Guiyou Liu,Qinghua Jiang*. Alzheimer’s disease CD33 rs3865444 variant does not contribute to congnitive performance. 2016. PNAS. DOI: 10.1073/pnas.1600852113 (SCI IF: 9.674) (*通訊作者）Guiyou Liu,Qinghua Jiang, Yongshuai Jiang, Keshen Li. Junwei Hao*. Ischaemic stroke variants from genome-wide association studies and Alzheimeru2019s disease susceptibility. Annals of Neurology. 2016. (SCI IF: 9.977) (Accepted)Qinghua Jiang, Guiyou Liu*. Lack of association between MC1R variants and Parkinsonu2019s disease in European descent. 2016. Annals of Neurology. DOI: 10.1002/ana.24627 (SCI IF: 9.977)Qinghua Jiang, Guiyou Liu*. REST rs3796529 variant does not influence human subcortical brain structures. Annals of Neurology. 2016 Feb;79(2):334-5. (SCI IF: 9.977)Qinghua Jiang#, Shuilin Jin#, Yongshuai Jiang, Mingzhi Liao, Rennan Feng,Liangcai Zhang, Guiyou Liu*, Junwei Hao*. Alzheimer’s disease variants with the genome-wide significance are significantly enriched in immune pathways and active in immune cells. 2016. doi:10.1007/s12035-015-9670-8. Molecular Neurobiology. (SCI, IF: 5.137)Guiyou Liu#, Yining Xu#, Yongshuai Jiang, Mingzhi Liao, Rennan Feng,Qinghua Jiang*. PICALM rs3851179 variant confers susceptibility to Alzheimer’s disease in Chinese population. 2016. Molecular Neurobiology. (SCI, IF: 5.137) (Accepted) (*通訊作者）Yining Xu,Qinghua Jiang, Guiyou Liu*. PICALM rs3851179 variant and Alzheimer’s disease in Asian population. 2016. NeuroMolecular Medicine. (SCI, IF: 3.678) (Accepted)Weiyang Bai, Wen Yang, Wenjing Wang, Yang Wang, Can Liu,Qinghua Jiang, Jinlian Hua, Mingzhi Liao*. GED: a manually curated comprehensive resource for epigenetic modification of gametogenesis. Briefings in Bioinformatics. 2016 Feb 5. pii: bbw007. (SCI, IF: 9.617)

Jiang QH, Wang JX, Wu XL, Ma R, Jin SL, Han ZJ, Tan RJ, Peng JJ, Liu GY, Li Y, Wang YD*. LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression. 2015. Nucleic Acids Research. DOI 10.1093/nar/gku1173 (SCI, IF: 9.112)Jiang QH, Ma R, Wang JX, Wu XL, Jin SL, Peng JJ, Tan RJ, Zhang TJ, Li Y, Wang YD*. LncRNA2Function: a comprehensive resource for functional investigation of human lncRNAs based on RNA-seq data. 2015. BMC genomics. 16(s3):s2. (SCI, IF: 3.986)Han ZJ,Jiang QH*, Zhang TJ, Wu XL, Ma R, Wang JX, Bai Y, Wang RJ, Tan RJ, Wang YD*. Analyzing large-scale samples confirms the association between the rs1051730 polymorphism and lung cancer susceptibility. 2015. Scientific Reports. (Accepted) (SCI, IF: 5.578) (*通訊作者）Zhang SY, Li X, Ma G, Jiang YS, Liao MZ, Feng RN, Zhang LC, Liu JF, Wang GY, Zhao B,Jiang QH*, Li KS*, Liu GY*. CLU rs9331888 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Caucasian But Not East Asian Populations. 2015. Molecular Neurobiology, 53(3), 1446-1451. (*通訊作者) (SCI, IF: 5.137)Li YN, Song DJ, Jiang YS, Wang J, Feng R, Zhang LC, Wang GY, Chen ZG, Wang RZ*,Jiang QH*, Liu GY*. CR1 rs3818361 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Chinese Population. Molecular Neurobiology. 2015 July 21. [Epub ahead of print]. (*通訊作者) (SCI, IF: 5.137)Li KS,Jiang QH, Xu AD, Liu GY. REST rs3796529 variant does not confer susceptibility to Alzheimer’s disease. Annals of Neurology. 2015 Aug 18. doi: 10.1002/ana.24503. [Epub ahead of print] (SCI IF: 9.977)Guiyou Liu, Yongquan Liu,Qinghua Jiang, Yongshuai Jiang, Rennan Feng, Liangcai Zhang, Zugen Chen, Keshen Li , Jiafeng Liu. Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinsonu2019s Disease Susceptibility. Molecular Neurobiology. 2015. DOI 10.1007/s12035-015-9416-7. (SCI, IF: 5.137)Bai Y, Ji SF,Jiang QH, Wang YD. Identification exon skipping events from high-throughput RNA sequencing data. IEEE Transactions on NanoBioscience. 2015 Jul;14(5):562-9 (SCI IF: 2.309)Xinjie Bao, Gengfeng Chen, Yongshuai Jiang,Qinghua Jiang, Mingzhi Liao, Rennan Feng, LiangcaiZhang, Guoda Ma, Shuyan Zhang, Zugen Chen, Bin Zhao, Renzhi Wang*, Keshen Li*, Guiyou Liu*. Cell adhesion molecules pathways genes are regulated by cis-regulatory SNPs and show significantly altered expression in Alzheimeru2019s disease brains. Neurobiol Aging. 2015 Jun 12 (SCI, IF: 5.013)Xiao Zhu, Henry C.M. Leung, Rongjie Wang, Francis Y.L. Chin, Siu Ming Yiu, Guangri Quan, Yajie Li, Rui Zhang,Qinghua Jiang, Bo Liu, Yucui Dong, Guohui Zhou, Yadong Wang. misFinder: Identify mis-assemblies in an unbiased manner using reference and paired-end reads. BMC Bioinformatics. 2015 (Accepted) (SCI IF: 2.44)Peng JJ, Li HX, Liu YZ, Juan LR,Jiang QH, Wang YD*. InteGO2: a web tool for measuring and visualizing gene semantic similarities using Gene Ontology. BMC Bioinformatics. 2015 (Accepted) (SCI, IF: 2.576)Zhu X, Leung HC, Wang R, Chin FY, Yiu SM, Quan G, Li Y, Zhang R,Jiang Q, Liu B, Dong Y, Zhou G, Wang Y. misFinder: identify mis-assemblies in an unbiased manner using reference and paired-end reads. BMC Bioinformatics. 2015 Nov 16;16(1):386 (SCI, IF: 2.576)

