人物簡介
1981-09-01—1985-06-30河南農(nóng)業(yè)大學(xué)本科
1998-06-15—2002-12-30 加拿大Queen’s University博士
2002年畢業(yè)于加拿大Queenu2019s University，獲生物化學(xué)和分子生物學(xué)博士學(xué)位。2003-2004年在Queenu2019s University蛋白質(zhì)功能中心和生物化學(xué)系從事博士后研究，2005年后在美國Duke University Medical Center任助理研究員、助理教授。2009年入選中國科學(xué)院“百人計劃”，2010年起擔(dān)任中國科學(xué)院動物研究所研究員、博士生導(dǎo)師、昆蟲發(fā)育與生殖基因調(diào)控研究組組長，2011年獲“百人計劃”擇優(yōu)支持。
主要成就
長期從事發(fā)育生物學(xué)，轉(zhuǎn)錄調(diào)控機制，細(xì)胞因子與信號通路，功能基因進化及環(huán)境脅迫適應(yīng)等方面的研究。曾獲美國PRS NIH/NICHD Young Investigator Award，擔(dān)任Journal of Allergy and Therapy編委。近年的研究成果發(fā)表于PNAS, Insect Biochemistry and Molecular Biology, Journal of Cell Science, American Journal of Physiology等SCI期刊上。授權(quán)國際專利1項。
研究方向
綜合運用分子生物學(xué)、生物化學(xué)、細(xì)胞生物學(xué)等手段，研究昆蟲生殖發(fā)育與變態(tài)的基因調(diào)控機制，昆蟲與寄主植物的相互作用和昆蟲適應(yīng)環(huán)境脅迫的分子機理。包括昆蟲激素（保幼激素、蛻皮激素、肽激素等）或環(huán)境與寄主因子誘導(dǎo)下的基因轉(zhuǎn)錄與調(diào)控、蛋白表達(dá)與修飾、信號傳導(dǎo)等。
出版著作
1、S. Zhou*, E.Potts, F. Cuttitta, W.M. Foster, and M.E. Sunday*. Gastrin-releasing peptide blockade: broad-spectrum anti-inflammatory therapy for asthma.* Co-corresponding authors. Submitted.
2、S. Zhou, S. Degan, E.N. Potts, W.M. Foster and M.E. Sunday. 2009. NPAS3 is a trachealess homolog critical for lung development and homeostasis. Proceeding of the National Academy of Science. 106, 11699u201311704.
3、B.M. Levesque*, S. Zhou*, L. Shan, Y. Kong and M.E. Sunday. 2007. NPAS1 regulates branching morphogenesis in embryonic lung. American Journal of Respiratory Cell and Molecular Biology. 36, 427-434. * contributed equally as co-first authors
4、S. Zhou, M. Tejada, G.R. Wyatt, V.K. Walker. 2006. A DNA-binding protein, tfp1, involved in juvenile hormone-regulated gene expression in Locusta migratoria. Insect Biochemistry and Molecular Biology. 36: 724-734.
5、S. Zhou, B.A. Webb, R. Eves, and A.S. Mak. 2006. Effects of Tyr-phosphorylation of cortactin on podosome-formation in A7r5 vascular smooth muscle cells. AJP-Cell Physiology.290, C463-471.
6、B.A. Webb, S. Zhou, R. Eves, and A.S. Mak. 2006. Phosphorylation of cortactin by p21-activated kinase. Archives of Biochemistry Biophysics. 456, 183-193.
7、R. Eves, B.A. Webb, S. Zhou, and A.S. Mak. 2006. Caldesmon is an integral component of podosomes in smooth muscle cells. Journal of Cell Science. 119, 1691-1702.
8、B.A. Webb, R. Eves, S. Crawley, S. Zhou, G.P., Côté and A.S. Mak. 2005. p21-activated kinase induces podosome formation in A7r5 vascular smooth muscle cells in a PIX-dependent manner. AJP-Cell Physiology. 289: C898-907.
9、D.C. Hayward, T.S. Dhadialla, S. Zhou, M.J. Kuiper, E.E. Ball, G.R. Wyatt, V.K. Walker. 2003. Ligand specificity and developmental expression of RXR and ecdysone receptor in the migratory locust. Journal of Insect Physiology. 49, 1135-1144.
10、S. Zhou, J. Zhang, M. Hirai, Y. Chinzei, H. Kayser, G.R. Wyatt, V.K. Walker. 2002. A DNA-binding protein involved in gene regulation by juvenile hormone. Molecular and Cellular Endocrinology. 190, 177-185.
11、S. Zhou, J. Zhang, M.D. Fam, G.R. Wyatt, V.K. Walker. 2002. Sequences of elongation factors-1a and -1g and stimulation by juvenile hormone in Locusta migratoria. Insect Biochemistry and Molecular Biology. 32, 1567-1576.
