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  • 張兆國

    張兆國(上海交大教授)

    張兆國,1968年11月出生于山東,上海交通大學(xué)博士,上海交通大學(xué)化學(xué)與化工學(xué)院教授。


    基本信息

    1968年11月出生于山東

    1987-1991:山東大學(xué)化學(xué)系畢業(yè),獲學(xué)士學(xué)位

    1991-1994:南京大學(xué)化學(xué)系畢業(yè),獲碩士學(xué)位 導(dǎo)師:徐建華教授

    1994-1997:中國科學(xué)院上海有機化學(xué)研究所畢業(yè),獲博士學(xué)位 導(dǎo)師:陸熙炎院士

    1997-2000:賓西法尼亞州立大學(xué)化學(xué)系博士后 導(dǎo)師:張緒穆教授

    張兆國

    2000,6- :中國科學(xué)院上海有機化學(xué)研究所研究員

    2000年度中國科學(xué)院百人計劃

    2002年上海市科技啟明星

    2004年中國科學(xué)院優(yōu)秀研究生導(dǎo)師

    2006年科技啟明星跟蹤

    2007年曙光學(xué)者

    2005-至今:上海交通大學(xué)化學(xué)與化工學(xué)院,教授

    研究興趣

    1、金屬有機化學(xué)與不對稱催化

    2、精細(xì)有機合成

    3、可見光條件下的催化反應(yīng)

    科研項目

    主持和參加國家自然科學(xué)基金項目、中國科學(xué)院基金項目、國家重點實驗室開放基金項目和國際、國內(nèi)企業(yè)合作項目。

    榮譽獎勵

    1、2000年獲中國科學(xué)院百人計劃

    2、2002年獲上海市“科技啟明星”

    3、2004年被評為中國科學(xué)院優(yōu)秀研究生導(dǎo)師2

    4、2006年獲得美國Eli Lilly Research Excellence Award

    5、2007年獲上海市曙光學(xué)者

    學(xué)術(shù)兼職

    美國化學(xué)會會員

    教學(xué)工作

    1、本科生:《有機合成》、

    2、研究生:《高等有機合成》

    發(fā)表論文

    Zhu, L., Chen, H., Meng, Q., Fan, W., Xie, X., Zhang, Z., "Highly enantioselective hydrogenation of 2-oxo-4-arybutanoic acids to 2-hydroxy-4-arylbutanoic acids." Tetrahedron 2011, 67 (34), 6186-6190.

    Yao, Y., Fan, W., Li, W., Ma, X., Zhu, L., Xie, X., Zhang, Z., "Synthesis of (S)-7-amino-5-azaspiro[2.4]heptane via highly enantioselective hydrogenation of protected ethyl 1-(2-aminoaceto)cyclopropanecarboxylates." J. Org. Chem. 2011, 76 (8), 2807-2813.

    Yang, Y., Chen, L., Zhang, Z., Zhang, Y., "Palladium-catalyzed oxidative C-H bond and C=C double bond cleavage: C-3 acylation of indolizines with α,β-unsaturated carboxylic acids." Organic Letters 2011, 13 (6), 1342-1345.

    Xie, X., Ni, G., Ma, F., Ding, L., Xu, S., Zhang, Z., "Palladium-catalyzed monoarylation of aryl amine with aryl tosylates." Synlett 2011, (7), 955-958.

    Ma, F. F., Peng, Z. Y., Li, W. F., Xie, X. M.,Zhang, Z., "An efficient Pd-catalyzed coupling of hydrazine derivatives with aryl halides." Synlett 2011, (17), 2555-2558.

    Ma, F., Xie, X., Ding, L., Gao, J., Zhang, Z., "Palladium-catalyzed coupling reaction of amino acids (esters) with aryl bromides and chlorides." Tetrahedron 2011, 67 (48), 9405-9410.

    Li, X., Ma, X., Li, W., Tao, X., Meng, Q., Fan, W., Zhang, Z., "Catalytic asymmetric hydrogenation of ethyl 2-(benzo[b]thiophen-5-yl)-2- oxoacetate with ru-sunphos in the formal synthesis of T-588." Chinese Journal of Chemistry 2011, 29 (12), 2581-2583.

    Li, W., Ma, X., Fan, W., Tao, X., Li, X., Xie, X., Zhang, Z., "Ru-catalyzed asymmetric hydrogenation of 3-oxoglutaric acid derivatives via solvent-assisted pinpoint recognition of carbonyls in close chemical propinquity." Organic Letters 2011, 13 (15), 3876-3879.

    Fan, W., Li, W., Ma, X., Tao, X., Li, X., Yao, Y., Xie, X., Zhang, Z., "Ru-catalyzed asymmetric hydrogenation of γ-heteroatom substituted β-keto esters." J. Org. Chem. 2011, 76 (22), 9444-9451.

