研究方向
核開關(guān)三維結(jié)構(gòu)與機(jī)理 X-ray晶體結(jié)構(gòu)、RNA調(diào)節(jié)因子發(fā)現(xiàn)、功能和機(jī)理。
論文論著
從事RNA的結(jié)構(gòu)與功能、基因的表達(dá)與調(diào)控等研究:核開關(guān)和其他非編碼RNA 的結(jié)構(gòu)、機(jī)理和功能；Packaging RNA (pRNA)的晶體結(jié)構(gòu)與復(fù)合體的包裝機(jī)理；外切體復(fù)合物的晶體結(jié)構(gòu)與機(jī)理；昆蟲胚胎耐凍性的分子機(jī)理,其成果發(fā)表于Nature SMB、PNAS、Journal of Molecular Biology等國(guó)際著名雜志。
1、Ding F,Lu Changruiet al. Structure and assembly of the essential RNA ring component of a viral DNA packaging motor.PNAS.2011
2、Lu Changrui, Ding F, Ke A. Folding of the SAM-III/SMK box riboswitch is hypersensitive to sequences outside the SAM-binding core.Journal of Molecular Biology.2011
3、Lu Changrui,et al. SAM Recognition and Conformational Switching Mechanism in theBacillus subtilis yitJ SBox/SAM-I Riboswitch.Journal of Molecular Biology.2010
4、Lu Changrui, Ding F, Ke A. Crystal structure of theS. solfataricusarchaeal exosome reveals conformational flexibility in the RNA-binding ring.PLoS ONE.2010
5、Lu Changrui.et al. Crystal Structures of the SMK box (SAM-III) Riboswitch Reveal the SAM-dependent Translation Inhibition Mechanism.Nature SMB.2008
6、Pruitt NL,Changrui Lu.Seasonal changes in phospholipid class and class-specific fatty acid composition associated with the onset of freeze tolerance in third-instar larvae of Eurosta solidaginis.Physiological and biochemical zoology. 2008
7、Perreira M, Jiang JK, Klutz AM, Gao ZG, Shainberg A, Changrui Lu, Thomas CJ, Jacobson KA.“Reversine” and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.Journal of medicinal chemistry. 2005
8、Jeong LS, Lee HW, Jacobson KA, Kim HO, Shin DH, Lee JA, Gao ZG,Changrui Lu, Duong HT, Gunaga P, Lee SK, Jin DZ, Chun MW, Moon HR. Structure-activity relationships of 2-chloro-N6-substituted-4u2018-thioadenosine-5u2019-uronamides as highly potent and selective agonists at the human A3 adenosine receptor.J Med Chem. 2006
9、Cosyn L, Gao ZG, Van Rompaey P,Changrui Lu, Jacobson KA, Van Calenbergh S. Synthesis of hypermodified adenosine derivatives as selective adenosine A3 receptor ligands.Bioorg Med Chem.2006