· 2014年，獲得安永復(fù)旦“中國(guó)最具潛力種子企業(yè)獎(jiǎng)”

· 2014年，獲得吉林省自然科學(xué)學(xué)術(shù)成果二等獎(jiǎng)

項(xiàng)目：螺旋型抗菌肽的從頭設(shè)計(jì)及作用機(jī)理研究

獲獎(jiǎng)人：陳育新、黃宜兵、劉 煜、黃金豐、李桂榮、何麗艷、翟乃翠、趙連靜

編號(hào)：20142038

· 2014年，獲得中華全國(guó)歸國(guó)華僑聯(lián)合會(huì)“第五屆中國(guó)僑界創(chuàng)新成果貢獻(xiàn)獎(jiǎng)”

· 2014年，獲得江陰市國(guó)家高新區(qū)“科技領(lǐng)軍型團(tuán)隊(duì)”

· 2013年，獲得吉林省“第四批拔尖創(chuàng)新人才第二層次人選”

· 2013年，獲得長(zhǎng)春市政府“友誼獎(jiǎng)”

· 2013年，獲得江陰市國(guó)家高新區(qū)“科技領(lǐng)軍型團(tuán)隊(duì)”

· 2013年。獲得江陰市國(guó)家高新區(qū)“海歸創(chuàng)業(yè)先鋒”

· 2012年，獲得吉林省科技進(jìn)步三等獎(jiǎng)

項(xiàng)目：細(xì)胞膜活性多肽抗菌及抗癌活性及作用機(jī)理研究

獲獎(jiǎng)人：陳育新、黃宜兵、劉煜、黃金豐、王笑非、王紅葉

編號(hào)：2012J30075

· 2012年，獲得長(zhǎng)春市 “第五批有突出貢獻(xiàn)專家”稱號(hào)

· 2012年，獲得長(zhǎng)春市 “優(yōu)秀外國(guó)專家”稱號(hào)

· 2012年，獲得長(zhǎng)春市“五四”青年獎(jiǎng)?wù)?/p>

· 2012年，獲得江陰市國(guó)家高新區(qū)“科技領(lǐng)軍型團(tuán)隊(duì)”

· 2011年，獲得國(guó)家人社部“留學(xué)人員科技創(chuàng)新創(chuàng)業(yè)項(xiàng)目擇優(yōu)資助”

· 2011年，入選吉林省“百千萬(wàn)”人才工程

· 2011年，獲得吉林省人民政府人才開發(fā)基金

· 2011年，獲得長(zhǎng)春市“優(yōu)秀外資企業(yè)家”稱號(hào)

· 2011年，入選江蘇省“333”人才工程第三層次計(jì)劃

2011年，獲得江陰市經(jīng)濟(jì)開發(fā)區(qū)“科技領(lǐng)軍型團(tuán)隊(duì)”

· 2010年，獲得人社部“留學(xué)人員科技創(chuàng)新創(chuàng)業(yè)項(xiàng)目擇優(yōu)資助”

· 2010年，入選人社部“留學(xué)人員回國(guó)創(chuàng)業(yè)啟動(dòng)支持計(jì)劃”

· 2010年，入選江蘇省“企業(yè)博士聚集計(jì)劃”

· 2010年， 享受長(zhǎng)春市“政府特殊津貼”

· 2010年，獲得江陰市經(jīng)濟(jì)開發(fā)區(qū)“科技領(lǐng)軍型團(tuán)隊(duì)”

· 2009年12月，獲得國(guó)務(wù)院僑辦第二屆“百名華人華僑專業(yè)人士杰出創(chuàng)業(yè)獎(jiǎng)”

· 2009年12月，獲得國(guó)務(wù)院僑辦首批“重點(diǎn)華人華僑創(chuàng)業(yè)團(tuán)隊(duì)”

· 2008年12月，項(xiàng)目獲得ChinaBio風(fēng)投高峰論壇“最具投資潛力企業(yè)獎(jiǎng)”

· 2008年，獲得無錫市“530”計(jì)劃項(xiàng)目

· 2007年，獲得吉林省“杰出青年基金”

· 2007年，獲得長(zhǎng)春市高新區(qū)“科技創(chuàng)業(yè)先進(jìn)個(gè)人”

· 2006年，獲得長(zhǎng)春市高新區(qū)“科技創(chuàng)業(yè)優(yōu)秀獎(jiǎng)”

· 2004 年，獲得加拿大阿爾伯塔大學(xué) “J. Gordin Kaplan Graduate Student Award”

· 1999 年，獲得加拿大阿爾伯塔大學(xué) “University of Alberta Ph.D. Scholarship”

