人物履歷
1982年 獲浙江醫(yī)科大學(xué)醫(yī)學(xué)學(xué)士學(xué)位。
1988年 獲浙江醫(yī)科大學(xué)醫(yī)學(xué)碩士學(xué)位。
1998年 獲香港大學(xué)博士學(xué)位。
1998-2005,美國辛辛那提大學(xué),加拿大卡爾加里大學(xué)博士后。
2005-2008,加拿大卡爾加里大學(xué)Assistant Professor。
2009年至今浙江大學(xué)教授,博士生導(dǎo)師。
研究方向
細(xì)胞信號(hào)傳導(dǎo)和干細(xì)胞分化。
主要貢獻(xiàn)
在FASEB J,JBC,Am J Physiol,JPET,Biophysical J, Br J Pharmacol,Biopysical J, J Clin Endocrinol Metab, Biol Reprod,Human Reproduction 等SCI雜志發(fā)表論文數(shù)十篇。
實(shí)驗(yàn)室隸屬生殖遺傳教育部重點(diǎn)實(shí)驗(yàn)室。擁有離子熒光成像,熒光顯微鏡,膜片鉗,細(xì)胞內(nèi)微注射,小血管收縮,無創(chuàng)傷小動(dòng)物動(dòng)脈血壓檢測(cè),實(shí)時(shí)RNA檢測(cè),酶標(biāo)儀,以及其它分子生物學(xué),生物化學(xué)和生理學(xué)實(shí)驗(yàn)設(shè)備。
在研基金
1. 國家重大科學(xué)研究計(jì)劃:雌性生育力維持調(diào)節(jié)機(jī)制研究及生殖資源庫建立No.2011CB944500-2011CB944502,250萬,2011.1-2015.12。子項(xiàng)目研究卵母細(xì)胞中水通道在卵母細(xì)胞冰凍保存中的作用。
2. 國家自然科學(xué)基金: 血管內(nèi)皮細(xì)胞FSH受體介導(dǎo)的更年期血管功能紊亂的分子機(jī)制研究。No.81070268,32萬,2011.1-2013.12。
3. 浙江省自然科學(xué)基金: No.Y2100452, 10萬,2010.10-2013.9。
4. 教育部博士點(diǎn)基金:6萬,2011-2013。
5. 浙江省衛(wèi)生廳生殖醫(yī)學(xué)研究團(tuán)隊(duì)建設(shè)基金:50萬,2010-2014。
SCI論文
1. Zhou LB, Zhang RJ, Tan YJ, Ding GL, Shi S, Zhang D, Liu AX, Wang TT, Leung PCK, Sheng JZ*, Huang HF. Identification of estrogen response element in the aquaporin-2 gene that mediates estrogen-induced cell migration and invasion in human endometrial carcinoma. J Clin Endocrinol Metab.2011 accepted (SCI收錄,IF:6.202).
2. Raqeeb A, Sheng JZ,Ao N, Braun A. Purinergic P2Y2 Receptors Mediate Rapid Ca2+ Mobilization, Membrane Hyperpolarization and Nitric Oxide Production in Human Vascular Endothelial Cells. Cell Calcium 2011 Apr;49(4):240-8. (SCI收錄,IF:4.288).
3. Liu AX, He WH, Yin LJ, Lv PP, Zhang Y, Sheng JZ, Leung PCK, Huang HF. Sustained endoplasmic reticulum stress as a cofactor of oxidative stress in decidual cells from patients with early pregnancy loss. J Clin Endocrinol Metab.2011 Mar;96(3):E493-7. (SCI收錄,IF:6.202).
4. Wang TT, Wu YT, Dong MY, Sheng JZ, Leung PCK, Huang HF. G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve. Fertil Steril. 2010 Nov;94(6):2490-2.(SCI收錄,IF:3.970).
5. Qu F, Wang FF, Lu XE, Dong MY, Sheng JZ, Lv PP, Ding GL, Shi BW, Zhang D, Huang HF. Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. Hum Reprod. 2010, 25(6):1441-450.(SCI收錄,IF:3.859).
6. Yang Y, Wu X, Gui P, Wu J, Sheng JZ, Ling S, Braun AP, Davis GE, Davis MJ. Alpha5beta1 integrin engagement increases large conductance, Ca2+-activated K+ channel current and Ca2+ sensitivity through c-src-mediated channel phosphorylation. J Biol Chem. 2010 Jan 1;285(1):131-41.(SCI收錄,IF:5.520).
7. Tang L, Zhang Y, Pan H, Luo Q, Zhu XM, Dong MY, Leung PC, Sheng JZ, Huang HF. Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell. Reprod Biol Endocrinol. 2009 Dec 7;7:144(SCI收錄,IF:2.634).
8. Sheng JZ, Ella S, Hill M, Davis M, Braun A. Openers of SKCa and IKCa Channels Enhance Agonist-evoked Endothelial Nitric Oxide Synthesis and Arteriolar Vasodilation. FASEB J. 2009 Apr;23(4):1138-45 (SCI收錄,IF:7.049).