研究方向及內(nèi)容
1．重大疾病相關(guān)的內(nèi)源性糖鏈精細(xì)結(jié)構(gòu)分析及其高靈敏分析方法學(xué)研究；
2. 海洋糖類化合物的提取分離、結(jié)構(gòu)鑒定及其構(gòu)效關(guān)系研究；
3. 糖類藥物分析、質(zhì)量控制新方法研究。
主要代表性論文
1.G. Li, C. Cai, L. Li, L. Fu, T. Toida, C. Xue, R.J. Linhardt. Method to detect contaminants in heparin using radical depolymerization and liquid chromatography-mass spectrometry,Anal Chem, 2014,86(1): 326-330 (IF: 5.825)
2.G. Li,J. Steppich,Z. Wang,Y. Sun,C. Xue,R.J. Linhardt,L. Li. Bottom-up low molecular weight heparin analysis using LC-FTMS for extensive characterization.Anal Chem.2014,86(13):6626-6632 （IF: 5.825)
3.G. Li, L. Li, F. Tian, L. Zhang, C. Xue, R. J. Linhardt. Glycosaminoglycanomics of cultured cells using a rapid and sensitive LC-MS/MS approach.ACS Chem Biol, 2015, 10(5):1303-1310 (IF: 5.356)
4.G. Li, L. Li, C. Xue, D. Middleton, R. J. Linhardt, F. V. Avci. Profiling pneumococcal type 3-derived oligosaccharides by high resolution liquid chromatography-tandem mass spectrometry.J Chromatogr A, 2015,1397:43-51 (IF: 4.258)
5.G. Li, B. Yang, L. Li, F. Zhang, C. Xue, R. J. Linhardt. Analysis of 3-O-sulfo group containing tetrasaccharides in heparin by liquid chromatography-mass spectrometry.Anal Biochem, 2014, 455: 3-9. (IF: 2.305)
6.G. Li, S. Masuko, D. E. Green, Y. Xu, L. Li, F. Zhang, R. J. Linhardt. N-sulfotestosteronan, a novel substrate for heparan sulfate 6-O-sulfotransferases and its analysis by oxidative degradation.Biopolymers, 2013, 99(10):675-685 (IF: 2.228)
7.G. Li,S. Chen, C. Xue. A novel glycosaminoglycan-like polysaccharide from abalone Haliotis discus hannai Ino: Purification, structure identification and anticoagulant activity.Int J Biol Macromol, 2011, 49(5): 1160-1166 (IF: 3.096)
8. P. Datta,G. Li, B. Yang, X. Zhao, J. Baik, R.J. Linhardt. Bioengineered Chinese hamster ovary cells with Golgi-targeted 3-O-sulfotransferase-1 biosynthesize heparan sulfate with an antithrombin binding site.J Biol Chem, 2013, 288(52): 37308-37318. (IF: 4.600)
9. E.P. Schmidt,G. Li, L. Li, L. Fu, Y. Yang, K.H. Overdier, I. S. Douglas, R. J. Linhardt: The circulating glycosaminoglycan signature of respiratory failure in critically Ill adults.J Biol Chem, 2014, 289(12):8194-202 (IF: 4.600)
10. W. He, L. Fu,G. Li, J. A. Jones, R. J. Linhardt, M. Koffas. Production of chondroitin in metabolically engineered E. coli.,Metab Eng, 2015, 27: 92-100 (IF: 8.258)
11. E. Sterner, S. Masuko,G. Li, L. Li, D. E. Green, N. J. Otto, Y. Xu, P. L. DeAngelis, J. Liu, J. S. Dordick, R. J. Linhardt. Fibroblast growth factor-based signaling through synthetic heparan sulfate block copolymers studied using high-cell density 3D cell printing,J Biol Chem2014, 289(14): 9754-9765. (IF: 4.600)
12. S. Chen,G. Li, N. Liao, C. Xue. Sulfation pattern of the fucose branch is important for the anticoagulant and antithrombotic activities of fucosylated chondroitin sulfates,BBA-Gen Subjects, 2013, 1830 (4):3054-3066 (IF: 3.892)
13. L. Fu,G. Li, B. Yang, A. Onishi, L. Li, P. Sun, , R. J. Linhardt. Structural characterization of pharmaceutical heparins prepared from different animal tissues.J Pharm Sci-US, 2013,102: 1447-1457 (IF: 3.007)
14. U. Bhaskar,G. Li, L. Fu, A. Onishi, M. Suflita, R. J. Linhardt. Combinatorial one-pot chemoenzymatic synthesis of heparin,Carbohyd Polym, 2015, 122:399-407. (IF: 3.916)