2014年無錫市330高層次領(lǐng)軍團(tuán)隊(duì)計(jì)劃

300萬(wàn)元

題目：基于抗菌肽的靶向抗腫瘤納米藥物研發(fā)與產(chǎn)業(yè)化

起止時(shí)間：2015.3-2018.2

2014年吉林省科技廳重大科技攻關(guān)項(xiàng)目（項(xiàng)目負(fù)責(zé)人）

50萬(wàn)元

題目：1.1新藥抗菌肽滴眼液篩選研究與開發(fā)

編號(hào)：20140203010YY 起止時(shí)間：2014.1-2016.12

2014年國(guó)家自然科學(xué)基金面上項(xiàng)目（項(xiàng)目負(fù)責(zé)人）

75萬(wàn)元

題目：膜活性肽對(duì)不同類型細(xì)胞膜親和機(jī)制的研究

編號(hào)：81373455 起止時(shí)間：2014.1-2017.12

2013年吉林大學(xué)基本科研業(yè)務(wù)費(fèi)項(xiàng)目─平臺(tái)基地建設(shè)項(xiàng)目

5萬(wàn)元

題目：抗腫瘤Miniprotein的設(shè)計(jì)及機(jī)理研究

起止時(shí)間：2013.1-2014.12

2013年吉林大學(xué)發(fā)明專利種子基金

0.5萬(wàn)元

題目：提高多肽固相合成效率的二甲苯溶劑配方及應(yīng)用

專利號(hào)：ZL2010101851296 2013年第七批138號(hào)

2012年國(guó)家科學(xué)技術(shù)部“重大新藥創(chuàng)制”科技重大專項(xiàng)“十二五”項(xiàng)目

147.93萬(wàn)

題目：抗耐藥菌的抗菌肽候選藥物研究

編號(hào)：2012ZX09103101-065 起止時(shí)間：2012.1-2015.12

2012年吉林省新型抗耐藥菌多肽藥物研究創(chuàng)新團(tuán)隊(duì)

20萬(wàn)元

題目：新型抗耐藥菌多肽藥物的設(shè)計(jì)及機(jī)理研究

編號(hào)：20121807 起止時(shí)間：2012.1-2014.12

2011年國(guó)家科技部“科技型中小企業(yè)技術(shù)創(chuàng)新基金”（成長(zhǎng)型）

90萬(wàn)

題目：I類抗菌肽新藥PL-5臨床前研究

編號(hào)：11C26212214338 起止時(shí)間：2011.6-2013.6

2011年江蘇省科技廳“江蘇省科技型企業(yè)技術(shù)創(chuàng)新資金項(xiàng)目”

25萬(wàn)

題目：國(guó)家I類抗菌新藥—抗菌肽臨床前研究

編號(hào)：BC2011047 起止時(shí)間：2011.4-2014.3

2010年吉林省科學(xué)技術(shù)廳“雙十”項(xiàng)目“重大科技攻關(guān)項(xiàng)目”

300萬(wàn)

題目：I類抗菌新藥樂舒肽（Lysotide）臨床前及I期臨床研究

編號(hào)：10ZDGG006 起止時(shí)間：2010.1-2012.12

2010年長(zhǎng)春市科學(xué)技術(shù)局“長(zhǎng)春市國(guó)際科技合作計(jì)劃”

20萬(wàn)

