�。� 陳樹(shù)勛，宋國(guó)杰 中華心血管病雜志 1988;16:27）

4. Left ventricular dysfunction and obstructive lung disease: an echocardiographic and angiographic study of cor pulmonale patients with decreased mitral E-F slope

Song G and Oldershaw P J International Journal of Cardiology 1989;25:47

5. Atria-ventricular interaction and the origins of "a" wave in left ventricular disease. Jones CJH, Song G ,Gibson DG British Heart Journal 1991;65（1）:31

6. Myocardial ischemia in identical twins discordant for type one diabetes. Dubrey S, Song G , Akhras F, Hardman T, Noble MIM and Leslie RDG European Heart Journal　 1991; （12） Supplemen:223

7. Haemodynamic and neurohumoral response in heart failure produced by rapid ventricular pacing. Travill C M, Williams T D, Pate P, Song G , Chalmers J, Lightman SL, Sutton R, Noble M I M. Cardiovascular Research 1992;26（8）:783

8. Does insulin dependent diabetes （IDDM） cause myocardial ischemia: a study of 70 identical twins IDDM. Dubrey S, Akhras F, Song G , Noble M I M , et al. Clinical Science 1992;82:（3）4

9. The effects of renal denervation on the renal and humoral response to fluid load. Song G, Belcher P, Travill C M, Noble M I M , et al. European Heart Journal 1993; （14） Supplemen:1639

10. Heart failure induced by rapid ventricular pacing enhanced renin gene expression. Song G, Gao Y, Belcher P, Noble M I M, et al. European Heart Journal 1993; （14） Supplemen:413

11. Myocardial renin gene expression in heart failure induced by rapid ventricular pacing in association with renal denervation. GJ Song, Y Gao K. Kanayama, PR Belcher, S. Dubrey, M. I. M. Noble. European Heart Journal 1994; （15） Supplemen:199

12. Myocardial neuropeptide Y gene expression in heart failure induced by rapid ventricular pacing. GJ Song, Y Gao, D. Larhammar, PR Belcher, S. Dubrey, M. I. M. Noble. European Heart Journal 1994; （15） Supplemen:199

13. Exercise electrocardiography and aortic Doppler velocimetry in asymptomatic identical twins discordant for type I （insulin dependent） diabetes. Dubrey S, Akhars F, Guojie Song , Hardman T, Travill C, Hynd J, Noble MI, Lo SS, Leslie RD. British Heart Journal 1994;71（4）:341

14. Depressed intracellular Ca2+ homeostasis and mechanical properties of cardiomyocytes in annexin VI transgenic mouse. Guojie Song , Ann-Marie E. Gunteski-Hamblin, Gerald W. Dorn II, Darryl L. Kirkpatrick, John R. Dedman, Richard A. Walsh. Journal of the American College of Cardiology Special Issue: 1995; 277A

15. Abnormal Na+/Ca2+ Exchanger Activity in Annexin VI Overexpression Transgenic Mice. Guojie Song , Gerald W. Dorn II, Ann-Marie E. Gunteski-Hamblin, Darryl L. Kirkpatrick, John R. Dedman, Richard A. Walsh. Journal of Molecular and Cellular Cardiology 1995; 27（6）: A133

16. Unchanged intracellular Ca2+ levels and depressed mechanical properties of cardiomyocytes in myosin light chain transgenic mice. Guojie Song , Darryl L. Kirkpatrick, Gerald W. Dorn II, Joe Palermo, Jeffrey Robbins, Richard A. Walsh. Circulation 1995;92（8）:I-321

17. Abnormal Na+/Ca2+ Exchanger Activity in Transgenic Mice with Cardiac Specific Overexpression of Annexin VI. Guojie Song , Darryl L. Kirkpatrick, Ann-Marie E. Gunteski-Hamblin, Gerald W. Dorn II, John R. Dedman, Richard A. Walsh. Circulation 1995;92 （8）:I-697

18. Annexin VI overexpression in transgenic mouse heart alters cardiac myocyte contractile function, calcium dynamics and heart pathology. Gunteski-Hamblin AE, Guojie Song , Walsh RA, Frenzke M, Dorn II GW, Kaetzel MA, Horseman ND, Dedman JR. Am J Physiol Physiol 1996;270 （3 Pt 2）:H1091-100

19. Decreased Ca2+ sensitivity: a reason for depressed mechanical properties of cardiomyocytes from myosin light chain overexpression transgenic mice. Guojie Song , Darryl L. Kirkpatrick, Gerald W. Dorn II, Jeffrey Robbins, Richard A. Walsh. Journal of the American College of Cardiology 1996;27 （2, Supplement）: 277A

20. Altered protein levels of cardiac annexins in human end-stage congestive heart failure. Guojie Song , Corinn M. Pawloski-Dahm, Darryl L. Kirkpatrick, Richard A. Walsh. Circulation 1996;94 （8）:I-725

21. Natriuresis caused by blood volume expansion in dogs is not mediated by the renal nerves. Drake-Holland AJ, Song G, Belcher PR, Noble MI Experiment Physiology 1996;81 （2）:285

22. Down-regulated annexin VI mRNA and protein levels in guinea pigs with aortiac banding-induced heart failure. Guojie Song , Nancy Ball, John R. Dedman and Richard A. Walsh. European Heart Journal 1997; 18 （Suppl）:512

23. Transcripational regulation of cardiac annexins in human end-stage congestive heart failure. Guojie Song , Begonia Campos, Lynne E. Wagoner, John R. Dedman, Richard A. Walsh. Circulation 1997;96（8）:I-138

24. Altered cardiac annexin mRNA and protein levels in the left ventricle of patients with end-stage heart failure. Guojie Song , Begonia Campos, Lynne E. Wagoner, John R. Dedman, Richard A. Walsh. Journal of Molecular & Cellular Cardiology, 1998;30:443

25. Effects of total replacement of atrial myosin light chain-2 with the ventricular isoform in atrial myocytes of transgenic mice Pawloski-Dahm CM, Song G, Kirkpatrick DL, Palermo J, Gulick J, Dorn GW 2nd, Robbins J, Walsh RA. Circulation 1998; 97（15）:150827.

