蒲雪梅, 女，理學(xué)博士，四川大學(xué)教授，博士生導(dǎo)師，四川省學(xué)術(shù)和技術(shù)帶頭人后備人選。1987-1991年在四川理工學(xué)院獲得工業(yè)分析學(xué)士學(xué)位，1991-1995年在中國(guó)天府可樂集團(tuán)公司工作，1995-1998年獲得四川大學(xué)分析化學(xué)專業(yè)碩士學(xué)位，2000-2004年獲得四川大學(xué)物理化學(xué)專業(yè)博士學(xué)位，2002-2003年在香港浸會(huì)大學(xué)作訪問學(xué)者。1998年至今在四川大學(xué)化學(xué)學(xué)院工作。

蛋白質(zhì)結(jié)構(gòu)與功能的理論研究及計(jì)算機(jī)輔助藥物設(shè)計(jì)

光電材料功能化合物的分子設(shè)計(jì)與結(jié)構(gòu)性能的研究

高能物質(zhì)結(jié)構(gòu)性能的研究及波譜解析

科研工作：利用多學(xué)科交叉技術(shù)在蛋白質(zhì)和功能材料領(lǐng)域的復(fù)雜體系和復(fù)雜數(shù)據(jù)的快速準(zhǔn)確解析方面開展了一系列的研究工作，所建立的計(jì)算和實(shí)驗(yàn)相結(jié)合的一些計(jì)算機(jī)輔助分析和設(shè)計(jì)系統(tǒng)已在相關(guān)單位和研究所得到實(shí)際應(yīng)用和推廣。近五年作為負(fù)責(zé)人主持了三項(xiàng)國(guó)家自然科學(xué)基金和兩項(xiàng)四川省科技項(xiàng)目，發(fā)表了五十余篇SCI論文，獲得一項(xiàng)國(guó)家計(jì)算機(jī)軟件著作權(quán)，并申請(qǐng)了兩項(xiàng)專利，第十一批四川省學(xué)術(shù)和技術(shù)帶頭人后備人選。

教學(xué)工作：承擔(dān)本科生 "分析化學(xué)"和"儀器分析"的教學(xué)任務(wù)，是四川省精品課程《大學(xué)化學(xué)實(shí)驗(yàn)》和《分析化學(xué)》的第一主講教師，主持了七項(xiàng)校級(jí)教改項(xiàng)目，并參加了多項(xiàng)省部級(jí)教改項(xiàng)目。近五年發(fā)表教改論文十余篇，主編出版了兩本教材(四川省十二五規(guī)劃教材和四川大學(xué)優(yōu)秀教材)，獲得了四川省教學(xué)成果三等獎(jiǎng)和四川大學(xué)校級(jí)教學(xué)成果一等獎(jiǎng)各一項(xiàng)，榮獲四川大學(xué)優(yōu)秀教師，唐立新教學(xué)名師，青年骨干教師的稱號(hào)。

1. 2013-2016，一些重要A族G蛋白偶聯(lián)受體激活機(jī)制及其配體影響作用的理論研究，國(guó)家自然科學(xué)基金，項(xiàng)目負(fù)責(zé)人

2. 2013-2015，基于PBX 炸藥波譜結(jié)構(gòu)解析的化學(xué)計(jì)量學(xué)方法研究，國(guó)家自然科學(xué)基金，項(xiàng)目負(fù)責(zé)人

3. 2010-2012. 水量調(diào)控有機(jī)相絲氨酸蛋白酶催化活性分子機(jī)制的理論研究，國(guó)家自然科學(xué)基金，項(xiàng)目負(fù)責(zé)人

4. 2015-2016，炸藥快速識(shí)別和測(cè)定的新方法及計(jì)算機(jī)專家智能系統(tǒng)的構(gòu)建，四川省科技支撐項(xiàng)目，項(xiàng)目負(fù)責(zé)人

5. 2011-2013. 非水相蛋白酶在手性藥物拆分中催化性能的分子機(jī)制研究，四川省國(guó)際合作項(xiàng)目，項(xiàng)目負(fù)責(zé)人

1. 陳華，蒲雪梅主編，大學(xué)化學(xué)實(shí)驗(yàn)，化學(xué)工業(yè)出版社，2010

2. 李夢(mèng)龍，蒲雪梅主編，分析化學(xué)數(shù)據(jù)速查手冊(cè)，化學(xué)工業(yè)出版社，2009

代表性成果（獲獎(jiǎng)成果、專著、論文、專利）

1. Liyun Zhang, Xiuchan Xiao, Yuan Yuan, Yanzhi Guo, Menglong Li, Xuemei Pu,* Probing Immobilization Mechanism of alpha-chymotrypsin onto Carbon Nanotube in Organic Media by Molecular Dynamics Simulation, Sci. Rep., 2015, 5: 9297

