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  • 李沉簡

    李沉簡

    李沉簡,男,1969年10月生,前任北京大學元培學院常務副院長、生命科學學院教授。


    學術經(jīng)歷

    1984年至1987年就讀于北京大學生物系醫(yī)預班,

    1987年至1988年在北京協(xié)和醫(yī)學院學習基礎醫(yī)學,

    1997年博士畢業(yè)于美國普度大學神經(jīng)生物及分子遺傳專業(yè)。

    工作經(jīng)歷

    1997年至2003年在美國紐約Rockefeller大學從事博士后研究工作,

    2003年至2009年在美國康奈爾大學醫(yī)學院任助理教授,

    李沉簡

    2009年至2010年在美國康奈爾大學醫(yī)學院任副教授,

    2010年至今在美國紐約大學西奈山醫(yī)學院任講席教授。

    2016年任北京大學元培學院常務副院長。

    代表性論文

    1. Zheng, S.,Geghman, K., Shenoy, S., Li, C , Retake the Center Stage - New Development of Rat Genetics. , Journal of Genetics and Genomics. , 2012 , 39(6):261-8.

    2. Yong Huang and Chenjian Li , Proteasome dysfunction in animal models for PINK1 Parkinsonu2019s disease , J Neurogenetics , 2012 , 26(2):158-67

    3. Qing Xu, Sushila Shenoy and Chenjian Li , Mouse Models for LRRk2 Parkinsonu2019s Disease , Parkinsonism and Related Disorders , 2012 , 18, 186-189.

    4. Dagda R, Gusdon A, Pien I, Strack S, C Li, Cherra J, and Chu C. , Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson’s disease. , Cell Death and Differentiation. , 2011 , 18, 1914-1923.

    5. Kindiya Geghman and Chenjian Li , ractical consideration of genetic rodent models for neurodegenerative disease. , Methods in Mol Biol. , 2011 , 793:185-193.

    6. Wencheng Liu, Rebeca Acin-Perez, Kindiya Geghman, Giovanni Manfredi, Bing Wei Lu and Chenjian Li , Pink1 regulates the assembly of oxidative phosphorylation machinery via mitochondrial fission , Proc Natl Acad Sci.USA. , 2011 , 108, 12920-12924.

    7. Cristofol Vives-Bauza, Chun Zhou, Yong Huang, VAlina Dawson, Darren More, Grailhe, Ted Dawson, Chenjian Li, Serge Przedborski. , PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. , Proc Natl Acad Sci. USA. , 2010 , 107, 378-383.

    8. Wencheng Liu, Cristofol Vives-Bauza, Rebeca Acin-Perez, Ai Yamamoto, Yingcai Tan, Yanping Li, Jordi Magrane, , Mihaela Stavarache, Michael Kaplitt, Xin-Yun Huang, M. Flint Beal, Giovanni Manfredi and Chenjian Li , Mutant PINK1 causes mitochondrial dysfunction, proteasomal deficit and α-synuclein aggregation in Parkinsonu2019s disease models. , PLoS ONE. , 2009 , 4(2): e4597.

    9. Yanping Li, Wencheng Liu, Tinmarlar F. Oo, Lei Wang, Yi Tang, Vernice Jackson-Lewis, Chun Zhou, Kindiya Geghman, Serge Przedborski, M.Flint Beal Robert Burke and Chenjian Li , BAC transgenic mouse model for LRRK2 recapitulates robust Parkinsonu2019s disease phenotypes. , Nature Neuroscience. , 2009 , 12, 826-828.

    10. Younghwa Kim, Ping Zhou, Liping Qian, Jesica Lee, Chenjian Li, Constantino Iadecola, Carl Nathan and Aihao Ding. , MyD88-5 links mitochondra, microtubules and JNK3 in Neurons and regulates Neuronal survival. , J. Exp Medicine (Cover). , 2007 , 204(9):2063-74.

    11. Chenjian Li and M Flint Beal. , Leucine-rich repeat kinase 2: a New player with a familiar theme for Parkinsonu2019s disease pathogenesis. , Proc Natl Acad Sci. USA. , 2005 , 102, 16535-16537.

    12. Tsu-kang Sang, Chenjian Li, Lawrence Zipursky, George Jackson. , Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis. , Hum Mol Genet. , 2005 , 14(3):357-72

    13. Xiaofeng Gu, Chenjian Li, Weicheng Wei, Victor Lo, Shiaoching Gong, Shihua Li, TAkuji Iwasato, Shigeyoshi Itohara, XiaoJiang Li, Istvan Mody, Nathaniel Heintz, William Yang, , Pathological cell-cell interactions elicited by a neuropathogenic form of mutant huntingtin contribute to cortical pathogenesis in HD mice. , Neuron. , 2005 , 46, 433-444.

    14. Chenjian Li, Wayne Brake, Russell Romeo, Marisa Gordon, Rodica Buzescu, Patrick Allen, Paul Greengard, Bruce McEwen , Hippocampal neuron dendritic spine maturation, synaptic proteins immunoreactivity and performance in spatial learning tasks in mice. , Proc Natl Acad Sci.USA. , 2004 , 101, 2185-90.

    15. Shaoching Gong, William Yang, Chenjian Li, Nathaniel Heintz , Highly Efficient Modification of Bacterial Artificial Chromosomes (BACs) Using Novel Shuttle Vectors Containing the R6Kr Origin of Replication. , Genome Research. , 2002 , 12:1992-1998.

    16. Bruce McEwen, Keith Akama, Steve Alves, Wayne Brake, Chenjian Li, Yuen G , Tracking the estrogen receptor in neurons: implications for estrogen-induced synapse formation. , Proc Natl Acad Sci USA. , 2001 , 98:7093-7100.

    17. Milner, T. A., McEwen, B. S., Hayashi, S., Chenjian Li, Reagan, L. P., Alves, S. E. , Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites. , J Comp Neurol. , 2001 , 429(3)355-371.

    18. Chenjian Li, Chaoxian Geng, Hung-Tat Leung, Young Seok Hong, Lydia R. Strong, William L. Pak. , InaF, a Protein Required For Transient Receptor Potential Ca2+ Channel Function. , Proc Natl Acad Sci.USA. , 1999 , 96(23):13474-13479.

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