26. Protein Kinase C-b2 expression and activity in non-failed and failed human hearts Nancy Bowling, Guojie Song , Richard A. Walsh, George L. King, George E Sandusky, Chris J. Vlahos. Circulation 1999;99（3）:384

27. PKC translocation without changes in Gq and PLC-b protein abundance in cardiac hypertrophy and failure Jalili T, Song G , Takeishi Y, Ball NA, Howles G, Walsh RA Am J Physiol 1999 Dec;277（6 Pt 2）:H2298

28. Altered mechanical properties and intracellular calcium homeostasis in cardiomy-

ocytes from mice with targeted disruption of the annexin VI Gene. Guojie Song , Sian Harding, Michael Duchen, Peter Ou2019Gara, Tim Hawkins, Stephen Moss Circulation 1999;100（18）:I762

29. Changes in Ca2+ cycling proteins underlie cardiac action potential prolongation in a pressure-overloaded guinea pig model with cardiac hypertrophy and failure. Ahmmed GU, Dong PH, Song G, Ball NA, Xu Y, Walsh RA, Chiamvimonvat N Circulation Research 2000 Mar 17;86（5）:558-570

30. Increased cardiac expression of the Na+/Ca2+ exchanger may be responsible for altered myocyte intracellular Ca2+ cycling in mice with targeted disruption of the annexin-6 gene. Guojie Song , Richard E. Tunwell, Timothy E. Hawkins, Stephen E. Moss Circulation 2000;102（18）: II141

31. Targeted Disruption of the Annexin 6 GeneImproves Resistanceto Hypoxia Injury in the Cardiaomyocyte. Guojie Song, Timothy E. Hawkins, Stephen E. Moss Circulation 2001;104（14）: I330

32. Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice. Song G, Harding SE, Duchen MR, Tunwell R, O’Gara P, Hawkins TE, Moss SE. FASEB J. 2002 Apr;16（6）:622-4.

33. Increased intracellular ATP in adult mice cardiomyocytes treated with ACE inhibitor. Guojie Song , Ying Hong, John F. Martin, Jorge D. Erusalimsky Circulation 2003;Suppl 11（22）: 98

34. Dynamic changes in myocardial matrix metalloproteinase activity in mice with viral myocarditis. Meng XH, Wang Y, Zhuang JX, Han XZ, Chen Y, Jin YP, Wang YL, Yu YH, Spires JP, Song GJ. Chin Med J （Engl）. 2004 Aug;117（8）:1195

35. Novel cardioprotective effects by the small heat shock preotein Hsp20. Fan GC, Yuan Q, Qian J, Nicolaou P, Song G, Chen G, Chu G, Kranias EG. Circulation Research, 2005, 97 （2）: E18

36. Alterations in vascular matrix metalloproteinase due to ageing and chronic hypertension: effects of endothelin receptor blockade. Spiers JP, Kelso EJ, Siah WF, Edge G, Song G, McDermott BJ, Hennessy M. J Hypertens. 2005 Sep; 23（9）:1717-24.

37. Adrenoceptor blockade alters plasma gelatinase activity in patients with heart failure and MMP-9 promoter activity in a human cell line （ECV304）. Song G, Hennessy M, Zhao YL, Li Q, Han WD, Qi Y, Zhao WN, Silke B, Barry M, Doyle R, Spiers JP. Pharmacol Res. 2006 Jul;54（1）:57-64.

38. Statin therapy for patients with chronic heart failure. Gong K, Song G, Zhang Z. Am J Cardiol. 2006 Sep 1;98（5）:707

39. Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1. Fan GC, Yuan Q, Song G, Wang Y, Chen G, Qian J, Zhou X, Lee YJ, Ashraf M, Kranias EG. Circ Res. 2006 Nov 24;99（11）:1233-42.

40. Activation of immune and inflammatory systems in chronic heart failure: novel therapeutic approaches. Gong KZ, Song G, Spiers JP, Kelso EJ, Zhang ZG. Int J Clin Pract. 2007 Apr;61（4）:611-21.

宋國(guó)杰 主編：《臨床分子心臟病學(xué)¾¾現(xiàn)代心臟病學(xué)的新領(lǐng)域》

天津科技出版社出版， 2001年5月， 中國(guó)，天津

獲獎(jiǎng)情況

1987-1988 Sino-British Scholar Fellowship （UK） 英國(guó)英中基金會(huì)學(xué)者獎(jiǎng)

1989 Wellcome Trust Outstanding Scholar Travel Fellowship （UK）

英國(guó) Wellcome 信托基金會(huì)學(xué)者出訪(fǎng)講學(xué)獎(jiǎng)

1995 American Heart Association Research Fellowship （USA）美國(guó)心臟協(xié)會(huì)研究獎(jiǎng)

博士論文題目

The Haemodynamic, Neurohormonal and Molecular Biological Response in Pacing-Induced Heart Failure with Renal or Cardiac Denervation

腎臟和心臟去神經(jīng)時(shí)起搏誘發(fā)的心力衰竭中血液動(dòng)力學(xué)、神經(jīng)激素系統(tǒng)和分子生物學(xué)的反應(yīng)性改變