題目：I類抗菌新藥—樂舒肽的臨床前藥物研究

編號(hào)：10GH03 起止時(shí)間：2010.6-2011.6

2010年吉林省自然科學(xué)基金（項(xiàng)目負(fù)責(zé)人）

5萬(wàn)元

題目：抗菌肽對(duì)原核細(xì)胞膜與真核細(xì)胞膜作用方式的比較研究

編號(hào)：201015103 起止時(shí)間：2010.1-2012.12

2010年吉林省青年基金（第一參加人）

5萬(wàn)元

題目：螺旋度對(duì)抗癌肽活性的貢獻(xiàn)及其抗腫瘤作用機(jī)理的研究

編號(hào)：20100126 起止時(shí)間：2010.9-2012.9

2009年國(guó)家自然科學(xué)基金（主任基金）（項(xiàng)目負(fù)責(zé)人）

10萬(wàn)元

題目：多肽疏水性與帶電性的變化對(duì)抗菌肽作用機(jī)理的影響

編號(hào)：30940016 起止時(shí)間：2010.1-2010.12

2009年吉林大學(xué)科學(xué)前沿與交叉學(xué)科創(chuàng)新項(xiàng)目（項(xiàng)目負(fù)責(zé)人）

5萬(wàn)元

題目：抗菌肽對(duì)口腔細(xì)菌的抗菌活性及機(jī)理研究

編號(hào)：200903095 起止時(shí)間：2010.1-2011.12

2008年教育部博士點(diǎn)基金新教師項(xiàng)目（項(xiàng)目負(fù)責(zé)人）

3.6萬(wàn)元

題目：疏水性對(duì)螺旋型抗菌肽生物活性的影響

編號(hào)：200801831064 起止時(shí)間：2009.1-2010.12

2008年國(guó)家自然科學(xué)基金（主任基金）（項(xiàng)目負(fù)責(zé)人）

9萬(wàn)元

題目：氨基酸取代與疏水性變化對(duì)提高螺旋型抗菌肽特異性及作用機(jī)理的研究

編號(hào)：30840029 起止時(shí)間：2009.1-2009.12

2007年吉林省杰出青年基金 （項(xiàng)目負(fù)責(zé)人）

重點(diǎn)項(xiàng)目 10萬(wàn)元

題目：正電性氨基酸對(duì)提高螺旋型抗菌肽抗菌特異性及作用機(jī)理的研究

編號(hào)：20070111 起止年限：2008.1-2009.12

2007年吉林大學(xué)種子基金 （項(xiàng)目負(fù)責(zé)人）

4萬(wàn)元

2007年吉林大學(xué)引進(jìn)人才啟動(dòng)基金（項(xiàng)目負(fù)責(zé)人）

5萬(wàn)元

2007年吉林大學(xué)985人才引進(jìn)計(jì)劃 （項(xiàng)目負(fù)責(zé)人）

50萬(wàn)元

· 肽類與蛋白類藥物的從頭設(shè)計(jì)與機(jī)理研究

· Irisin對(duì)血糖控制及肥胖調(diào)控的機(jī)理研究

·人工模擬酶研究

·高效液相色譜在蛋白質(zhì)工程與酶學(xué)研究上的應(yīng)用

· 國(guó)家自然科學(xué)基金委同行評(píng)議專家

· 吉林省科技項(xiàng)目評(píng)審專家（醫(yī)藥領(lǐng)域）

· 2012年 丹麥自然科學(xué)基金委（The Danish Council for Independent Research | Natural Sciences）國(guó)際評(píng)審專家

· 2011年南京理工大學(xué)環(huán)境與生物學(xué)院 兼職教授

· 2009年江南大學(xué)醫(yī)藥學(xué)院客座教授

·中國(guó)細(xì)胞生物學(xué)學(xué)會(huì)會(huì)員

·中國(guó)生物物理學(xué)會(huì)會(huì)員

· 吉林省生物化學(xué)與分子生物學(xué)會(huì)會(huì)員

雜志編輯及編委會(huì)委員

· Medicine, Academic Editor

· Pharmacologia, Editorial Board Member

審稿人：

· International Journal of Analytical Chemistry

· Chemical Biology and Drug Design

· Journal of Peptide Science

· Applied Microbiology and Biotechnology

· European Journal of Medicinal Chemistry

· Peptides

· Anti-Cancer Drugs

· 高等學(xué)�；瘜W(xué)學(xué)報(bào)

· 生物化學(xué)與生物物理進(jìn)展

· ScienceAsia

發(fā)表論文：（SCI收錄）

1. Yi, T. H., Sun, S. Y. Huang, Y. B. andChen, Y. X.* Prokaryotic expression and mechanism of action of a-helical antimicrobial peptide A20L using fusion tags,BMC Biotechnol.2015,15, 69

2. Mai, X. T., Huang, J. F., Tan, J. J., Huang, Y. B. andChen, Y. X.*Effects and mechanisms of the secondary structure on the antimicrobial activity and specificity of antimicrobial peptides,J. Pept. Sci.2015,21, 561-568

3. Zhao, J., Huang, Y. B., Liu, D. andChen, Y. X.*Two hits are better than one: synergistic anticancer activity of α-helical peptides and doxorubicin/epirubicin,Oncotarget, 2015,6, 1769-1778

4. Huang, Y. B., Feng, Q., Yan, Q. Y., Hao, X. Y. andChen, Y. X.*Alpha-helical cationic anticancer peptides: a promising candidate of novel anticancer drugs,Mini-Rev. Med. Chem.,2015,15, 73-81

5. Yi, T. H., Huang, Y. B. andChen, Y. X.* Prokaryotic expression and antimicrobial mechanism of xpf-st7-derived α-helical peptides,J. Pept. Sci. 2015,21,46-52

