個(gè)人簡(jiǎn)歷
碩士生導(dǎo)師。1994 年，武漢大學(xué)生物化學(xué)專業(yè)畢業(yè)，獲學(xué)士學(xué)位；2004年第四軍醫(yī)大學(xué)全軍神經(jīng)科學(xué)研究所神經(jīng)生物學(xué)研究生畢業(yè)，獲博士學(xué)位。2005年底轉(zhuǎn)業(yè)到上海交通大學(xué)，聘為神經(jīng)科學(xué)研究所副研究員。中國(guó)神經(jīng)科學(xué)學(xué)會(huì)會(huì)員。實(shí)驗(yàn)室的研究興趣為：中樞神經(jīng)發(fā)育再生分子信號(hào)和腦腫瘤的分子干預(yù)。近十年來(lái), 一直聚焦研究Nogo和srGAPs的功能和信號(hào)機(jī)制研究。主持四項(xiàng)國(guó)家自然科學(xué)基金委的面上項(xiàng)目，如“精神發(fā)育遲滯候選基因MEGAP/srGAP3調(diào)控樹(shù)突發(fā)育的雙模態(tài)機(jī)制研究” 、 “神經(jīng)元Nogo剪接異構(gòu)體對(duì)突起生長(zhǎng)和細(xì)胞凋亡的雙重調(diào)控作用及其機(jī)制研究” 和“nNOS基因作為神經(jīng)元細(xì)胞核Nogo-A蛋白的靶標(biāo)研究”。相關(guān)結(jié)果已經(jīng)整理論文發(fā)表在Cell、Cell Death and Differention、Mol Cell Neurosci、Anesthesiology、J Comp Neurol、Cell Mol Neurobiol、Neurosignals、Neurosci Lett等國(guó)際雜志上。實(shí)驗(yàn)室研究成果被國(guó)際廣泛關(guān)注和引用。次引用。
研究方向
1． 神經(jīng)發(fā)育
2． 中樞神經(jīng)損傷和再生
3． 惡性膠質(zhì)瘤的分子干預(yù)
4． 表觀遺傳學(xué)
發(fā)表論文
1. Charrier C，Joshi K，Coutinho-Budd J , Kim J, Lambert N, Jacqueline de Marchena Powell , Wei-Lin Jin, Vanderhaeghen P, Ghosh A, Sassa K and Franck Polleux. Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny of spine maturation. Cell. Accepted.
2. Mi Ya-Jing, Hou Bing, Liao Qiu-Ming, Ma Yue, Luo Qian, Dai Yun-Kai , Ju Gong and Jin Wei-Lin *. Amino-Nogo-A antagonizes reactive oxygen species generation and protects immature primary cortical neurons from oxidative toxicity. Cell Death Differ. 2012 Jan 20. doi: 10.1038/cdd.2011.206. [Epub ahead of print]
3. Chen Keng, Mi Ya-Jing, Ma Yue, Fu Hua-Lin, Jin Wei-Lin*.The Mental Retardation Associated Protein, srGAP3 Negatively Regulates VPA-Induced Neuronal Differentiation of Neuro2A Cells.Cell Mol Neurobiol. 2011 Jul; 31 (5):675-86. （*Corresponding author）
4. Guerrier Sabrice, Coutinho-Budd Jaeda, Sassa Takayuki, Gresset Aurélie, Jordan Nicole Vincent, Chen Keng, Jin Wei-Lin, Frost Adam, Polleux Franck. The F-BAR Domain of srGAP2 Induces Membrane Protrusions Required for Neuronal Migration and Morphogenesis. Cell, Volume 138, Issue 5, 990-1004, 4 September 2009. (Mini review in Development Cell. Calson BR and Soderling S. 2009)
5. Dai Jin-Xiang; Chen Keng; Jin Wei-Lin*, Ju Gong*. Nogo-A activates NF-κB through its N-terminal proline rich domain. Prog Biochem Biophys, 2009; 36(3): 371-377. （Co-corresponding authors）
6. Wang Qiang, Gou Xing-Chun, Jin Wei-Lin, Xiong Li-Ze, Hou Li-Chao, Chen Shao-Yang, Zhang Hui, Zhu Xiao-Lin, Xu Li-Xian. TAT-Mediated Protein Transduction of Nogo Extracellular Peptide 1-40 and its Biological Activity. Cell Mol Neurobiol. 2009 Feb; 29(1):97-108.
7. Wang Qiang, Gou Xing-chun, Xiong Li-ze, Jin Wei-Lin, Chen Shao-Yang, Hou Li-chao, Xu Li-Xian.Trans-activator of transcription-mediated delivery of NEP1-40 protein into brain has a neuroprotective effect against focal cerebral ischemic injury via inhibition of neuronal apoptosis. Anesthesiology. 2008 Jun; 108 (6):1071-80.
8. Zhao Xiang-Hui 1, Jin Wei-Lin *1 , Wu Jiang, Mi Sha , Ju Gong *. Inactivation of Glycogen Synthase Kinase-3beta and Up-regulation of LINGO-1 are Involved in LINGO-1 Antagonist Regulated Survival of Cerebellar Granular Neurons. Cell Mol Neurobiol. 2008 Aug; 28 (5): 727-735.（*Co-corresponding authors and 1Co-first-authors）
9. Yao Qin1, Jin Wei-Lin*1, Wang Ying, Ju Gong*.Regulated Shuttling of Slit-Robo-GTPase Activating Proteins Between Nucleus and Cytoplasm During Brain Development. Cell Mol Neurobiol. 2008 Feb;28(2):205-221.（*Co-corresponding authors and 1Co-first-authors）
10. Zhao Xiang-Hui 1, Jin Wei-Lin *1 , Ju Gong *. An in vitro study on the involvement of LINGO-1 and Rho GTPases in Nogo-A regulated differentiation of oligodendrocyte precursor cells. Mol Cell Neurosci. 2007 Oct;36(2):260-9.（*Co-corresponding authors and 1Co-first-authors）
11. ZHAO Xiang-Hui, JIN Wei-Lin *, Mi Sha, JU Gong *. LINGO-1-Fc fusion protein prevents apoptosis of cerebellar granule neurons induced by low-potassium. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS. 2006 APR. 33 (4): 336-342（*Co-corresponding authors）
12. Liu Xia, LiuYing-Ying, Jin Wei-Lin, Liu Hui-Lin, Ju Gong. Nogo-66 receptor at cerebellar cortical glia gap junctions in the rat. NEUROSIGNALS 14 (3): 96-101 2005
13. Liu Ying-Ying, Jin Wei-Lin, Liu Hui-Ling, Ju Gong. Electron microscopic localization of Nogo-A at the postsynaptic active zone of the rat NEUROSCIENCE LETTERS 346 (3): 153-156 AUG 7 2003.
14. Jin Wei-Lin, Liu Ying-Ying, Liu Hui-Ling, Yang Hao, Wang Ying, Jiao Xi-Ying, Ju Gong. Intraneuronal localization of Nogo-A in the rat.JOURNAL OF COMPARATIVE NEUROLOGY 458 (1): 1-10 MAR 24 2003。