基本信息
學(xué) 歷： 博士
通訊地址： 云南省昆明市教場(chǎng)東路32號(hào)中國(guó)科學(xué)院昆明動(dòng)物研究所馬普青年科學(xué)家小組
簡(jiǎn)歷
2004至今 昆明動(dòng)物研究所,研究員,馬普青年科學(xué)家小組組長(zhǎng)
1998—2003 德國(guó)癌癥中心,博士后
山東大學(xué),獲博士學(xué)位
山東大學(xué),獲學(xué)士學(xué)位
研究方向
主要以非洲爪蛙和小鼠為模式動(dòng)物，研究脊椎動(dòng)物神經(jīng)系統(tǒng)發(fā)育的分子機(jī)制。實(shí)驗(yàn)室主要采用分子生物學(xué)、胚胎學(xué)等技術(shù)，側(cè)重研究神經(jīng)系統(tǒng)早期發(fā)育中圖式形成和神經(jīng)嵴發(fā)育的分子機(jī)制，以期為預(yù)防和治療人類神經(jīng)系統(tǒng)發(fā)育相關(guān)疾病提供理論依據(jù)。同時(shí)，以脊椎動(dòng)物的祖先類型—文昌魚(yú)為模型，開(kāi)展過(guò)對(duì)其神經(jīng)發(fā)育機(jī)制的比較研究，以揭示神經(jīng)系統(tǒng)發(fā)育機(jī)制的演化過(guò)程。
科研項(xiàng)目
1.國(guó)家自然科學(xué)基金面上項(xiàng)目， Akirin在非洲爪蛙神經(jīng)發(fā)育中的功能與作用機(jī)制(2012?2015)
2. 國(guó)家自然科學(xué)基金面上項(xiàng)目，EphA7在腎小管發(fā)生中的功能與作用機(jī)制研究 （2013?2016）
3. 中國(guó)科學(xué)院重點(diǎn)部署項(xiàng)目，脊椎動(dòng)物第四胚層發(fā)育的調(diào)控（2013?2015）
4. NSFC-云南聯(lián)合基金重點(diǎn)支持項(xiàng)目， 基于Hedgehog信號(hào)通路和纖毛形成的抗腫瘤化合物的發(fā)現(xiàn)與機(jī)制研究（2014?2017）
專家類別
杰出青年;百人計(jì)劃;研究員
代表論著
1. Ma P, Xia Y, Ma L, Zhao S, Mao B. 2013. Xenopus Nkx6.1 and Nkx6.2 are required for mid-hindbrain boundary development. Dev Genes Evol
2. Chen Y, Ding Y, Zhang Z, Wang W, Chen J, Naoto Ueno, Mao B. 2011. Evolution of vertebrate central nervous system is accompanied by novel expression changes of duplicate genes. J Genet Genomics
3. Li J, Shi Y, Sun J, Zhang Y, Mao B. 2011. Xenopus reduced folate carrier regulates neural crest development epigenetically, PLoS ONE
4. Ma P, Zhao S, Zeng W, Yang Q, Li C, Lv X, Zhou Q, Mao B. 2011. Xenopus Dbx2 is involved in primary neurogenesis and early neural plate patterning. Biochem Biophys Res Commun
5. Zhang Y, Mao B. 2010. Embryonic expression and evolutionary analysis of the amphioxus Dickkopf and Kremen family genes. J Genet Genomics
6. Zeng W, Kong Q, Li C, Mao B. 2010. Xenopus RCOR2 (REST corepressor 2) interacts with ZMYND8, which is involved in neural differentiation. Biochem Biophy Res Comm
7. Kong Q, Zeng W, Wu J, Hu W, Li C, Mao B. 2010. RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination，Biochem. Biophy Res Comm
8. Wu J, Li C, Zhao S, Mao B. 2010. Differential expression of the Brunol/CELF family genes during Xenopus laevis early development. Int J Dev
9. Shi Y, Zhao S, Li J, Mao B. 2009. Islet-1 is required for ventral neuron survival in Xenopus. Biochem. Biophys. Res Commun
10. Ma L, Pan XF, Wei YH, Li ZY, Li CC, Yang JX, Mao BY. 2008. Embryonic stages and eye specific gene expression of the local cyprinoid fish Anabarilius grahami in Fuxian Lake, China. J Fish Biol
11. Zhao S, Jiang H, Wang W, Mao B. 2007. Cloning and developmental expression of the Xenopus Nkx6 genes. Dev Genes Evol,
12. Mao B and Niehrs C. 2003. Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. Gene,
13. Mao B, Wu W, Davidson G, Marhold J, Li M, Mechler BM, Delius H, Hoppe D, Stannek P, Walter C, Glinka A, Niehrs C. 2002. Kremen proteins are Dickkopf receptors that regulate Wnt/beta- catenin signalling. Nature,
14. Davidson G, Mao B, Del Barco Barrantes I, Niehrs C. 2002. Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning. Development
15. Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C. 2001. LDL- receptor-related protein 6 is a receptor for Dickkopf proteins. Nature