6. Yi, T. H., Huang, Y. B. andChen, Y. X.* Production of an antimicrobial peptide AN5-1 inEscherichia coliand its dual mechanisms against bacteria,Chem. Biol. Drug Des.2015,85,598-607

7. Feng, Q., Huang, Y. B., Chen, M. X., Li, G. R. andChen, Y. X.*Functional synergy of a-helical antimicrobial peptides and traditional antibiotics against Gram-negative and Gram-positive bacteriain vitroandin vivo,Eur. J. Clin. Microbiol.2015,34， 197-204

8. Li, G. R., Huang, Y. B., Feng, Q. andChen, Y. X.*Tryptophan as a probe to study the anticancer mechanism of action and specificity of α-helical anticancer peptides,Molecules2014,19, 12224-12241

9. Tan, J. J., Huang, J. F., Huang, Y. B. andChen, Y. X.* Effects of single amino acid substitution on the biophysical properties and biological activities of an amphipathic a-helical antibacterial peptide against gram-negative bacteria,Molecules2014,19, 10803-10817

10. Huang, Y. B., He, L. Y., Li, G. R., Zhai, N. C., Jiang, H. Y., andChen, Y. X.*Role of helicity of α-helical antimicrobial peptides to improve specificity,Protein Cell2014,5, 631-642

11. Huang Y., Pan L., Zhao L., Mant C. T., Hodges R. S.,Chen Y. X.*. Structure-guided RP-HPLC chromatography of diastereomeric α-helical peptide analogs substituted with single amino acid stereoisomersBiomed. Chromatogr.2014,28, 511-517

12. Zhao, L. J., Huang, Y. B., Gao, S., Cui, Y., He, D., Wang, L.,Chen, Y. X.* Comparison on effect of hydrophobicity on the antibacterial and antifungal activities of a-helical antimicrobial peptides,Sci. China Chem.2013,56, 1307-1314

趙連靜，黃宜兵，高嵩，崔巖，賀丹，王麗，陳育新*，螺旋型抗菌肽的疏水性對(duì)抗細(xì)菌與抗真菌活性的影響比較中國(guó)科學(xué)：化學(xué)， 2013，43，1041-1050

13. Liu, X. Y., Huang, Y. B., Cheng, M., Pan, L., Si, Y. H., Li, G. R., Niu, Y. Q., Zhao, L. J., Zhao, J., Li, X.,Chen, Y. X.*, and Yang, W. Screening and rational design of hepatitis C virus entry inhibitory peptides derived from GB virus A NS5A,J. Virol. 2013, 87, 1649-1657

14. 黃宜兵，翟乃翠，高貴，陳育新，凈電荷對(duì)螺旋型抗癌肽生物活性的影響，高等學(xué)�；瘜W(xué)學(xué)報(bào)，2012，33，1252-1258

15. Huang, Y. B., He, L. Y., Jiang, H. Y., andChen, Y. X.*Role of helicity on the anticancer mechanism of action of cationic-helical peptides,Int. J. Mol. Sci.2012,13, 6849-6862

16. Shan, Y. P., Huang, J. F., Tan, J. J., Gao, G., Liu, S. H., Wang, H. D., andChen, Y. X.*The study of single anticancer peptides interacting with HeLa cell membranes by single molecule force spectroscopy,Nanoscale2012,4, 1283-1286.

17. Li G.R., He L.Y., Liu X.Y., Liu A.P., Huang Y.B., Qiu C., Zhang X.Y., Xu J.Q., Yang W.,Chen Y.X.*Rational Design of Peptides with Anti-HCV/HIV Activities and Enhanced Specificity, Chem. Biol. Drug Des.2011,78, 835-843

18. Dong, A., Lan, S., Huang, J. F., Wang, T., Zhao, T. Y., Xiao, L. H., Wang, W. W., Zheng, X., Liu, F. G., Gao, G.,Chen, Y. X.*, Modifying Fe₃O₄-functionalozed nanoparticles with N-halamine and their magnetic/antibacterial properties,Appl. Mater. Interfaces2011,3, 4228-4235

19. Dong, A., Lan, S., Huang, J. F., Wang, T., Zhao, T. Y., Wang, W. W., Xiao, L. H., Zheng, X., Liu, F. G., Gao, G.,Chen, Y. X.*, Preparation of magnetically separableN-halamine nanocomposites for the improved antibacterial application,J. Colloid Interf. Sci.2011,364, 333-340