Jiang QH, Wang JX, Wu XL, Ma R, Jin SL, Han ZJ, Tan RJ, Peng JJ, Liu GY, Li Y, Wang YD. LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression. 2014.Nucleic Acids Research. DOI 10.1093/nar/gku1173 (SCI,IF: 8.808)Quan BK, Qi XS, Yu ZH, Jiang YS, Liao MZ, Wang GY, Feng RN, Zhang LC, Chen ZG,Jiang QH*, Liu GY*. Pathway analysis of genome-wide association study and transcriptome data highlights new biological pathways in colorectal cancer. 2014.Molecular Genetics and Genomics. DOI 10.1007/s00438-014-0945-y. (*通訊作者) (SCI,IF: 2.831)Liu GY, Bao XJ, Jiang Y,S Liao MZ,Jiang QH, Feng RN, Zhang LC, Ma GD, Chen ZG, Wang GY, Wang RZ, Zhao B, Li KS.Identifying the Association Between Alzheimer’s Disease and Parkinson’s Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network. 2014.Molecular Neurobiology. DOI 10.1007/s12035-014-8946-8 (SCI,IF=5.286)Li X, Shen N, Zhang SY, Liu JF,Jiang QH, Liao MZ, Feng RN, Zhang LC, Wang GY, Ma GD, Zhou HH, Chen ZG, Jiang YS*, Zhao B*, Li KS*, Liu GY* (2014) CD33 rs3865444 polymorphism contributes to Alzheimeru2019s disease susceptibility in European and North American but not Asian populations.Molecular Neurobiology. DOI 10.1007/s12035-014-8880-9 (SCI,IF=5.286)Xiang ZM, Xu ML, Liao MZ, Jiang YS,Jiang QH, Feng RN, Zhang LC, Ma GD, Wang GY, Chen ZG, Zhao B, Sun TS*, Li KS*, Liu GY* (2014) Integrating genome-wide association study and brain expression data highlights cell adhesion molecules and purine metabolism in Alzheimeru2019s disease.Molecular Neurobiology. DOI 10.1007/s12035-014-8884-5 (SCI,IF=5.286)Peng JJ, Li HX,Jiang QH, Wang YD, Chen J. TITLE: An Integrative Approach for Measuring Semantic Similarities using Gene Ontology.BMC systems biology. 2014, 8 (Suppl 5): S8 (SCI,IF: 2.853)Tan RJ, Wang YD, Kleinstein S, Liu YZ, Zhu XL,Jiang QH, Zhu MF. An Evaluation of Copy Number Variation Detection Tools from Whole-Exome Sequencing Data.Human mutation.2014 Mar 5. doi: 10.1002/humu.22537. [Epub 2014 May 1] (SCI,IF: 5.213)Jin SL, Tan RJ,Jiang QH, Xu L, Peng JJ, Wang Y, Wang YD. A generalized topological entropy for analyzing the complexity of DNA sequences.PLoS One. 2014 Feb 12;9(2):e88519 (SCI,IF: 3.73)Jiang QH, Wang JX, Wang YD, Ma R, Wu XL, Li Y. TF2LncRNA: Identifying common transcription factors for a list of lncRNA genes from ChIP-Seq data.BioMed Research International. vol. 2014, Article ID 317642, 5 pages, 2014. doi:10.1155/2014/317642 (SCI,IF: 2.706)

