研究方向
研究抗感染天然免疫應(yīng)答及腫瘤免疫相關(guān)蛋白質(zhì)復(fù)合物的結(jié)構(gòu)基礎(chǔ)與功能機制。包括：1，細胞程序性壞死及炎癥反應(yīng)相關(guān)蛋白的結(jié)構(gòu)生物學(xué)研究；2，天然免疫應(yīng)答與神經(jīng)退行性疾病交互調(diào)控的分子機制。
在Cell、Immunity、Annu Rev Immunol、PNAS等期刊上發(fā)表40余篇SCI論文，申請/授權(quán)發(fā)明專利11項。主持及參加的科研項目包括國家重點研發(fā)計劃（2016YFA0500600）、科技部重大研究計劃（2015CB943300）及國家自然科學(xué)基金面上項目（31470724、31670878）等。
獲獎情況
國家重點研發(fā)計劃“蛋白質(zhì)機器與生命過程調(diào)控”首席科學(xué)家（2016）；復(fù)旦大學(xué)復(fù)星醫(yī)藥獎教金（特等獎）（2016）；上海市“東方學(xué)者”特聘教授（2014）；哈佛大學(xué)華人生命科學(xué)年度杰出研究獎（2013）；國家留學(xué)基金委惠普獎學(xué)金（2005）。
個人論文
1. Kleino A, Ramia N, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK, Wu H*,Li J*, Silverman N*. Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-kB Signaling.Immunity2017 Oct 17; 47:635-647
2. Kuang S, Zheng J, Yang H, Li S, Duan S, Shen Y, Ji C, Gan J, Xu XW,Li J*. Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis.Proc Natl Acad Sci U S A. 2017 Sep 19. pii: 201708194. doi: 10.1073/pnas.1708194114.
3. Huo YY, Li S, Huang J, Rong Z, Wang Z, Li Z, Ji R, Kuang S, Cui HL,Li J*, Xu XW*. Crystal structure of Pelagibacterium halotolerans PE8: New insight into its substrate-binding pattern.Sci Rep.2017 June 30;7: 4422. doi:10.1038/s41598-017-04550-7
4. Cao X, Li C, Xiao S, Tang Y, Huang J, Zhao S, Li X,Li J, Zhang R, Yu W. Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage.Proc Natl Acad Sci U S A.2017 Jan 24;114(4):687-692.
5. Huang J, Huo YY, Ji R, Kuang S, Ji C, Xu XW*,Li J*.Structural insights of a hormone sensitive lipase homologue Est22.Sci Rep.2016 Jun 22;6:28550. doi: 10.1038/srep28550.
6. Yin Q, Fu T,Li J*,Wu H*. Structural Biology of Innate Immunity.Annu Rev Immunol.2015 Mar 21;33:393-416.
7.Li J, Yin Q, Wu H. Structural basis for TNFR mediating signal pathways.Adv Immunol.2013;119:135-53.
8. Lee J, Yi L,Li J, Schweitzer K, Borgmann M, Naumann M, Wu H. Crystal Structure and Versatile Functional Roles of the COP9 Signalosome Subunit 1.Proc Natl Acad Sci U S A.2013 Jul 16;110(29):11845-50.
9.Li J, McQuade T, Siemer A, Napetschnig J, Damko E, Hsiao Y, Moquin D, Walz T, Mcdermott A, Chan FK, Wu H. The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis.Cell2012 Jul 20;150(2):339-50. (Highlighted by Nature Reviews Molecular Cell Biology 2012 Aug 1;13(9):540-1)
10.Li J, Wei Z, Zheng M, Gu X, Deng Y, Qiu R, Chen F, Ji C, Gong W, Xie Y, Mao Y. Crystal structure of human Guanosine Monophosphate reductase 2 (GMPR2) in complex with GMP.J Mol Biol.2006, 355(5):980-988