2. Xiuchan Xiao, Xiaojun Zeng, Yuan Yuan, Nan Gao, Yanzhi Guo, Xuemei Pu*, Menglong Li*, Understanding the conformation transition in the activation pathway of β2 adrenergic Receptor via Target Molecular Dynamics Simulation. Phys. Chem. Chem. Phys. 2015, 17, 2512 u2013 2522

3. Yunqing Chen, Yi Wang, Yuan Yuan, Yan Jiao, Xuemei Pu,* and Zhiyun Lu,* Deactivation Mechanism of a Novel AIE-active Naphthalimide Derivative in More Polar Solutions. Phys. Chem. Chem. Phys., 2015, 17, 1309 u2013 1316

4. Tao Lu, Yuan Yuan, Xuan He, Menglong Li, Xuemei Pu*, Tao Xu*, Zhining Wen, Simultaneous determination of multicomponent in explosives using ultraviolet spectrophotometry and partial least square method, RSC adv., 2015, 5, 13021 u2013 13027

5. Jian Hu, Qian Luo, Zhanyuan Zhang, Yan Huang*, Daobin Yang, Xuemei Pu* and Zhiyun Lu*, Self-assembled nanopillar arrays by simple spin coating from blending systems comprising PC61BM and conjugated polymers with special structure, RSC Adv., 2014,4, 24316-24319

6. Yanyan Zhu, Yuan Yuan, Xiuchan Xiao, Liyun Zhang, Yanzhi Guo, Xuemei Pu*, Understanding effects of D130N mutation on constitutive activation of β2 adrenergic receptor and drug binding via Molecular Dynamics Simulation, J. Mol. Model, 2014, 20, 2491

7. Dongbing Zhao, Gaocan Li, Di Wu, Xurong Qin, Patrik Neuhaus, Yangyang Cheng, Shuaijun Yang, Zhiyun Lu, Xuemei Pu, Chao Long, and Jingsong You,* Regiospecific N-Heteroarylation of Amidines for Full-Color-Tunable Boron Difluoride Dyes with Mechanochromic Luminescence, Angew. Chem. 2013, 125, 13921 u201313925

8. Xue Tian, Lin Jiang, Yuan Yuan, Minqi Wang, Yanzhi Guo, Xiaojun Zeng, Menglong Li, Xuemei Pu*, Effects of water content on the tetrahedral intermediate of chymotrypsin -rifluoromethylketone in polar and non-polar media: observations from molecular dynamics simulation, J. Mol. Model, 2013, 19, 2025-2038

9. Yanyan Meng, Yuan Yuan, Yanyan Zhu, Yanzhi Guo, Menglong Li, Zhimeng Wang, Xuemei Pu,* Lin Jiang,* Effects of organic solvents and substrate binding on trypsin in acetonitrile and hexane media, J. Mol. Model, 2013, 19, 3749-3766

10. Wei Yang, Li-yun Zhang, Meng-long Li, Xue-mei Pu*, Nan-rong Zhao*, Effects of Non-specific and Specific Solvation on Adsorption of BPTI on Au Surface: Insight from Molecular Dynamics Simulation, Chinese Journal of Chemical Physics, 2013, 26, 558-568

11. Xiaojiao Yang, Yanzhi Guo*, Jiesi Luo,Xuemei Pu, Menglong Li, Effective Identification of Gram-Negative Bacterial Type III Secreted Effectors Using Position-Specific Residue Conservation Profiles, Plos One, 2013, 8:e84439

12. Lijuan Zhu, Wei Yang, YanYan Meng, Yanzhi Gao, Xuemei Pu*, Menglong Li, Effects of organic solvent and the crystal water on γ-chymotrypsin in acetonitrile media: observations from molecular dynamics simulation and DFT calculation, J. Phys .Chem. B, 2012, 116, 3292-3304

13. Xiuchan Xiao, Ying Tan, Lijuan Zhu, Yanzhi Guo, Zhining Wen, Menglong Li,Xuemei Pu*, Anmin Tian, Effects of the position and manner of hydration on the stability of solvated N-methylacetamides and the strength of binding between N-methylacetamide and water clusters: a computational study, J. Mol. Model, 2012, 138, 1389-1399

14. Ming Li, Hui Zeng, Yanyan Meng, Huiqin Sun, Song Liu, Zhiyun Lu, Yan Huanga, Xuemei Pu*, Fine tuning of emission color of iridium(III) complexes from yellow to red via substituent effect on 2-phenylbenzothiazole ligands: synthesis, photophysical,electrochemical and DFT study, Dalton Trans., 2011, 40, 7153-7164

15. Ying Tan, Lijuan Zhu, Xiuchan Xiao， Yanzhi Guo, Menglong Li, Anmin Tian, Xuemei Pu,*, A Comparative study of Meta/Para Substitution effects on the Hydrogen-Bonded Complex of Aniline-H2O：Observations from Computation, J.Theor.Comput. Chem.,2011, 10, 567-579