    Zhu, L., Meng, Q., Fan, W., Xie, X., Zhang, Z., "Direct asymmetric hydrogenation of 2-oxo-4-arylbut-3-enoic acids." J. Org. Chem. 2010, 75 (17), 6027-6030.

    Xie, X., Ding, L., Ni, G., Zhang, Z., Gao, J., "A general and facile approach for the synthesis of 2’-functionalized 1,1’-binapthyl-2-ols." Chinese Journal of Chemistry 2010, 28 (9), 1630-1634.

    Wang, J., Tong, X., Xie, X., Zhang, Z., "Rhodium-catalyzed activation of C(sp3)-X (X = Cl, Br) bond: An intermolecular halogen exchange case." Organic Letters 2010, 12 (23), 5370-5373.

    Peng, Z. Y., Ma, F. F., Zhu, L. F., Xie, X. M., Zhang, Z., "Lewis acid promoted carbon - Carbon double-bond formation via organozinc reagents and carbonyl compounds." J. Org. Chem. 2009, 74 (17), 6855-6858.

    Lin, X., Busch-Petersen, J., Deng, J., Edwards, C., Zhang, Z., Kerns, J. K., "Efficient and scalable synthesis of 3,5,7-trisubstituted 1H-indazoles as potent IKK2 inhibitors." Synlett 2008, (20), 3216-3220.

    Xie, X., Zhang, T. Y., Zhang, Z., "Synthesis of bulky and electron-rich MOP-type ligands and their applications in palladium-catalyzed C-N bond formation." J. Org. Chem. 2006, 71 (17), 6522-6529.

    Zhu, L., Chen, H., Meng, Q., Fan, W., Xie, X., Zhang, Z., "Highly enantioselective hydrogenation of 2-oxo-4-arybutanoic acids to 2-hydroxy-4-arylbutanoic acids." Tetrahedron 2011, 67 (34), 6186-6190.

    Yao, Y., Fan, W., Li, W., Ma, X., Zhu, L., Xie, X., Zhang, Z., "Synthesis of (S)-7-amino-5-azaspiro[2.4]heptane via highly enantioselective hydrogenation of protected ethyl 1-(2-aminoaceto)cyclopropanecarboxylates." J. Org. Chem. 2011, 76 (8), 2807-2813.

    Xie, X., Zhang, T. Y., Zhang, Z., "Synthesis of bulky and electron-rich MOP-type ligands and their applications in palladium-catalyzed C-N bond formation." J. Org. Chem. 2006, 71 (17), 6522-6529.

    Wang, D.; Zhang, Z. “Activation and reaction of carboxylic anhydride catalyzed by palladium ” Chin. J. Org. Chem.2004, 24, 258-269.

    Guo, M.; Li, D.; Sun, Y.; Zhang, Z. “Selective Reduction of the Carbonyl Group in b,g-Unsaturated a-Ketoesters by Transfer Hydrogenation with Ru-TsDPEN” Synlett, 2004, 741-743

    Luo, Y.; Wang, F.; Zhu, G.; Zhang, Z. “A concise synthesis of 2-diarylphosphino-20-methoxy-1,10-binaphthalenes (MOPs) by simple resolution”, Tetrahedron Asymm. 2004, 15, 15-17.

    Guo, M.; Li, D.; Zhang, Z. “Novel Synthesis of 2-Oxo-3-butynoates by Copper-Catalyzed Cross-Coupling Reaction of Terminal Alkynes and Monooxalyl Chloride”, J. Org. Chem. 2003, 68, 10172-10175.

    Wang, D.; Zhang, Z. “Palladium-Catalyzed Cross-Coupling Reactions of Carboxylic Anhydrides with Organozinc Reagents”, Org. Lett., 2003, 5, 4645-4648.

    Zhu, G.; Zhang, Z. “Palladium-Catalyzed Tandem Cyclization/Suzuki Coupling of 1,6-Enynes”, Org. Lett., 2003, 5, 3645-3648.

    Cheng, J.; Wang, F.; Xu, J.-H.; Pan, Y.; Zhang, Z. “Palladium-catalyzed Suzukiu2013Miyaura reaction using aminophosphine as ligand”, Tetrahedron Lett., 2003, 44, 7095-7098.

    Tong, X., Zhang, Z., Zhang, X., “Novel Rhodium-Catalyzed Cycloisomerization of 1,6-Enynes with an Intramolecular Halogen Shift” J. Am. Chem. Soc. 2003, 125, 6370-6371.

    Zhang, Z.; Lu, X*. and Lang, S. “An Unexpected Reaction of Allyl Propynoate under Palladium Catalysis” Chin. J. Chem. 2002, 20, 1287-1290.

