基本內(nèi)容
任職大學(xué):廈門大學(xué)醫(yī)學(xué)院
職稱:副教授/博導(dǎo)
學(xué)科(專業(yè)):轉(zhuǎn)化醫(yī)學(xué)
研究方向:計(jì)算生物學(xué),基因組學(xué)
教育背景:
1996-2000華東理工大學(xué)本科
2000-2003廈門大學(xué)細(xì)胞生物學(xué)碩士
2004-2006丹麥科技大學(xué)生物信息學(xué)碩士
2006-2010丹麥科技大學(xué)系統(tǒng)生物學(xué)博士
2010.03-1012.03哈佛癌癥中心 博士后
2012.05-2017.07廈門大學(xué)副教授
主要研究領(lǐng)域:
李奇淵主要從事針與腫瘤基因組相關(guān)的轉(zhuǎn)化醫(yī)學(xué)研究:運(yùn)用統(tǒng)計(jì)學(xué)模型從基因組大數(shù)據(jù)中尋找與腫瘤分型,預(yù)后,化療敏感性等臨床特征有關(guān)的遺傳標(biāo)記;通過多元模型對腫瘤遺傳多態(tài)性,體細(xì)胞變異,綜合表觀遺傳學(xué)特征和基因表達(dá)進(jìn)行分析建模,認(rèn)識和理解腫瘤風(fēng)險(xiǎn)因子的生物學(xué)功能;分析腫瘤基因組體細(xì)胞水平上的各種變異類型及其調(diào)控機(jī)制
主要學(xué)術(shù)成果:
論文: | |
1 | Li Q,Seo J H, Stranger B, et al. Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci[J]. Cell, 2013, 152(3):633-41. |
2 | Li Q,Eklund A C, Birkbak N J, et al. Consistent metagenes from cancer expression profiles yield agent specific predictors of chemotherapy response[J]. Bmc Bioinformatics, 2011, 12(2):: 310. |
3 | Li Q,Birkbak N J, Gyorffy B, et al. Jetset: selecting the optimal microarray probe set to represent a gene[J]. Bmc Bioinformatics, 2011, 12(1):1-7. |
4 | Seo J H,Li Q, Fatima A, et al. Deconvoluting complex tissues for expression quantitative trait locus-based analyses.[J]. Philosophical Transactions of the Royal Society B Biological Sciences, 2013, 368(1620):20120363-20120363. |
5 | Li Q, Stram A, Chen C, et al. Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types[J]. Human Molecular Genetics, 2014, 23(19):5294-302. |
6 | Lawrenson K,Li Q, Kar S, et al. Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.[J]. Nature Communications, 2015, 6:45-53. |
7 | Li Y, Zou L,Li Q, et al. Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer.[J]. Nature Medicine, 2010, 16(2):214-8. |
主持課題: | Chen W, Li Z, Hu J, Zhang Z, Chen L, Chen Y,Liu Z(corresponding).Corneal alternations induced by topical application of benzalkonium chloride in rabbit.PLoS One. 2011;6(10):e26103 |