20. Dong, A., Huang, J. F., Lan, S., Wang, T., Xiao, L. H., Wang, W. W., Zhao, T. Y., Zheng, L., Liu, F. Q., Gao, G.,Chen, Y. X.*, Synthesis ofN-halamine-functionalized silicau2013polymer coreu2013shell nanoparticles and their enhanced antibacterial activity,Nanotechnology2011,22, 295602

21. Huang, J. F., Hao, D. M., Chen, Y., Xu, Y. M., Tan, J. J., Huang, Y. B., Li, F.,Chen, Y. X.*, Inhibitory effects and mechanisms of physiological conditions on the activity of enantiomeric forms of an α-helical antibacterial peptide against bacteria,Peptides2011,32,1488-1495

22. Huang, Y. B., Wang, X. F., Wang, H. Y., Liu, Y.,Chen, Y. X.*, Studies on mechanism of action of anticancer peptides by modulation of hydrophobicity within a defined structural framework,Mol. Cancer Ther.2011,10，416-426

23. Huang, J. F., Xu, Y. M., Hao, D. M., Huang, Y. B.,Chen, Y. X.*, A feasible method for designing of alpha-helical antimicrobial peptide with enhanced specificity,J. Nanjing Univ. (Natural Sciences), 2010,46, 133-137

24. Huang, Y. B., Huang, J. F.,Chen, Y. X.*, Alpha-Helical Cationic Antimicrobial Peptides: Relationships of Structure and Function,Protein Cell2010,1，143-152

25. Huang, J. F., Xu, Y. M., Hao, D. M., Huang, Y. B., Liu, Y.,Chen, Y. X.*, Structure GuidedDe novoDesign of Alpha-Helical Antimicrobial Peptide with Enhanced Specificity,Pure Appl. Chem.2010,82, 243-257

26.Chen, Y.*De novodesign of a-helical antimicrobial peptides with enhanced therapeutic index,J. Biotechnol.2008,136S, S77

27.Chen, Y., Guarnieri, M. T., Vasil, A. I., Vasil, M. L., Mant, C. T. and Hodges, R. S. The role of peptide hydrophobicity in the mechanism of action of a-helical antimicrobial peptides,Antimicrob. Agents Chemother., 2007,51, 1398-1406

28. Lewis, R. N. A. H., Liu, F., Krivanek, R., Rybar, P., Hianik, T., Flach, C. R., Mendelsohm, R.,Chen, Y., Mant, C. T., Hodges, R. S. and McElhaney, R. N. Studies of the minimum hydrophobicity of a-helical peptides required to maintain a stable transmembrane association with phospholipid bilayer membranesBiochemistry2007,46, 1042-1054

29.Chen, Y., Mant, C. T. and Hodges, R. S. Preparative reversed-phase high-performance liquid chromatography collection efficiency for an antimicrobial peptide on columns of varying diameters (1mm to 9.4mm I.D.)J. Chromatogr. 2007,1140, 112-120

30.Chen, Y., Vasil, A. I., Rehaume, L., Mant, C. T., Burns, J. L., Vasil, M. L., Hancock, R. E. W. and Hodges, R. S. Comparison of biophysical and biological properties of a-helical enantiomeric antimicrobial peptides,Chem. Biol. Drug Des., 2006,67, 162-173

31.Chen, Y., Mant, C. T., Farmer, S., Vasil, M., Hancock, R. E. W. and Hodges, R. S. Rational Design of a-Helical Antimicrobial Peptides with Enhanced Activities and Specificity/Therapeutic Index,J. Biol. Chem., 2005,280, 12316-12329

32. Hodges R. S.,Chen, Y.,Ziemba B., and Guarnieri M. Thede novodesign of antimicrobial peptides with broad spectrum activity and specificity between bacterial and human cell membranes,Biopolymers, 2005,80,544-544

33.Chen, Y., Mehok, A. R., Mant, C. T. and Hodges, R. S. Optimum concentration of trifluoroactic acid (TFA) for reversed-phase chromatography of peptides revisitedJ. Chromatogr. 2004,1043, 9-18

34.Chen, Y., Mant, C. T. and Hodges, R. S. Selectivity differences in the separation of amphipathic a-helical peptides during reversed-phase chromatography at pH 2.0 and pH 7.0: Effects of different packings, mobile phase conditions and temperatureJ. Chromatogr. 2004,1043, 99-111

35. Hodges, R. S.,Chen, Y., Kopecky, E. and Mant, C. T. Monitoring the Hydrophilicity/Hydrophobicity of Amino Acid Side-chains in the Non-polar and Polar Faces of Amphipathic a-Helices by Reversed-Phase and Hydrophilic Interaction/Cation-Exchange ChromatographyJ. Chromatogr. 2004,1043, 161-172

