基本介紹
楊子恒 ( Ziheng Yang )
職 稱: 研究員
職 務(wù): 博士生導(dǎo)師
學(xué)科類別: 遺傳學(xué) 貝葉斯統(tǒng)計(jì) 生物信息學(xué)
工作經(jīng)歷
2010至今: Director, R.A. Fisher 計(jì)算生物學(xué)中心，倫敦大學(xué)學(xué)院
2010至今: R.A. Fisher 統(tǒng)計(jì)遺傳學(xué)教授，遺傳進(jìn)化與環(huán)境系，倫敦大學(xué)學(xué)院
2006: 皇家科學(xué)院院士
2001-2010: 統(tǒng)計(jì)遺傳學(xué)教授，生物系，倫敦大學(xué)學(xué)院
2000-2001: 進(jìn)化遺傳學(xué)高級(jí)講師, 生物系, Galton 實(shí)驗(yàn)室, 倫敦大學(xué)學(xué)院
1997-2000:講師, 生物系, Galton 實(shí)驗(yàn)室, 倫敦大學(xué)學(xué)院.
1995-1997: 博士后, 綜合生物學(xué)系, 加州大學(xué)伯克利分校
1994-1995:博士后, 分子進(jìn)化與遺傳學(xué)院, 賓夕法尼亞州立大學(xué).
1993-1994: 博士后，動(dòng)物科學(xué)系, 倫敦自然歷史博物館
1992-1993: 博士后，動(dòng)物科學(xué)系, 劍橋大學(xué).
1992-1997: 講師，動(dòng)物科學(xué)系，北京農(nóng)業(yè)大學(xué).
1987-1989: 講師，動(dòng)物科學(xué)系，北京農(nóng)業(yè)大學(xué)
主要研究領(lǐng)域
遺傳學(xué) 貝葉斯統(tǒng)計(jì) 生物信息學(xué)
承擔(dān)科研項(xiàng)目情況
本研究組從事群體遺傳學(xué)，統(tǒng)計(jì)基因組學(xué)，計(jì)算生物學(xué)方面的研究。主要是開(kāi)發(fā)分析遺傳學(xué)基因組學(xué)數(shù)據(jù)的統(tǒng)計(jì)學(xué)方法及計(jì)算機(jī)軟件。大量使用極大似然法，貝葉斯方法，MCMC等計(jì)算機(jī)模擬算法，并與生物遺傳學(xué)家合作開(kāi)展數(shù)據(jù)分析工作。
代表論著
1. Z. Yang. 2014. Molecular Evolution: A Statistical Approach, Oxford University Press, in press
2. dos Reis, M., T. Zhu, and Z. Yang. 2014. The impact of the rate prior on Bayesian estimation of divergence times with multiple loci. Systematic Biology submitted
3. Yoder, A. D., L. M. Chan, M. dos Reis, P. A. Larsen, C. R. Campbell, R. Rasolarison, M. Barrett, C. Roos, P. Kappeler, J. P. Bielawski, and Z. Yang. 2014. Molecular evolutionary characterization of a V1R subfamily unique to Strepsirrhine primates. Genome Biology and Evolution, in press
4. dos Reis, M.*, M. J. Donoghue, and Z. Yang. 2014. Neither phylogenomic nor palaeontological data support a Paleogene origin of placental mammals. Biology Letters, in press
5. Leaché AD, Harris RB, Rannala B, Yang Z. 2014. The influence of gene flow on species tree estimation: a simulation study. Systematic Biology
6. Yang Z., and C.E. Rodríguez. 2013. Searching for efficient Markov chain Monte Carlo proposal kernels. Proceedings of the National Academy of Sciences of U.S.A.