Jiang QH, Wang GH, Li Y, Jin SL, Wang YD. Predicting Human microRNA-disease Associations Based on Support Vector Machine. International Journal of Data Mining and Bioinformatics. 2013.vol.8, No.3. 282-239

Jin SL, Xu L,Jiang QH*, Duan GR. A Joint Spectral Characterization of C* Independence. Infinite Dimensional Analysis Quantum Probability and Related Topics. Vol. 15, No. 2 (2012) 1250013:1-5 ( *通訊作者)Jin SL, Jiang QH*, Wang YD*, Duan GR. On joint spectrum of infinite direct sums. Operators and Matrices. Vol. 6, No. 3 (2012), 529u2013533 ( *通訊作者)Jin SL, Xu L, Jiang QH* and L Li*. Conditions equivalent to C* independence, Studia Math. 2012,211, 191-197 ( *通訊作者)Jin SL, Xu L, Jiang QH. Joint Spectrum and Joint Distribution. Complex analysis and operator theory. 2012. DOI 10.1007/s11785-012-0258-2

Zhu SJ, Jiang QH, Wang GH, Liu B, Teng MX, Wang YD. Chromatin structure characteristics of pre-miRNA genomic sequences. BMC genomics.2011. 12(1):329.

Jiang QH, Hao YY, Wang GH, Juan LR, Zhang TJ, Teng MX, Liu YL, Wang YD. Prioritization of disease microRNAs through a human phenome-microRNAome network, Bmc Systems Biology, 2010, 4 Suppl 1, S2.Jiang QH, Hao YY, Wang GH, Zhang TJ, Wang YD. Weighted network-based inference of human microRNA-disease associations. The 5th International Conference on Frontier of Computer Science and Technology - Workshop on Bioinformatics and System Biology. 2010. 431-435Jiang QH, Wang GH, Wang YD. An approach for prioritizing disease-related microRNAs based on genomic data integration. The 3rd International Conference on BioMedical Engineering and Informatics. 2010. 2270-2274

Jiang QH, Wang YD, Hao YY, Juan LR, Teng MX, Zhang XJ, Li MM, Wang GH, Liu YL. miR2Disease: a manually curated database for microRNA deregulation in human disease. Nucleic Acids Res．2009，37: D98-104

本課程主要介紹生物信息學(xué)基本概念及特點(diǎn)、常用生物數(shù)據(jù)庫、基因組瀏覽器、Linux系統(tǒng)常用命令、R語言編程、基因芯片原理及數(shù)據(jù)分析、新一代DNA測序技術(shù)原理及其數(shù)據(jù)分析、生物信息學(xué)熱點(diǎn)問題分析等內(nèi)容。通過本課程的講授，旨在使學(xué)生了解生命科學(xué)學(xué)術(shù)前沿技術(shù)及研究問題、培養(yǎng)學(xué)生運(yùn)用所學(xué)的數(shù)據(jù)分析技術(shù)解決生命科學(xué)中前沿問題的能力，為今后從事生命科學(xué)研究奠定基礎(chǔ)。

2017年招生：博士生2名，碩士生3名，歡迎計(jì)算機(jī)、數(shù)學(xué)、生物、生物信息學(xué)等相關(guān)專業(yè)的同學(xué)報(bào)考。

蔣慶華教授歡迎所有喜歡閱讀頂級期刊論文，希望在哈工大生命學(xué)院攻讀碩士學(xué)位并以發(fā)表學(xué)術(shù)論文為樂趣的有志青年加入他的研究團(tuán)隊(duì)，有意者可致信qhjiang at hit.edu.cn。

對于沒有任何編程及信息技術(shù)基礎(chǔ)的學(xué)生，蔣慶華教授會用大約半年的時(shí)間與他們一起學(xué)習(xí)經(jīng)典實(shí)用的編程語言（R、Python等），指導(dǎo)學(xué)生掌握基本的統(tǒng)計(jì)與數(shù)據(jù)挖掘方法，發(fā)現(xiàn)并跟蹤最前沿的生命科學(xué)熱點(diǎn)問題，并用所學(xué)的編程技能及信息學(xué)方法解決這些問題。

蔣慶華教授鼓勵(lì)他的學(xué)生將科研作為畢生的追求和事業(yè)，支持他的學(xué)生在畢業(yè)后繼續(xù)攻讀博士學(xué)位（出國攻博或公派出國進(jìn)行二年的博士生聯(lián)合培養(yǎng)）。