36. Popa, T. V., Mant, C. T.,Chen, Y.and Hodges, R. S. Capillary zone electrophoresis of a-helical diastereomeric peptide pairs with anionic ion-pairing reagentsJ. Chromatogr. 2004,1043, 113-122

37.Chen, Y., Mant, C. T. and Hodges, R. S. Temperature selectivity effects in reversed-phase chromatography due to conformation differences between helical and non-helical peptidesJ. Chromatogr.2003,1010, 45-61

38. Mant, C. T.Chen, Y. and Hodges, R. S. Temperature profiling of polypeptides in reversed-phase chromatography: I. Monitoring of dimerization and unfolding of amphipathic a-helical peptidesJ. Chromatogr.2003,1009, 29-43

39. Hartmann E.,Chen, Y., Mant, C. T., Jungbauer, A. and Hodges, R. S. Comparison of reversed-phase chromatography and hydrophilic interaction/cation-exchange chromatography for the separation of amphipathic a-helical peptides with L- and D-amino acid substitutions in the hydrophilic faceJ. Chromatogr.2003,1009, 61-71

40.Chen, Y.and Hodges, R. S. Effect of secondary structure on selectivity of reversed-phase chromatography for peptide separations at varying temperatures.Biopolymers2003，71，334-334

41.Chen, Y., Mant, C. T. and Hodges, R. S. Determination of stereochemistry stability coefficients of amino acid side-chains in an amphipathic a-helixJ. Peptide Res. 2002,59, 18-33

42.Chen, Y., Zhang, X., Chen, S., You, D., Wu, X., Yang, X. and Guan W. Kinetically controlled syntheses catalyzed by proteases in reverse micelles and separation of precursor dipeptides of RGDEnzyme Microb. Technol. 1999,25, 310-315

43.Chen, Y., Zhang, X., Zheng, K., Chen, S., Wang, Q. and Wu, X. Protease-catalyzed synthesis of precursor dipeptides of RGD with reverse micellesEnzyme Microb. Technol. 1998,23, 243-248

綜述、專著章節(jié)和會(huì)議文章

1. Mant, C. T.,Chen, Y., Yan, Z., Popa, T. V., Kovacs, J. M., Mills, J. B., Tripet, B. P. and Hodges, R. S. HPLC analysis and purification of peptides, In “Peptide Characterization and Application Protocols”Methods in Mol. Biol. Vol. 386 pp3-55 (Ed. G. B. Fields) Humana Press Inc. Totowa, NJ 2007

2.Chen, Y.and Hodges, R. S. Effect of secondary structure on selectivity of reversed-phase chromatography for peptide separations at varying temperatures. In “Peptide Revolution: Genomics, Proteomics and Therapeutics”, Proceedings of the Eighteenth American Peptide Symposium(M. Chorev and T. K. Sawyer, Eds.), Kluwer Academic Publishers pp. 151-152 (2004)

3.Chen, Y., Mant, C. T. and R. S. Hodges. The determination of helix stability coefficients using D-amino acid substitutions in the non-polar face of an amphipathic a-helical model peptide. In “Peptide: The Wave of the Future”, Proceedings of the Second International/Seventeenth American Peptide Symposium(R. A. Houghton and M. Lebl, Eds.), Kluwer Academic Publishers pp. 353-354 (2001)

4. Lee, D. L.,Chen Y., Wagschal, K. C., McHenna, S. A., Harland, B., Mant, C. T. and Hodges, R. S. Effect of D-amino acid substitutions on amphipathic a-helical structure. In “Peptides for the New Millennium”, Proceedings of the Sixteenth American Peptide Symposium(Barany, G. and Fields, G, Eds) Kluwer Academic Publishers pp. 289-290 (1999)

發(fā)明專利：

中國(guó)發(fā)明專利: 止癢組合物及其在制備止癢劑中的應(yīng)用

中國(guó)專利號(hào): 201210568326.5

發(fā)明人:陳育新，陳明俠，李楊，王勇，付強(qiáng)

國(guó)際發(fā)明專利: Antibiotic peptide and preparation method therefor and application therefor

國(guó)際專利號(hào)(PCT): PCT/CN2012/000079

發(fā)明人:Chen, Y.

