個(gè)人經(jīng)歷
王侃侃，博士生導(dǎo)師，研究員。2002年回國后加入上海交通大學(xué)醫(yī)學(xué)院附屬瑞金醫(yī)院醫(yī)學(xué)基因組學(xué)國家重點(diǎn)實(shí)驗(yàn)室，擔(dān)任課題組組長，主要研究方向是應(yīng)用系統(tǒng)生物學(xué)理念和方法研究白血病發(fā)生及治療的分子機(jī)制，研究成果發(fā)表在Cancer Cell、Blood、PNAS、Oncogene、Cancer Research等國際知名刊物上。近年來，承擔(dān)863、973和國家自然基金、上海市科委國際合作等多項(xiàng)國家級和省部級課題，并先后獲得上海市科技啟明星計(jì)劃、啟明星跟蹤計(jì)劃、教育部新世紀(jì)優(yōu)秀人才計(jì)劃、上海市曙光計(jì)劃、明治乳業(yè)杰出獎(jiǎng)等人才基金的資助。近年來的科研成果獲得中華醫(yī)學(xué)科技獎(jiǎng)二等獎(jiǎng)、上海市科技進(jìn)步一等獎(jiǎng)、教育部科技進(jìn)步一等獎(jiǎng)等。
研究方向
白血病發(fā)生機(jī)制的研究
代表性論著
1.Wang K, Wang P, Shi J, Zhu X, He M, Jia X, Yang X, Qiu F, Jin W, Qian M, Fang H, Mi J, Yang X, Xiao H, Mark Minden, Du Y, Chen Z, and Zhang J. PML/RAR Targets Promoter Regions Containing PU.1 Consensus and RARE Half Sites in Acute Promyelocytic Leukemia. Cancer Cell 2010, 17, 186-197
2.Yan J, Wang K, Dong L, Liu H, Chen W, Xi W, Ding Q, Kieffer N, Caen J, Chen S, Chen Z and Xi X. PML/RARα fusion protein transactivates the tissue factor promoter through a GAGC-containing element without direct DNA association. PNAS 2010, 107:3716-3721
3.Wang K, Fang H, Xiao D, Zhu X, He M, Pan X, Shi J, Zhang H, Jia X, Du Y and Zhang J. Converting Redox Signaling to Apoptotic Activities by Stress-Responsive Regulators HSF1 and NRF2 in Fenretinide Treated Cancer Cells. PLoS One 2009, 4, e7538
4.Fang H, Zhang J and Wang K. Connecting biological themes using a single human network of gene associations. IEEE Computer Society IJCBS 2009, 463-471
5.Luo R, Wei H, Ye L, Wang K, Chen F, Luo L, Liu L, Li Y, Crabbe MJ, Jin L, Li Y, and Zhong Y. Photosynthetic metabolism of C3 plants shows highly cooperative regulation under changing environments: a systems biological analysis. PNAS 2009, 106(3):847-852.
6.Fang H, Wang K, Zhang J. Transcriptome and proteome analyses of drug interactions with natural products. Current Drug Metabolism 2008, 9(10):1037-1047
7.Du Y, Wang K, Fang H, Li J, Xiao D, Zheng P, Chen Y, Pan X, Fan H, Zhao C, Zhang Q, Auffray C, Chen S, Chen Z and Zhang J. Coordination of Intrinsic, Extrinsic and Endoplasmic Reticulum- Mediated Apoptosis by Imatinib Mesylate Combined with Arsenic Trioxide in Chronic Myeloid Leukemia. Blood 2006, 107 (4) :1582-1590
8.Zheng P, Wang K, Zhang Q, Huang Q, Du Y, Zhang Q, Xiao D, Shen S, Imbeaud S, Eveno E, Zhao CJ, Chen YL, Fan HY, Waxman S, Auffray C, Jin G, Chen SJ, Chen Z and Zhang J. Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. PNAS 2005, 102:7653-7658
