個人經(jīng)歷
2006年8月，進(jìn)入美國伊利諾伊大學(xué)芝加哥校區(qū)從事博士后研究，主攻藥物化學(xué)方向；2009年8月，就職于華東師范大學(xué)生命科學(xué)學(xué)院生命醫(yī)學(xué)研究所，擔(dān)任副教授，課題組研究方向為藥物化學(xué)。
研究方向
化學(xué)生物學(xué)、藥物化學(xué)
學(xué)術(shù)成就
1. Alan P. Kozikowski*, Yihua Chen, Tapadar Subhasish, Nancy E. Lewin, Peter M. Blumberg, Zhenyu Zhong, Melissa A. D’’Annibale, Wenglong Wang, Yong Shen, Brett C. Langley. Searching for Disease Modifiers - PKC Activation and HDAC Inhibition - A Dual Drug Approach to Alzheimer’’s Disease that Reduces Aβ Production while Blocking Oxidative Stress. ChemMedChem. 2009, 4, 1095-1105.
2. Rong He, Yufeng Chen, Yihua CHen, Andrei V. Ougolkov, Jin-San Zhang, Doris N. Savoy, Daniel D. Billadeau, Alan P. Kozikowski, Synthesis and Biological Evaluation of Triazol-4-ylphenyl-Bearing Histone Deacetylase Inhibitors as Anticancer Agents. J. Med. Chem. 2010.53.1347-1356.
3. Yufeng Chen, Rong He, Yihua Chen, Melissa A. D’’Annibale, Brett C. Langley, Alan P. Kozikowski. Studies of Benzamide- and Thiol-Based Histone Deacetylase Inhibitors in Models of Oxidative Stress-Induced Neuronal Death u2013 Identification of Some HDAC3 Selective Inhibitors. ChemMedChem, 2009, 4, 842-852.
4. Alan P. Kozikowski, J. Brek Eaton, Krishina Mohan Bajjuri, Sheela K. Chellappan, Yihua Chen, Barbara Caldarone, Michael Manzano, Ronald J. Lukas. Chemistry and Pharmacology of New Nicotinic Ligands: 6-[5-(Azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol [AMOP-H-OH, aka Sazetidine A] Based Ligands for Possible Use in Depression. ChemMedChem, 2009, 4, 1279-12914.
5. Yihua Chen, Wen-Long Wang, Rong He, Nancy E. Lewin, Peter M. Blumberg, Alan P. Kozikowski. Design, Synthesis and Biological Evaluation of Ether-Bearing Benzolactam-V8 Derivatives as Potent Modulators for Protein Kinase C. (In Preparation)
6. Jun-Qing Du, Jian Wu, Hua-Jie Zhang, Ya-Hui Zhang, Bei-Ying Qiu, Fang Wu, Yi-Hua Chen, Jing-Ya Li, Fa-Jun Nan, Jian-Ping Ding, and Jia Li. Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species. J. Biol. Chem. 2008, 283, 30205-30215.
7. Xue-Qin Ma, Hua-Jie Zhang, Ya-Hui Zhang, Yi-Hua Chen, Fang Wu, Jun-Qing Du, Hai-Ping Yu, Zhong-Liang Zhou, Jing-Ya Li, Fa-Jun Nan, Jia Li. Novel irreversible caspase-1 inhibitor attenuates the maturation of intracellular interleukin-1Biochem. Cell Biol. 2007, 85, 56-65.
8. Ya-Hui Zhang, Hua-Jie Zhang, Fang Wu, Yi-Hua Chen, Xue-Qin Ma, Jun-Qin Du, Zhong-Liang Zhou, Jing-Ya Li, Fa-Jun Nan, Jia Li. Isoquinoline-1,3,4-trione and its derivatives attenuate ?-amyloid-induced apoptosis of neuronal cells. FEBS J. 2006, 273, 4842-4852.
9. Yi-Hua Chen, Ya-Hui Zhang, Hua-Jie Zhang, Da-Zhi Liu, Min Gu, Jing-Ya Li, Fang Wu, Xing-Zu Zhu, Jia Li, Fa-Jun Nan. Design, synthesis and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J. Med. Chem. 2006, 49, 1613-1623.
10. Ya Zhao, Wen Zhang, Yi-Hua Chen, Fa-Jun Nan, Yue-Wei Guo. Oblongifolinol, a new long chain diol from bark of Litsea rotundnifolia var. oblongifolia. Nat. Prod. Res. 2006, 20, 107-111.
11.Yihua Chen, Huajie Zhang,and Fajun Nan. Construction of a 3-Amino-2-pyridone Library by Ring-Closing Metathesis of a-Amino Acrylamide. J. Comb. Chem., 2004, 6, 684-687.
12. Yi-Hua Chen, Gang Liu, Hua-Jie Zhang, Yu-Lin Li, Fa-Jun Nan. RCM Reaction of ?-amino-acrylamide and its Application in Synthesizing Bioactive Natural Products. Chinese Organic Chemistry (suppl) 2004, 24, 383.
13. Fa-Jun Nan, Jia Li, Yi-Hua Chen, Ya-Hui Zhang, Min Gu, Hua-Jie Zhang, The Preparation and Application of isoquinoline-1,3,4-trione derivatives (2004). PCT/CN2004/000567.
14. Alan P. Kozikowski, Yihua Chen. Method of Treating Neurological Diseases. WO2010/017272 A2