中國(guó)發(fā)明專利: 一種抗菌肽及其制備方法和應(yīng)用

中國(guó)專利號(hào): 201110095737.2

發(fā)明人:陳育新，陳明俠，黃宜兵，李楊，王勇，曲莉莉，王文仁

中國(guó)發(fā)明專利: 提高多肽固相合成效率的二甲苯溶劑配方及應(yīng)用

中國(guó)專利號(hào): 201010185129.6

發(fā)明人:陳育新，毛世忠，黃宜兵，王笑非，潘玲

美國(guó)發(fā)明專利: Antimicrobial peptides and methods of use

專利號(hào): 60/636,220

發(fā)明人:Chen, Y., Hodges, R. S., Vasil, M., Hancock, R. E. W. and Farmer, S.

國(guó)際發(fā)明專利: Antimicrobial peptides and methods of use

國(guó)際專利號(hào)(PCT): WO 2006/065977 A2

發(fā)明人:Chen, Y., Hodges, R. S., Vasil, M., Hancock, R. E. W. and Farmer, S.

中國(guó)發(fā)明專利: 抗菌肽及其使用方法

中國(guó)專利號(hào): 200580047492.9

發(fā)明人: 羅伯特S. 霍金斯，陳育新，邁克爾 瓦茲，羅伯特 E. W. 漢考克，蘇珊 W. 法莫

會(huì)議：

大會(huì)發(fā)言：

1.Chen, Y.Synergistic anticancer mechanism of α-helical peptides and doxorubicin/epirubicin. Presented at the 13 Chinese International Peptide Symposium, Jul. 2-4, Datong,China2014

2.Chen, Y.Screening and rational design of hepatitis C virus entry inhibitory peptides derived from GB virus A NS5A. Presented at the “CAMPUS ASIA” Pilot Program, Winter Seminar on Life and Material Sciences in Okayama, Jan. 23-24, Okayama, Japan 2014

3.Chen, Y.Role of Hydrophobicity on Mechanism of Action of Anticancer Peptides. Presented at the 12 Chinese International Peptide Symposium, Jul. 26, Shenyang,China2012

4.Chen, Y.Mechanism of Action of a-helical anticancer peptides: apoptosis or necrosis. Presented at the 14th Korean-Chinese Regional Symposium of Biotechnology, Feb. 16-18, Incheon,Korea2012

Yi-bing Huang, li-yan He, Xu Bai*,Yu-xin Chen*. Improving Therapeutic Index of Alpha-Helical Antimicrobial Peptides by Introducing D-Amino Acids. 17International Biophysics congress & 12 Chinese Biophisics Congress. Oct. 30-Nov. 3, 2011, Beijing,ChinaSponsored by Protein & Cell. S27-O4Gui-rong Li, Li-yan He, Yi-bing Huang,Yu-xin Chen*. Modulation of Helicity and Hydrophobicity of Peptides to Improve Anti-HCV/HIV Activities and Specificity. 17 International Biophysics congress & 12 Chinese Biophisics Congress. Oct. 30-Nov. 3, 2011, Beijing,ChinaSponsored by Protein & Cell. S27-O5Chen, Y.Role of Hydrophobicity on Mechanism of Action of Anticancer Peptides. Presented at the BIT Life Sciences’ 4th Annual Protein & Peptide Conference (PepCon 2011), Mar. 23-25, Beijing, China 2011 (大會(huì)發(fā)言及分會(huì)主席)陳育新，抗菌肽的從頭設(shè)計(jì)提高其抗菌特異性，抗菌肽開發(fā)與應(yīng)用技術(shù)研討會(huì)，深圳，2009.12.15-16Chen, Y.De novodesign of a-helical antimicrobial peptides with enhanced therapeutic index. Presented at the 13 International Biotechnology Symposium and Exhibition, Oct 12-17, Dalian,China2008Chen, Y.Rational Design of a-Helical Antimicrobial Peptide with Enhanced Activities and Specificity. Presented at the 11 Chinese-Korean Regional Symposium on Biotechnology, Dalian,China2007Chen, Y.Role of Peptide Hydrophobicity in the Mechanism of Action of
a-Helical Antimicrobial Peptides. The 6th Symposium on Frontiers in Protein Chemistry and Biotechnology, Changchun,China2007Chen, Y.Role of Peptide Hydrophobicity in the Mechanism of Action of
a-Helical Antimicrobial Peptides. International Symposium on Channelopathy and New Strategies of Drug Discovery，October 29 u2013 30, 2007, Changchun, China

大會(huì)墻報(bào)：

1.Huang, Y.B., Chen, Y.Synergistic anticancer activity and mechanism of a-helical peptides and doxorubicin/epirubicin. Presented at the 13 Chinese International Peptide Symposium, Jul. 2-4, Datong,China2014