7. Rannala B, Yang Z. 2013. Molecular clock dating. pages 68-74 in Princeton Handbook of Evolution (ed. D.A. Baum).
8. dos Reis, M., and Z. Yang. 2013. Why do more divergent sequences produce smaller nonsynonymous/synonymous rate ratios in pairwise sequence comparisons? Genetics
9. Stadler T, Yang Z 2013. Dating phylogenies with sequentially sampled tips. Systematic Biology
10. Zou X-H, Yang Z, Doyle JJ & Ge S. 2013. Multilocus estimation of divergence times and ancestral effective population sizes of Oryza species and implications for the rapid diversification of the genus. New Phytologist
11. Rannala, B, and Yang, Z. 2013. Improved reversible jump algorithms for Bayesian species delimitation. Genetics
12. dos Reis, M., and Z. Yang. 2013. The unbearable uncertainty of Bayesian divergence time estimation. Journal of Systematics and Evolution
13. dos Reis M., Inoue J., Hasegawa M., Asher R., Donoghue P.C., Yang Z. 2012. Phylogenomic data sets provide both precision and accuracy in estimating the timescale of placental mammal evolution. Proc. R. Soc. Lond. B. Biol. Sc
14. Zhai W, Nielsen R, Goldman N, Yang Z. 2012. Looking for Darwin in genomic sequences - validity and success of statistical methods. Molecular Biology and Evolution
15. Zhu T, Yang Z. 2012. Maximum likelihood implementation of an isolation-with-migration model with three species for testing speciation with gene flow. Molecular Biology and Evolution
16. Zhang C, Rannala B, Yang Z. 2012. Robustness of compound Dirichlet priors for Bayesian inference of branch lengths. Systematic Biology
17. Yang Z., Rannala B. 2012. Molecular phylogenetics: principles and practice. Nature Review Genetics
18. Parham, J, Donoghue, P, Bell, C, Calway, T, Head, J, Holroyd, P, Inoue, J, Irmis, R, Joyce, W, Ksepka, D, Patane, J, Smith, N, Tarver, J, van Tuinen, M, Yang, Z, Angielczyk, K, Greenwood, J, Hipsley, C, Louis, J, Makovicky, P, Mueller, J, Smith, K, Theodor, J, Warnock, R and Benton, M, 2012. Systematic Biology
19. Warnock, R.C.M., Z. Yang, and P.C.J. Donoghue. 2012. Exploring uncertainty in the calibration of the molecular clock.
20. Rannala B., Zhu T., Yang Z. 2012. Tail paradox, partial identifiability and influential priors in Bayesian branch length inference. Molecular Biology and Evolution
21. Zhang C., Zhang D.-X., Yang Z. 2011. Evaluation of a Bayesian coalescent method of species delimitation. Systematic Biology
22. Brown RP, Yang Z. 2011. Rate variation and estimation of divergence times using strict and relaxed clocks. BMC Evolutionary Biology
23. Zang, L.-L., X.-H. Zou, F.-M. Zhang, Z. Yang, S. Ge, 2011 Phylogeny and species delimitation of the C-genome diploid species in Oryza. Journal of Systematics and Evolution
24. Groussin M., Pawlowski J., Yang Z. 2011. Bayesian relaxed clock estimation of divergence times in Foraminifera. Molecular Phylogenetics and Evolution,
25. Yoshida I, Sugiura W, Shibata J, Ren F, Yang Z, Tanaka H. 2011. Change of positive selection pressure on HIV-1 envelope gene inferred by early and recent samples
26. dos Reis M, Yang Z. 2011. Approximate likelihood calculation for Bayesian estimation of divergence times. Molecular Biology and Evolution
27. Zhu, T., Y. Hu, Z. Ma, D.-X. Zhang, T. Li, and Z. Yang. 2011. Efficient simulation under a population genetics model of carcinogenesis. Bioinformatics
28. Yang Z., dos Reis M. 2011. Statistical properties of the branch-site test of positive selection. Molecular Biology and Evolution
29. Wilkinson RD, Steiper ME, Soligo C, Martin RD, Yang Z, Tavare S. 2011. Dating primate divergences through an integrated analysis of palaeontological and molecular data. Systematic Biology
社會(huì)任職
分子生物與進(jìn)化學(xué)會(huì)會(huì)員；系統(tǒng)生物學(xué)家協(xié)會(huì)會(huì)員；曾任《遺傳學(xué)》、《分子生物學(xué)與進(jìn)化》和《分子系統(tǒng)學(xué)》等雜志副主編
獲獎(jiǎng)及榮譽(yù)
2010年 晉升為R.A. Fisher 講座教授
2010年 倫敦動(dòng)物學(xué)會(huì)Frink獎(jiǎng)
2006年 評(píng)選為皇家科學(xué)院院士