    Wang, F. and Zhang Z.* “Palladium Catalyzed Amidocarbonylation”, Chin. J. Org. Chem. 2002, 22, 536-542.

    Tian, J. Z.; Zhang, Z. G.; Yang, X. L.; Fun, K. H. and Xu*, J. H “Photooxygenation of Indolizines via Selective Excitation of Their Charge Transfer Complexes with Molecular Oxygen” J. Org. Chem. 2001, 66, 8230-8235

    Zhang,Z.; Lu, X.*; Xu, Z.; Zhang, Q. and Han, X. “Role of Halide Ions in Divalent Palladium-Mediated Reactions: Competition between u201a-Heteroatom Elimination and u201a-Hydride Elimination of a Carbon-Palladium Bond”, Organometallics 2001, 20, 3724-3728

    Zhang, Z.; Qian, H.; Longmire, J. and Zhang, X*. “Synthesis of Chiral Bisphosphines with Tunable Bite Angles and Their Applications in Asymmetric Hydrogenation of u2013Ketoesters”, J. Org. Chem. 2000; 65; 6223-6226.

    Li, W.; Zhang, Z.; Xiao, D. and Zhang, X*. “Synthesis of Chiral hydroxl Phosphines from D-Mannitol and Their Use in Asymmetric Catalytic Reactions” J. Org. Chem., 2000, 65, 3489-3496.

    Wang, Z.; Zhang, Z.; Lu, X*. “Effect of Halide Ligands on the Reactivity of Carbon-Palladium Bonds: Implications for Designing Catalytic Reactions” Organometallics, 2000, 19, 775-780.

    Li, W.; Zhang, Z.; Xiao, D.; Zhang, X*. “Rhodium-hydroxyl bisphospholane catalyzed highly enantioselective hydrogenation of dehydroamino acids and esters” Tetrahedron Lett., 1999, 40, 6701-6704.

    Jiang, Q.; Xiao, D.; Zhang, Z.; Cao, P.; Zhang, X*. “Highly enantioselective hydrogenation of cyclic enol acetates catalyzed by a Rh-PennPhos complex” Angew. Chem., Int. Ed., 1999, 38, 516-518.

    Zhang, Z.; Zhu, G.; Jiang, Q.; Xiao, D.; Zhang, X*. Highly Enantioselective Hydrogenation of Cyclic Enamides Catalyzed by a Rh-PennPhos Catalyst” J. Org. Chem., 1999, 64, 1774-1775.

    Xiao, D.; Zhang, Z.; Zhang, X*. “Synthesis of a Novel Chiral Binaphthyl Phospholane and Its Application in the Highly Enantioselective Hydrogenation of Enamides” Org. Lett., 1999, 1, 1679-1681.

    Xiao, D.; Zhang, Z.; Jiang, Q.; Zhang, X.. “Syntheses of novel chiral 2,5-dialkyl-7- azabicyclo[2.2.1]heptanes and 2,5-dialkyl-7-thiobicyclo[2.2.1]heptanes” Tetrahedron Lett., 1998, 39, 5331-5334.

    Wang, Z.; Lu, X*.; Lei, A.; Zhang, Z. “Efficient Preparation of Functionalized (E,Z) Dienes Using Acetylene as the Building Block” J. Org. Chem., 1998, 63, 3806-3807.

    Lu, X*.; Zhu, G.; Wang, Z.; Ma, S.; Ji, J.; Zhang, Z. “Enyne cyclization methodology for the synthesis of bioactive lactones” Pure Appl. Chem., 1997, 69, 553-558.

    Lu, X.; Zhu, G.; Wang, Z.; Ma, S.; Ji, J.; Zhang, Z. “Enyne cyclization methodology for the synthesis of bioactive lactones” Youji Huaxue, 1997. 17, 8-11.

    Zhang, Z.; Lu, X*. “Total synthesis of phaseolinic acid by enyne cyclization” Tetrahedron: Asymm. 1996, 7, 1923-1928.

    Xu, J.; Song, Y.; Zhang, Z.; Wang, L.; Xu, J*. “Photoinduced addition reactions of chloranil with alkenes - factors influencing the reaction site” Tetrahedron, 1994, 50, 1199-1210.

    Chen, C.; Zhang,Z.; Yan, B.; Xu, J*. “Phtoinduced Reactions of Chloranil with Aromatic Imines” Tetrahedron Lett. 1994, 35, 9221-9224.

    Yan, B.; Zhang, Z.; Yuan, H.; Wang, L. and Xu, J*. “Photoinduced Electron- transfer Reactions of Chloranil with Benzodioxoles” J. Chem. Soc. Perk. T 2, 1994, 2545-2550.

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