Yi-bing Huang, li-yan He, Xu Bai*,Yu-xin Chen*. Effect of Helicity of α-Helical Anticancer Peptides on Biological Activities, 17 International Biophysics congress & 12 Chinese Biophisics Congress. Beijing,China, 2011, Sponsored by Protein & Cell. P27-6Jin-feng Huang, Yu-ping Shan, Juan-juan Tan, Gui Gao, Hong-da Wang andYu-xin Chen. Force Events of Single Molecular Anticancer Peptide Interacting with HeLa Cell Membrane Recorded by Atomic Force Microscope. 17 International Biophysics congress & 12 Chinese Biophisics Congress. Beijing,China, 2011, Sponsored by Protein & Cell. P25-21Xuan-thanh Mai, Juan-juan Tan, Nai-cui Zhai, Li-yan He,Yu-xin Chen*Effects of Secondary Structure on the Antimicrobial Activity and Specificity of Antimicrobial Peptides. 17 International Biophysics congress & 12 Chinese Biophisics Congress. Beijing,China, 2011, Sponsored by Protein & Cell. P 6-3Nai-cui Zhai, Yi-bing Huang, andYu-xin Chen*.Role of Net Charge on the Biological Activities of Alpha-Helical Anticancer Peptides. 17 International Biophysics congress & 12 Chinese Biophisics Congress. Beijing,China, 2011, Sponsored by Protein & Cell. P 6-2Juan-juan Tan, Jin-feng Huang, Yi-bing Huang ,Yu-xin Chen*. The Effects of Single Amino Acid Substitution on the Biophysical and Biological Properties of an Amphipathic α-Helical Antibacterial Peptide. 17 International Biophysics congress & 12 Chinese Biophisics Congress. Beijing,China, 2011, Sponsored by Protein & Cell. P27-7Chen, Y., Guarnieri, M. T., Vasil, A. I., Vasil, M. L., Mant, C. T. and Hodges, R. S. (2006) The role of peptide hydrophobicity in the mechanism of action of a-helical antimicrobial peptides. Presented at the Gordon Research Conference, Chemistry and Biology of Peptides, Ventura, CAHodges R. S.,Chen, Y.,Ziemba B., and Guarnieri M. (2005) The rational design of a-helical antimicrobial peptides. Presented at the Nineteenth American Peptide Symposium, San Diego, CAChen Y. and Hodges, R. S. (2004) Rational design of a-helical antimicrobial peptides with improved specificity. Presented at the Eighth Chinese International Peptide Symposium, Kunming,ChinaChen, Y., Mant, C. T. and Hodges, R. S. (2003) Effect of column packing, mobile phase conditions and temperature on reversed-phase chromatography of amphipathic alpha-helical peptides at pH 2.0 and pH 7.0. Presented at the twenty-third International Symposium on the Separation of Proteins, Peptides and Polynucleotides, Delray Beach, FloridaChen, Y., Mehok, A. R., Mant, C. T. and Hodges, R. S. (2003) Trifluoroacetic acid revisited for reserved-phase chromatography of peptides. Presented at the twenty-third International Symposium on the Separation of Proteins, Peptides and Polynucleotides, Delray Beach, FloridaChen, Y. and Hodges, R. S. (2003) Effect of secondary structure on selectivity of reversed-phase chromatography for peptide separations at varying temperatures. Presented at the Eighteenth American Peptide Symposium, Boston, MAChen, Y., Hartmann, E. Mant C. T. and Hodges, R. S. (2002) Monitoring the hydrophilicity/ hydrophobicity of amino acid side-chains in the non-polar and polar faces of amphipathic a-helices by reversed-phase and mixed-mode hydrophilic interaction/ cation-exchange chromatography. Presented at the twenty-second International Symposium on the Separation of Proteins, Peptides and Polynucleotides, Heidelberg,GermanyChen, Y., Mant C. T. and Hodges, R. S. (2001) The determination of helix stability coefficients using D-amino acid substitutions in the non-polar face of an amphipathic a-helical model peptide. Presented at the Second International/Seventeenth American Peptide Symposium, San Diego, CAChen, Y., Lee, D. L., Mant, C. T. and Hodges, R. S. (2000) Monitoring the effect of D-amino acids on the structure of amphipathic a-helical peptides by reversed-phase chromatography. Presented at the nineteenth International Symposium on the Separation of Proteins, Peptides and Polynucleotides, Delray Beach, FloridaLee, D. L.,Chen Y., Wagschal, K. C., McHenna, S. A., Harland, B., Mant, C. T. and Hodges, R. S. (1999) Effect of D-amino acid substitutions on amphipathic a-helical structure. Presented at the Sixteenth American Peptide Symposium, Minneapolis, Minnesota